The topics in this issue represent the most current research areas of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Collaborative Pediatric Critical Care Research Network (CPCCRN). The CPCCRN is a national pediatric critical care research network that is charged with investigating the efficacy of treatment and management strategies to care for critically ill and injured children, as well as to better understand the pathophysiological basis of critical illness and injury in childhood. The proposed authors are past and present principal and co-investigators affiliated with the CPCCRN; the proposed topics represent the individual author’s area of clinical and research expertise. Each review article is an up-to-date review of the topic relevant to practicing clinicians and trainees in critical care medicine, with incorporation of the most recently published research findings pertinent to the topic, some of which may be the author’s own. The specific articles are devoted to the following topics: Cardiopulmonary resuscitation in pediatric and cardiac ICU; Approach to the critically ill pediatric trauma patient; Transfusion Decision Making in Pediatric Critical Illness; Pathophysiology and management of ARDS in children; Ventilator associate pneumonias in critically ill children; Mechanical ventilation and decision support in pediatric intensive care; Inflammation, pathobiology, phenotypes and sepsis: From meningococcemia to H1N1-MRSA, to Ebola; Immune paralysis in pediatric critical care; Molecular biology of critical illness; Sedation in pediatric critical illness; Delirium in pediatric critical illness; Challenges of drug development in pediatric intensive care; Potential of All Steroid Hormone Subclasses as Adjunctive Treatment for Sepsis; Morbidity: Changing the outcome paradigm; and End-of-Life and Bereavement Care in Pediatric Intensive Care Units.
1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. i 4. Copyright - p. ii 5. CME Accreditation Page - p. iii 6. Contributors - p. v 7. Forthcoming Issues - p. xiii 8. Foreword - p. xv 9. Preface - p. xvii 10. Cardiopulmonary Resuscitation in Pediatric and Cardiac Intensive Care Units - p. 961 11. Management Issues in Critically Ill Pediatric Patients with Trauma - p. 973 12. Transfusion Decision Making in Pediatric Critical Illness - p. 991 13. Pathophysiology and Management of Acute Respiratory Distress Syndrome in Children - p. 1017 14. Ventilator-Associated Pneumonia in Critically Ill Children: A New Paradigm - p. 1039 15. Mechanical Ventilation and Decision Support in Pediatric Intensive Care - p. 1057 16. Rationale for Adjunctive Therapies for Pediatric Sepsis Induced Multiple Organ Failure - p. 1071 17. Immunoparalysis in Pediatric Critical Care - p. 1089 18. Sedation Analgesia and Neuromuscular Blockade in Pediatric Critical Care: Overview and Current Landscape - p. 1103 19. Delirium in Pediatric Critical Care - p. 1117 20. Adjunctive Steroid Therapy for Treatment of Pediatric Septic Shock - p. 1133 21. Morbidity: Changing the Outcome Paradigm for Pediatric Critical Care - p. 1147 22. End-of-Life and Bereavement Care in Pediatric Intensive Care Units - p. 1167
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The topics in this issue represent the most current research areas of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Collaborative Pediatric Critical Care Research Network (CPCCRN). The CPCCRN is a national pediatric critical care research network that is charged with investigating the efficacy of treatment and management strategies to care for critically ill and injured children, as well as to better understand the pathophysiological basis of critical illness and injury in childhood. The proposed authors are past and present principal and co-investigators affiliated with the CPCCRN; the proposed topics represent the individual author’s area of clinical and research expertise. Each review article is an up-to-date review of the topic relevant to practicing clinicians and trainees in critical care medicine, with incorporation of the most recently published research findings pertinent to the topic, some of which may be the author’s own. The specific articles are devoted to the following topics: Cardiopulmonary resuscitation in pediatric and cardiac ICU; Approach to the critically ill pediatric trauma patient; Transfusion Decision Making in Pediatric Critical Illness; Pathophysiology and management of ARDS in children; Ventilator associate pneumonias in critically ill children; Mechanical ventilation and decision support in pediatric intensive care; Inflammation, pathobiology, phenotypes and sepsis: From meningococcemia to H1N1-MRSA, to Ebola; Immune paralysis in pediatric critical care; Molecular biology of critical illness; Sedation in pediatric critical illness; Delirium in pediatric critical illness; Challenges of drug development in pediatric intensive care; Potential of All Steroid Hormone Subclasses as Adjunctive Treatment for Sepsis; Morbidity: Changing the outcome paradigm; and End-of-Life and Bereavement Care in Pediatric Intensive Care Units.
1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. i 4. Copyright - p. ii 5. CME Accreditation Page - p. iii 6. Contributors - p. v 7. Forthcoming Issues - p. xiii 8. Foreword - p. xv 9. Preface - p. xvii 10. Cardiopulmonary Resuscitation in Pediatric and Cardiac Intensive Care Units - p. 961 11. Management Issues in Critically Ill Pediatric Patients with Trauma - p. 973 12. Transfusion Decision Making in Pediatric Critical Illness - p. 991 13. Pathophysiology and Management of Acute Respiratory Distress Syndrome in Children - p. 1017 14. Ventilator-Associated Pneumonia in Critically Ill Children: A New Paradigm - p. 1039 15. Mechanical Ventilation and Decision Support in Pediatric Intensive Care - p. 1057 16. Rationale for Adjunctive Therapies for Pediatric Sepsis Induced Multiple Organ Failure - p. 1071 17. Immunoparalysis in Pediatric Critical Care - p. 1089 18. Sedation Analgesia and Neuromuscular Blockade in Pediatric Critical Care: Overview and Current Landscape - p. 1103 19. Delirium in Pediatric Critical Care - p. 1117 20. Adjunctive Steroid Therapy for Treatment of Pediatric Septic Shock - p. 1133 21. Morbidity: Changing the Outcome Paradigm for Pediatric Critical Care - p. 1147 22. End-of-Life and Bereavement Care in Pediatric Intensive Care Units - p. 1167
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