Fundamentals of Redox Biology is a comprehensive guide to understanding the complex roles of cellular redox systems in biological processes and human health. Exploring the regulation, physiological functions, and pathological implications of reactive oxygen species (ROS) and free radicals, this book serves as an essential resource for students and professionals in biochemistry and related fields. It delves into the fundamentals of redox signaling, the impact of antioxidants on homeostasis, and the intricate balance between oxidative stress and disease development, including conditions like cancer and neurological disorders. This foundational text is invaluable for advancing knowledge in redox biology.
In addition to providing a historical perspective on redox biology, the book examines how ROS influence epigenetic regulation and mitochondrial function, particularly in immune responses to infections. It also integrates discussions on the role of redox systems across multiple disciplines, making it relevant to cell biology, molecular biology, immunology, and beyond. With its detailed exploration of both theoretical and applied aspects, the book positions itself as a pivotal resource for understanding the mechanisms underlying redox balance and its broad applications in life sciences.
1. Cover image - p. c 2. Title page - p. i 3. Copyright - p. iv 4. Dedication - p. v 5. Contents - p. vii 6. About the Author - p. xi 7. Foreword - p. xiii 8. Preface - p. xvii 9. Acknowledgements - p. xix 10. Section A General topics - p. 1 11. Chapter 1 Free radicals and other reactive oxygen species in human health and diseases—A historical perspective - p. 3 12. Chapter 2 Biochemistry of free radicals and reactive oxygen species - p. 27 13. Chapter 3 Antioxidants and their physiological roles in redox homeostasis - p. 69 14. Chapter 4 Tools and techniques for the detection and estimation of free radicals and other reactive species - p. 105 15. Chapter 5 Redox signaling - p. 139 16. Chapter 6 Role of ROS in genetic and epigenetic regulations - p. 167 17. Chapter 7 Cellular compartmentalization and its importance in the physiological functions of ROS - p. 195 18. Section B Specialized topics - p. 209 19. Chapter 8 Role of ROS in metabolism: The cancer cell paradigm - p. 211 20. Chapter 9 The role of ROS in cardiovascular and neurological disorders - p. 231 21. Chapter 10 Iron/copper homeostasis, ROS, and ferroptosis - p. 251 22. Contents - p. 251 23. 10.1 The preamble - p. 251 24. 10.2 Calcium and the cellular redox system - p. 252 25. 10.3 Iron homeostasis and cellular redox - p. 255 26. 10.4 Iron and neurodegenerative diseases - p. 260 27. 10.5 Ferroptosis, the iron-induced cell death - p. 262 28. 10.6 Copper homeostasis and ROS - p. 262 29. 10.7 Concluding remarks - p. 263 30. 10.8 Exercise - p. 263 31. References - p. 264 32. Chapter 11 Role of cellular redox in organismal biology: Lessons from C. elegans, zebrafish, Drosophila, and mouse - p. 267 33. Contents - p. 267 34. 11.1 The preamble - p. 267 35. 11.2 Drosophila as a model organism for redox studies - p. 267 36. 11.3 Caenorhabditis elegans as a model organism for studying redox regulation - p. 270 37. 11.4 Zebrafish as a model organism for studying the role of oxidative stress in diseases - p. 271 38. 11.5 Mouse as a model system for studying oxidative stress and regulatory ROS - p. 272 39. 11.6 Concluding remarks - p. 273 40. References - p. 274 41. Chapter 12 ROS in stress response and long-distance signaling in plants - p. 277 42. Index - p. 295
Fundamentals of Redox Biology is a comprehensive guide to understanding the complex roles of cellular redox systems in biological processes and human health. Exploring the regulation, physiological functions, and pathological implications of reactive oxygen species (ROS) and free radicals, this book serves as an essential resource for students and professionals in biochemistry and related fields. It delves into the fundamentals of redox signaling, the impact of antioxidants on homeostasis, and the intricate balance between oxidative stress and disease development, including conditions like cancer and neurological disorders. This foundational text is invaluable for advancing knowledge in redox biology.
In addition to providing a historical perspective on redox biology, the book examines how ROS influence epigenetic regulation and mitochondrial function, particularly in immune responses to infections. It also integrates discussions on the role of redox systems across multiple disciplines, making it relevant to cell biology, molecular biology, immunology, and beyond. With its detailed exploration of both theoretical and applied aspects, the book positions itself as a pivotal resource for understanding the mechanisms underlying redox balance and its broad applications in life sciences.
1. Cover image - p. c 2. Title page - p. i 3. Copyright - p. iv 4. Dedication - p. v 5. Contents - p. vii 6. About the Author - p. xi 7. Foreword - p. xiii 8. Preface - p. xvii 9. Acknowledgements - p. xix 10. Section A General topics - p. 1 11. Chapter 1 Free radicals and other reactive oxygen species in human health and diseases—A historical perspective - p. 3 12. Chapter 2 Biochemistry of free radicals and reactive oxygen species - p. 27 13. Chapter 3 Antioxidants and their physiological roles in redox homeostasis - p. 69 14. Chapter 4 Tools and techniques for the detection and estimation of free radicals and other reactive species - p. 105 15. Chapter 5 Redox signaling - p. 139 16. Chapter 6 Role of ROS in genetic and epigenetic regulations - p. 167 17. Chapter 7 Cellular compartmentalization and its importance in the physiological functions of ROS - p. 195 18. Section B Specialized topics - p. 209 19. Chapter 8 Role of ROS in metabolism: The cancer cell paradigm - p. 211 20. Chapter 9 The role of ROS in cardiovascular and neurological disorders - p. 231 21. Chapter 10 Iron/copper homeostasis, ROS, and ferroptosis - p. 251 22. Contents - p. 251 23. 10.1 The preamble - p. 251 24. 10.2 Calcium and the cellular redox system - p. 252 25. 10.3 Iron homeostasis and cellular redox - p. 255 26. 10.4 Iron and neurodegenerative diseases - p. 260 27. 10.5 Ferroptosis, the iron-induced cell death - p. 262 28. 10.6 Copper homeostasis and ROS - p. 262 29. 10.7 Concluding remarks - p. 263 30. 10.8 Exercise - p. 263 31. References - p. 264 32. Chapter 11 Role of cellular redox in organismal biology: Lessons from C. elegans, zebrafish, Drosophila, and mouse - p. 267 33. Contents - p. 267 34. 11.1 The preamble - p. 267 35. 11.2 Drosophila as a model organism for redox studies - p. 267 36. 11.3 Caenorhabditis elegans as a model organism for studying redox regulation - p. 270 37. 11.4 Zebrafish as a model organism for studying the role of oxidative stress in diseases - p. 271 38. 11.5 Mouse as a model system for studying oxidative stress and regulatory ROS - p. 272 39. 11.6 Concluding remarks - p. 273 40. References - p. 274 41. Chapter 12 ROS in stress response and long-distance signaling in plants - p. 277 42. Index - p. 295
