Toxicological Evaluation of Electronic Nicotine Delivery Products (ENDP) discusses the scientific basis for the toxicological assessment and evaluation of ENDPs. The book covers aerosol chemistry, in vitro and in vivo studies as well as clinical studies. It provides the basis for the evaluation of short and long term-effects, along with relative risks. It also examines the potential role of ENDPs in tobacco harm reduction and how they may reduce the risk of disease in smokers who switch to them. This book is a comprehensive resource for toxicologists, health practitioners and public health professionals who want the scientific information necessary to assess the relative risk of ENDPs when compared with cigarette smoking and cessation.
1. Toxicological Evaluation of Electronic Nicotine Delivery Products - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iv 6. List of Contributors - p. Page v 7. Acknowledgments - p. Page v 8. Preamble - p. Page vii 9. List of Illustrations - p. Page x 10. List of Tables - p. Page xi 11. Chapter 1 : Tobacco Harm Reduction Concepts and Policy Approaches - p. Page xi 12. Chapter 2 : Electronic Nicotine Delivery Products - p. Page 13 13. Chapter 3 : Scientific Basis for Assessment of Electronic Nicotine Delivery Products - p. Page 21 14. Chapter 4 : Quantification of HPHCs in ENDP Aerosols - p. Page 39 15. Chapter 5 : Aerosol Physics and Dynamics - p. Page 76 16. Chapter 6 : Advanced Analytical Chemistry Methods to Characterize ENDP Aerosols - p. Page 99 17. Chapter 7 : Other Species of Toxicological Concern not Classified as HPHCs - p. Page 126 18. Chapter 8 : Environmental Impact: Influence of ENDPs on Indoor Air Quality - p. Page 133 19. Chapter 9 : A Systems-Based Approach to Toxicity Testing - p. Page 180 20. Chapter 10 : Translational Models for ENDP Assessment - p. Page 201 21. Chapter 11 : Aerosol Dosimetry and Human-Relevant Exposure - p. Page 217 22. Chapter 12 : Systems for Generation of ENDP Aerosols and Their Administration to In Vitro and In Vivo Experimental Models - p. Page 231 23. Chapter 13 : Toxicological Assessment In Vitro - p. Page 252 24. Chapter 14 : Toxicological Assessment of ENDPs In Vivo - p. Page 297 25. Chapter 15 : Assessment of ENDPs in Animal Models of Disease - p. Page 315 26. Chapter 16 : Toxicological Assessment of Flavors Used in E-vapor Products - p. Page 354 27. Chapter 17 : Clinical Assessment of ENDPs - p. Page 380 28. Chapter 18 : Smoking-Related Disease Risk Reduction Potential of ENDPs - p. Page 452 29. Chapter 19 : Passive Exposure to ENDP Aerosols - p. Page 490 30. Chapter 20 : Residual Risk of Nicotine - p. Page 510 31. Chapter 21 : Conclusions and Outlook - p. Page 567 32. Postface - p. Page 594 33. Index - p. Page 594
Toxicological Evaluation of Electronic Nicotine Delivery Products (ENDP) discusses the scientific basis for the toxicological assessment and evaluation of ENDPs. The book covers aerosol chemistry, in vitro and in vivo studies as well as clinical studies. It provides the basis for the evaluation of short and long term-effects, along with relative risks. It also examines the potential role of ENDPs in tobacco harm reduction and how they may reduce the risk of disease in smokers who switch to them. This book is a comprehensive resource for toxicologists, health practitioners and public health professionals who want the scientific information necessary to assess the relative risk of ENDPs when compared with cigarette smoking and cessation.
1. Toxicological Evaluation of Electronic Nicotine Delivery Products - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iv 6. List of Contributors - p. Page v 7. Acknowledgments - p. Page v 8. Preamble - p. Page vii 9. List of Illustrations - p. Page x 10. List of Tables - p. Page xi 11. Chapter 1 : Tobacco Harm Reduction Concepts and Policy Approaches - p. Page xi 12. Chapter 2 : Electronic Nicotine Delivery Products - p. Page 13 13. Chapter 3 : Scientific Basis for Assessment of Electronic Nicotine Delivery Products - p. Page 21 14. Chapter 4 : Quantification of HPHCs in ENDP Aerosols - p. Page 39 15. Chapter 5 : Aerosol Physics and Dynamics - p. Page 76 16. Chapter 6 : Advanced Analytical Chemistry Methods to Characterize ENDP Aerosols - p. Page 99 17. Chapter 7 : Other Species of Toxicological Concern not Classified as HPHCs - p. Page 126 18. Chapter 8 : Environmental Impact: Influence of ENDPs on Indoor Air Quality - p. Page 133 19. Chapter 9 : A Systems-Based Approach to Toxicity Testing - p. Page 180 20. Chapter 10 : Translational Models for ENDP Assessment - p. Page 201 21. Chapter 11 : Aerosol Dosimetry and Human-Relevant Exposure - p. Page 217 22. Chapter 12 : Systems for Generation of ENDP Aerosols and Their Administration to In Vitro and In Vivo Experimental Models - p. Page 231 23. Chapter 13 : Toxicological Assessment In Vitro - p. Page 252 24. Chapter 14 : Toxicological Assessment of ENDPs In Vivo - p. Page 297 25. Chapter 15 : Assessment of ENDPs in Animal Models of Disease - p. Page 315 26. Chapter 16 : Toxicological Assessment of Flavors Used in E-vapor Products - p. Page 354 27. Chapter 17 : Clinical Assessment of ENDPs - p. Page 380 28. Chapter 18 : Smoking-Related Disease Risk Reduction Potential of ENDPs - p. Page 452 29. Chapter 19 : Passive Exposure to ENDP Aerosols - p. Page 490 30. Chapter 20 : Residual Risk of Nicotine - p. Page 510 31. Chapter 21 : Conclusions and Outlook - p. Page 567 32. Postface - p. Page 594 33. Index - p. Page 594
