Huntington Disease summarizes the most recent findings related to the disease, providing both cutting edge coverage for clinical/research specialists looking to expand their knowledge base of Huntington disease information, as well as solid groundwork for advanced students from various backgrounds (neurology, psychiatry, neuropsychology, genetics). The volume includes all major areas of Huntington disease clinical care and research, whereas many other HD texts focus solely on neurological symptoms.
This book also addresses behavioral and cognitive symptoms, brain imaging, and family dynamics and therapeutic alliances in working with individuals affected by HD. Clinical trials are covered extensively, including design considerations for therapeutic studies. The devastating nature of Huntington’s disease is well appreciated throughout the neuroscience, neurology, and psychiatric communities, and a great amount of basic and clinical research is currently taking place. However, much of that occurs in isolated research silos, and it is critical that an interdisciplinary resource be developed to provide in depth information to enhance communication and collaboration. This volume in the Handbook of Clinical Neurology series is that resource.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Handbook of Clinical Neurology 3rd Series - p. v 6. Foreword - p. vii 7. Preface - p. ix 8. Contributors - p. xi 9. Section I: Basic science - p. xi 10. Chapter 1: Genetics of Huntington disease - p. xi 11. Chapter 2: Mechanisms underlying neurodegeneration in Huntington disease: applications to novel disease-modifying therapies - p. 14 12. Section II: Clinical aspects - p. 28 13. Chapter 3: Epidemiology of Huntington disease - p. 28 14. Chapter 4: Statistical modeling of Huntington disease onset - p. 46 15. Chapter 5: The diagnosis and natural history of Huntington disease - p. 61 16. Chapter 6: Cognitive and behavioral changes in Huntington disease before diagnosis - p. 67 17. Chapter 7: Preclinical motor manifestations of Huntington disease - p. 91 18. Chapter 8: The highly anxious individual presenting for Huntington disease-predictive genetic testing: the psychiatrist's role in assessment and counseling - p. 98 19. Chapter 9: Preimplantation genetics and other reproductive options in Huntington disease - p. 105 20. Chapter 10: Genetic testing for Huntington disease - p. 111 21. Section III: Treatment of Huntington disease - p. 126 22. Chapter 11: Medical treatment of behavioral manifestations of Huntington disease - p. 126 23. Chapter 12: Medical management of motor manifestations of Huntington disease - p. 139 24. Chapter 13: The role of rehabilitation therapy in Huntington disease - p. 150 25. Chapter 14: Contemporary health care for Huntington disease - p. 165 26. Chapter 15: The impact of Huntington disease on young people - p. 178 27. Chapter 16: Making a measurable difference in advanced Huntington disease care - p. 182 28. Section IV: Experimental therapeutics - p. 196 29. Chapter 17: New symptomatic therapies for Huntington disease - p. 196 30. Chapter 18: Motor outcome measures in Huntington disease clinical trials - p. 207 31. Chapter 19: Cognitive assessment in Huntington disease clinical drug trials - p. 225 32. Section V: Biomarkers - p. 244 33. Chapter 20: Structural imaging in premanifest and manifest Huntington disease - p. 244 34. Chapter 21: Functional imaging in Huntington disease - p. 261 35. Index - p. 289
Huntington Disease summarizes the most recent findings related to the disease, providing both cutting edge coverage for clinical/research specialists looking to expand their knowledge base of Huntington disease information, as well as solid groundwork for advanced students from various backgrounds (neurology, psychiatry, neuropsychology, genetics). The volume includes all major areas of Huntington disease clinical care and research, whereas many other HD texts focus solely on neurological symptoms.
This book also addresses behavioral and cognitive symptoms, brain imaging, and family dynamics and therapeutic alliances in working with individuals affected by HD. Clinical trials are covered extensively, including design considerations for therapeutic studies. The devastating nature of Huntington’s disease is well appreciated throughout the neuroscience, neurology, and psychiatric communities, and a great amount of basic and clinical research is currently taking place. However, much of that occurs in isolated research silos, and it is critical that an interdisciplinary resource be developed to provide in depth information to enhance communication and collaboration. This volume in the Handbook of Clinical Neurology series is that resource.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Handbook of Clinical Neurology 3rd Series - p. v 6. Foreword - p. vii 7. Preface - p. ix 8. Contributors - p. xi 9. Section I: Basic science - p. xi 10. Chapter 1: Genetics of Huntington disease - p. xi 11. Chapter 2: Mechanisms underlying neurodegeneration in Huntington disease: applications to novel disease-modifying therapies - p. 14 12. Section II: Clinical aspects - p. 28 13. Chapter 3: Epidemiology of Huntington disease - p. 28 14. Chapter 4: Statistical modeling of Huntington disease onset - p. 46 15. Chapter 5: The diagnosis and natural history of Huntington disease - p. 61 16. Chapter 6: Cognitive and behavioral changes in Huntington disease before diagnosis - p. 67 17. Chapter 7: Preclinical motor manifestations of Huntington disease - p. 91 18. Chapter 8: The highly anxious individual presenting for Huntington disease-predictive genetic testing: the psychiatrist's role in assessment and counseling - p. 98 19. Chapter 9: Preimplantation genetics and other reproductive options in Huntington disease - p. 105 20. Chapter 10: Genetic testing for Huntington disease - p. 111 21. Section III: Treatment of Huntington disease - p. 126 22. Chapter 11: Medical treatment of behavioral manifestations of Huntington disease - p. 126 23. Chapter 12: Medical management of motor manifestations of Huntington disease - p. 139 24. Chapter 13: The role of rehabilitation therapy in Huntington disease - p. 150 25. Chapter 14: Contemporary health care for Huntington disease - p. 165 26. Chapter 15: The impact of Huntington disease on young people - p. 178 27. Chapter 16: Making a measurable difference in advanced Huntington disease care - p. 182 28. Section IV: Experimental therapeutics - p. 196 29. Chapter 17: New symptomatic therapies for Huntington disease - p. 196 30. Chapter 18: Motor outcome measures in Huntington disease clinical trials - p. 207 31. Chapter 19: Cognitive assessment in Huntington disease clinical drug trials - p. 225 32. Section V: Biomarkers - p. 244 33. Chapter 20: Structural imaging in premanifest and manifest Huntington disease - p. 244 34. Chapter 21: Functional imaging in Huntington disease - p. 261 35. Index - p. 289
