Toxicology Handbook is a practical evidence-based guide on the care of the poisoned patient. This concise text is informed by the latest clinical research and takes a rigorous and structured risk assessment-based approach to decision making in the context of clinical toxicology. It assists the clinician to quickly find information on poisons, toxins, antidotes, envenomings and antivenoms and determine the appropriate treatment for the acutely poisoned patient. Key features include guides through drug administration and treatment, handy tips" and "pitfalls", and drug dosages and administration based on current pharmacological regulations.
1. Cover image - p. Cover 2. Title page - p. ii 3. Copyright - p. ii 4. Foreword - p. ii 5. Preface - p. ii 6. Editors - p. ii 7. Contributors - p. ii 8. Reviewers - p. ii 9. List of Illustrations - p. ii 10. List of Tables - p. ii 11. Chapter 1: Approach to the Poisoned Patient - p. ii 12. Chapter 2: Specific Considerations - p. ii 13. 2.1 Approach to Snakebite - p. ii 14. 2.2 Approach to Mushroom Poisoning - p. ii 15. 2.3 Approach to Plant Poisoning - p. ii 16. 2.4 Coma - p. ii 17. 2.5 Hypotension - p. ii 18. 2.6 Seizures - p. ii 19. 2.7 Delirium and Agitation - p. ii 20. 2.8 Serotonin Syndrome - p. ii 21. 2.9 Anticholinergic Syndrome - p. ii 22. 2.10 Cholinergic Syndrome - p. ii 23. 2.11 Neuroleptic Malignant Syndrome - p. ii 24. 2.12 Alcohol Use Disorder - p. ii 25. 2.13 Amphetamine Use Disorder - p. ii 26. 2.14 Opioid Use Disorder - p. ii 27. 2.15 Sedative-Hypnotic Use Disorder - p. ii 28. 2.16 Solvent Abuse - p. ii 29. 2.17 Body Packers and Stuffers - p. ii 30. 2.18 Osmolar Gap - p. ii 31. 2.19 Acid–Base Disorders - p. ii 32. 2.20 The 12-Lead Ecg in Toxicology - p. ii 33. 2.21 Poisoning During Pregnancy and Lactation - p. ii 34. 2.22 Poisoning in Children - p. ii 35. 2.23 Poisoning in the Elderly - p. ii 36. Review Questions - p. ii 37. Chapter 3: Specific Toxins - p. ii 38. 3.1 Alcohol: Ethanol - p. ii 39. 3.2 Alcohol: Ethylene Glycol - p. ii 40. 3.3 Alcohol: Isopropanol (isopropyl alcohol) - p. ii 41. 3.4 Alcohol: Methanol (methyl alcohol) - p. ii 42. 3.5 Alcohol: Other Toxic Alcohols - p. ii 43. 3.6 Amiodarone - p. ii 44. 3.7 Amisulpride - p. ii 45. 3.8 Amphetamines and Other Sympathomimetics - p. ii 46. 3.9 Angiotensin-Converting Enzyme Inhibitors - p. ii 47. 3.10 Anticoagulant Rodenticides - p. ii 48. 3.11 Anticonvulsants: Newer Agents - p. ii 49. 3.12 Antihistamines (non-sedating) - p. ii 50. 3.13 Antihistamines (sedating) - p. ii 51. 3.14 Arsenic - p. ii 52. 3.15 Baclofen - p. ii 53. 3.16 Barbiturates - p. ii 54. 3.17 Benzodiazepines - p. ii 55. 3.18 Benztropine - p. ii 56. 3.19 Beta-Blockers - p. ii 57. 3.20 Bupropion - p. ii 58. 3.21 Button Batteries - p. ii 59. 3.22 Calcium Channel Blockers - p. ii 60. 3.23 Cannabinoids (marijuana) - p. ii 61. 3.24 Carbamazepine - p. ii 62. 