Did you know that high levels of toxins in the human body can be linked to common conditions such as infertility, obesity, rheumatoid arthritis, heart disease, and diabetes? With therapeutic guidance designed for clinicians, Clinical Environmental Medicine focuses on how toxins such as arsenic, lead, mercury and organophosphates have become one of the leading causes of chronic disease in the industrial world. The first edition of this text describes how to treat these undesirable elements and molecules that can poison enzyme systems, damage DNA, increase inflammation and oxidative stress, and damage cell membranes. Expert authors Walter Crinnion and Joseph E. Pizzorno offer practical guidance for assessing both total body load as well as specific toxins. In addition, evidence-based treatment procedures provide recommendations for decreasing toxin exposure and supporting the body’s biotransformation and excretion processes.
1. Section I Introduction to Environmental Medicine - p. ix 2. 1 The Science of Environmental Medicine - p. 1 3. 2 Oxidative Damage and Inflammation - p. 8 4. 3 Food Pollution - p. 25 5. 4 Water Pollution - p. 41 6. 5 Indoor Air Pollution - p. 61 7. 6 Outdoor Air Pollution - p. 72 8. 7 Health and Beauty Products - p. 92 9. 8 Drugs - p. 106 10. Section II The Toxicants - p. 119 11. Metals - p. 119 12. 9 Arsenic - p. 120 13. 10 Cadmium - p. 132 14. 11 Hexavalent Chromium - p. 144 15. 12 Cobalt - p. 150 16. 13 Lead - p. 161 17. 14 Mercury - p. 177 18. 15 Other Metals - p. 202 19. Inorganic Chemicals - p. 211 20. 16 Fluoride - p. 212 21. Solvents - p. 221 22. 17 Benzene, Toluene, Ethylbenzene, Xylenes (BTEX) - p. 222 23. 18 Chlorinated Solvents - p. 226 24. 19 Styrene - p. 231 25. Pesticides - p. 234 26. 20 Organochlorine Pesticides - p. 235 27. 21 Organophosphate Pesticides - p. 247 28. 22 Pyrethroid Pesticides - p. 260 29. Herbicides - p. 266 30. 23 Glyphosate and Petroleum Distillates - p. 267 31. 24 Chlorophenoxy Herbicides - p. 278 32. Plasticizers - p. 281 33. 25 Bisphenol A - p. 282 34. 26 Phthalates - p. 290 35. Other Persistants - p. 298 36. 27 Polybrominated Diphenyl Ethers - p. 299 37. 28 Polychlorinated Biphenyls - p. 304 38. 29 Perfluorocarbons - p. 312 39. Preservatives - p. 320 40. 30 Parabens - p. 321 41. Airborne - p. 324 42. 31 Mold and Water-Damaged Building Toxicity - p. 325 43. 32 Ozone - p. 336 44. 33 Particulate Matter and Polycyclic Aromatic Hydrocarbons - p. 340 45. 34 Sulfur and Nitrogen Oxides - p. 348 46. Endogenous - p. 351 47. 35 Endotoxicity - p. 352 48. Toxins of Choice - p. 360 49. 36 Alcohol - p. 361 50. 37 Marijuana - p. 369 51. 38 High Fructose Corn Syrup - p. 379 52. 39 Salt - p. 387 53. 40 Smoking - p. 394 54. 41 Wheat - p. 407 55. Section III Systemic Effects of Toxins and Toxicants - p. 424 56. 42 Neurotoxicity - p. 425 57. 43 Immunotoxicity - p. 456 58. 44 Endocrine Toxicity - p. 486 59. 45 Mitochondrial Toxicity - p. 524 60. 46 Respiratory Toxicity - p. 535 61. 47 Cardiovascular Toxicity - p. 549 62. 48 Musculoskeletal Toxicity - p. 561 63. 49 Liver Toxicity - p. 577 64. 50 Renal Toxicity - p. 587 65. 51 Cancer - p. 602 66. Section IV Assessment of Toxic Load - p. 619 67. 52 Assessment - p. 620 68. 53 Laboratory Assessment of Toxicant Levels - p. 632 69. 54 Conventional Laboratory Tests to Assess Toxic Load - p. 642 70. 55 8-Hydroxy-2'-deoxyguanosine and Other Nucleoside Metabolites - p. 657 71. Section V Biotransformation and Excretion - p. 666 72. 56 Biotransformation and Elimination - p. 667 73. 57 Lung Excretion - p. 686 74. 58 Hair Excretion - p. 692 75. 59 Breast Milk Excretion - p. 704 76. Section VI Therapeutics - p. 708 77. 60 Avoidance - p. 709 78. 61 Sauna - p. 724 79. 62 Gastrointestinal and Renal Elimination - p. 737 80. 63 Microbiome - p. 748 81. 64 Chelation (Oral and Intravenous) - p. 765 82. 65 Nutritional Supplementation for Environmental Toxins and Toxicants - p. 777 83. Appendix A Dimercaptosuccinic Acid Metal Mobilization Protocol: Two Days On and Five Days Off - p. 798 84. Appendix B Dimercaptosuccinic Acid Metal Mobilization Protocol: Five Days On and Nine Days Off - p. 799 85. Appendix C CaEDTA/DMPS IV Metal Mobilization Protocol - p. 800 86. Appendix D Intravenous Metal Mobilization Testing - p. 802 87. Appendix E Oral Metal Mobilization Testing - p. 803 88. Appendix F Environmental Exposure Questionnaire - p. 804 89. Appendix G Environmental Exposure Questionnaire: Interpretation Guide - p. 810 90. Index - p. 816
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Did you know that high levels of toxins in the human body can be linked to common conditions such as infertility, obesity, rheumatoid arthritis, heart disease, and diabetes? With therapeutic guidance designed for clinicians, Clinical Environmental Medicine focuses on how toxins such as arsenic, lead, mercury and organophosphates have become one of the leading causes of chronic disease in the industrial world. The first edition of this text describes how to treat these undesirable elements and molecules that can poison enzyme systems, damage DNA, increase inflammation and oxidative stress, and damage cell membranes. Expert authors Walter Crinnion and Joseph E. Pizzorno offer practical guidance for assessing both total body load as well as specific toxins. In addition, evidence-based treatment procedures provide recommendations for decreasing toxin exposure and supporting the body’s biotransformation and excretion processes.
