Liver Pathophysiology: Therapies and Antioxidants is a complete volume on morphology, physiology, biochemistry, molecular biology and treatment of liver diseases. It uses an integral approach towards the role of free radicals in the pathogenesis of hepatic injury, and how their deleterious effects may be abrogated by the use of antioxidants.
Written by the most prominent authors in the field, this book will be of use to basic and clinical scientists and clinicians working in the biological sciences, especially those dedicated to the study and treatment of liver pathologies.
1. Section I. Introduction - p. xxxi 2. Chapter 1. The Liver: General Aspects and Epidemiology - p. 3 3. Chapter 2. Structure and Ultrastructure of the Normal and Diseased Liver - p. 23 4. Section II. Liver Pathophysiology - p. 44 5. Chapter 3. Hepatic Apoptosis and Necrosis: Mechanisms and Clinical Relevance - p. 47 6. Chapter 4. Autoimmune Hepatitis - p. 61 7. Selection and Presentation of Indigenous Foreign Antigens - p. 62 8. Breaking Immune Tolerance of Self-Antigens - p. 65 9. Neoantigens and Epitope Spread - p. 65 10. Implicated Self-Antigens - p. 66 11. Cell Mediators of Liver Injury - p. 67 12. Molecular Mechanisms of Immune-Mediated Liver Injury - p. 71 13. Overview - p. 76 14. Chapter 5. Pathogenesis of Idiosyncratic Drug Induced Liver Injury - p. 87 15. Chapter 6. Acetaminophen - p. 101 16. Chapter 7. Liver Regeneration - p. 113 17. Chapter 8. Nitric Oxide in Liver Ischemia–Reperfusion Injury - p. 125 18. Chapter 9. The Immune System and Viral Hepatitis - p. 129 19. Chapter 10. The Pathophysiology of Alcoholic Liver Disease - p. 141 20. Chapter 11. Cytokines in Steatohepatitis - p. 159 21. Chapter 12. Redox Signaling in NASH - p. 169 22. Chapter 13. Amebic Liver Abscess - p. 181 23. Chapter 14. Role of Cytokines and Reactive Oxygen Species in the Amebic Liver Abscess Produced by Entamoeba histolytica - p. 187 24. Chapter 15. Epigenetics in Liver Disease: Involvement of Oxidative Stress - p. 199 25. Chapter 16. Role of Oxidative and Nitrosative Stress in Hepatic Fibrosis - p. 213 26. Chapter 17. Oxidative and Nitrosative Stress in Chronic Cholestasis - p. 225 27. Chapter 18. Cholestasis, Contraceptives, and Free Radicals - p. 239 28. Chapter 19. Is Human Cirrhosis a Reversible Disease? - p. 259 29. Chapter 20. Obesity and Hepatocellular Carcinoma - p. 267 30. Chapter 21. Oxidative Stress as a Mechanism for Hepatocellular Carcinoma - p. 279 31. Chapter 22. Nuclear Factor-Kappa B Actions During the Development of Hepatocellular Carcinoma - p. 289 32. Chapter 23. The Role of Senescence in Hepatic Diseases - p. 295 33. Chapter 24. Exercise, Liver Steatosis, and Free Radicals - p. 309 34. Chapter 25. The Metabolic Syndrome, Oxidative Stress, and the Liver - p. 323 35. Chapter 26. Liver Diseases in the Elderly - p. 331 36. Chapter 27. Cytokines in Hepatic Injury - p. 341 37. Chapter 28. Nrf2: A Key Regulator of Redox Signaling in Liver Diseases - p. 355 38. Introduction - p. 355 39. General Principles of Nrf2 Signaling - p. 356 40. Role of Nrf2 in Liver Diseases - p. 361 41. Conclusion - p. 367 42. Chapter 29. Redox Regulation by HGF/c-Met in Liver Disease - p. 375 43. Section III. Liver Metabolism - p. 387 44. Chapter 30. Hepatic Metabolism in Liver Health and Disease - p. 391 45. Chapter 31. Cytochrome P450 and Oxidative Stress in the Liver - p. 401 46. Chapter 32. Drug Hepatic Clearance in Spinal Cord Injury - p. 421 47. Section IV. Cirrhosis and Its Complications - p. 424 48. Chapter 33. Complications of Cirrhosis: Introduction - p. 427 49. Chapter 34. Portal Hypertension—Molecular Mechanisms - p. 435 50. Chapter 35. Gastroesophageal Varices - p. 451 51. Chapter 36. Ascites - p. 475 52. Chapter 37. Reactive Nitrogen and Oxygen Species