3.25 Carbon Monoxide - p. ii 63. 3.26 Chloroquine and Hydroxychloroquine - p. ii 64. 3.27 Chloral Hydrate - p. ii 65. 3.28 Clonidine - p. ii 66. 3.29 Clozapine - p. ii 67. 3.30 Cocaine - p. ii 68. 3.31 Colchicine - p. ii 69. 3.32 Corrosives - p. ii 70. 3.33 Cyanide - p. ii 71. 3.34 Digoxin: Acute Overdose - p. ii 72. 3.35 Digoxin: Chronic Poisoning - p. ii 73. 3.36 Diphenoxylate–Atropine - p. ii 74. 3.37 Gamma-Hydroxybutyrate (GHB) - p. ii 75. 3.38 Glyphosate - p. ii 76. 3.39 Hydrocarbons - p. ii 77. 3.40 Hydrofluoric Acid - p. ii 78. 3.41 Hydrogen Peroxide - p. ii 79. 3.42 Insulin - p. ii 80. 3.43 Iron - p. ii 81. 3.44 Isoniazid - p. ii 82. 3.45 Lead - p. ii 83. 3.46 Lithium: Acute Overdose - p. ii 84. 3.47 Lithium: Chronic Poisoning - p. ii 85. 3.48 Local Anaesthetic Agents - p. ii 86. 3.49 Mercury - p. ii 87. 3.50 Metformin - p. ii 88. 3.51 Methotrexate - p. ii 89. 3.52 Mirtazapine - p. ii 90. 3.53 Monoamine Oxidase Inhibitors (MAOIs) - p. ii 91. 3.54 New Oral Anticoagulants - p. ii 92. 3.55 Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) - p. ii 93. 3.56 Olanzapine - p. ii 94. 3.57 Opioids - p. ii 95. 3.58 Organochlorines - p. ii 96. 3.59 Organophosphorus Agents (organophosphates and carbamates) - p. ii 97. 3.60 Paracetamol: Acute Overdose - p. ii 98. 3.61 Paracetamol: Modified-Release Formulations - p. ii 99. 3.62 Paracetamol: Repeated Supratherapeutic Ingestion - p. ii 100. 3.63 Paraquat - p. ii 101. 3.64 Phenothiazines and Butyrophenones (antipsychotic agents) - p. ii 102. 3.65 Phenytoin - p. ii 103. 3.66 Potassium Chloride - p. ii 104. 3.67 Quetiapine - p. ii 105. 3.68 Quinine - p. ii 106. 3.69 Risperidone - p. ii 107. 3.70 Salicylates - p. ii 108. 3.71 Selective Serotonin Reuptake Inhibitors (SSRIs) - p. ii 109. 3.72 Strychnine - p. ii 110. 3.73 Sulfonylureas - p. ii 111. 3.74 Theophylline - p. ii 112. 3.75 Thyroxine - p. ii 113. 3.76 Tramadol - p. ii 114. 3.77 Tricyclic Antidepressants (TCAs) - p. ii 115. 3.78 Valproic Acid (sodium valproate) - p. ii 116. 3.79 Venlafaxine and Desvenlafaxine - p. ii 117. 3.80 Warfarin - p. ii 118. Review Questions - p. ii 119. Chapter 4: Antidotes - p. ii 120. 4.1 Atropine - p. ii 121. 4.2 Calcium - p. ii 122. 4.3 Cyproheptadine - p. ii 123. 4.4 Desferrioxamine - p. ii 124. 4.5 Dicobalt Edetate - p. ii 125. 4.6 Digoxin Immune Fab - p. ii 126. 4.7 Dimercaprol - p. ii 127. 4.8 Ethanol - p. ii 128. 4.9 Flumazenil - p. ii 129. 4.10 Folinic Acid - p. ii 130. 4.11 Fomepizole - p. ii 131. 4.12 Glucose - p. ii 132. 4.13 Hydroxocobalamin - p. ii 133. 4.14 Insulin (high-dose) - p. ii 134. 4.15 Intravenous Lipid Emulsion - p. ii 135. 4.16 Methylene Blue - p. ii 136. 4.17 N-Acetylcysteine - p. ii 137. 4.18 Naloxone - p. ii 138. 4.19 Octreotide - p. ii 139. 4.20 Penicillamine - p. ii 140. 4.21 Physostigmine - p. ii 141. 4.22 Pralidoxime - p. ii 142. 4.23 Pyridoxine - p. ii 143. 