Polymer-Drug Conjugates: Linker Chemistry, Protocols and Applications discusses important concepts, fundamentals and prospective applications of ‘Linker Chemistry’ in a clear-and-concise manner. The book provides vital information on chemical entities binding with the drug-polymer complex for targeted drug delivery systems. It highlights roles and significance, different classes and synthetic protocols as well as mechanisms of chemical bond formation in drug-polymer conjugation in drug delivery, also offering insights into the mechanism of polymer interaction with linker and drug molecules by biodegradable chemical bonding.
The protocol of binding with drug molecules is clearly explained and justified with case studies, helping researchers and advanced students in the pharmaceutical sciences understand fundamentals involved and related aspects in molecule designing for effective therapeutic benefits.
1. Polymer-Drug Conjugates - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iv 6. Dedication - p. Page v 7. Contributors - p. Page v 8. Editors - p. Page viii 9. Preface - p. Page xi 10. Acknowledgment - p. Page xii 11. List of Illustrations - p. Page xiii 12. List of Tables - p. Page xiv 13. Chapter 1 : Drug delivery: The conceptual perspectives and therapeutic applications - p. Page xiv 14. Chapter 2 : Rational design of linkers in polymer–drug conjugates - p. Page 30 15. Chapter 3 : Exploration of polymers in drug delivery: The structural and functional considerations - p. Page 51 16. Chapter 4 : Chemistry of conjugation in drug delivery: The prospects of biodegradable bonds in polymer–drug conjugates - p. Page 85 17. Chapter 5 : Polymer–drug conjugation using ester and ortho-ester bond: Mechanism, protocols, and applications - p. Page 117 18. Chapter 6 : Polymer–drug linking through amide bonds: the chemistry and applications in drug delivery - p. Page 141 19. Chapter 7 : Drug–polymer conjugate tailoring by disulfide linkage for controlled and targeted drug delivery - p. Page 168 20. Chapter 8 : Thioether linkage chemistry: perspectives and prospects in therapeutic designing - p. Page 190 21. Chapter 9 : Drug targeting to cancer cells through stimuli-responsive imine bonds: fascinating aspects of site specificity - p. Page 204 22. Chapter 10 : Carbamate–drug conjugates in drug delivery: structural and mechanistic considerations - p. Page 220 23. Chapter 11 : Bonding through phosphodiester moiety: Its implications in pharmaceutical modifications - p. Page 240 24. Chapter 12 : Enzymatically degradable linkers - p. Page 271 25. Chapter 13 : Dendrimer–drug conjugates - p. Page 303 26. Chapter 14 : Antibody–drug conjugate: Emerging trend for targeted treatment - p. Page 340 27. Chapter 15 : Drug–polymer conjugates: Challenges, opportunities, and future prospects in clinical trials - p. Page 378 28. Index - p. Page 454
Polymer-Drug Conjugates: Linker Chemistry, Protocols and Applications discusses important concepts, fundamentals and prospective applications of ‘Linker Chemistry’ in a clear-and-concise manner. The book provides vital information on chemical entities binding with the drug-polymer complex for targeted drug delivery systems. It highlights roles and significance, different classes and synthetic protocols as well as mechanisms of chemical bond formation in drug-polymer conjugation in drug delivery, also offering insights into the mechanism of polymer interaction with linker and drug molecules by biodegradable chemical bonding.
The protocol of binding with drug molecules is clearly explained and justified with case studies, helping researchers and advanced students in the pharmaceutical sciences understand fundamentals involved and related aspects in molecule designing for effective therapeutic benefits.
1. Polymer-Drug Conjugates - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iv 6. Dedication - p. Page v 7. Contributors - p. Page v 8. Editors - p. Page viii 9. Preface - p. Page xi 10. Acknowledgment - p. Page xii 11. List of Illustrations - p. Page xiii 12. List of Tables - p. Page xiv 13. Chapter 1 : Drug delivery: The conceptual perspectives and therapeutic applications - p. Page xiv 14. Chapter 2 : Rational design of linkers in polymer–drug conjugates - p. Page 30 15. Chapter 3 : Exploration of polymers in drug delivery: The structural and functional considerations - p. Page 51 16. Chapter 4 : Chemistry of conjugation in drug delivery: The prospects of biodegradable bonds in polymer–drug conjugates - p. Page 85 17. Chapter 5 : Polymer–drug conjugation using ester and ortho-ester bond: Mechanism, protocols, and applications - p. Page 117 18. Chapter 6 : Polymer–drug linking through amide bonds: the chemistry and applications in drug delivery - p. Page 141 19. Chapter 7 : Drug–polymer conjugate tailoring by disulfide linkage for controlled and targeted drug delivery - p. Page 168 20. Chapter 8 : Thioether linkage chemistry: perspectives and prospects in therapeutic designing - p. Page 190 21. Chapter 9 : Drug targeting to cancer cells through stimuli-responsive imine bonds: fascinating aspects of site specificity - p. Page 204 22. Chapter 10 : Carbamate–drug conjugates in drug delivery: structural and mechanistic considerations - p. Page 220 23. Chapter 11 : Bonding through phosphodiester moiety: Its implications in pharmaceutical modifications - p. Page 240 24. Chapter 12 : Enzymatically degradable linkers - p. Page 271 25. Chapter 13 : Dendrimer–drug conjugates - p. Page 303 26. Chapter 14 : Antibody–drug conjugate: Emerging trend for targeted treatment - p. Page 340 27. Chapter 15 : Drug–polymer conjugates: Challenges, opportunities, and future prospects in clinical trials - p. Page 378 28. Index - p. Page 454
