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This issue of Medical Clinics covers the important advances surrounding the early intervention of Alzheimer's Disease. Guest edited by world-renowned experts from around the world, the topics covered will include evaluation of new diagnostic criteria, CSF biomarkers, diagnostic imaging, neurocognitive approaches, breaking clinical trials and more.

1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. CME Accreditation Page and Author Disclosure - p. 4 5. Medical Clinics of North America - p. 5 6. Contributors - p. 6 7. Preface - p. 7 8. International Work Group Criteria for the Diagnosis of Alzheimer Disease - p. 8 9. The Application of Cerebrospinal Fluid Biomarkers in Early Diagnosis of Alzheimer Disease - p. 12 10. Amyloid Imaging with PET in Early Alzheimer Disease Diagnosis - p. 17 11. Relevance of Magnetic Resonance Imaging for Early Detection and Diagnosis of Alzheimer Disease - p. 31 12. Cognitive Approaches to Early Alzheimer’s Disease Diagnosis - p. 40 13. Clinical Trials in Predementia Stages of Alzheimer Disease - p. 47 14. Emotional and Psychological Implications of Early AD Diagnosis - p. 58 15. Applying the IWG Research Criteria in Clinical Practice - p. 68 16. FDG-PET in Early AD Diagnosis - p. 73 17. Index - p. 78

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This issue of Medical Clinics covers the important advances surrounding the early intervention of Alzheimer's Disease. Guest edited by world-renowned experts from around the world, the topics covered will include evaluation of new diagnostic criteria, CSF biomarkers, diagnostic imaging, neurocognitive approaches, breaking clinical trials and more.

1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. CME Accreditation Page and Author Disclosure - p. 4 5. Medical Clinics of North America - p. 5 6. Contributors - p. 6 7. Preface - p. 7 8. International Work Group Criteria for the Diagnosis of Alzheimer Disease - p. 8 9. The Application of Cerebrospinal Fluid Biomarkers in Early Diagnosis of Alzheimer Disease - p. 12 10. Amyloid Imaging with PET in Early Alzheimer Disease Diagnosis - p. 17 11. Relevance of Magnetic Resonance Imaging for Early Detection and Diagnosis of Alzheimer Disease - p. 31 12. Cognitive Approaches to Early Alzheimer’s Disease Diagnosis - p. 40 13. Clinical Trials in Predementia Stages of Alzheimer Disease - p. 47 14. Emotional and Psychological Implications of Early AD Diagnosis - p. 58 15. Applying the IWG Research Criteria in Clinical Practice - p. 68 16. FDG-PET in Early AD Diagnosis - p. 73 17. Index - p. 78

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