in Hepatic Encephalopathy - p. 485 53. Chapter 38. Hepatorenal Syndrome - p. 501 54. Chapter 39. Hepatopulmonary Syndrome and Portopulmonary Hypertension - p. 511 55. Section V. Methods in Liver Disease - p. 526 56. Chapter 40. Experimental Models of Liver Damage Mediated by Oxidative Stress - p. 529 57. Chapter 41. Monitoring of Liver Fibrogenesis and Biochemical Diagnosis of Fibrosis - p. 547 58. Chapter 42. In Vitro Models of HCC - p. 563 59. Section VI. Therapies in Liver Disease - p. 579 60. Chapter 43. The Liver, Oxidative Stress, and Antioxidants - p. 583 61. Chapter 44. Herbal Drugs on the Liver - p. 605 62. Chapter 45. Silymarin for Liver Disease - p. 621 63. Chapter 46. Naringenin and the Liver - p. 633 64. Chapter 47. Antioxidant, Antiinflammatory, and Antifibrotic Properties of Quercetin in the Liver - p. 653 65. Chapter 48. Coffee and the Liver - p. 675 66. Chapter 49. Hepatoprotective Properties of Curcumin - p. 687 67. Chapter 50. Retinoids in Liver Function - p. 705 68. Chapter 51. Stevia as a Putative Hepatoprotector - p. 715 69. Chapter 52. Are N-Acetylcysteine and Resveratrol Effective Treatments for Liver Disease? - p. 729 70. Chapter 53. Does Nutrition Matter in Liver Disease? - p. 743 71. Chapter 54. One-Carbon Metabolism in Liver Health and Disease - p. 761 72. Chapter 55. Ursodeoxycholic Acid for the Treatment of Liver Diseases - p. 767 73. Chapter 56. Current Treatment of Chronic Hepatitis C - p. 781 74. Chapter 57. An Adenosine Derivative Compound as a Hepatoprotective Agent - p. 791 75. Chapter 58. Nitric Oxide and the Liver - p. 799 76. Chapter 59. Repopulation of Cirrhotic Liver by Hepatic Stem/Progenitor Cells: A Promising Strategy Alternative to Liver Transplantation - p. 817 77. Chapter 60. Gene Therapy for Liver Disease - p. 837 78. Chapter 61. Role of Oxidative Stress in Liver Transplantation - p. 853 79. Index - p. 869
Liver Pathophysiology: Therapies and Antioxidants is a complete volume on morphology, physiology, biochemistry, molecular biology and treatment of liver diseases. It uses an integral approach towards the role of free radicals in the pathogenesis of hepatic injury, and how their deleterious effects may be abrogated by the use of antioxidants.
Written by the most prominent authors in the field, this book will be of use to basic and clinical scientists and clinicians working in the biological sciences, especially those dedicated to the study and treatment of liver pathologies.
1. Section I. Introduction - p. xxxi 2. Chapter 1. The Liver: General Aspects and Epidemiology - p. 3 3. Chapter 2. Structure and Ultrastructure of the Normal and Diseased Liver - p. 23 4. Section II. Liver Pathophysiology - p. 44 5. Chapter 3. Hepatic Apoptosis and Necrosis: Mechanisms and Clinical Relevance - p. 47 6. Chapter 4. Autoimmune Hepatitis - p. 61 7. Selection and Presentation of Indigenous Foreign Antigens - p. 62 8. Breaking Immune Tolerance of Self-Antigens - p. 65 9. Neoantigens and Epitope Spread - p. 65 10. Implicated Self-Antigens - p. 66 11. Cell Mediators of Liver Injury - p. 67 12. Molecular Mechanisms of Immune-Mediated Liver Injury - p. 71 13. Overview - p. 76 14. Chapter 5. Pathogenesis of Idiosyncratic Drug Induced Liver Injury - p. 87 15. Chapter 6. Acetaminophen - p. 101 16. Chapter 7. Liver Regeneration - p. 113 17. Chapter 8. Nitric Oxide in Liver Ischemia–Reperfusion Injury - p. 125 18. Chapter 9. The Immune System and Viral Hepatitis - p. 129 19. Chapter 10. The Pathophysiology of Alcoholic Liver Disease - p. 141 20. Chapter 11. Cytokines in Steatohepatitis - p. 159 21. Chapter 12. Redox Signaling in NASH - p. 169 22. Chapter 13. Amebic Liver Abscess - p. 181 23. Chapter 14. Role of Cytokines and Reactive Oxygen Species in the Amebic Liver Abscess Produced