This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of nonneoplastic pediatric pathology, it incorporates the most recent clinical, pathologic, and molecular knowledge in this challenging field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the second edition of Diagnostic Pathology: Nonneoplastic Pediatrics is a one-stop reference for accurate, complete pathology reports, ideal as a day-to-day reference for both pediatric and general pathologists or as a reliable training resource.
Provides a clear framework for a better understanding of the clinical and histopathologic appearances of more than 270 nonneoplastic entities, covering every organ system with a focus on reactive, infectious, congenital, and genetic conditions
Covers significant advances in this complex field, including recent molecular discoveries and updated disease entities, new information on multiple immunologic disorders, changes and expansions to several classification systems (such as WHO, Banff, and ISSVA), and updates in other scoring systems
Contains new chapters on manifestations of pediatric COVID-19 infection, tumoral calcinosis, multiple skeletal dysplasia, skeletal muscle, collagenous gastritis and colitis, adenovirus appendicitis, intestinal pseudo-obstruction, disorders of sexual development, and Kikuchi disease
Features a thoroughly updated Molecular Factors Index, which cross-references gene names and locations with chapter-content specifics
Includes approximately 2,400 high-quality clinical and histological images, gross pathology images, radiologic images, and full-color drawings to help practicing and in-training pathologists reach a confident diagnosis—as well as more than 300 additional images online
Employs consistently templated chapters and bulleted content for quick, expert reference at the point of care
1. Cover image - p. Cover 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iii 5. Dedications - p. iii 6. Contributing Authors - p. v 7. Preface - p. v 8. Acknowledgments - p. v 9. List of Tables - p. xi 10. Sections - p. xi 11. SECTION 1: SKIN - p. xiii 12. SPONGIOTIC AND PSORIASIFORM DERMATOSES - p. xiii 13. Chapter 1: Pityriasis Rosea - p. xiii 14. Chapter 2: Contact Dermatitis - p. 5 15. Chapter 3: Atopic Dermatitis - p. 9 16. Chapter 4: Perniosis - p. 11 17. Chapter 5: Seborrheic Dermatitis - p. 13 18. INFLAMMATORY/INTERFACE DERMATOSES - p. 15 19. Chapter 6: Erythema Multiforme and Related Disorders - p. 15 20. Chapter 7: Pityriasis Lichenoides - p. 19 21. VESICOBULLOUS DERMATOSES - p. 23 22. Chapter 8: Acropustulosis of Infancy - p. 23 23. Chapter 9: Dermatitis Herpetiformis - p. 25 24. Chapter 10: Epidermolysis Bullosa, Inherited - p. 27 25. Chapter 11: Erythema Toxicum Neonatorum - p. 31 26. Chapter 12: Hailey-Hailey Disease - p. 33 27. Chapter 13: Chronic Bullous Disease of Childhood - p. 35 28. Chapter 14: Transient Neonatal Pustular Melanosis - p. 37 29. VASCULAR AND RELATED DISEASES - p. 39 30. Chapter 15: Urticaria and Variants - p. 39 31. Chapter 16: Leukocytoclastic Vasculitis - p. 43 32. PANNICULITIDES - p. 47 33. Chapter 17: Erythema Nodosum - p. 47 34. Chapter 18: Subcutaneous Fat Necrosis of Newborn - p. 51 35. Chapter 19: Sclerema Neonatorum - p. 53 36. CONNECTIVE TISSUE - p. 55 37. Chapter 20: Lupus Erythematosus - p. 55 38. Chapter 21: Morphea/Scleroderma - p. 61 39. Chapter 22: Dermatomyositis - p. 65 40. METABOLIC/DEPOSITION DISEASES - p. 69 41. Chapter 23: Calcinosis Cutis - p. 69 42. NONINFECTIOUS GRANULOMATOUS DISEASES - p. 73 43. Chapter 24: Chalazion - p. 73 44. Chapter 25: Granuloma Annulare - p. 75 45. PILOSEBACEOUS DISEASE - p. 77 46. Chapter 26: Acne Vulgaris - p. 77 47. ALOPECIAS - p. 79 48. Chapter 27: Trichotillomania - p. 79 49. DISORDERS OF EPIDERMAL MATURATION AND KERATINIZATION - p. 83 50. Chapter 28: Ichthyosis - p. 83 51. Chapter 29: Darier Disease - p. 85 52. Chapter 30: Porokeratosis - p. 87 53. Chapter 31: Incontinentia Pigmenti - p. 91 54. DISORDER OF COLLAGEN - p. 93 55. Chapter 32: Aplasia Cutis Congenita - p. 93 56. BACTERIAL INFECTIONS - p. 95 57. Chapter 33: Impetigo - p. 95 58. Chapter 34: Staphylococcal Scalded Skin Syndrome - p. 99 59. Chapter 35: Ecthyma and Ecthyma Gangrenosum - p. 101 60. Chapter 36: Cat-Scratch Disease - p. 103 61. Chapter 37: Atypical Mycobacterial Infections - p. 109 62. VIRAL INFECTIONS - p. 111 63. Chapter 38: Molluscum Contagiosum - p. 111 64. Chapter 39: Herpesvirus - p. 113 65. FUNGAL INFECTIONS - p. 115 66. Chapter 40: Candidiasis - p. 115 67. ARTHROPODS/PARASITES - p. 119 68. Chapter 41: Bite Reactions - p. 119 69. Chapter 42: Scabies - p. 123 70. CYSTS - p. 125 71. Chapter 43: Epidermal Inclusion Cyst - p. 125 72. Chapter 44: Dermoid Cyst - p. 127 73. SECTION 2: SOFT TISSUE - p. 131 74. Chapter 45: Necrotizing Fasciitis - p. 131 75. Chapter 46: Tumoral Calcinosis - p. 135 76. SECTION 3: BONE AND JOINT - p. 137 77. CONGENITAL/GENETIC/HEREDITARY - p. 137 78. Chapter 47: Osteogenesis Imperfecta - p. 137 79. Chapter 48: Chondrodysplasia Punctata - p. 