Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics is an authoritative and timely resource bringing together the major findings in the field for ease of access to those working in the field or with an interest in metals and their role in brain function, disease, and as therapeutic targets. Chapters cover metals in Alzheimer’s Disease, Parkinson’s Disease, Motor Neuron Disease, Autism and lysosomal storage disorders.
This book is written for academic researchers, clinicians and advanced graduate students studying or treating patients in neurodegeneration, neurochemistry, neurology and neurotoxicology. The scientific literature in this field is advancing rapidly, with approximately 300 publications per year adding to our knowledge of how biometals contribute to neurodegenerative diseases.
Despite this rapid increase in our understanding of biometals in brain disease, the fields of biomedicine and neuroscience have often overlooked this information. The need to bring the research on biometals in neurodegeneration to the forefront of biomedical research is essential in order to understand neurodegenerative disease processes and develop effective therapeutics.
1. Cover - p. i 2. Title page - p. iii 3. Table of Contents - p. iii 4. Copyright - p. ii 5. Contributors - p. iv 6. Preface - p. x 7. Chapter 1: Biometals and Alzheimer’s Disease - p. xiv 8. Chapter 2: Copper in Alzheimer’s Disease - p. 17 9. Chapter 3: The Role of Selenium in Neurodegenerative Diseases - p. 34 10. Chapter 4: Does HFE Genotype Impact Macrophage Phenotype in Disease Process and Therapeutic Response? - p. 49 11. Chapter 5: Chemical Elements and Oxidative Status in Neuroinflammation - p. 66 12. Chapter 6: Metals and Neuroinflammation - p. 81 13. Chapter 7: Metals and Prions: Twenty Years of Mining the Awe - p. 93 14. Chapter 8: Manganese and Neurodegeneration - p. 115 15. Chapter 9: Zinc in Autism - p. 151 16. Chapter 10: Metals and Motor Neuron Disease - p. 173 17. Chapter 11: Metals and Lysosomal Storage Disorders - p. 193 18. Chapter 12: Developmental Exposure to Metals and its Contribution to Age-Related Neurodegeneration - p. 215 19. Chapter 13: Metal Biology Associated with Huntington’s Disease - p. 229 20. Chapter 14: Metal-Binding to Amyloid-β Peptide: Coordination, Aggregation, and Reactive Oxygen Species Production - p. 263 21. Chapter 15: Metals and Mitochondria in Neurodegeneration - p. 281 22. Chapter 16: Metal Transporters in Neurodegeneration - p. 311 23. Chapter 17: Metal Imaging in the Brain - p. 347 24. Chapter 18: Metalloregulation of Protein Clearance: New Therapeutic Avenues for Neurodegenerative Diseases - p. 362 25. Chapter 19: Metals and Autophagy in Neurotoxicity - p. 376 26. Chapter 20: An Overview of Multifunctional Metal Chelators as Potential Treatments for Neurodegenerative Diseases - p. 398 27. Chapter 21: Abnormal Function of Metalloproteins Underlies Most Neurodegenerative Diseases - p. 414 28. Index - p. 438
Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics is an authoritative and timely resource bringing together the major findings in the field for ease of access to those working in the field or with an interest in metals and their role in brain function, disease, and as therapeutic targets. Chapters cover metals in Alzheimer’s Disease, Parkinson’s Disease, Motor Neuron Disease, Autism and lysosomal storage disorders.
This book is written for academic researchers, clinicians and advanced graduate students studying or treating patients in neurodegeneration, neurochemistry, neurology and neurotoxicology. The scientific literature in this field is advancing rapidly, with approximately 300 publications per year adding to our knowledge of how biometals contribute to neurodegenerative diseases.
Despite this rapid increase in our understanding of biometals in brain disease, the fields of biomedicine and neuroscience have often overlooked this information. The need to bring the research on biometals in neurodegeneration to the forefront of biomedical research is essential in order to understand neurodegenerative disease processes and develop effective therapeutics.
1. Cover - p. i 2. Title page - p. iii 3. Table of Contents - p. iii 4. Copyright - p. ii 5. Contributors - p. iv 6. Preface - p. x 7. Chapter 1: Biometals and Alzheimer’s Disease - p. xiv 8. Chapter 2: Copper in Alzheimer’s Disease - p. 17 9. Chapter 3: The Role of Selenium in Neurodegenerative Diseases - p. 34 10. Chapter 4: Does HFE Genotype Impact Macrophage Phenotype in Disease Process and Therapeutic Response? - p. 49 11. Chapter 5: Chemical Elements and Oxidative Status in Neuroinflammation - p. 66 12. Chapter 6: Metals and Neuroinflammation - p. 81 13. Chapter 7: Metals and Prions: Twenty Years of Mining the Awe - p. 93 14. Chapter 8: Manganese and Neurodegeneration - p. 115 15. Chapter 9: Zinc in Autism - p. 151 16. Chapter 10: Metals and Motor Neuron Disease - p. 173 17. Chapter 11: Metals and Lysosomal Storage Disorders - p. 193 18. Chapter 12: Developmental Exposure to Metals and its Contribution to Age-Related Neurodegeneration - p. 215 19. Chapter 13: Metal Biology Associated with Huntington’s Disease - p. 229 20. Chapter 14: Metal-Binding to Amyloid-β Peptide: Coordination, Aggregation, and Reactive Oxygen Species Production - p. 263 21. Chapter 15: Metals and Mitochondria in Neurodegeneration - p. 281 22. Chapter 16: Metal Transporters in Neurodegeneration - p. 311 23. Chapter 17: Metal Imaging in the Brain - p. 347 24. Chapter 18: Metalloregulation of Protein Clearance: New Therapeutic Avenues for Neurodegenerative Diseases - p. 362 25. Chapter 19: Metals and Autophagy in Neurotoxicity - p. 376 26. Chapter 20: An Overview of Multifunctional Metal Chelators as Potential Treatments for Neurodegenerative Diseases - p. 398 27. Chapter 21: Abnormal Function of Metalloproteins Underlies Most Neurodegenerative Diseases - p. 414 28. Index - p. 438
