ATP: From Neurotransmission to Cancer Therapy delivers a comprehensive discussion of extracellular ATP biology and its communication role in both homeostasis and pathologic states. It explores the function of ATP across the nervous, sensory, musculoskeletal, cutaneous cardiovascular, pulmonary, gastrointestinal, urinary, reproductive, exocrine, haematopoietic and immune systems. The book considers ATP in the context of various disease states, including cardiovascular, respiratory, psychiatric, inflammatory and neurodegenerative disorders, as well as pain and sensory disorders, infectious diseases, and cancer. ATP in humans is explored alongside other species, including rodents, fish, and plants. This is the latest volume in the Molecular Mediators in Health and Disease series. With contributions from specialists across pharmacology, physiology, biophysics, biochemistry, immunology, anatomy, molecular biology, therapeutics, and other critical fields, this volume provides a broad and detailed overview of ATP which will be helpful to researchers working in these areas and beyond.
1. Part I: Introduction to extracellular ATP - p. P1 2. Chapter 1. History of ATP and purinergic signaling - p. 3 3. Chapter 2. Extracellular ATP in normal biology - p. 27 4. Part II: Molecular biology of extracellular ATP signalling - p. P38 5. Chapter 3. Release of ATP into the extracellular space - p. 39 6. Chapter 4. P2X receptors - p. 55 7. Chapter 5. Extracellular ATP and P2X receptors - p. 79 8. Chapter 6. Human P2Y receptor subtypes - p. 105 9. Chapter 7. Pharmacology of P2Y receptors: mechanisms, ligands, and therapeutic applications - p. 127 10. Chapter 8. Nucleoside triphosphate diphosphohydrolases in extracellular nucleotide regulation: activity, structural insights, and pathophysiological implications - p. 149 11. Part III: Extracellular ATP in organ function - p. P182 12. Chapter 9. Extracellular ATP and the central nervous system - p. 183 13. Chapter 10. Extracellular ATP and the peripheral nervous system - p. 205 14. Chapter 11. The contribution of extracellular ATP to retinal function and potentiating retinal degenerations - p. 223 15. Chapter 12. Extracellular ATP and hearing - p. 243 16. Chapter 13. Extracellular ATP and the normal respiratory system - p. 275 17. Chapter 14. Extracellular ATP and blood vessels - p. 309 18. Chapter 15. Extracellular ATP and its receptors in the oral cavity - p. 361 19. Chapter 16. Extracellular ATP signaling in the gastrointestinal tract - p. 389 20. Chapter 17. Extracellular ATP and the liver - p. 437 21. Chapter 18. Extracellular ATP and the pancreas - p. 453 22. Chapter 19. Extracellular ATP and the kidneys - p. 471 23. Chapter 20. Extracellular ATP and the bladder - p. 487 24. Chapter 21. Extracellular ATP and the reproductive organs - p. 507 25. Chapter 22. Extracellular ATP and the bone - p. 521 26. Chapter 23. Extracellular ATP and skeletal muscle - p. 545 27. Chapter 24. Extracellular ATP in the skin: the role of purinergic signaling in cutaneous homeostasis balance and imbalance - p. 557 28. Chapter 25. Extracellular and intracellular ATP regulate hematopoietic stem/progenitor cells - p. 573 29. Chapter 26. Extracellular ATP and ADP and platelet function in hemostasis, thrombosis, and inflammation - p. 589 30. Chapter 27. ATP release and purinergic signaling in erythrocytes - p. 609 31. Chapter 28. Extracellular ATP and innate immune cells - p. 627 32. Chapter 29. Extracellular ATP and adaptive immunity - p. 647 33. Part IV: Extracellular ATP in non-mammalian biology - p. P668 34. Chapter 30. Extracellular ATP in unicellular microorganisms - p. 669 35. Chapter 31. Extracellular ATP in plants: discovery, mechanisms, and integration - p. 693 36. Chapter 32. Extracellular ATP in fish - p. 717 37. Part V: Extracellular ATP in Disease - p. P732 38. Chapter 33. Extracellular ATP in brain diseases - p. 733 39. Chapter 34. Extracellular ATP in neurodegenerative disorders - p. 755 40. Chapter 35. Extracellular ATP in psychiatric disorders - p. 777 41. Chapter 36. Extracellular ATP in pain - p. 805 42. Chapter 37. Extracellular ATP in sensory disorders with a focus on protective purinergic hearing adaptation - p. 823 43. Chapter 38. ATP and its P2 receptors in pulmonary disorders - p. 837 44. Chapter 39. Extracellular ATP signaling in gastrointestinal disorders - p. 847 45. Chapter 40. The ATP-gated P2X7 receptor in infectious diseases - p. 887 46. Chapter 41. Extracellular ATP in inflammatory disorders - p. 917 47. Chapter 42. Extracellular ATP in cancer - p. 937 48. Index - p. 953
ATP: From Neurotransmission to Cancer Therapy delivers a comprehensive discussion of extracellular ATP biology and its communication role in both homeostasis and pathologic states. It explores the function of ATP across the nervous, sensory, musculoskeletal, cutaneous cardiovascular, pulmonary, gastrointestinal, urinary, reproductive, exocrine, haematopoietic and immune systems. The book considers ATP in the context of various disease states, including cardiovascular, respiratory, psychiatric, inflammatory and neurodegenerative disorders, as well as pain and sensory disorders, infectious diseases, and cancer. ATP in humans is explored alongside other species, including rodents, fish, and plants. This is the latest volume in the Molecular Mediators in Health and Disease series. With contributions from specialists across pharmacology, physiology, biophysics, biochemistry, immunology, anatomy, molecular biology, therapeutics, and other critical fields, this volume provides a broad and detailed overview of ATP which will be helpful to researchers working in these areas and beyond.