143 80. Chapter 49: Thanatophoric Dysplasia - p. 147 81. TRAUMA/INJURY/REACTIVE - p. 149 82. Chapter 50: Bone Fracture and Repair - p. 149 83. Chapter 51: Osteomyelitis - p. 153 84. Chapter 52: Stress and Costochondral Junction - p. 157 85. Chapter 53: Juvenile Idiopathic Arthritis - p. 159 86. SECTION 4: SKELETAL MUSCLE - p. 163 87. CONGENITAL/GENETIC/HEREDITARY - p. 163 88. Chapter 54: Spinal Muscular Atrophy - p. 163 89. Chapter 55: X-Linked Muscular Dystrophy: Duchenne and Becker - p. 167 90. Chapter 56: Congenital Myopathies - p. 171 91. SECTION 5: CENTRAL NERVOUS SYSTEM - p. 173 92. CONGENITAL/GENETIC/HEREDITARY - p. 173 93. Chapter 57: Cerebral Heterotopia and Ectopia - p. 173 94. Chapter 58: Focal Cortical Dysplasia - p. 177 95. Chapter 59: Myelomeningocele - p. 191 96. Chapter 60: Encephalocele - p. 193 97. Chapter 61: Tethered Cord - p. 195 98. Chapter 62: Cerebral Arteriovenous Malformations - p. 197 99. Chapter 63: Cerebral Cavernous Malformation - p. 201 100. TRAUMA/INJURY/REACTIVE - p. 205 101. Chapter 64: Hypoxic-Ischemic Encephalopathy - p. 205 102. Chapter 65: Periventricular Leukomalacia - p. 209 103. Chapter 66: Arachnoid Cysts - p. 213 104. Chapter 67: Meningioangiomatosis - p. 215 105. Chapter 68: Germinal Matrix-Intraventricular Hemorrhage - p. 221 106. INFECTIOUS - p. 225 107. Chapter 69: Bacterial Meningoencephalitis - p. 225 108. Chapter 70: Fungal Meningoencephalitis - p. 231 109. Chapter 71: Viral Meningoencephalitis - p. 237 110. Chapter 72: Protozoal Meningoencephalitis - p. 241 111. SECTION 6: ENDOCRINE - p. 245 112. CONGENITAL/GENETIC/HEREDITARY - p. 245 113. Chapter 73: Adrenal Cytomegaly - p. 245 114. Chapter 74: Adrenal Heterotopia - p. 249 115. Chapter 75: Adrenal Hypoplasia and Malformations - p. 251 116. Chapter 76: Adrenal Cortical Hyperplasia - p. 253 117. Chapter 77: Dyshormonogenetic Goiter - p. 257 118. Chapter 78: Ectopic Thyroid - p. 263 119. Chapter 79: Thyroglossal Duct Cyst - p. 265 120. Chapter 80: Cystic Fibrosis, Pancreas - p. 267 121. TRAUMA/INJURY/REACTIVE - p. 269 122. Chapter 81: Stress Reactions in Adrenal Gland - p. 269 123. Chapter 82: Hemorrhagic Necrosis of Adrenal Gland - p. 271 124. Chapter 83: Chronic Lymphocytic Thyroiditis - p. 273 125. Chapter 84: Graves Disease - p. 277 126. Chapter 85: Hypertrophy of Pancreatic Islets - p. 283 127. SECTION 7: RESPIRATORY - p. 285 128. CONGENITAL/GENETIC/HEREDITARY - p. 285 129. Chapter 86: Bronchogenic Cyst - p. 285 130. Chapter 87: Congenital Alveolar Capillary Dysplasia - p. 289 131. Chapter 88: Congenital Lobar Emphysema - p. 293 132. Chapter 89: Congenital Pulmonary Lymphangiectasis - p. 295 133. Chapter 90: Diffuse Pulmonary Lymphangiomatosis - p. 297 134. Chapter 91: Congenital Pulmonary Airway Malformation - p. 301 135. Chapter 92: Congenital Surfactant Deficiency - p. 305 136. Chapter 93: Cystic Fibrosis - p. 309 137. Chapter 94: Sequestrations - p. 313 138. TRAUMA/INJURY/REACTIVE - p. 315 139. Chapter 95: Aspiration - p. 315 140. Chapter 96: Asthma - p. 319 141. Chapter 97: Bronchopulmonary Dysplasia - p. 321 142. Chapter 98: Hyaline Membrane Disease - p. 325 143. Chapter 99: Interstitial Pulmonary Emphysema - p. 327 144. Chapter 100: Persistent Pulmonary Hypertension - p. 329 145. Chapter 101: Idiopathic Pulmonary Hemosiderosis - p. 331 146. Chapter 102: Pulmonary Venoocclusive Disease/Pulmonary Capillary Hemangiomatosis - p. 333 147. Chapter 103: Nonspecific Interstitial Pneumonia - p. 337 148. Chapter 104: Hypersensitivity Pneumonitis - p. 339 149. Chapter 105: Eosinophilic Pneumonia - p. 341 150. INFECTIOUS - p. 345 151. Chapter 106: Adenovirus - p. 345 152. Chapter 107: Human Metapneumovirus - p. 347 153. Chapter 108: Respiratory Syncytial Virus - p. 351 154. MISCELLANEOUS - p. 353 155. Chapter 109: Neuroendocrine Cell Hyperplasia of Infancy - p. 353 156. SECTION 8: CARDIOVASCULAR - p. 355 157. CONGENITAL/GENETIC/HEREDITARY - p. 355 158. Chapter 110: Arrhythmogenic Right Ventricular Cardiomyopathy - p. 355 159. Chapter 111: Hypertrophic Cardiomyopathy - p. 361 160. Chapter 112: Dilated Cardiomyopathy - p. 363 161. Chapter 113: Fabry Disease - p. 367 162. Chapter 114: Fatty Acid Metabolic Disorders - p. 371 163. Chapter 115: Glycogen Storage Diseases - p. 373 164. Chapter 116: Mitochondrial Myopathies - p. 375 165. Chapter 117: Capillary Malformations - p. 379 166. Chapter 118: Lymphatic Malformations - p. 383 167. Chapter 119: Venous Malformations - p. 387 168. Chapter 120: Arteriovenous Malformations and Fistulas - p. 391 169. TRAUMA/INJURY/REACTIVE - p. 395 170. Chapter 121: Endocardial Fibroelastosis - p. 395 171. INFECTIOUS - p. 397 172. Chapter 122: Lymphocytic Myocarditis - p. 397 173. Chapter 123: Acute Pericarditis - p. 401 174. Chapter 124: Acute Rheumatic Fever - p. 405 175. Chapter 125: Kawasaki Disease - p. 409 176. Chapter 126: COVID-19-Related Pathology and Pediatric Multisystem Inflammatory Syndrome - p. 413 177. SECTION 9: ALIMENTARY CANAL - p. 423 178. ESOPHAGUS - p. 423 179. CONGENITAL/GENETIC/HEREDITARY - p. 423 180. Chapter 127: Inlet Patch - p. 423 181. Chapter 128: Tracheoesophageal Fistula and Esophageal Atresia - p. 429 182. Chapter 129: Esophageal Duplication Cyst - p. 433 183. TRAUMA/INJURY/REACTIVE - p. 437 184. Chapter 130: Gastroesophageal Reflux Disease - p. 437 185. Chapter 131: Eosinophilic Esophagitis - p. 443 186. INFECTIOUS - p. 447 187. Chapter 132: Herpes Simplex Virus Esophagitis - p. 447 188. Chapter 133: Candida - p. 449 189. STOMACH - p. 451 190. TRAUMA/INJURY/REACTIVE - p. 451 191. Chapter 134: Chemical Gastropathy - p. 451 192. Chapter 135: Chronic Gastritis - p. 455 193. Chapter 136: Granulomatous Gastritis - p. 457 194. Chapter 137: Lymphocytic Gastritis - p. 461 195. Chapter 138: Eosinophilic Gastroenteritis - p. 467 196. Chapter 139: Fundic Gland Polyp - p. 469 197. Chapter 140: Collagenous Gastritis - p. 471 198. INFECTIOUS - p. 475 199. Chapter 141: Helicobacter heilmannii Gastritis - p. 475 200. Chapter 142: Helicobacter pylori Gastritis - p. 477 201. SMALL BOWEL - p. 481 202. CONGENITAL/GENETIC/HEREDITARY - p. 481 203. Chapter 143: Small Intestine Duplication Cyst - p. 481 204. Chapter 144: Ectopic Pancreas - p. 483 205. Chapter 145: Gastric Heterotopia - p. 487 206. Chapter 146: Meckel Diverticulum - p. 489 207. Chapter 147: Microvillous Inclusion Disease - p. 491 208. Chapter 148: Primary Intestinal Lymphangiectasia - p. 493 209. Chapter 149: Abetalipoproteinemia - p. 495 210. Chapter 150: Tufting Enteropathy - p. 499 211. Chapter 151: Autoimmune Enteropathy - p. 503 212. INFLAMMATORY/IMMUNE DYSFUNCTION - p. 507 213. Chapter 152: Celiac Disease - p. 507 214. Chapter 153: Common Variable Immunodeficiency - p. 513 215. INFECTIOUS - p. 517 216. Chapter 154: Giardia - p. 517 217. Chapter 155: Cryptosporidium - p. 519 218. APPENDIX - p. 521 219. Chapter 156: Acute Appendicitis - p. 521 220. Chapter 157: Granulomatous Appendicitis - p. 525 221. Chapter 158: Enterobius Vermicularis Appendicitis - p. 527 222. Chapter 159: Fibrous Obliteration - p. 529 223. COLON - p. 531 224. CONGENITAL/GENETIC/HEREDITARY - p. 531 225. Chapter 160: Cystic Fibrosis, Intestinal - p. 531 226. Chapter 161: Colonic Duplications, Cysts, and Congenital Diverticula - p. 533 227. Chapter 162: Hirschsprung Disease - p. 537 228. Chapter 163: Intestinal Motility Disorders - p. 543 229. TRAUMA/INJURY/REACTIVE - p. 545 230. Chapter 164: Diversion Colitis - p. 545 231. Chapter 165: Pneumatosis Intestinalis - p. 547 232. Chapter 166: Solitary Rectal Ulcer Syndrome/Mucosal Prolapse - p. 553 233. Chapter 167: Necrotizing Enterocolitis - p. 559 234. INFLAMMATORY/IMMUNE DYSFUNCTION - p. 561 235. Chapter 168: Eosinophilic/Allergic Colitis - p. 561 236. Chapter 169: Focal Active Colitis - p. 567 237. Chapter 170: Crohn Disease - p. 569 238. Chapter 171: Ulcerative Colitis - p. 581 239. Chapter 172: Collagenous Colitis - p. 589 240. INFECTIOUS - p. 597 241. Chapter 173: Cytomegalovirus - p. 597 242. Chapter 174: Entamoeba Histolytica - p. 603 243. Chapter 175: Adenovirus - p. 605 244. Chapter 176: Acute Infectious Colitis - p. 607 245. Chapter 177: Pseudomembranous Colitis - p. 609 246. SECTION 10: LIVER/GALLBLADDER - p. 613 247. CONGENITAL/GENETIC/HEREDITARY - p. 613 248. Chapter 178: Congenital Hepatic Fibrosis - p. 613 249. Chapter 179: Caroli Disease - p. 617 250. Chapter 180: Cystic Fibrosis, Hepatic - p. 619 251. Chapter 181: Dubin-Johnson Syndrome - p. 623 252. Chapter 182: Gilbert Disease - p. 625 253. Chapter 183: Progressive Familial Intrahepatic Cholestasis - p. 627 254. Chapter 184: Biliary Atresia - p. 635 255. Chapter 185: Syndromic Paucity of Intrahepatic Bile Ducts (Alagille Syndrome) - p. 641 256. Chapter 186: Paucity of Intrahepatic Bile Ducts (Nonsyndromic) - p. 645 257. Chapter 187: Autoimmune Hepatitis - p. 649 258. Chapter 188: α-1-Antitrypsin Deficiency - p. 655 259. Chapter 189: Glycogen Storage Disease - p. 659 260. Chapter 190: Niemann-Pick Disease - p. 665 261. Chapter 191: Tyrosinemia - p. 667 262. Chapter 192: Gaucher Disease - p. 669 263. Chapter 193: Neonatal Hemochromatosis - p. 671 264. Chapter 194: Wilson Disease - p. 673 265. Chapter 195: Choledochal Cyst - p. 679 266. TRAUMA/INJURY/REACTIVE - p. 681 267. Chapter 196: Intestinal Failure-Associated Liver Disease (Total Parenteral Nutrition Injury) - p. 681 268. Chapter 197: Neonatal Hepatitis - p. 685 269. Chapter 198: Reye Syndrome - p. 689 270. Chapter 199: Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis - p. 691 271. Chapter 200: Primary Sclerosing Cholangitis - p. 695 272. Chapter 201: Venoocclusive Disease - p. 699 273. Chapter 202: Drug-Related Acute Hepatitis - p. 701 274. INFECTIOUS - p. 705 275. Chapter 203: Viral Hepatitis - p. 705 276. Chapter 204: Epstein-Barr Virus - p. 709 277. Chapter 205: Herpes Simplex Virus Hepatitis - p. 713 278. Chapter 206: Cytomegalovirus - p. 715 279. SECTION 11: GENITOURINARY - p. 717 280. KIDNEY/URINARY TRACT - p. 717 281. GLOMERULAR DISEASES - p. 717 282. Chapter 207: Congenital Nephrotic Syndrome - p. 717 