Through five well-regarded editions, Dr. David Dabbs’ Diagnostic Immunohistochemistry has set the standard for concise, complete, guidance on the use and interpretation of immunohistochemical stains. The 6th Edition continues this tradition of excellence, bringing you fully up to date with all aspects of this dynamic field. Easy to use and understand, this practical resource distills the large body of information on immunohistochemistry into a single, convenient reference that is invaluable for today’s surgical pathologists.
Covers all aspects of the field, with an emphasis on the role of genomics in diagnosis and theranostic applications that will better inform treatment options.
Includes the latest grading schemes in several organs along with new antibodies to cover more genomic immunohistochemistry applications.
Contains current biomarker guidelines and up-to-date references throughout.
Offers a systematic approach to the diagnostic entities of each organ system, including detailed differential diagnoses, diagnostic algorithms, and immunohistograms that depict immunostaining patterns of tumors.
Contains numerous charts and tables, as well as 1,500 high-quality color histologic images that assist in making a definitive diagnosis.
Discusses diagnostic pitfalls through immunohistologic differential diagnosis wherever appropriate so you can provide the most accurate diagnoses.
Covers many more antigens than other texts, and discusses antibody specifications with tables that convey information on uses, clones, vendors, sources, antibody titers, and types of antigen retrieval.
1. Introduction - p. 254 2. Squamoproliferative Lesions - p. 254 3. Nasal Cavity and Paranasal Sinuses - p. 259 4. Nasopharynx - p. 291 5. Oral Cavity - p. 297 6. Larynx/Hypopharynx - p. 300 7. Salivary Glands - p. 303 8. Ear and Temporal Bone - p. 328 9. Metastatic Tumors - p. 338 10. Summary - p. 340 11. References - p. 340 12. 10. Immunohistology of Endocrine and Neuroendocrine Neoplasms - p. 342 13. Overview - p. 342 14. Biology of Antigens and Antibodies - p. 342 15. Tumors of Specific Sites - p. 346 16. Neuroendocrine Tumors in Other Sites - p. 387 17. Summary - p. 392 18. References - p. 392 19. 11. Immunohistology of the Mediastinum - p. 393 20. 12. Immunohistology of Pulmonary and Pleural Neoplasms - p. 434 21. 13. Immunohistology of Skin Tumors - p. 498 22. 14. Immunohistology of the Gastrointestinal Tract - p. 528 23. Biology of Antigens and Antibodies: General and Tissue Specific - p. 528 24. Diagnostic Immunohistochemistry: Epithelial Lesions of the Gastrointestinal Tract - p. 530 25. Diagnostic Immunohistochemistry: Neuroendocrine Neoplasms of the Gastrointestinal Tract - p. 549 26. Diagnostic Immunohistochemistry: Mesenchymal Lesions of the Gastrointestinal Tract - p. 553 27. Beyond Immunohistochemistry: Theranostic and Genomic Applications - p. 558 28. Summary - p. 560.e11 29. References - p. 560.e11 30. 15. Immunohistology of Pancreas and Hepatobiliary Tract - p. 561 31. Pancreas - p. 561 32. Extrahepatic Biliary Tract (Extrahepatic Bile Ducts and Gallbladder) - p. 580 33. Ampulla - p. 584 34. Liver - p. 588 35. Summary - p. 605 36. References - p. 605 37. 16. Immunohistology of the Prostate - p. 607 38. Overview - p. 607 39. Biology of Antigens and Antibodies - p. 607 40. Diagnostic Immunohistochemistry of Specific Prostate Lesions - p. 610 41. Beyond Immunohistochemistry: Theranostic and Genomic Applications - p. 626 42. Summary - p. 641 43. References - p. 641 44. 17. Immunohistology of the Bladder, Kidney, and Testis - p. 642 45. Overview - p. 642 46. Immunohistology of the Urinary Bladder - p. 642 47. Immunohistology of Renal Neoplasms - p. 657 48. Immunohistology of Testicular Tumors - p. 673 49. Summary - p. 681 50. References - p. 682 51. 