Toxicological Survey of African Medicinal Plants, Second Edition bridges traditional knowledge with modern science, providing a comprehensive and detailed overview of toxicological studies related to traditionally used African medicinal plants with special emphasis on practical insights and scientifically validated methodologies, and tools used for data collection and interpretation. Completely revised and updated, the book considers the physical parameters of novel plants and their effect on specific areas of the body and overall human health, including chapters dedicated to genotoxicity, hepatotoxicity, nephrotoxicity, cardiotoxicity, neurotoxicity, and specific organs and systems.
The new edition also considers advances in omics approaches and the increased use of advanced analytical techniques to understand plant toxicity and improved the identification of toxic compounds in medicinal plants. With contributions from a distinguished team of researchers in the field, this book is an invaluable resource for researchers, advanced students and postgraduates, industry professionals, and policymakers who require an integrated understanding of toxicology, pharmacology, ethnopharmacology, as well as regulatory and policy frameworks for African medicinal plants.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. List of contributors - p. xxvii 7. Preface - p. xxxi 8. Acknowledgments - p. xxxiii 9. Part I: Foundational and methodological advances - p. P1 10. Chapter 1. Toxicological societies in Africa: advances in their implication in policy making and living conditions - p. 3 11. Chapter 2. Advancements in managing ethical concerns regarding animal use in toxicological research in Africa - p. 21 12. Chapter 3. Advances and evolving methodologies in toxicological research and guidelines in Africa - p. 53 13. Chapter 4. Discordant results in plant toxicity studies in Africa: established standards and recent advances - p. 73 14. Part II: Toxicological profiles of African medicinal plants - p. P99 15. Chapter 5. Acute and subacute toxicities of African medicinal plants: an update - p. 101 16. Chapter 6. Subchronic and chronic toxicities of African medicinal plants: an updated review - p. 157 17. Chapter 7. Toxic plants used in African traditional medicine: an update - p. 237 18. Chapter 8. Cytotoxicity of African medicinal plants against normal animal and human cells: an updated review - p. 297 19. Chapter 9. Genotoxicity and teratogenicity of African medicinal plants: an updated review - p. 393 20. Chapter 10. Mutagenicity and carcinogenicity of African medicinal plants: an update - p. 461 21. Chapter 11. Hepatotoxicity and hepatoprotective effects of African medicinal plants: an updated review - p. 497 22. Chapter 12. Nephrotoxicity and nephroprotective potential of African medicinal plants: an updated review - p. 553 23. Chapter 13. Cardiotoxicity and cardioprotective effects of African medicinal plants: an update - p. 593 24. Chapter 14. Neurotoxicity and neuroprotective effects of African medicinal plants: an update - p. 629 25. Chapter 15. The dual nature of African plants: exploring their impact on reproductive health - p. 649 26. Chapter 16. Update on African plants relevant to dermatology and ophthalmology - p. 737 27. Chapter 17. Toxicity and protective effects of African medicinal plants on the spleen and lung: an updated review - p. 775 28. Chapter 18. Safe African medicinal plants for clinical studies - p. 801 29. Part III: Toxic and protective phytochemical constituents - p. P831 30. Chapter 19. Update on the harmful and protective effects of terpenoids in African medicinal plants - p. 833 31. Chapter 20. Harmful and protective effects of phenolic compounds from African medicinal plants: an update - p. 893 32. Chapter 21. An updated review of the health effects of alkaloids from African medicinal plants - p. 949 33. Part IV: Physiological and biochemical responses - p. P981 34. Chapter 22. Physical, hematological, and histopathological signs of toxicity induced by African medicinal plants: an update - p. 983 35. Chapter 23. Biochemical parameters in toxicological studies in Africa: an update for their significance, principles of methods, data interpretation, and use in plant screenings - p. 1019 36. Index - p. 1057
Toxicological Survey of African Medicinal Plants, Second Edition bridges traditional knowledge with modern science, providing a comprehensive and detailed overview of toxicological studies related to traditionally used African medicinal plants with special emphasis on practical insights and scientifically validated methodologies, and tools used for data collection and interpretation. Completely revised and updated, the book considers the physical parameters of novel plants and their effect on specific areas of the body and overall human health, including chapters dedicated to genotoxicity, hepatotoxicity, nephrotoxicity, cardiotoxicity, neurotoxicity, and specific organs and systems.
The new edition also considers advances in omics approaches and the increased use of advanced analytical techniques to understand plant toxicity and improved the identification of toxic compounds in medicinal plants. With contributions from a distinguished team of researchers in the field, this book is an invaluable resource for researchers, advanced students and postgraduates, industry professionals, and policymakers who require an integrated understanding of toxicology, pharmacology, ethnopharmacology, as well as regulatory and policy frameworks for African medicinal plants.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. List of contributors - p. xxvii 7. Preface - p. xxxi 8. Acknowledgments - p. xxxiii 9. Part I: Foundational and methodological advances - p. P1 10. Chapter 1. Toxicological societies in Africa: advances in their implication in policy making and living conditions - p. 3 11. Chapter 2. Advancements in managing ethical concerns regarding animal use in toxicological research in Africa - p. 21 12. Chapter 3. Advances and evolving methodologies in toxicological research and guidelines in Africa - p. 53 13. Chapter 4. Discordant results in plant toxicity studies in Africa: established standards and recent advances - p. 73 14. Part II: Toxicological profiles of African medicinal plants - p. P99 15. Chapter 5. Acute and subacute toxicities of African medicinal plants: an update - p. 101 16. Chapter 6. Subchronic and chronic toxicities of African medicinal plants: an updated review - p. 157 17. Chapter 7. Toxic plants used in African traditional medicine: an update - p. 237 18. Chapter 8. Cytotoxicity of African medicinal plants against normal animal and human cells: an updated review - p. 297 19. Chapter 9. Genotoxicity and teratogenicity of African medicinal plants: an updated review - p. 393 20. Chapter 10. Mutagenicity and carcinogenicity of African medicinal plants: an update - p. 461 21. Chapter 11. Hepatotoxicity and hepatoprotective effects of African medicinal plants: an updated review - p. 497 22. Chapter 12. Nephrotoxicity and nephroprotective potential of African medicinal plants: an updated review - p. 553 23. Chapter 13. Cardiotoxicity and cardioprotective effects of African medicinal plants: an update - p. 593 24. Chapter 14. Neurotoxicity and neuroprotective effects of African medicinal plants: an update - p. 629 25. Chapter 15. The dual nature of African plants: exploring their impact on reproductive health - p. 649 26. Chapter 16. Update on African plants relevant to dermatology and ophthalmology - p. 737 27. Chapter 17. Toxicity and protective effects of African medicinal plants on the spleen and lung: an updated review - p. 775 28. Chapter 18. Safe African medicinal plants for clinical studies - p. 801 29. Part III: Toxic and protective phytochemical constituents - p. P831 30. Chapter 19. Update on the harmful and protective effects of terpenoids in African medicinal plants - p. 833 31. Chapter 20. Harmful and protective effects of phenolic compounds from African medicinal plants: an update - p. 893 32. Chapter 21. An updated review of the health effects of alkaloids from African medicinal plants - p. 949 33. Part IV: Physiological and biochemical responses - p. P981 34. Chapter 22. Physical, hematological, and histopathological signs of toxicity induced by African medicinal plants: an update - p. 983 35. Chapter 23. Biochemical parameters in toxicological studies in Africa: an update for their significance, principles of methods, data interpretation, and use in plant screenings - p. 1019 36. Index - p. 1057