283. Chapter 208: Diffuse Mesangial Sclerosis - p. 725 284. Chapter 209: Minimal Change Disease - p. 731 285. Chapter 210: Focal Segmental Glomerulosclerosis - p. 739 286. Chapter 211: Acute Postinfectious Glomerulonephritis - p. 751 287. Chapter 212: Membranoproliferative Glomerulonephritis - p. 759 288. Chapter 213: C3 Glomerulonephritis - p. 767 289. Chapter 214: Dense Deposit Disease - p. 773 290. Chapter 215: Systemic Lupus Erythematosus - p. 779 291. Chapter 216: IgA Nephropathy - p. 797 292. Chapter 217: Henoch-Schönlein Purpura Nephritis - p. 807 293. Chapter 218: Thin Basement Membrane Nephropathy - p. 815 294. Chapter 219: Alport Syndrome - p. 819 295. TUBULOINTERSTITIAL DISEASES - p. 829 296. Chapter 220: Acute Tubular Injury - p. 829 297. Chapter 221: Acute Pyelonephritis - p. 835 298. Chapter 222: Tubulointerstitial Nephritis With Uveitis - p. 843 299. Chapter 223: Primary Hyperoxaluria - p. 847 300. VASCULAR DISEASES - p. 849 301. Chapter 224: Fibromuscular Dysplasia (Renal Artery Stenosis) - p. 849 302. Chapter 225: Hemolytic Uremic Syndrome, Infection Related and Atypical - p. 855 303. Chapter 226: Vasculitis, ANCA Related - p. 861 304. CYSTIC AND DEVELOPMENTAL DISEASES - p. 867 305. Chapter 227: Reflux Nephropathy - p. 867 306. Chapter 228: Polycystic Kidney Disease, Autosomal Recessive - p. 871 307. Chapter 229: Polycystic Kidney Disease, Autosomal Dominant - p. 875 308. Chapter 230: Medullary Cystic Kidney Disease/Nephronophthisis - p. 879 309. Chapter 231: Renal Dysplasia - p. 881 310. Chapter 232: Renal Tubular Dysgenesis - p. 885 311. Chapter 233: Ask-Upmark Kidney - p. 887 312. REPRODUCTIVE SYSTEM - p. 889 313. CONGENITAL/GENETIC/HEREDITARY - p. 889 314. Chapter 234: Accessory Breast Tissue - p. 889 315. Chapter 235: Cryptorchidism - p. 891 316. Chapter 236: Testicular Regression Syndrome - p. 895 317. Chapter 237: Disorders of Sexual Development - p. 897 318. INFLAMMATORY/IMMUNE DYSFUNCTION - p. 905 319. Chapter 238: Hidradenitis Suppurativa - p. 905 320. Chapter 239: Childhood Behçet Disease - p. 907 321. TRAUMA/INJURY/REACTIVE - p. 911 322. Chapter 240: Adnexal (Ovarian) Torsion - p. 911 323. Chapter 241: Meconium Periorchitis - p. 913 324. Chapter 242: Testicular Torsion - p. 915 325. MISCELLANEOUS - p. 917 326. Chapter 243: Ovarian Cysts - p. 917 327. SECTION 12: HEMATOPOIETIC - p. 921 328. LYMPH NODES - p. 921 329. REACTIVE LYMPHADENOPATHIES - p. 921 330. Chapter 244: Reactive Follicular Hyperplasia - p. 921 331. Chapter 245: Reactive Paracortical Hyperplasia - p. 929 332. Chapter 246: Progressive Transformation of Germinal Centers - p. 937 333. Chapter 247: Hyaline-Vascular Castleman Disease - p. 943 334. Chapter 248: Dermatopathic Lymphadenitis - p. 949 335. Chapter 249: Kimura Disease - p. 955 336. Chapter 250: Kikuchi-Fujimoto Disease - p. 963 337. Chapter 251: Rosai-Dorfman Disease - p. 973 338. INFECTIOUS LYMPHADENOPATHIES - p. 983 339. Chapter 252: Infectious Mononucleosis Lymphadenitis - p. 983 340. Chapter 253: Cat-Scratch Disease - p. 987 341. Chapter 254: Mycobacterial Infection - p. 993 342. Chapter 255: Chronic Granulomatous Lymphadenitis - p. 1001 343. Chapter 256: Toxoplasma Lymphadenitis - p. 1009 344. BLOOD AND BONE MARROW - p. 1015 345. CONGENITAL/GENETIC/HEREDITARY - p. 1015 346. Chapter 257: Chediak-Higashi Syndrome - p. 1015 347. Chapter 258: Congenital Amegakaryocytic Thrombocytopenia - p. 1019 348. Chapter 259: Congenital Thrombotic Thrombocytopenic Purpura - p. 1023 349. Chapter 260: Congenital Erythrocytosis - p. 1027 350. Chapter 261: Diamond-Blackfan Anemia - p. 1031 351. Chapter 262: Hereditary Spherocytosis - p. 1035 352. Chapter 263: Hereditary Elliptocytosis - p. 1041 353. Chapter 264: Fanconi Anemia - p. 1045 354. Chapter 265: Pyruvate Kinase Deficiency - p. 1049 355. Chapter 266: Shwachman-Diamond Syndrome - p. 1051 356. Chapter 267: Severe Congenital Neutropenia and Cyclic Neutropenia - p. 1055 357. Chapter 268: Sickle Cell Anemia - p. 1059 358. Chapter 269: Hemophagocytic Lymphohistiocytosis - p. 1063 359. Chapter 270: Thalassemia - p. 1073 360. INFECTIOUS - p. 1079 361. Chapter 271: Infectious Mononucleosis Syndromes - p. 1079 362. Chapter 272: Parvovirus B19 Infection - p. 1089 363. MISCELLANEOUS - p. 1093 364. Chapter 273: Transient Erythroblastopenia of Childhood - p. 1093 365. THYMUS - p. 1095 366. TRAUMA/INJURY/REACTIVE - p. 1095 367. Chapter 274: Acute Thymic Involution - p. 1095 368. INDEX - p. 1097
This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all areas of nonneoplastic pediatric pathology, it incorporates the most recent clinical, pathologic, and molecular knowledge in this challenging field to provide a comprehensive overview of all key issues relevant to today’s practice. Richly illustrated and easy to use, the second edition of Diagnostic Pathology: Nonneoplastic Pediatrics is a one-stop reference for accurate, complete pathology reports, ideal as a day-to-day reference for both pediatric and general pathologists or as a reliable training resource.
