Advances in Chemical Proteomics provides essential concepts and recent applications on probes, tool compounds and concepts for chemical proteomics and then moves on to applications, including solid-phase reagents, fragment screening, designer compounds and protein lipidation. As the second volume in the Developments in Organic Chemistry series, each chapter is written by experts in the field. Users will find this to be a valuable reference for organic chemists and chemical biologists who are interested in developing tool compounds and reagents to measure and interrogate proteome, develop drug leads, and measure off-target effects and drug toxicity.
Analytical chemists who are interested in better understanding organic chemistry behind commonly used reagents for quantitative proteomics and tools compounds in the emerging field of chemical proteomics will also benefit from this comprehensive resource on the topics presented.
1. Chapter 1 : Introduction to proteomics for chemical biology - p. Page viii 2. Chapter 2 : Warheads for designing covalent inhibitors and chemical probes - p. Page 38 3. Chapter 3 : Chemical derivatization of peptides for quantitative proteomics - p. Page 66 4. Chapter 4 : Open search algorithms discover patterns of chemical modifications via LC-MS/MS - p. Page 91 5. Chapter 5 : Utility of chemical probes for mass spectrometry based chemical proteomics - p. Page 122 6. Chapter 6 : Chemical proteomics of reactive molecules - p. Page 151 7. Chapter 7 : Mass spectrometry for human kinome analysis - p. Page 185 8. Chapter 8 : Recent progress of subcellular-compartment-focused chemical proteomics - p. Page 210 9. Index - p. Page 241
Advances in Chemical Proteomics provides essential concepts and recent applications on probes, tool compounds and concepts for chemical proteomics and then moves on to applications, including solid-phase reagents, fragment screening, designer compounds and protein lipidation. As the second volume in the Developments in Organic Chemistry series, each chapter is written by experts in the field. Users will find this to be a valuable reference for organic chemists and chemical biologists who are interested in developing tool compounds and reagents to measure and interrogate proteome, develop drug leads, and measure off-target effects and drug toxicity.
Analytical chemists who are interested in better understanding organic chemistry behind commonly used reagents for quantitative proteomics and tools compounds in the emerging field of chemical proteomics will also benefit from this comprehensive resource on the topics presented.
1. Chapter 1 : Introduction to proteomics for chemical biology - p. Page viii 2. Chapter 2 : Warheads for designing covalent inhibitors and chemical probes - p. Page 38 3. Chapter 3 : Chemical derivatization of peptides for quantitative proteomics - p. Page 66 4. Chapter 4 : Open search algorithms discover patterns of chemical modifications via LC-MS/MS - p. Page 91 5. Chapter 5 : Utility of chemical probes for mass spectrometry based chemical proteomics - p. Page 122 6. Chapter 6 : Chemical proteomics of reactive molecules - p. Page 151 7. Chapter 7 : Mass spectrometry for human kinome analysis - p. Page 185 8. Chapter 8 : Recent progress of subcellular-compartment-focused chemical proteomics - p. Page 210 9. Index - p. Page 241
