Diagnostic and Therapeutic Applications of Exosomes in Cancer evaluates the potential of exosome content manipulation in the development of novel therapeutics. In recent years, exosomes, the small vesicles produced by all cell types, have been identified as contributors to cancer growth and metastasis. However, due to their unique biophysical properties, they are also being tested for use in therapeutic design and delivery, as well as in diagnostics. This book presents a comprehensive analysis on exosomes, with a main emphasis on their biogenesis and signaling, use as biomarkers, and as tools for imaging, drug delivery and the treatment of cancer.
1. 1. Introduction to Exosomes and Cancer - p. 1 2. 2. Extracellular Vesicle Biogenesis in Cancer - p. 11 3. 3. Composition, Physicochemical and Biological Properties of Exosomes Secreted From Cancer Cells - p. 27 4. 4. Heterogeneity of Tumor Exosomes – Role in Precision Medicine - p. 59 5. 5. Proteomic Profiling of Tumor Exosomes - p. 69 6. 6. Nucleic Acid Profiling in Tumor Exosomes - p. 93 7. 7. Nanotechnology Platforms for Cancer Exosome Analyses - p. 119 8. 8. Exosome RNAs as Biomarkers and Targets for Cancer Therapy - p. 129 9. 9. Diagnostic Potential of Tumor Exosomes - p. 161 10. 10. Biodistribution of Cancer-Derived Exosomes - p. 175 11. 11. Exosome-Mediated Communication in the Tumor Microenvironment - p. 187 12. 12. Exosomes and Tunneling Nanotube Conduits: Synergistic Interaction That Facilitates Intercellular Communication Between Malignant and Stromal Cells in the Tumor Microenvironment - p. 219 13. 13. Exosomes in Tumor Angiogenesis—Multifunctional Messengers With Mixed Intentions - p. 235 14. 14. Role of Exosomes in Development of Premetastatic Niche - p. 247 15. 15. Exosomes: Key Supporters of Tumor Metastasis - p. 261 16. 16. The Emerging Roles and Clinical Potential of Exosomes in Cancer: Drug Resistance - p. 285 17. 17. Exosomes in Cancer Immunotherapy - p. 313 18. 18. Extracellular Vesicles as Vehicles of B Cell Antigen Presentation: Implications for Cancer Vaccine Therapies - p. 325 19. 19. Translational Potential of Tumor Exosomes in Diagnosis and Therapy - p. 343 20. Index - p. 355
Diagnostic and Therapeutic Applications of Exosomes in Cancer evaluates the potential of exosome content manipulation in the development of novel therapeutics. In recent years, exosomes, the small vesicles produced by all cell types, have been identified as contributors to cancer growth and metastasis. However, due to their unique biophysical properties, they are also being tested for use in therapeutic design and delivery, as well as in diagnostics. This book presents a comprehensive analysis on exosomes, with a main emphasis on their biogenesis and signaling, use as biomarkers, and as tools for imaging, drug delivery and the treatment of cancer.
1. 1. Introduction to Exosomes and Cancer - p. 1 2. 2. Extracellular Vesicle Biogenesis in Cancer - p. 11 3. 3. Composition, Physicochemical and Biological Properties of Exosomes Secreted From Cancer Cells - p. 27 4. 4. Heterogeneity of Tumor Exosomes – Role in Precision Medicine - p. 59 5. 5. Proteomic Profiling of Tumor Exosomes - p. 69 6. 6. Nucleic Acid Profiling in Tumor Exosomes - p. 93 7. 7. Nanotechnology Platforms for Cancer Exosome Analyses - p. 119 8. 8. Exosome RNAs as Biomarkers and Targets for Cancer Therapy - p. 129 9. 9. Diagnostic Potential of Tumor Exosomes - p. 161 10. 10. Biodistribution of Cancer-Derived Exosomes - p. 175 11. 11. Exosome-Mediated Communication in the Tumor Microenvironment - p. 187 12. 12. Exosomes and Tunneling Nanotube Conduits: Synergistic Interaction That Facilitates Intercellular Communication Between Malignant and Stromal Cells in the Tumor Microenvironment - p. 219 13. 13. Exosomes in Tumor Angiogenesis—Multifunctional Messengers With Mixed Intentions - p. 235 14. 14. Role of Exosomes in Development of Premetastatic Niche - p. 247 15. 15. Exosomes: Key Supporters of Tumor Metastasis - p. 261 16. 16. The Emerging Roles and Clinical Potential of Exosomes in Cancer: Drug Resistance - p. 285 17. 17. Exosomes in Cancer Immunotherapy - p. 313 18. 18. Extracellular Vesicles as Vehicles of B Cell Antigen Presentation: Implications for Cancer Vaccine Therapies - p. 325 19. 19. Translational Potential of Tumor Exosomes in Diagnosis and Therapy - p. 343 20. Index - p. 355
