Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals is a unique reference that provides a complete overview of the non-vitamin micronutrients, including calcium, copper, iodine, iron, magnesium, manganese, molybdenum, phosphorus, potassium, selenium, sodium, and zinc.
In addition, the book covers the nutritional and toxicological properties of nonessential minerals chromium, fluoride and boron, and silicon and vanadium, as well as ultra-trace minerals and those with no established dietary requirement for humans. Users will find in-depth chapters on each essential mineral and mineral metabolism, along with discussions of dietary recommendations in the United States and around the world.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. List of Contributors - p. xiii 6. Series Preface - p. xvii 7. Part I. Calcium - p. xvii 8. Chapter 1. Calcium-Sensing Receptor Polymorphisms and Human Disease - p. 3 9. Chapter 2. Molecular Aspects of the Calcium-Sensing Receptor and Calcium Homeostasis - p. 15 10. Chapter 3. New Developments in Our Understanding of the Regulation of Calcium Homeostasis by Vitamin D - p. 27 11. Chapter 4. Calcium in Obesity and Related Diseases: The Calcium-Sensing Receptor as a Novel Mediator - p. 35 12. Chapter 5. Calcium: Basic Nutritional Aspects - p. 45 13. Chapter 6. Molecular Aspects of Calcium and Bone Mineralization - p. 59 14. Part II. Copper - p. 65 15. Chapter 7. Copper: Basic Physiological and Nutritional Aspects - p. 69 16. Chapter 8. Copper and Molecular Aspects of Cell Signaling - p. 85 17. Chapter 9. Copper and Hypoxia-Inducible Transcription Factor Regulation of Gene Expression - p. 101 18. Chapter 10. Copper in Wilson’s and Alzheimer’s Diseases, Copper-Lowering Therapy in Cancer and Other Diseases, and Copper Deficiency - p. 115 19. Part III. Iodine - p. 129 20. Chapter 11. Iodine: Basic Nutritional Aspects - p. 133 21. Chapter 12. Iodine and Thyroid Hormone Synthesis, Metabolism, and Action - p. 143 22. Chapter 13. Iodine and Adipocytokines: Cellular Aspects - p. 151 23. Part IV. Iron - p. 157 24. Chapter 14. Iron: Basic Nutritional Aspects - p. 161 25. Chapter 15. Hepcidin and the Hormonal Control of Iron Homeostasis - p. 175 26. Chapter 16. Genetic Rodent Models of Systemic Iron Homeostasis - p. 187 27. Chapter 17. Iron, Cancer, and Hypoxia-Inducible Factor Signaling - p. 203 28. Chapter 18. Iron Transporters and Iron Homeostasis - p. 215 29. Chapter 19. Regulation of Divalent Metal-Ion Transporter-1 Expression and Function - p. 227 30. Part V. Zinc - p. 238 31. Chapter 20. Discovery of Zinc for Human Health and Biomarkers of Zinc Deficiency - p. 241 32. Chapter 21. Zinc Signals and Immune Function - p. 261 33. Chapter 22. Posttranslational Mechanisms of Zinc Signaling - p. 273 34. Chapter 23. Zinc Transporters in Health and Disease - p. 283 35. Chapter 24. Genetic Study of Zinc Transporters and Zinc Signaling - p. 293 36. Part VI. Magnesium - p. 303 37. Chapter 25. Magnesium: Basic Nutritional Aspects - p. 307 38. Chapter 26. Magnesium and the Immune Response - p. 319 39. Chapter 27. Magnesium Intake and Chronic Disease in Humans - p. 333 40. Chapter 28. Magnesium and Embryonic Development - p. 343 41. Chapter 29. Magnesium, Vascular Function, and Hypertension - p. 353 42. Part VII. Manganese - p. 364 43. Chapter 30. Nutritional, Genetic, and Molecular Aspects of Manganese Intoxication - p. 367 44. Chapter 31. Manganese and Nutritional Immunity - p. 377 45. Chapter 32. Manganese and Mitochondrial Function - p. 389 46. Part VIII. Molybdenum - p. 396 47. Chapter 33. Molybdenum Cofactor in Humans: Health, Disease, and Treatment - p. 399 48. Part IX. Phosphorus - p. 410 49. Chapter 34. Phosphorus: Basic Nutritional Aspects - p. 413 50. Chapter 35. Molecular Mechanisms of Adverse Health Effects Associated With Excess Phosphorus Intake - p. 429 51. Chapter 36. Transcriptional Regulation of Sodium-Phosphate Cotransporter Gene Expression - p. 437 52. Part X. Selenium - p. 445 53. Chapter 37. Selenium: Basic Nutritional Aspects - p. 449 54. Chapter 38. Selenium and Cancer - p. 463 55. Chapter 39. Could Selenium Be a Double-Edged Sword? - p. 475 56. Part XI. Electrolytes - p. 486 57. Chapter 40. Sodium: Basic Nutritional Aspects - p. 489 58. Chapter 41. Potassium Channel Mutations and Human Disease: Focus on Adrenal Hypertension - p. 503 59. Part XII. Nonessentials - p. 516 60. Chapter 42. Chromium: Basic Nutritional and Toxicological Aspects - p. 519 61. Chapter 43. Nonessential Trace Minerals: Basic Nutritional and Toxicological Aspects - p. 527 62. Chapter 44. Fluoride: Intake and Metabolism, Therapeutic and Toxicological Consequences - p. 539 63. Index - p. 551
Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals is a unique reference that provides a complete overview of the non-vitamin micronutrients, including calcium, copper, iodine, iron, magnesium, manganese, molybdenum, phosphorus, potassium, selenium, sodium, and zinc.
