Pharmaceutical Applications of Dendrimers explores the applications of dendrimers in the solubilization of hydrophobic active ingredients, drug delivery, gene delivery, imaging, diagnosis and photodynamic therapy. The book discusses the diagnostic applications of dendrimers, including their use as MRI contrast agents and in the imaging of diseased areas. In addition, the anti-inflammatory, antimicrobial and antiviral properties of PPI and PAMAM are also covered, along with a discussion on photosensitizers, such as rose Bengal and protoporphyrin IX that have been delivered using PAMAM and PPI dendrimers for the treatment of cancer.
This book is an important research reference for those who want to learn more about the development of dendrimer-based solutions for drug delivery.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Contributors - p. xi 6. Preface - p. xv 7. Section A: Dendrimers and their properties - p. xv 8. 1: Engineering critical nanoscale design parameters (CNDPs): A strategy for developing effective nanomedicine therapies and assessing quantitative nanoscale structure-activity relationships (QNSARs) - p. xv 9. 2: Dendrimers in drug delivery and the role of “critical nanoscale design parameters” (CNDPs) - p. 47 10. Section B: Dendrimers for pharmaceutical applications - p. 56 11. 3: Dendrimers for drug solubilization, dissolution and bioavailability - p. 56 12. 4: Pharmacokinetic considerations in design of dendrimer-based nanomedicines - p. 92 13. 5: Dendrimer-based targeted drug delivery - p. 106 14. 6: Dendrimers for anticancer drug delivery - p. 129 15. 7: Cancer-targeted chemotherapy: Emerging role of the folate anchored dendrimer as drug delivery nanocarrier - p. 150 16. 8: Design of dendrimer based prodrugs - p. 198 17. 9: Dendrimers in gene delivery - p. 210 18. 10: Dendrimers in immunotherapy and hormone therapy - p. 231 19. 11: Toxicity and biocompatibility aspects of dendrimers - p. 249 20. 12: Therapeutic dendrimers - p. 274 21. Section C: Dendrimers for non-pharmaceutical applications - p. 287 22. 13: Dendrimers for diagnostic applications - p. 287 23. 14: Dendrimer-based marketed formulations and miscellaneous applications in cosmetics, veterinary, and agriculture - p. 324 24. Author Index - p. 335 25. Subject Index - p. 371
Pharmaceutical Applications of Dendrimers explores the applications of dendrimers in the solubilization of hydrophobic active ingredients, drug delivery, gene delivery, imaging, diagnosis and photodynamic therapy. The book discusses the diagnostic applications of dendrimers, including their use as MRI contrast agents and in the imaging of diseased areas. In addition, the anti-inflammatory, antimicrobial and antiviral properties of PPI and PAMAM are also covered, along with a discussion on photosensitizers, such as rose Bengal and protoporphyrin IX that have been delivered using PAMAM and PPI dendrimers for the treatment of cancer.
This book is an important research reference for those who want to learn more about the development of dendrimer-based solutions for drug delivery.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Contributors - p. xi 6. Preface - p. xv 7. Section A: Dendrimers and their properties - p. xv 8. 1: Engineering critical nanoscale design parameters (CNDPs): A strategy for developing effective nanomedicine therapies and assessing quantitative nanoscale structure-activity relationships (QNSARs) - p. xv 9. 2: Dendrimers in drug delivery and the role of “critical nanoscale design parameters” (CNDPs) - p. 47 10. Section B: Dendrimers for pharmaceutical applications - p. 56 11. 3: Dendrimers for drug solubilization, dissolution and bioavailability - p. 56 12. 4: Pharmacokinetic considerations in design of dendrimer-based nanomedicines - p. 92 13. 5: Dendrimer-based targeted drug delivery - p. 106 14. 6: Dendrimers for anticancer drug delivery - p. 129 15. 7: Cancer-targeted chemotherapy: Emerging role of the folate anchored dendrimer as drug delivery nanocarrier - p. 150 16. 8: Design of dendrimer based prodrugs - p. 198 17. 9: Dendrimers in gene delivery - p. 210 18. 10: Dendrimers in immunotherapy and hormone therapy - p. 231 19. 11: Toxicity and biocompatibility aspects of dendrimers - p. 249 20. 12: Therapeutic dendrimers - p. 274 21. Section C: Dendrimers for non-pharmaceutical applications - p. 287 22. 13: Dendrimers for diagnostic applications - p. 287 23. 14: Dendrimer-based marketed formulations and miscellaneous applications in cosmetics, veterinary, and agriculture - p. 324 24. Author Index - p. 335 25. Subject Index - p. 371
