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This issue of Endocrinology and Metabolism Clinics, edited by Dr. Ashley Grossman, will focus on Innovations in the Management of Neuroendocrine Tumors. Topics include, but are not limited to, Molecular targeted therapy of NETs – State of the art; Surgical approaches to the management of liver metastases; Liquid biopsies for NETs – circulating tumour cells and DNA; Novel functional imaging of NETs; The problem of appendiceal carcinoids; Peptide radioreceptor therapy comes of age; Current chemotherapy use in NETs; The problem of grade 3 NETs; Molecular genetic studies of pancreatic neuroendocrine tumours reveal new therapeutic approaches; The new WHO classification; Gastrinomas – medical or surgical treatment; When and how to use somatostatin analogues; The NETest as the way forward; Lung and thymic carcinoids; Carcinoid heart disease; Gastric carcinoids; New treatments for the carcinoid syndrome; and The genesis of the NETs concept – From Oberdorfer to 2018.

1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. i 4. Copyright - p. ii 5. Contributors - p. iii 6. Forthcoming Issues - p. xii 7. Foreword - p. xiii 8. Preface - p. xv 9. The New World Health Organization Classification for Pancreatic Neuroendocrine Neoplasia - p. 463 10. Liquid Biopsies for Neuroendocrine Tumors: Circulating Tumor Cells, DNA, and MicroRNAs - p. 471 11. The NETest: The Clinical Utility of Multigene Blood Analysis in the Diagnosis and Management of Neuroendocrine Tumors - p. 485 12. Novel Functional Imaging of Neuroendocrine Tumors - p. 505 13. Molecular Genetic Studies of Pancreatic Neuroendocrine Tumors: New Therapeutic Approaches - p. 525 14. When and How to Use Somatostatin Analogues - p. 549 15. New Treatments for the Carcinoid Syndrome - p. 557 16. Gastrinomas: Medical or Surgical Treatment - p. 577 17. Current Chemotherapy Use in Neuroendocrine Tumors - p. 603 18. Peptide Receptor Radiotherapy Comes of Age - p. 615 19. Surgical Approaches to the Management of Neuroendocrine Liver Metastases - p. 627 20. Gastric Carcinoids - p. 645 21. The Problem of Appendiceal Carcinoids - p. 661 22. Carcinoid Heart Disease: A Review - p. 671 23. The Problem of High-Grade Gastroenteropancreatic Neuroendocrine Neoplasms: Well-Differentiated Neuroendocrine Tumors, Neuroendocrine Carcinomas, and Beyond - p. 683 24. Lung and Thymic Carcinoids - p. 699 25. The Genesis of the Neuroendocrine Tumors Concept: From Oberndorfer to 2018 - p. 711

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This issue of Endocrinology and Metabolism Clinics, edited by Dr. Ashley Grossman, will focus on Innovations in the Management of Neuroendocrine Tumors. Topics include, but are not limited to, Molecular targeted therapy of NETs – State of the art; Surgical approaches to the management of liver metastases; Liquid biopsies for NETs – circulating tumour cells and DNA; Novel functional imaging of NETs; The problem of appendiceal carcinoids; Peptide radioreceptor therapy comes of age; Current chemotherapy use in NETs; The problem of grade 3 NETs; Molecular genetic studies of pancreatic neuroendocrine tumours reveal new therapeutic approaches; The new WHO classification; Gastrinomas – medical or surgical treatment; When and how to use somatostatin analogues; The NETest as the way forward; Lung and thymic carcinoids; Carcinoid heart disease; Gastric carcinoids; New treatments for the carcinoid syndrome; and The genesis of the NETs concept – From Oberdorfer to 2018.

1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. i 4. Copyright - p. ii 5. Contributors - p. iii 6. Forthcoming Issues - p. xii 7. Foreword - p. xiii 8. Preface - p. xv 9. The New World Health Organization Classification for Pancreatic Neuroendocrine Neoplasia - p. 463 10. Liquid Biopsies for Neuroendocrine Tumors: Circulating Tumor Cells, DNA, and MicroRNAs - p. 471 11. The NETest: The Clinical Utility of Multigene Blood Analysis in the Diagnosis and Management of Neuroendocrine Tumors - p. 485 12. Novel Functional Imaging of Neuroendocrine Tumors - p. 505 13. Molecular Genetic Studies of Pancreatic Neuroendocrine Tumors: New Therapeutic Approaches - p. 525 14. When and How to Use Somatostatin Analogues - p. 549 15. New Treatments for the Carcinoid Syndrome - p. 557 16. Gastrinomas: Medical or Surgical Treatment - p. 577 17. Current Chemotherapy Use in Neuroendocrine Tumors - p. 603 18. Peptide Receptor Radiotherapy Comes of Age - p. 615 19. Surgical Approaches to the Management of Neuroendocrine Liver Metastases - p. 627 20. Gastric Carcinoids - p. 645 21. The Problem of Appendiceal Carcinoids - p. 661 22. Carcinoid Heart Disease: A Review - p. 671 23. The Problem of High-Grade Gastroenteropancreatic Neuroendocrine Neoplasms: Well-Differentiated Neuroendocrine Tumors, Neuroendocrine Carcinomas, and Beyond - p. 683 24. Lung and Thymic Carcinoids - p. 699 25. The Genesis of the Neuroendocrine Tumors Concept: From Oberndorfer to 2018 - p. 711

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