Neuroepidemiology covers the foundations of neuroepidemiological research and the epidemiology of disorders primarily affecting the nervous system, as well as those originating outside the nervous system. The etiology of many important central nervous system disorders remains elusive. Even with diseases where the key risk determinants have been identified, better prevention and therapy is needed to reduce high incidence and mortality. Although evolving technologies for studying disease provide opportunities for such, it is essential for researchers and clinicians to understand how best to apply such technology in the context of carefully characterized patient populations.
By paying special attention to methodological approaches, this volume prepares new investigators from a variety of disciplines to conduct epidemiological studies in order to discern the etiologic factors and underlying mechanisms that influence the onset, progression, and recurrence of CNS disorders and diseases. The book also provides current information on methodological approaches for clinical neurologists seeking to expand their knowledge in research.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Handbook of Clinical Neurology 3rd Series - p. v 6. Foreword - p. vii 7. Preface - p. ix 8. Contributors - p. xi 9. Chapter 1: Epidemiology for the clinical neurologist - p. xi 10. Chapter 2: Population neuroscience - p. 16 11. Chapter 3: Advanced epidemiologic and analytical methods - p. 37 12. Chapter 4: Basics of neuroanatomy and neurophysiology - p. 52 13. Chapter 5: Population imaging in neuroepidemiology - p. 68 14. Chapter 6: Use of “omics” technologies to dissect neurologic disease - p. 90 15. Chapter 7: Neuropsychologic assessment - p. 106 16. Chapter 8: Dementias - p. 119 17. Chapter 9: Epidemiology of alpha-synucleinopathies: from Parkinson disease to dementia with Lewy bodies - p. 151 18. Chapter 10: Epidemiology of epilepsy - p. 158 19. Chapter 11: The epidemiology of multiple sclerosis: insights to a causal cascade - p. 171 20. Chapter 12: Neuroepidemiology of traumatic brain injury - p. 206 21. Chapter 13: The epidemiology of amyotrophic lateral sclerosis - p. 223 22. Chapter 14: Cerebrovascular disease - p. 238 23. Chapter 15: Peripheral neuropathies - p. 261 24. Chapter 16: Migraine - p. 282 25. Chapter 17: Neuroepidemiology of cancer and treatment-related neurocognitive dysfunction in adult-onset cancer patients and survivors - p. 293 26. Chapter 18: Sickle cell disease - p. 309 27. Index - p. 325
Neuroepidemiology covers the foundations of neuroepidemiological research and the epidemiology of disorders primarily affecting the nervous system, as well as those originating outside the nervous system. The etiology of many important central nervous system disorders remains elusive. Even with diseases where the key risk determinants have been identified, better prevention and therapy is needed to reduce high incidence and mortality. Although evolving technologies for studying disease provide opportunities for such, it is essential for researchers and clinicians to understand how best to apply such technology in the context of carefully characterized patient populations.
By paying special attention to methodological approaches, this volume prepares new investigators from a variety of disciplines to conduct epidemiological studies in order to discern the etiologic factors and underlying mechanisms that influence the onset, progression, and recurrence of CNS disorders and diseases. The book also provides current information on methodological approaches for clinical neurologists seeking to expand their knowledge in research.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Handbook of Clinical Neurology 3rd Series - p. v 6. Foreword - p. vii 7. Preface - p. ix 8. Contributors - p. xi 9. Chapter 1: Epidemiology for the clinical neurologist - p. xi 10. Chapter 2: Population neuroscience - p. 16 11. Chapter 3: Advanced epidemiologic and analytical methods - p. 37 12. Chapter 4: Basics of neuroanatomy and neurophysiology - p. 52 13. Chapter 5: Population imaging in neuroepidemiology - p. 68 14. Chapter 6: Use of “omics” technologies to dissect neurologic disease - p. 90 15. Chapter 7: Neuropsychologic assessment - p. 106 16. Chapter 8: Dementias - p. 119 17. Chapter 9: Epidemiology of alpha-synucleinopathies: from Parkinson disease to dementia with Lewy bodies - p. 151 18. Chapter 10: Epidemiology of epilepsy - p. 158 19. Chapter 11: The epidemiology of multiple sclerosis: insights to a causal cascade - p. 171 20. Chapter 12: Neuroepidemiology of traumatic brain injury - p. 206 21. Chapter 13: The epidemiology of amyotrophic lateral sclerosis - p. 223 22. Chapter 14: Cerebrovascular disease - p. 238 23. Chapter 15: Peripheral neuropathies - p. 261 24. Chapter 16: Migraine - p. 282 25. Chapter 17: Neuroepidemiology of cancer and treatment-related neurocognitive dysfunction in adult-onset cancer patients and survivors - p. 293 26. Chapter 18: Sickle cell disease - p. 309 27. Index - p. 325