1. Part I: Introduction to extracellular ATP - p. P1 2. Chapter 1. History of ATP and purinergic signaling - p. 3 3. Chapter 2. Extracellular ATP in normal biology - p. 27 4. Part II: Molecular biology of extracellular ATP signalling - p. P38 5. Chapter 3. Release of ATP into the extracellular space - p. 39 6. Chapter 4. P2X receptors - p. 55 7. Chapter 5. Extracellular ATP and P2X receptors - p. 79 8. Chapter 6. Human P2Y receptor subtypes - p. 105 9. Chapter 7. Pharmacology of P2Y receptors: mechanisms, ligands, and therapeutic applications - p. 127 10. Chapter 8. Nucleoside triphosphate diphosphohydrolases in extracellular nucleotide regulation: activity, structural insights, and pathophysiological implications - p. 149 11. Part III: Extracellular ATP in organ function - p. P182 12. Chapter 9. Extracellular ATP and the central nervous system - p. 183 13. Chapter 10. Extracellular ATP and the peripheral nervous system - p. 205 14. Chapter 11. The contribution of extracellular ATP to retinal function and potentiating retinal degenerations - p. 223 15. Chapter 12. Extracellular ATP and hearing - p. 243 16. Chapter 13. Extracellular ATP and the normal respiratory system - p. 275 17. Chapter 14. Extracellular ATP and blood vessels - p. 309 18. Chapter 15. Extracellular ATP and its receptors in the oral cavity - p. 361 19. Chapter 16. Extracellular ATP signaling in the gastrointestinal tract - p. 389 20. Chapter 17. Extracellular ATP and the liver - p. 437 21. Chapter 18. Extracellular ATP and the pancreas - p. 453 22. Chapter 19. Extracellular ATP and the kidneys - p. 471 23. Chapter 20. Extracellular ATP and the bladder - p. 487 24. Chapter 21. Extracellular ATP and the reproductive organs - p. 507 25. Chapter 22. Extracellular ATP and the bone - p. 521 26. Chapter 23. Extracellular ATP and skeletal muscle - p. 545 27. Chapter 24. Extracellular ATP in the skin: the role of purinergic signaling in cutaneous homeostasis balance and imbalance - p. 557 28. Chapter 25. Extracellular and intracellular ATP regulate hematopoietic stem/progenitor cells - p. 573 29. Chapter 26. Extracellular ATP and ADP and platelet function in hemostasis, thrombosis, and inflammation - p. 589 30. Chapter 27. ATP release and purinergic signaling in erythrocytes - p. 609 31. Chapter 28. Extracellular ATP and innate immune cells - p. 627 32. Chapter 29. Extracellular ATP and adaptive immunity - p. 647 33. Part IV: Extracellular ATP in non-mammalian biology - p. P668 34. Chapter 30. Extracellular ATP in unicellular microorganisms - p. 669 35. Chapter 31. Extracellular ATP in plants: discovery, mechanisms, and integration - p. 693 36. Chapter 32. Extracellular ATP in fish - p. 717 37. Part V: Extracellular ATP in Disease - p. P732 38. Chapter 33. Extracellular ATP in brain diseases - p. 733 39. Chapter 34. Extracellular ATP in neurodegenerative disorders - p. 755 40. Chapter 35. Extracellular ATP in psychiatric disorders - p. 777 41. Chapter 36. Extracellular ATP in pain - p. 805 42. Chapter 37. Extracellular ATP in sensory disorders with a focus on protective purinergic hearing adaptation - p. 823 43. Chapter 38. ATP and its P2 receptors in pulmonary disorders - p. 837 44. Chapter 39. Extracellular ATP signaling in gastrointestinal disorders - p. 847 45. Chapter 40. The ATP-gated P2X7 receptor in infectious diseases - p. 887 46. Chapter 41. Extracellular ATP in inflammatory disorders - p. 917 47. Chapter 42. Extracellular ATP in cancer - p. 937 48. Index - p. 953
