Polycomb Group Proteins is a comprehensive volume detailing the mechanisms that are key to the management of genome function in many different contexts, from embryonic stem cells to terminal differentiation. The book discusses the regulation of cell lineages, cell proliferation, apoptosis, X chromosome inactivation, and most major genome programming choices.
In the last few years, the biochemical understanding of PRC1-type complexes has greatly expanded in terms of the number of components involved and the intricacies of their interactions. The functionalities of these various complexes and their components are not all well understood, but recent work has shown an important division of labor and roles in the recruitment of stable binding in the ability to lay the groundwork of histone modifications and in the epigenetic maintenance of repressed states.
In an effort to provide clarity in this topical research area, the book provides a cluster of chapters that deal with variant PRC1 complexes, their taxonomy, their components, their interactions, and what is known of their functions.
1. Chapter 1. Introduction to Polycomb Group Mechanisms - p. 1 2. Chapter 2. The Role of RAWUL and SAM in Polycomb Repression Complex 1 Assembly and Function - p. 5 3. Chapter 3. The Chromodomain of Polycomb: Methylation Reader and Beyond - p. 33 4. Chapter 4. Unraveling the Roles of Canonical and Noncanonical PRC1 Complexes - p. 57 5. Chapter 5. Structure and Biochemistry of the Polycomb Repressive Complex 1 Ubiquitin Ligase Module - p. 81 6. Chapter 6. Cooperative Recruitment of Polycomb Complexes by Polycomb Response Elements - p. 111 7. Chapter 7. Polycomb Function and Nuclear Organization - p. 131 8. Chapter 8. Molecular Architecture of the Polycomb Repressive Complex 2 - p. 165 9. Chapter 9. Polycomb Repressive Complex 2 Structure and Function - p. 191 10. Chapter 10. Regulation of PRC2 Activity - p. 225 11. Chapter 11. Activating Mutations of the EZH2 Histone Methyltransferase in Cancer - p. 259 12. Chapter 12. PcG Proteins in Caenorhabditis elegans - p. 289 13. Chapter 13. Global Functions of PRC2 Complexes - p. 317 14. Index - p. 349
Polycomb Group Proteins is a comprehensive volume detailing the mechanisms that are key to the management of genome function in many different contexts, from embryonic stem cells to terminal differentiation. The book discusses the regulation of cell lineages, cell proliferation, apoptosis, X chromosome inactivation, and most major genome programming choices.
In the last few years, the biochemical understanding of PRC1-type complexes has greatly expanded in terms of the number of components involved and the intricacies of their interactions. The functionalities of these various complexes and their components are not all well understood, but recent work has shown an important division of labor and roles in the recruitment of stable binding in the ability to lay the groundwork of histone modifications and in the epigenetic maintenance of repressed states.
In an effort to provide clarity in this topical research area, the book provides a cluster of chapters that deal with variant PRC1 complexes, their taxonomy, their components, their interactions, and what is known of their functions.
1. Chapter 1. Introduction to Polycomb Group Mechanisms - p. 1 2. Chapter 2. The Role of RAWUL and SAM in Polycomb Repression Complex 1 Assembly and Function - p. 5 3. Chapter 3. The Chromodomain of Polycomb: Methylation Reader and Beyond - p. 33 4. Chapter 4. Unraveling the Roles of Canonical and Noncanonical PRC1 Complexes - p. 57 5. Chapter 5. Structure and Biochemistry of the Polycomb Repressive Complex 1 Ubiquitin Ligase Module - p. 81 6. Chapter 6. Cooperative Recruitment of Polycomb Complexes by Polycomb Response Elements - p. 111 7. Chapter 7. Polycomb Function and Nuclear Organization - p. 131 8. Chapter 8. Molecular Architecture of the Polycomb Repressive Complex 2 - p. 165 9. Chapter 9. Polycomb Repressive Complex 2 Structure and Function - p. 191 10. Chapter 10. Regulation of PRC2 Activity - p. 225 11. Chapter 11. Activating Mutations of the EZH2 Histone Methyltransferase in Cancer - p. 259 12. Chapter 12. PcG Proteins in Caenorhabditis elegans - p. 289 13. Chapter 13. Global Functions of PRC2 Complexes - p. 317 14. Index - p. 349