18. Immunohistology of the Female Genital Tract - p. 683 52. Biology of Antigens and Antibodies - p. 683 53. Lower Female Genital Tract and Uterus - p. 687 54. Upper Female Genital Tract - p. 718 55. Summary - p. 741 56. References - p. 741 57. 19. Immunohistology of the Breast - p. 742 58. Introduction - p. 742 59. Myoepithelial Cells and Assessment of Stromal Invasion - p. 742 60. Immunohistochemistry of Papillary Lesions - p. 748 61. Proliferative Ductal Epithelial Lesions and In Situ Carcinoma - p. 752 62. Tumor Type Identification by Immunohistochemistry - p. 754 63. Immunohistochemistry for Identifying Special Types of Breast Carcinomas - p. 759 64. Paget Disease of the Breast - p. 764 65. Detection of Lymphatic Space Invasion - p. 765 66. Sentinel Lymph Node Examination - p. 766 67. Systemic Metastasis of Breast Carcinoma - p. 770 68. Fibroepithelial Tumors - p. 772 69. Theranostic Applications - p. 775 70. Genomic Applications of Immunohistochemistry: Breast Cancer Molecular Classification and Immunogenomics - p. 784 71. Other Tumor Markers - p. 791 72. Summary - p. 796 73. References - p. 796 74. 20. Immunohistology of the Nervous System - p. 797 75. Overview - p. 797 76. Clinical and Radiologic Perspective of Lesions - p. 798 77. Nonneoplastic Brain Lesions - p. 799 78. Tumors of the Nervous System - p. 809 79. Cysts of the Nervous System - p. 865 80. Dementias - p. 866 81. Demyelination - p. 868 82. Epilepsy - p. 869 83. Cortical Malformations - p. 871 84. Pitfalls in Diagnosis - p. 871 85. Summary - p. 875 86. References - p. 875.e8 87. 21. Immunocytology - p. 876 88. 22. Immunohistology of Pediatric Neoplasms - p. 905 89. Overview - p. 905 90. Biology of Antigens and Antibodies: Principal Antibodies - p. 905 91. Specific Tumors - p. 906 92. Summary - p. 925 93. References - p. 925 94. 23. Imaging and Quantitative Immunohistochemistry - p. 927 95. 24. Molecular Anatomic Pathology: Principles, Techniques, and Application to Immunohistologic Diagnosis - p. 936 96. INDEX - p. 953
Through five well-regarded editions, Dr. David Dabbs’ Diagnostic Immunohistochemistry has set the standard for concise, complete, guidance on the use and interpretation of immunohistochemical stains. The 6th Edition continues this tradition of excellence, bringing you fully up to date with all aspects of this dynamic field. Easy to use and understand, this practical resource distills the large body of information on immunohistochemistry into a single, convenient reference that is invaluable for today’s surgical pathologists.
Covers all aspects of the field, with an emphasis on the role of genomics in diagnosis and theranostic applications that will better inform treatment options.
Includes the latest grading schemes in several organs along with new antibodies to cover more genomic immunohistochemistry applications.
Contains current biomarker guidelines and up-to-date references throughout.
Offers a systematic approach to the diagnostic entities of each organ system, including detailed differential diagnoses, diagnostic algorithms, and immunohistograms that depict immunostaining patterns of tumors.
Contains numerous charts and tables, as well as 1,500 high-quality color histologic images that assist in making a definitive diagnosis.
Discusses diagnostic pitfalls through immunohistologic differential diagnosis wherever appropriate so you can provide the most accurate diagnoses.
Covers many more antigens than other texts, and discusses antibody specifications with tables that convey information on uses, clones, vendors, sources, antibody titers, and types of antigen retrieval.