In addition, the book covers the nutritional and toxicological properties of nonessential minerals chromium, fluoride and boron, and silicon and vanadium, as well as ultra-trace minerals and those with no established dietary requirement for humans. Users will find in-depth chapters on each essential mineral and mineral metabolism, along with discussions of dietary recommendations in the United States and around the world.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. List of Contributors - p. xiii 6. Series Preface - p. xvii 7. Part I. Calcium - p. xvii 8. Chapter 1. Calcium-Sensing Receptor Polymorphisms and Human Disease - p. 3 9. Chapter 2. Molecular Aspects of the Calcium-Sensing Receptor and Calcium Homeostasis - p. 15 10. Chapter 3. New Developments in Our Understanding of the Regulation of Calcium Homeostasis by Vitamin D - p. 27 11. Chapter 4. Calcium in Obesity and Related Diseases: The Calcium-Sensing Receptor as a Novel Mediator - p. 35 12. Chapter 5. Calcium: Basic Nutritional Aspects - p. 45 13. Chapter 6. Molecular Aspects of Calcium and Bone Mineralization - p. 59 14. Part II. Copper - p. 65 15. Chapter 7. Copper: Basic Physiological and Nutritional Aspects - p. 69 16. Chapter 8. Copper and Molecular Aspects of Cell Signaling - p. 85 17. Chapter 9. Copper and Hypoxia-Inducible Transcription Factor Regulation of Gene Expression - p. 101 18. Chapter 10. Copper in Wilson’s and Alzheimer’s Diseases, Copper-Lowering Therapy in Cancer and Other Diseases, and Copper Deficiency - p. 115 19. Part III. Iodine - p. 129 20. Chapter 11. Iodine: Basic Nutritional Aspects - p. 133 21. Chapter 12. Iodine and Thyroid Hormone Synthesis, Metabolism, and Action - p. 143 22. Chapter 13. Iodine and Adipocytokines: Cellular Aspects - p. 151 23. Part IV. Iron - p. 157 24. Chapter 14. Iron: Basic Nutritional Aspects - p. 161 25. Chapter 15. Hepcidin and the Hormonal Control of Iron Homeostasis - p. 175 26. Chapter 16. Genetic Rodent Models of Systemic Iron Homeostasis - p. 187 27. Chapter 17. Iron, Cancer, and Hypoxia-Inducible Factor Signaling - p. 203 28. Chapter 18. Iron Transporters and Iron Homeostasis - p. 215 29. Chapter 19. Regulation of Divalent Metal-Ion Transporter-1 Expression and Function - p. 227 30. Part V. Zinc - p. 238 31. Chapter 20. Discovery of Zinc for Human Health and Biomarkers of Zinc Deficiency - p. 241 32. Chapter 21. Zinc Signals and Immune Function - p. 261 33. Chapter 22. Posttranslational Mechanisms of Zinc Signaling - p. 273 34. Chapter 23. Zinc Transporters in Health and Disease - p. 283 35. Chapter 24. Genetic Study of Zinc Transporters and Zinc Signaling - p. 293 36. Part VI. Magnesium - p. 303 37. Chapter 25. Magnesium: Basic Nutritional Aspects - p. 307 38. Chapter 26. Magnesium and the Immune Response - p. 319 39. Chapter 27. Magnesium Intake and Chronic Disease in Humans - p. 333 40. Chapter 28. Magnesium and Embryonic Development - p. 343 41. Chapter 29. Magnesium, Vascular Function, and Hypertension - p. 353 42. Part VII. Manganese - p. 364 43. Chapter 30. Nutritional, Genetic, and Molecular Aspects of Manganese Intoxication - p. 367 44. Chapter 31. Manganese and Nutritional Immunity - p. 377 45. Chapter 32. Manganese and Mitochondrial Function - p. 389 46. Part VIII. Molybdenum - p. 396 47. Chapter 33. Molybdenum Cofactor in Humans: Health, Disease, and Treatment - p. 399 48. Part IX. Phosphorus - p. 410 49. Chapter 34. Phosphorus: Basic Nutritional Aspects - p. 413 50. Chapter 35. Molecular Mechanisms of Adverse Health Effects Associated With Excess Phosphorus Intake - p. 429 51. Chapter 36. Transcriptional Regulation of Sodium-Phosphate Cotransporter Gene Expression - p. 437 52. Part X. Selenium - p. 445 53. Chapter 37. Selenium: Basic Nutritional Aspects - p. 449 54. Chapter 38. Selenium and Cancer - p. 463 55. Chapter 39. Could Selenium Be a Double-Edged Sword? - p. 475 56. Part XI. Electrolytes - p. 486 57. Chapter 40. Sodium: Basic Nutritional Aspects - p. 489 58. Chapter 41. Potassium Channel Mutations and Human Disease: Focus on Adrenal Hypertension - p. 503 59. Part XII. Nonessentials - p. 516 60. Chapter 42. Chromium: Basic Nutritional and Toxicological Aspects - p. 519 61. Chapter 43. Nonessential Trace Minerals: Basic Nutritional and Toxicological Aspects - p. 527 62. Chapter 44. Fluoride: Intake and Metabolism, Therapeutic and Toxicological Consequences - p. 539 63. Index - p. 551