Provides a clear framework for a better understanding of the clinical and histopathologic appearances of more than 270 nonneoplastic entities, covering every organ system with a focus on reactive, infectious, congenital, and genetic conditions
Covers significant advances in this complex field, including recent molecular discoveries and updated disease entities, new information on multiple immunologic disorders, changes and expansions to several classification systems (such as WHO, Banff, and ISSVA), and updates in other scoring systems
Contains new chapters on manifestations of pediatric COVID-19 infection, tumoral calcinosis, multiple skeletal dysplasia, skeletal muscle, collagenous gastritis and colitis, adenovirus appendicitis, intestinal pseudo-obstruction, disorders of sexual development, and Kikuchi disease
Features a thoroughly updated Molecular Factors Index, which cross-references gene names and locations with chapter-content specifics
Includes approximately 2,400 high-quality clinical and histological images, gross pathology images, radiologic images, and full-color drawings to help practicing and in-training pathologists reach a confident diagnosis—as well as more than 300 additional images online
Employs consistently templated chapters and bulleted content for quick, expert reference at the point of care
1. Cover image - p. Cover 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iii 5. Dedications - p. iii 6. Contributing Authors - p. v 7. Preface - p. v 8. Acknowledgments - p. v 9. List of Tables - p. xi 10. Sections - p. xi 11. SECTION 1: SKIN - p. xiii 12. SPONGIOTIC AND PSORIASIFORM DERMATOSES - p. xiii 13. Chapter 1: Pityriasis Rosea - p. xiii 14. Chapter 2: Contact Dermatitis - p. 5 15. Chapter 3: Atopic Dermatitis - p. 9 16. Chapter 4: Perniosis - p. 11 17. Chapter 5: Seborrheic Dermatitis - p. 13 18. INFLAMMATORY/INTERFACE DERMATOSES - p. 15 19. Chapter 6: Erythema Multiforme and Related Disorders - p. 15 20. Chapter 7: Pityriasis Lichenoides - p. 19 21. VESICOBULLOUS DERMATOSES - p. 23 22. Chapter 8: Acropustulosis of Infancy - p. 23 23. Chapter 9: Dermatitis Herpetiformis - p. 25 24. Chapter 10: Epidermolysis Bullosa, Inherited - p. 27 25. Chapter 11: Erythema Toxicum Neonatorum - p. 31 26. Chapter 12: Hailey-Hailey Disease - p. 33 27. Chapter 13: Chronic Bullous Disease of Childhood - p. 35 28. Chapter 14: Transient Neonatal Pustular Melanosis - p. 37 29. VASCULAR AND RELATED DISEASES - p. 39 30. Chapter 15: Urticaria and Variants - p. 39 31. Chapter 16: Leukocytoclastic Vasculitis - p. 43 32. PANNICULITIDES - p. 47 33. Chapter 17: Erythema Nodosum - p. 47 34. Chapter 18: Subcutaneous Fat Necrosis of Newborn - p. 51 35. Chapter 19: Sclerema Neonatorum - p. 53 36. CONNECTIVE TISSUE - p. 55 37. Chapter 20: Lupus Erythematosus - p. 55 38. Chapter 21: Morphea/Scleroderma - p. 61 39. Chapter 22: Dermatomyositis - p. 65 40. METABOLIC/DEPOSITION DISEASES - p. 69 41. Chapter 23: Calcinosis Cutis - p. 69 42. NONINFECTIOUS GRANULOMATOUS DISEASES - p. 73 43. Chapter 24: Chalazion - p. 73 44. Chapter 25: Granuloma Annulare - p. 75 45. PILOSEBACEOUS DISEASE - p. 77 46. Chapter 26: Acne Vulgaris - p. 77 47. ALOPECIAS - p. 79 48. Chapter 27: Trichotillomania - p. 79 49. DISORDERS OF EPIDERMAL MATURATION AND KERATINIZATION - p. 83 50. Chapter 28: Ichthyosis - p. 83 51. Chapter 29: Darier Disease - p. 85 52. Chapter 30: Porokeratosis - p. 87 53. Chapter 31: Incontinentia Pigmenti - p. 91 54. DISORDER OF COLLAGEN - p. 93 55. Chapter 32: Aplasia Cutis Congenita - p. 93 56. BACTERIAL INFECTIONS - p. 95 57. Chapter 33: Impetigo - p. 95 58. Chapter 34: Staphylococcal Scalded Skin Syndrome - p. 99 59. Chapter 35: Ecthyma and Ecthyma Gangrenosum - p. 101 60. Chapter 36: Cat-Scratch Disease - p. 103 61. Chapter 37: Atypical Mycobacterial Infections - p. 109 62. VIRAL INFECTIONS - p. 111 63. Chapter 38: Molluscum Contagiosum - p. 111 64. Chapter 39: Herpesvirus - p. 113 65. FUNGAL INFECTIONS - p. 115 66. Chapter 40: Candidiasis - p. 115 67. ARTHROPODS/PARASITES - p. 119 68. Chapter 41: Bite Reactions - p. 119 69. Chapter 42: Scabies - p. 123 70. CYSTS - p. 125 71. Chapter 43: Epidermal Inclusion Cyst - p. 125 72. Chapter 44: Dermoid Cyst - p. 127 73. SECTION 2: SOFT TISSUE - p. 131 74. Chapter 45: Necrotizing Fasciitis - p. 131 75. Chapter 46: Tumoral Calcinosis - p. 135 76. SECTION 3: BONE AND JOINT - p. 137 77. CONGENITAL/GENETIC/HEREDITARY - p. 137 78. Chapter 47: Osteogenesis Imperfecta - p. 137 79. Chapter 48: Chondrodysplasia Punctata - p. 143 80. Chapter 49: Thanatophoric Dysplasia - p. 147 81. TRAUMA/INJURY/REACTIVE - p. 149 82. Chapter 50: Bone Fracture and Repair - p. 149 83. Chapter 51: Osteomyelitis - p. 153 84. Chapter 52: Stress and Costochondral Junction - p. 157 85. Chapter 53: Juvenile Idiopathic Arthritis - p. 159 86. SECTION 4: SKELETAL MUSCLE - p. 163 87. CONGENITAL/GENETIC/HEREDITARY - p. 163 88. Chapter 54: Spinal Muscular Atrophy - p. 163 89. Chapter 55: X-Linked Muscular Dystrophy: Duchenne and Becker - p. 167 90. Chapter 56: Congenital Myopathies - p. 171 91. SECTION 5: CENTRAL NERVOUS SYSTEM - p. 173 92. CONGENITAL/GENETIC/HEREDITARY - p. 173 93. Chapter 57: Cerebral Heterotopia and Ectopia - p. 173 94. Chapter 58: Focal Cortical Dysplasia - p. 177 95. Chapter 59: Myelomeningocele - p. 191 96. Chapter 60: Encephalocele - p. 193 97. Chapter 61: Tethered Cord - p. 195 98. Chapter 62: Cerebral Arteriovenous Malformations - p. 197 99. Chapter 63: Cerebral Cavernous Malformation - p. 201 100. TRAUMA/INJURY/REACTIVE - p. 205 101. Chapter 64: Hypoxic-Ischemic Encephalopathy - p. 205 102. Chapter 65: Periventricular Leukomalacia - p. 209 103. Chapter 66: Arachnoid Cysts - p. 213 104. Chapter 67: Meningioangiomatosis - p. 215 105. Chapter 68: Germinal Matrix-Intraventricular Hemorrhage - p. 221 106. INFECTIOUS - p. 225 107. Chapter 69: Bacterial Meningoencephalitis - p. 225 108. Chapter 70: Fungal Meningoencephalitis - p. 231 109. Chapter 71: Viral Meningoencephalitis - p. 237 110. Chapter 72: Protozoal Meningoencephalitis - p. 241 111. SECTION 6: ENDOCRINE - p. 245 112. CONGENITAL/GENETIC/HEREDITARY - p. 245 113. Chapter 73: Adrenal Cytomegaly - p. 245 114. Chapter 74: Adrenal Heterotopia - p. 249 115. Chapter 75: Adrenal Hypoplasia and Malformations - p. 251 116. Chapter 76: Adrenal Cortical Hyperplasia - p. 253 117. Chapter 77: Dyshormonogenetic Goiter - p. 257 118. Chapter 78: Ectopic Thyroid - p. 263 119. Chapter 79: Thyroglossal Duct Cyst - p. 265 120. Chapter 80: Cystic Fibrosis, Pancreas - p. 267 121. TRAUMA/INJURY/REACTIVE - p. 269 122. Chapter 81: Stress Reactions in Adrenal Gland - p. 269 123. Chapter 82: Hemorrhagic Necrosis of Adrenal Gland - p. 271 124. Chapter 83: Chronic Lymphocytic Thyroiditis - p. 273 125. Chapter 84: Graves Disease - p. 277 126. Chapter 85: Hypertrophy of Pancreatic Islets - p. 283 127. SECTION 7: RESPIRATORY - p. 285 128. CONGENITAL/GENETIC/HEREDITARY - p. 285 129. Chapter 86: Bronchogenic Cyst - p. 285 130. Chapter 87: Congenital Alveolar Capillary Dysplasia - p. 289 131. Chapter 88: Congenital Lobar Emphysema - p. 293 132. Chapter 89: Congenital Pulmonary Lymphangiectasis - p. 295 133. Chapter 90: Diffuse Pulmonary Lymphangiomatosis - p. 297 134. Chapter 91: Congenital Pulmonary Airway Malformation - p. 301 135. Chapter 92: Congenital Surfactant Deficiency - p. 305 136. Chapter 93: Cystic Fibrosis - p. 309 137. Chapter 94: Sequestrations - p. 313 138. TRAUMA/INJURY/REACTIVE - p. 315 139. Chapter 95: Aspiration - p. 315 140. Chapter 96: Asthma - p. 319 141. Chapter 97: Bronchopulmonary Dysplasia - p. 321 142. Chapter 98: Hyaline Membrane Disease - p. 325 143. Chapter 99: Interstitial Pulmonary Emphysema - p. 327 144. Chapter 100: Persistent Pulmonary Hypertension - p. 329 145. Chapter 101: Idiopathic Pulmonary Hemosiderosis - p. 331 146. Chapter 102: Pulmonary Venoocclusive Disease/Pulmonary Capillary Hemangiomatosis - p. 333 147. Chapter 103: Nonspecific Interstitial Pneumonia - p. 337 148. Chapter 104: Hypersensitivity Pneumonitis - p. 339 149. Chapter 105: Eosinophilic Pneumonia - p. 341 150. INFECTIOUS - p. 345 151. Chapter 106: Adenovirus - p. 345 152. Chapter 107: Human Metapneumovirus - p. 347 153. Chapter 108: Respiratory Syncytial Virus - p. 351 154. MISCELLANEOUS - p. 353 155. Chapter 109: Neuroendocrine Cell Hyperplasia of Infancy - p. 353 156. SECTION 8: CARDIOVASCULAR - p. 355 157. CONGENITAL/GENETIC/HEREDITARY - p. 355 158. Chapter 110: Arrhythmogenic Right Ventricular Cardiomyopathy - p. 355 159. Chapter 111: Hypertrophic Cardiomyopathy - p. 361 160. Chapter 112: Dilated Cardiomyopathy - p. 363 161. Chapter 113: Fabry Disease - p. 367 162. Chapter 114: Fatty Acid Metabolic Disorders - p. 371 163. Chapter 115: Glycogen Storage Diseases - p. 373 164. Chapter 116: Mitochondrial Myopathies - p. 375 165. Chapter 117: Capillary Malformations - p. 379 166. Chapter 118: Lymphatic Malformations - p. 383 167. Chapter 119: Venous Malformations - p. 387 168. Chapter 120: Arteriovenous Malformations and Fistulas - p. 391 169. TRAUMA/INJURY/REACTIVE - p. 395 170. Chapter 121: Endocardial Fibroelastosis - p. 395 171. INFECTIOUS - p. 397 172. Chapter 122: Lymphocytic Myocarditis - p. 397 173. Chapter 123: Acute Pericarditis - p. 401 174. Chapter 124: Acute Rheumatic Fever - p. 405 175. Chapter 125: Kawasaki Disease - p. 409 176. Chapter 126: COVID-19-Related Pathology and Pediatric Multisystem Inflammatory Syndrome - p. 413 177. SECTION 9: ALIMENTARY CANAL - p. 423 178. ESOPHAGUS - p. 423 179. CONGENITAL/GENETIC/HEREDITARY - p. 423 180. Chapter 127: Inlet Patch - p. 423 181. Chapter 128: Tracheoesophageal Fistula and Esophageal Atresia - p. 429 182. Chapter 129: Esophageal Duplication Cyst - p. 433 183. TRAUMA/INJURY/REACTIVE - p. 437 184. Chapter 130: Gastroesophageal Reflux Disease - p. 437 185. Chapter 131: Eosinophilic Esophagitis - p. 443 186. INFECTIOUS - p. 447 187. Chapter 132: Herpes Simplex Virus Esophagitis - p. 447 188. Chapter 133: Candida - p. 449 189. STOMACH - p. 451 190. TRAUMA/INJURY/REACTIVE - p. 451 191. Chapter 134: Chemical Gastropathy - p. 451 192. Chapter 135: Chronic Gastritis - p. 455 193. Chapter 136: Granulomatous Gastritis - p. 457 194. Chapter 137: Lymphocytic Gastritis - p. 461 195. Chapter 138: Eosinophilic Gastroenteritis - p. 467 196. Chapter 139: Fundic Gland Polyp - p. 469 197. Chapter 140: Collagenous Gastritis - p. 471 198. INFECTIOUS - p. 475 199. Chapter 141: Helicobacter heilmannii Gastritis - p. 475 200. Chapter 142: Helicobacter pylori Gastritis - p. 477 201. SMALL BOWEL - p. 481 202. CONGENITAL/GENETIC/HEREDITARY - p. 481 203. Chapter 143: Small Intestine Duplication Cyst - p. 481 204. Chapter 144: Ectopic Pancreas - p. 483 205. Chapter 145: Gastric Heterotopia - p. 487 206. Chapter 146: Meckel Diverticulum - p. 489 207. Chapter 147: Microvillous Inclusion Disease - p. 491 208. Chapter 148: Primary Intestinal Lymphangiectasia - p. 493 209. Chapter 149: Abetalipoproteinemia - p. 495 210. Chapter 150: Tufting Enteropathy - p. 499 211. Chapter 151: Autoimmune Enteropathy - p. 503 212. INFLAMMATORY/IMMUNE DYSFUNCTION - p. 507 213. Chapter 152: Celiac Disease - p. 507 214. Chapter 153: Common Variable Immunodeficiency - p. 513 215. INFECTIOUS - p. 517 216. Chapter 154: Giardia - p. 517 217. Chapter 155: Cryptosporidium - p. 519 218. APPENDIX - p. 521 219. Chapter 156: Acute Appendicitis - p. 521 220. Chapter 157: Granulomatous Appendicitis - p. 525 221. Chapter 158: Enterobius Vermicularis Appendicitis - p. 527 222. Chapter 159: Fibrous Obliteration - p. 529 223. COLON - p. 531 224. CONGENITAL/GENETIC/HEREDITARY - p. 531 225. Chapter 160: Cystic Fibrosis, Intestinal - p. 531 226. Chapter 161: Colonic Duplications, Cysts, and Congenital Diverticula - p. 533 227. Chapter 162: Hirschsprung Disease - p. 537 228. Chapter 163: Intestinal Motility Disorders - p. 543 229. TRAUMA/INJURY/REACTIVE - p. 545 230. Chapter 164: Diversion Colitis - p. 545 231. Chapter 165: Pneumatosis Intestinalis - p. 547 232. Chapter 166: Solitary Rectal Ulcer Syndrome/Mucosal Prolapse - p. 553 233. Chapter 167: Necrotizing Enterocolitis - p. 559 234. INFLAMMATORY/IMMUNE DYSFUNCTION - p. 561 235. Chapter 168: Eosinophilic/Allergic Colitis - p. 561 236. Chapter 169: Focal Active Colitis - p. 567 237. Chapter 170: Crohn Disease - p. 569 238. Chapter 171: Ulcerative Colitis - p. 581 239. Chapter 172: Collagenous Colitis - p. 589 240. INFECTIOUS - p. 597 241. Chapter 173: Cytomegalovirus - p. 597 242. Chapter 174: Entamoeba Histolytica - p. 603 243. Chapter 175: Adenovirus - p. 605 244. Chapter 176: Acute Infectious Colitis - p. 607 245. Chapter 177: Pseudomembranous Colitis - p. 609 246. SECTION 10: LIVER/GALLBLADDER - p. 613 247. CONGENITAL/GENETIC/HEREDITARY - p. 613 248. Chapter 178: Congenital Hepatic Fibrosis - p. 613 249. Chapter 179: Caroli Disease - p. 617 250. Chapter 180: Cystic Fibrosis, Hepatic - p. 619 251. Chapter 181: Dubin-Johnson Syndrome - p. 623 252. Chapter 182: Gilbert Disease - p. 625 253. Chapter 183: Progressive Familial Intrahepatic Cholestasis - p. 627 254. Chapter 184: Biliary Atresia - p. 635 255. Chapter 185: Syndromic Paucity of Intrahepatic Bile Ducts (Alagille Syndrome) - p. 641 256. Chapter 186: Paucity of Intrahepatic Bile Ducts (Nonsyndromic) - p. 645 257. Chapter 187: Autoimmune Hepatitis - p. 649 258. Chapter 188: α-1-Antitrypsin Deficiency - p. 655 259. Chapter 189: Glycogen Storage Disease - p. 659 260. Chapter 190: Niemann-Pick Disease - p. 665 261. Chapter 191: Tyrosinemia - p. 667 262. Chapter 192: Gaucher Disease - p. 669 263. Chapter 193: Neonatal Hemochromatosis - p. 671 264. Chapter 194: Wilson Disease - p. 673 265. Chapter 195: Choledochal Cyst - p. 679 266. TRAUMA/INJURY/REACTIVE - p. 681 267. Chapter 196: Intestinal Failure-Associated Liver Disease (Total Parenteral Nutrition Injury) - p. 681 268. Chapter 197: Neonatal Hepatitis - p. 685 269. Chapter 198: Reye Syndrome - p. 689 270. Chapter 199: Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis - p. 691 271. Chapter 200: Primary Sclerosing Cholangitis - p. 695 272. Chapter 201: Venoocclusive Disease - p. 699 273. Chapter 202: Drug-Related Acute Hepatitis - p. 701 274. INFECTIOUS - p. 705 275. Chapter 203: Viral Hepatitis - p. 705 276. Chapter 