by Entamoeba histolytica - p. 187 24. Chapter 15. Epigenetics in Liver Disease: Involvement of Oxidative Stress - p. 199 25. Chapter 16. Role of Oxidative and Nitrosative Stress in Hepatic Fibrosis - p. 213 26. Chapter 17. Oxidative and Nitrosative Stress in Chronic Cholestasis - p. 225 27. Chapter 18. Cholestasis, Contraceptives, and Free Radicals - p. 239 28. Chapter 19. Is Human Cirrhosis a Reversible Disease? - p. 259 29. Chapter 20. Obesity and Hepatocellular Carcinoma - p. 267 30. Chapter 21. Oxidative Stress as a Mechanism for Hepatocellular Carcinoma - p. 279 31. Chapter 22. Nuclear Factor-Kappa B Actions During the Development of Hepatocellular Carcinoma - p. 289 32. Chapter 23. The Role of Senescence in Hepatic Diseases - p. 295 33. Chapter 24. Exercise, Liver Steatosis, and Free Radicals - p. 309 34. Chapter 25. The Metabolic Syndrome, Oxidative Stress, and the Liver - p. 323 35. Chapter 26. Liver Diseases in the Elderly - p. 331 36. Chapter 27. Cytokines in Hepatic Injury - p. 341 37. Chapter 28. Nrf2: A Key Regulator of Redox Signaling in Liver Diseases - p. 355 38. Introduction - p. 355 39. General Principles of Nrf2 Signaling - p. 356 40. Role of Nrf2 in Liver Diseases - p. 361 41. Conclusion - p. 367 42. Chapter 29. Redox Regulation by HGF/c-Met in Liver Disease - p. 375 43. Section III. Liver Metabolism - p. 387 44. Chapter 30. Hepatic Metabolism in Liver Health and Disease - p. 391 45. Chapter 31. Cytochrome P450 and Oxidative Stress in the Liver - p. 401 46. Chapter 32. Drug Hepatic Clearance in Spinal Cord Injury - p. 421 47. Section IV. Cirrhosis and Its Complications - p. 424 48. Chapter 33. Complications of Cirrhosis: Introduction - p. 427 49. Chapter 34. Portal Hypertension—Molecular Mechanisms - p. 435 50. Chapter 35. Gastroesophageal Varices - p. 451 51. Chapter 36. Ascites - p. 475 52. Chapter 37. Reactive Nitrogen and Oxygen Species in Hepatic Encephalopathy - p. 485 53. Chapter 38. Hepatorenal Syndrome - p. 501 54. Chapter 39. Hepatopulmonary Syndrome and Portopulmonary Hypertension - p. 511 55. Section V. Methods in Liver Disease - p. 526 56. Chapter 40. Experimental Models of Liver Damage Mediated by Oxidative Stress - p. 529 57. Chapter 41. Monitoring of Liver Fibrogenesis and Biochemical Diagnosis of Fibrosis - p. 547 58. Chapter 42. In Vitro Models of HCC - p. 563 59. Section VI. Therapies in Liver Disease - p. 579 60. Chapter 43. The Liver, Oxidative Stress, and Antioxidants - p. 583 61. Chapter 44. Herbal Drugs on the Liver - p. 605 62. Chapter 45. Silymarin for Liver Disease - p. 621 63. Chapter 46. Naringenin and the Liver - p. 633 64. Chapter 47. Antioxidant, Antiinflammatory, and Antifibrotic Properties of Quercetin in the Liver - p. 653 65. Chapter 48. Coffee and the Liver - p. 675 66. Chapter 49. Hepatoprotective Properties of Curcumin - p. 687 67. Chapter 50. Retinoids in Liver Function - p. 705 68. Chapter 51. Stevia as a Putative Hepatoprotector - p. 715 69. Chapter 52. Are N-Acetylcysteine and Resveratrol Effective Treatments for Liver Disease? - p. 729 70. Chapter 53. Does Nutrition Matter in Liver Disease? - p. 743 71. Chapter 54. One-Carbon Metabolism in Liver Health and Disease - p. 761 72. Chapter 55. Ursodeoxycholic Acid for the Treatment of Liver Diseases - p. 767 73. Chapter 56. Current Treatment of Chronic Hepatitis C - p. 781 74. Chapter 57. An Adenosine Derivative Compound as a Hepatoprotective Agent - p. 791 75. Chapter 58. Nitric Oxide and the Liver - p. 799 76. Chapter 59. Repopulation of Cirrhotic Liver by Hepatic Stem/Progenitor Cells: A Promising Strategy Alternative to Liver Transplantation - p. 817 77. Chapter 60. Gene Therapy for Liver Disease - p. 837 78. Chapter 61. Role of Oxidative Stress in Liver Transplantation - p. 853 79. Index - p. 869
