Molecular Pathology: The Molecular Basis of Human Disease provides a current and comprehensive view of the molecular basis and mechanisms of human disease. Combining accepted principles with broader theoretical concepts and with contributions from a group of experts, the book looks into disease processes in the context of traditional pathology and their implications for translational molecular medicine. It also discusses concepts in molecular biology and genetics, recent scientific and technological advances in modern pathology, the concept of ""molecular pathogenesis"" of disease, and how disease evolves from normal cells and tissues due to perturbations in molecular pathways.
The book describes the integration of molecular and cellular pathogenesis using a bioinformatics approach and a systems biology approach to disease pathogenesis. It also discusses current and future strategies in molecular diagnosis of human disease, and the impact of molecular diagnosis on treatment decisions and the practice of personalized medicine.
This book is a valuable resource for students, biomedical researchers, practicing physician-scientists who undertake disease-related basic science and translational research, and pathology residents and other postdoctoral fellows.
1. INTRODUCTION - p. 304 2. NEOPLASTIC LUNG AND PLEURAL DISEASES - p. 305 3. NON-NEOPLASTIC LUNG DISEASE - p. 323 4. OBSTRUCTIVE LUNG DISEASES - p. 323 5. INTERSTITIAL LUNG DISEASES - p. 331 6. PULMONARY VASCULAR DISEASES - p. 338 7. PULMONARY INFECTIONS - p. 342 8. PULMONARY HISTIOCYTIC DISEASES - p. 352 9. PULMONARY OCCUPATIONAL DISEASES - p. 354 10. DEVELOPMENTAL ABNORMALITIES - p. 356 11. Chapter 19: Molecular Basis of Diseases of the Gastrointestinal Tract - p. 364 12. Chapter 20: Molecular Basis of Liver Disease - p. 393 13. Chapter 21: Molecular Basis of Diseases of the Exocrine Pancreas - p. 419 14. Chapter 22: Molecular Basis of Diseases of the Endocrine System - p. 433 15. Chapter 23: Molecular Basis of Gynecologic Diseases - p. 463 16. Chapter 24: Molecular Pathogenesis of Prostate Cancer: Somatic, Epigenetic, and Genetic Alterations - p. 487 17. Chapter 25: Molecular Biology of Breast Cancer - p. 500 18. Chapter 26: Molecular Basis of Skin Disease - p. 517 19. Chapter 27: Molecular Pathology: Neuropathology - p. 550 20. PART V: Practice of Molecular Medicine - p. 587 21. Chapter 28: Molecular Diagnosis of Human Disease - p. 587 22. Chapter 29: Molecular Assessment of Human Disease in the Clinical Laboratory - p. 604 23. Chapter 30: Pharmacogenomics and Personalized Medicine in the Treatment of Human Diseases - p. 612 24. Index - p. 622
Molecular Pathology: The Molecular Basis of Human Disease provides a current and comprehensive view of the molecular basis and mechanisms of human disease. Combining accepted principles with broader theoretical concepts and with contributions from a group of experts, the book looks into disease processes in the context of traditional pathology and their implications for translational molecular medicine. It also discusses concepts in molecular biology and genetics, recent scientific and technological advances in modern pathology, the concept of ""molecular pathogenesis"" of disease, and how disease evolves from normal cells and tissues due to perturbations in molecular pathways.
The book describes the integration of molecular and cellular pathogenesis using a bioinformatics approach and a systems biology approach to disease pathogenesis. It also discusses current and future strategies in molecular diagnosis of human disease, and the impact of molecular diagnosis on treatment decisions and the practice of personalized medicine.
This book is a valuable resource for students, biomedical researchers, practicing physician-scientists who undertake disease-related basic science and translational research, and pathology residents and other postdoctoral fellows.
1. INTRODUCTION - p. 304 2. NEOPLASTIC LUNG AND PLEURAL DISEASES - p. 305 3. NON-NEOPLASTIC LUNG DISEASE - p. 323 4. OBSTRUCTIVE LUNG DISEASES - p. 323 5. INTERSTITIAL LUNG DISEASES - p. 331 6. PULMONARY VASCULAR DISEASES - p. 338 7. PULMONARY INFECTIONS - p. 342 8. PULMONARY HISTIOCYTIC DISEASES - p. 352 9. PULMONARY OCCUPATIONAL DISEASES - p. 354 10. DEVELOPMENTAL ABNORMALITIES - p. 356 11. Chapter 19: Molecular Basis of Diseases of the Gastrointestinal Tract - p. 364 12. Chapter 20: Molecular Basis of Liver Disease - p. 393 13. Chapter 21: Molecular Basis of Diseases of the Exocrine Pancreas - p. 419 14. Chapter 22: Molecular Basis of Diseases of the Endocrine System - p. 433 15. Chapter 23: Molecular Basis of Gynecologic Diseases - p. 463 16. Chapter 24: Molecular Pathogenesis of Prostate Cancer: Somatic, Epigenetic, and Genetic Alterations - p. 487 17. Chapter 25: Molecular Biology of Breast Cancer - p. 500 18. Chapter 26: Molecular Basis of Skin Disease - p. 517 19. Chapter 27: Molecular Pathology: Neuropathology - p. 550 20. PART V: Practice of Molecular Medicine - p. 587 21. Chapter 28: Molecular Diagnosis of Human Disease - p. 587 22. Chapter 29: Molecular Assessment of Human Disease in the Clinical Laboratory - p. 604 23. Chapter 30: Pharmacogenomics and Personalized Medicine in the Treatment of Human Diseases - p. 612 24. Index - p. 622