204: Epstein-Barr Virus - p. 709 277. Chapter 205: Herpes Simplex Virus Hepatitis - p. 713 278. Chapter 206: Cytomegalovirus - p. 715 279. SECTION 11: GENITOURINARY - p. 717 280. KIDNEY/URINARY TRACT - p. 717 281. GLOMERULAR DISEASES - p. 717 282. Chapter 207: Congenital Nephrotic Syndrome - p. 717 283. Chapter 208: Diffuse Mesangial Sclerosis - p. 725 284. Chapter 209: Minimal Change Disease - p. 731 285. Chapter 210: Focal Segmental Glomerulosclerosis - p. 739 286. Chapter 211: Acute Postinfectious Glomerulonephritis - p. 751 287. Chapter 212: Membranoproliferative Glomerulonephritis - p. 759 288. Chapter 213: C3 Glomerulonephritis - p. 767 289. Chapter 214: Dense Deposit Disease - p. 773 290. Chapter 215: Systemic Lupus Erythematosus - p. 779 291. Chapter 216: IgA Nephropathy - p. 797 292. Chapter 217: Henoch-Schönlein Purpura Nephritis - p. 807 293. Chapter 218: Thin Basement Membrane Nephropathy - p. 815 294. Chapter 219: Alport Syndrome - p. 819 295. TUBULOINTERSTITIAL DISEASES - p. 829 296. Chapter 220: Acute Tubular Injury - p. 829 297. Chapter 221: Acute Pyelonephritis - p. 835 298. Chapter 222: Tubulointerstitial Nephritis With Uveitis - p. 843 299. Chapter 223: Primary Hyperoxaluria - p. 847 300. VASCULAR DISEASES - p. 849 301. Chapter 224: Fibromuscular Dysplasia (Renal Artery Stenosis) - p. 849 302. Chapter 225: Hemolytic Uremic Syndrome, Infection Related and Atypical - p. 855 303. Chapter 226: Vasculitis, ANCA Related - p. 861 304. CYSTIC AND DEVELOPMENTAL DISEASES - p. 867 305. Chapter 227: Reflux Nephropathy - p. 867 306. Chapter 228: Polycystic Kidney Disease, Autosomal Recessive - p. 871 307. Chapter 229: Polycystic Kidney Disease, Autosomal Dominant - p. 875 308. Chapter 230: Medullary Cystic Kidney Disease/Nephronophthisis - p. 879 309. Chapter 231: Renal Dysplasia - p. 881 310. Chapter 232: Renal Tubular Dysgenesis - p. 885 311. Chapter 233: Ask-Upmark Kidney - p. 887 312. REPRODUCTIVE SYSTEM - p. 889 313. CONGENITAL/GENETIC/HEREDITARY - p. 889 314. Chapter 234: Accessory Breast Tissue - p. 889 315. Chapter 235: Cryptorchidism - p. 891 316. Chapter 236: Testicular Regression Syndrome - p. 895 317. Chapter 237: Disorders of Sexual Development - p. 897 318. INFLAMMATORY/IMMUNE DYSFUNCTION - p. 905 319. Chapter 238: Hidradenitis Suppurativa - p. 905 320. Chapter 239: Childhood Behçet Disease - p. 907 321. TRAUMA/INJURY/REACTIVE - p. 911 322. Chapter 240: Adnexal (Ovarian) Torsion - p. 911 323. Chapter 241: Meconium Periorchitis - p. 913 324. Chapter 242: Testicular Torsion - p. 915 325. MISCELLANEOUS - p. 917 326. Chapter 243: Ovarian Cysts - p. 917 327. SECTION 12: HEMATOPOIETIC - p. 921 328. LYMPH NODES - p. 921 329. REACTIVE LYMPHADENOPATHIES - p. 921 330. Chapter 244: Reactive Follicular Hyperplasia - p. 921 331. Chapter 245: Reactive Paracortical Hyperplasia - p. 929 332. Chapter 246: Progressive Transformation of Germinal Centers - p. 937 333. Chapter 247: Hyaline-Vascular Castleman Disease - p. 943 334. Chapter 248: Dermatopathic Lymphadenitis - p. 949 335. Chapter 249: Kimura Disease - p. 955 336. Chapter 250: Kikuchi-Fujimoto Disease - p. 963 337. Chapter 251: Rosai-Dorfman Disease - p. 973 338. INFECTIOUS LYMPHADENOPATHIES - p. 983 339. Chapter 252: Infectious Mononucleosis Lymphadenitis - p. 983 340. Chapter 253: Cat-Scratch Disease - p. 987 341. Chapter 254: Mycobacterial Infection - p. 993 342. Chapter 255: Chronic Granulomatous Lymphadenitis - p. 1001 343. Chapter 256: Toxoplasma Lymphadenitis - p. 1009 344. BLOOD AND BONE MARROW - p. 1015 345. CONGENITAL/GENETIC/HEREDITARY - p. 1015 346. Chapter 257: Chediak-Higashi Syndrome - p. 1015 347. Chapter 258: Congenital Amegakaryocytic Thrombocytopenia - p. 1019 348. Chapter 259: Congenital Thrombotic Thrombocytopenic Purpura - p. 1023 349. Chapter 260: Congenital Erythrocytosis - p. 1027 350. Chapter 261: Diamond-Blackfan Anemia - p. 1031 351. Chapter 262: Hereditary Spherocytosis - p. 1035 352. Chapter 263: Hereditary Elliptocytosis - p. 1041 353. Chapter 264: Fanconi Anemia - p. 1045 354. Chapter 265: Pyruvate Kinase Deficiency - p. 1049 355. Chapter 266: Shwachman-Diamond Syndrome - p. 1051 356. Chapter 267: Severe Congenital Neutropenia and Cyclic Neutropenia - p. 1055 357. Chapter 268: Sickle Cell Anemia - p. 1059 358. Chapter 269: Hemophagocytic Lymphohistiocytosis - p. 1063 359. Chapter 270: Thalassemia - p. 1073 360. INFECTIOUS - p. 1079 361. Chapter 271: Infectious Mononucleosis Syndromes - p. 1079 362. Chapter 272: Parvovirus B19 Infection - p. 1089 363. MISCELLANEOUS - p. 1093 364. Chapter 273: Transient Erythroblastopenia of Childhood - p. 1093 365. THYMUS - p. 1095 366. TRAUMA/INJURY/REACTIVE - p. 1095 367. Chapter 274: Acute Thymic Involution - p. 1095 368. INDEX - p. 1097
