Cancer Genomics addresses how recent technological advances in genomics are shaping how we diagnose and treat cancer. Built on the historical context of cancer genetics over the past 30 years, the book provides a snapshot of the current issues and state-of-the-art technologies used in cancer genomics. Subsequent chapters highlight how these approaches have informed our understanding of hereditary cancer syndromes and the diagnosis, treatment and outcome in a variety of adult and pediatric solid tumors and hematologic malignancies. The dramatic increase in cancer genomics research and ever-increasing availability of genomic testing are not without significant ethical issues, which are addressed in the context of the return of research results and the legal considerations underlying the commercialization of genomic discoveries. Finally, the book concludes with "Future Directions", examining the next great challenges to face the field of cancer genomics, namely the contribution of non-coding RNAs to disease pathogenesis and the interaction of the human genome with the environment.
1. Part 1: Introduction - p. IV 2. Chapter 1. Historical Perspective and Current Challenges of Cancer Genomics - p. IV 3. Part 2: Genomics Technologies, Concepts and Resources - p. 8 4. Chapter 2. Second-Generation Sequencing for Cancer Genome Analysis - p. 8 5. Chapter 3. Cancer Transcriptome Sequencing and Analysis - p. 27 6. Chapter 4. The Significance of Transcriptome Sequencing in Personalized Cancer Medicine - p. 44 7. Chapter 5. Tissue Microarrays in Studying Gynecological Cancers - p. 61 8. Chapter 6. Cancer Pharmacogenomics in Children - p. 75 9. Chapter 7. Biomarker Discovery and Development through Genomics - p. 88 10. Chapter 8. Preclinical Animal Models for Cancer Genomics - p. 105 11. Chapter 9. Bioinformatics for Cancer Genomics - p. 126 12. Chapter 10. Genomic Resource Projects - p. 148 13. Part 3: Hereditary Cancer Syndromes - p. 170 14. Chapter 11. Genetic Basis of Hereditary Cancer Syndromes - p. 170 15. Part 4: Genomics of Adult and Pediatric Cancers - p. 188 16. 4.1: Adult Solid Tumors - p. 188 17. Chapter 12. Genomics and Molecular Profiling of Lung Cancer - p. 188 18. Chapter 13. Breast Cancer Genomics - p. 207 19. Chapter 14. Prostate Cancer Genomics as a Driver of Personalized Medicine - p. 229 20. Chapter 15. Genomics of Colorectal Cancer - p. 243 21. Chapter 16. Thyroid Cancer - p. 261 22. 4.2: Age Non-Specific Tumors and Hematopoietic Malignancies - p. 277 23. Chapter 17. Acute Myeloid Leukemia - p. 277 24. Chapter 18. Genomics in Multiple Myeloma: From Conventional Cytogenetics to Novel Whole-Genome Sequencing Approaches - p. 294 25. Chapter 19. Brain Tumor Genomics: Sequencing to Clinical Utility - p. 316 26. 4.3: Pediatric Cancers - p. 334 27. Chapter 20. Genomic Basis of Pediatric Lymphomas - p. 334 28. Chapter 21. Neuroblastoma - p. 351 29. Chapter 22. Soft Tissue Sarcomas - p. 372 30. Chapter 23. Wilms Tumors - p. 388 31. Part 5: Ethics of Genomics Research - p. 410 32. Chapter 24. Cancer Genomics and Biobanking: Exploring Key Ethical and Legal Issues - p. 410 33. Part 6: Future Directions - p. 429 34. Chapter 25. The Role of MicroRNAs and Ultraconserved Non-Coding RNAs in Cancer - p. 429 35. Chapter 26. The Impact of the Environment on Cancer Genomics - p. 445 36. Abbreviations - p. 464 37. Glossary - p. 471 38. Index - p. 471
Cancer Genomics addresses how recent technological advances in genomics are shaping how we diagnose and treat cancer. Built on the historical context of cancer genetics over the past 30 years, the book provides a snapshot of the current issues and state-of-the-art technologies used in cancer genomics. Subsequent chapters highlight how these approaches have informed our understanding of hereditary cancer syndromes and the diagnosis, treatment and outcome in a variety of adult and pediatric solid tumors and hematologic malignancies. The dramatic increase in cancer genomics research and ever-increasing availability of genomic testing are not without significant ethical issues, which are addressed in the context of the return of research results and the legal considerations underlying the commercialization of genomic discoveries. Finally, the book concludes with "Future Directions", examining the next great challenges to face the field of cancer genomics, namely the contribution of non-coding RNAs to disease pathogenesis and the interaction of the human genome with the environment.
1. Part 1: Introduction - p. IV 2. Chapter 1. Historical Perspective and Current Challenges of Cancer Genomics - p. IV 3. Part 2: Genomics Technologies, Concepts and Resources - p. 8 4. Chapter 2. Second-Generation Sequencing for Cancer Genome Analysis - p. 8 5. Chapter 3. Cancer Transcriptome Sequencing and Analysis - p. 27 6. Chapter 4. The Significance of Transcriptome Sequencing in Personalized Cancer Medicine - p. 44 7. Chapter 5. Tissue Microarrays in Studying Gynecological Cancers - p. 61 8. Chapter 6. Cancer Pharmacogenomics in Children - p. 75 9. Chapter 7. Biomarker Discovery and Development through Genomics - p. 88 10. Chapter 8. Preclinical Animal Models for Cancer Genomics - p. 105 11. Chapter 9. Bioinformatics for Cancer Genomics - p. 126 12. Chapter 10. Genomic Resource Projects - p. 148 13. Part 3: Hereditary Cancer Syndromes - p. 170 14. Chapter 11. Genetic Basis of Hereditary Cancer Syndromes - p. 170 15. Part 4: Genomics of Adult and Pediatric Cancers - p. 188 16. 4.1: Adult Solid Tumors - p. 188 17. Chapter 12. Genomics and Molecular Profiling of Lung Cancer - p. 188 18. Chapter 13. Breast Cancer Genomics - p. 207 19. Chapter 14. Prostate Cancer Genomics as a Driver of Personalized Medicine - p. 229 20. Chapter 15. Genomics of Colorectal Cancer - p. 243 21. Chapter 16. Thyroid Cancer - p. 261 22. 4.2: Age Non-Specific Tumors and Hematopoietic Malignancies - p. 277 23. Chapter 17. Acute Myeloid Leukemia - p. 277 24. Chapter 18. Genomics in Multiple Myeloma: From Conventional Cytogenetics to Novel Whole-Genome Sequencing Approaches - p. 294 25. Chapter 19. Brain Tumor Genomics: Sequencing to Clinical Utility - p. 316 26. 4.3: Pediatric Cancers - p. 334 27. Chapter 20. Genomic Basis of Pediatric Lymphomas - p. 334 28. Chapter 21. Neuroblastoma - p. 351 29. Chapter 22. Soft Tissue Sarcomas - p. 372 30. Chapter 23. Wilms Tumors - p. 388 31. Part 5: Ethics of Genomics Research - p. 410 32. Chapter 24. Cancer Genomics and Biobanking: Exploring Key Ethical and Legal Issues - p. 410 33. Part 6: Future Directions - p. 429 34. Chapter 25. The Role of MicroRNAs and Ultraconserved Non-Coding RNAs in Cancer - p. 429 35. Chapter 26. The Impact of the Environment on Cancer Genomics - p. 445 36. Abbreviations - p. 464 37. Glossary - p. 471 38. Index - p. 471
