This issue of Hematology/Oncology Clinics, edited by Dr. Ali Taher, focuses on Thalassemia. Topics include, but are not limited to, Molecular basis and genetic modifiers; Evolving spectrum of epidemiology; Clinical classification; Ineffective erythropoiesis, anemia and iron overload; Hypercoagulability and vascular disease; Clinical complications and their management; Transfusion and iron chelation therapy; Hematopoietic Stem Cell Transplantation in Thalassemia; Gene therapy and genome editing; Emerging therapies; Quality of life; Advances in understanding pathophysiology and treatment of fertility, pregnancy, and prenatal diagnosis in Thalassemia; and MRI for iron overload.
1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. i 4. Copyright - p. ii 5. Contributors - p. iii 6. Forthcoming Issues - p. xi 7. Erratum - p. xiii 8. Preface - p. xv 9. The Evolving Spectrum of the Epidemiology of Thalassemia - p. 165 10. Molecular Basis and Genetic Modifiers of Thalassemia - p. 177 11. Clinical Classification, Screening and Diagnosis for Thalassemia - p. 193 12. Ineffective Erythropoiesis: Anemia and Iron Overload - p. 213 13. Clinical Complications and Their Management - p. 223 14. Hypercoagulability and Vascular Disease - p. 237 15. Interaction of Transfusion and Iron Chelation in Thalassemias - p. 247 16. Iron Chelation Therapy as a Modality of Management - p. 261 17. MRI for Iron Overload in Thalassemia - p. 277 18. Fertility and Pregnancy in Women with Transfusion-Dependent Thalassemia - p. 297 19. Hematopoietic Stem Cell Transplantation in Thalassemia - p. 317 20. Gene Therapy and Genome Editing - p. 329 21. Emerging Therapies - p. 343
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This issue of Hematology/Oncology Clinics, edited by Dr. Ali Taher, focuses on Thalassemia. Topics include, but are not limited to, Molecular basis and genetic modifiers; Evolving spectrum of epidemiology; Clinical classification; Ineffective erythropoiesis, anemia and iron overload; Hypercoagulability and vascular disease; Clinical complications and their management; Transfusion and iron chelation therapy; Hematopoietic Stem Cell Transplantation in Thalassemia; Gene therapy and genome editing; Emerging therapies; Quality of life; Advances in understanding pathophysiology and treatment of fertility, pregnancy, and prenatal diagnosis in Thalassemia; and MRI for iron overload.
1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. i 4. Copyright - p. ii 5. Contributors - p. iii 6. Forthcoming Issues - p. xi 7. Erratum - p. xiii 8. Preface - p. xv 9. The Evolving Spectrum of the Epidemiology of Thalassemia - p. 165 10. Molecular Basis and Genetic Modifiers of Thalassemia - p. 177 11. Clinical Classification, Screening and Diagnosis for Thalassemia - p. 193 12. Ineffective Erythropoiesis: Anemia and Iron Overload - p. 213 13. Clinical Complications and Their Management - p. 223 14. Hypercoagulability and Vascular Disease - p. 237 15. Interaction of Transfusion and Iron Chelation in Thalassemias - p. 247 16. Iron Chelation Therapy as a Modality of Management - p. 261 17. MRI for Iron Overload in Thalassemia - p. 277 18. Fertility and Pregnancy in Women with Transfusion-Dependent Thalassemia - p. 297 19. Hematopoietic Stem Cell Transplantation in Thalassemia - p. 317 20. Gene Therapy and Genome Editing - p. 329 21. Emerging Therapies - p. 343
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