1. Introduction - p. 254 2. Squamoproliferative Lesions - p. 254 3. Nasal Cavity and Paranasal Sinuses - p. 259 4. Nasopharynx - p. 291 5. Oral Cavity - p. 297 6. Larynx/Hypopharynx - p. 300 7. Salivary Glands - p. 303 8. Ear and Temporal Bone - p. 328 9. Metastatic Tumors - p. 338 10. Summary - p. 340 11. References - p. 340 12. 10. Immunohistology of Endocrine and Neuroendocrine Neoplasms - p. 342 13. Overview - p. 342 14. Biology of Antigens and Antibodies - p. 342 15. Tumors of Specific Sites - p. 346 16. Neuroendocrine Tumors in Other Sites - p. 387 17. Summary - p. 392 18. References - p. 392 19. 11. Immunohistology of the Mediastinum - p. 393 20. 12. Immunohistology of Pulmonary and Pleural Neoplasms - p. 434 21. 13. Immunohistology of Skin Tumors - p. 498 22. 14. Immunohistology of the Gastrointestinal Tract - p. 528 23. Biology of Antigens and Antibodies: General and Tissue Specific - p. 528 24. Diagnostic Immunohistochemistry: Epithelial Lesions of the Gastrointestinal Tract - p. 530 25. Diagnostic Immunohistochemistry: Neuroendocrine Neoplasms of the Gastrointestinal Tract - p. 549 26. Diagnostic Immunohistochemistry: Mesenchymal Lesions of the Gastrointestinal Tract - p. 553 27. Beyond Immunohistochemistry: Theranostic and Genomic Applications - p. 558 28. Summary - p. 560.e11 29. References - p. 560.e11 30. 15. Immunohistology of Pancreas and Hepatobiliary Tract - p. 561 31. Pancreas - p. 561 32. Extrahepatic Biliary Tract (Extrahepatic Bile Ducts and Gallbladder) - p. 580 33. Ampulla - p. 584 34. Liver - p. 588 35. Summary - p. 605 36. References - p. 605 37. 16. Immunohistology of the Prostate - p. 607 38. Overview - p. 607 39. Biology of Antigens and Antibodies - p. 607 40. Diagnostic Immunohistochemistry of Specific Prostate Lesions - p. 610 41. Beyond Immunohistochemistry: Theranostic and Genomic Applications - p. 626 42. Summary - p. 641 43. References - p. 641 44. 17. Immunohistology of the Bladder, Kidney, and Testis - p. 642 45. Overview - p. 642 46. Immunohistology of the Urinary Bladder - p. 642 47. Immunohistology of Renal Neoplasms - p. 657 48. Immunohistology of Testicular Tumors - p. 673 49. Summary - p. 681 50. References - p. 682 51. 18. Immunohistology of the Female Genital Tract - p. 683 52. Biology of Antigens and Antibodies - p. 683 53. Lower Female Genital Tract and Uterus - p. 687 54. Upper Female Genital Tract - p. 718 55. Summary - p. 741 56. References - p. 741 57. 19. Immunohistology of the Breast - p. 742 58. Introduction - p. 742 59. Myoepithelial Cells and Assessment of Stromal Invasion - p. 742 60. Immunohistochemistry of Papillary Lesions - p. 748 61. Proliferative Ductal Epithelial Lesions and In Situ Carcinoma - p. 752 62. Tumor Type Identification by Immunohistochemistry - p. 754 63. Immunohistochemistry for Identifying Special Types of Breast Carcinomas - p. 759 64. Paget Disease of the Breast - p. 764 65. Detection of Lymphatic Space Invasion - p. 765 66. Sentinel Lymph Node Examination - p. 766 67. Systemic Metastasis of Breast Carcinoma - p. 770 68. Fibroepithelial Tumors - p. 772 69. Theranostic Applications - p. 775 70. Genomic Applications of Immunohistochemistry: Breast Cancer Molecular Classification and Immunogenomics - p. 784 71. Other Tumor Markers - p. 791 72. Summary - p. 796 73. References - p. 796 74. 20. Immunohistology of the Nervous System - p. 797 75. Overview - p. 797 76. Clinical and Radiologic Perspective of Lesions - p. 798 77. Nonneoplastic Brain Lesions - p. 799 78. Tumors of the Nervous System - p. 809 79. Cysts of the Nervous System - p. 865 80. Dementias - p. 866 81. Demyelination - p. 868 82. Epilepsy - p. 869 83. Cortical Malformations - p. 871 84. Pitfalls in Diagnosis - p. 871 85. Summary - p. 875 86. References - p. 875.e8 87. 21. Immunocytology - p. 876 88. 22. Immunohistology of Pediatric Neoplasms - p. 905 89. Overview - p. 905 90. Biology of Antigens and Antibodies: Principal Antibodies - p. 905 91. Specific Tumors - p. 906 92. Summary - p. 925 93. References - p. 925 94. 23. Imaging and Quantitative Immunohistochemistry - p. 927 95. 24. Molecular Anatomic Pathology: Principles, Techniques, and Application to Immunohistologic Diagnosis - p. 936 96. INDEX - p. 953