1. Section I Introduction to Environmental Medicine - p. ix 2. 1 The Science of Environmental Medicine - p. 1 3. 2 Oxidative Damage and Inflammation - p. 8 4. 3 Food Pollution - p. 25 5. 4 Water Pollution - p. 41 6. 5 Indoor Air Pollution - p. 61 7. 6 Outdoor Air Pollution - p. 72 8. 7 Health and Beauty Products - p. 92 9. 8 Drugs - p. 106 10. Section II The Toxicants - p. 119 11. Metals - p. 119 12. 9 Arsenic - p. 120 13. 10 Cadmium - p. 132 14. 11 Hexavalent Chromium - p. 144 15. 12 Cobalt - p. 150 16. 13 Lead - p. 161 17. 14 Mercury - p. 177 18. 15 Other Metals - p. 202 19. Inorganic Chemicals - p. 211 20. 16 Fluoride - p. 212 21. Solvents - p. 221 22. 17 Benzene, Toluene, Ethylbenzene, Xylenes (BTEX) - p. 222 23. 18 Chlorinated Solvents - p. 226 24. 19 Styrene - p. 231 25. Pesticides - p. 234 26. 20 Organochlorine Pesticides - p. 235 27. 21 Organophosphate Pesticides - p. 247 28. 22 Pyrethroid Pesticides - p. 260 29. Herbicides - p. 266 30. 23 Glyphosate and Petroleum Distillates - p. 267 31. 24 Chlorophenoxy Herbicides - p. 278 32. Plasticizers - p. 281 33. 25 Bisphenol A - p. 282 34. 26 Phthalates - p. 290 35. Other Persistants - p. 298 36. 27 Polybrominated Diphenyl Ethers - p. 299 37. 28 Polychlorinated Biphenyls - p. 304 38. 29 Perfluorocarbons - p. 312 39. Preservatives - p. 320 40. 30 Parabens - p. 321 41. Airborne - p. 324 42. 31 Mold and Water-Damaged Building Toxicity - p. 325 43. 32 Ozone - p. 336 44. 33 Particulate Matter and Polycyclic Aromatic Hydrocarbons - p. 340 45. 34 Sulfur and Nitrogen Oxides - p. 348 46. Endogenous - p. 351 47. 35 Endotoxicity - p. 352 48. Toxins of Choice - p. 360 49. 36 Alcohol - p. 361 50. 37 Marijuana - p. 369 51. 38 High Fructose Corn Syrup - p. 379 52. 39 Salt - p. 387 53. 40 Smoking - p. 394 54. 41 Wheat - p. 407 55. Section III Systemic Effects of Toxins and Toxicants - p. 424 56. 42 Neurotoxicity - p. 425 57. 43 Immunotoxicity - p. 456 58. 44 Endocrine Toxicity - p. 486 59. 45 Mitochondrial Toxicity - p. 524 60. 46 Respiratory Toxicity - p. 535 61. 47 Cardiovascular Toxicity - p. 549 62. 48 Musculoskeletal Toxicity - p. 561 63. 49 Liver Toxicity - p. 577 64. 50 Renal Toxicity - p. 587 65. 51 Cancer - p. 602 66. Section IV Assessment of Toxic Load - p. 619 67. 52 Assessment - p. 620 68. 53 Laboratory Assessment of Toxicant Levels - p. 632 69. 54 Conventional Laboratory Tests to Assess Toxic Load - p. 642 70. 55 8-Hydroxy-2'-deoxyguanosine and Other Nucleoside Metabolites - p. 657 71. Section V Biotransformation and Excretion - p. 666 72. 56 Biotransformation and Elimination - p. 667 73. 57 Lung Excretion - p. 686 74. 58 Hair Excretion - p. 692 75. 59 Breast Milk Excretion - p. 704 76. Section VI Therapeutics - p. 708 77. 60 Avoidance - p. 709 78. 61 Sauna - p. 724 79. 62 Gastrointestinal and Renal Elimination - p. 737 80. 63 Microbiome - p. 748 81. 64 Chelation (Oral and Intravenous) - p. 765 82. 65 Nutritional Supplementation for Environmental Toxins and Toxicants - p. 777 83. Appendix A Dimercaptosuccinic Acid Metal Mobilization Protocol: Two Days On and Five Days Off - p. 798 84. Appendix B Dimercaptosuccinic Acid Metal Mobilization Protocol: Five Days On and Nine Days Off - p. 799 85. Appendix C CaEDTA/DMPS IV Metal Mobilization Protocol - p. 800 86. Appendix D Intravenous Metal Mobilization Testing - p. 802 87. Appendix E Oral Metal Mobilization Testing - p. 803 88. Appendix F Environmental Exposure Questionnaire - p. 804 89. Appendix G Environmental Exposure Questionnaire: Interpretation Guide - p. 810 90. Index - p. 816
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