4.24 Sodium Bicarbonate - p. ii 144. 4.25 Sodium Calcium Edetate - p. ii 145. 4.26 Sodium Thiosulfate - p. ii 146. 4.27 Succimer - p. ii 147. 4.28 Vitamin K - p. ii 148. Review Questions - p. ii 149. Chapter 5: Envenomings - p. ii 150. Chapter 6: Antivenoms - p. ii 151. Appendices - p. ii 152. Poisons Information Telephone Numbers - p. ii 153. Example ECGs - p. ii 154. Conversion Factors and Therapeutic Ranges for Important Toxins - p. ii 155. Alcohol Pathways - p. ii 156. Therapeutic Over-Warfarinisation - p. ii 157. Management of Allergic Reactions to Antivenoms - p. ii 158. Index - p. ii
Toxicology Handbook is a practical evidence-based guide on the care of the poisoned patient. This concise text is informed by the latest clinical research and takes a rigorous and structured risk assessment-based approach to decision making in the context of clinical toxicology. It assists the clinician to quickly find information on poisons, toxins, antidotes, envenomings and antivenoms and determine the appropriate treatment for the acutely poisoned patient. Key features include guides through drug administration and treatment, handy tips" and "pitfalls", and drug dosages and administration based on current pharmacological regulations.
1. Cover image - p. Cover 2. Title page - p. ii 3. Copyright - p. ii 4. Foreword - p. ii 5. Preface - p. ii 6. Editors - p. ii 7. Contributors - p. ii 8. Reviewers - p. ii 9. List of Illustrations - p. ii 10. List of Tables - p. ii 11. Chapter 1: Approach to the Poisoned Patient - p. ii 12. Chapter 2: Specific Considerations - p. ii 13. 2.1 Approach to Snakebite - p. ii 14. 2.2 Approach to Mushroom Poisoning - p. ii 15. 2.3 Approach to Plant Poisoning - p. ii 16. 2.4 Coma - p. ii 17. 2.5 Hypotension - p. ii 18. 2.6 Seizures - p. ii 19. 2.7 Delirium and Agitation - p. ii 20. 2.8 Serotonin Syndrome - p. ii 21. 2.9 Anticholinergic Syndrome - p. ii 22. 2.10 Cholinergic Syndrome - p. ii 23. 2.11 Neuroleptic Malignant Syndrome - p. ii 24. 2.12 Alcohol Use Disorder - p. ii 25. 2.13 Amphetamine Use Disorder - p. ii 26. 2.14 Opioid Use Disorder - p. ii 27. 2.15 Sedative-Hypnotic Use Disorder - p. ii 28. 2.16 Solvent Abuse - p. ii 29. 2.17 Body Packers and Stuffers - p. ii 30. 2.18 Osmolar Gap - p. ii 31. 2.19 Acid–Base Disorders - p. ii 32. 2.20 The 12-Lead Ecg in Toxicology - p. ii 33. 2.21 Poisoning During Pregnancy and Lactation - p. ii 34. 2.22 Poisoning in Children - p. ii 35. 2.23 Poisoning in the Elderly - p. ii 36. Review Questions - p. ii 37. Chapter 3: Specific Toxins - p. ii 38. 3.1 Alcohol: Ethanol - p. ii 39. 3.2 Alcohol: Ethylene Glycol - p. ii 40. 3.3 Alcohol: Isopropanol (isopropyl alcohol) - p. ii 41. 3.4 Alcohol: Methanol (methyl alcohol) - p. ii 42. 3.5 Alcohol: Other Toxic Alcohols - p. ii 43. 3.6 Amiodarone - p. ii 44. 3.7 Amisulpride - p. ii 45. 3.8 Amphetamines and Other Sympathomimetics - p. ii 46. 3.9 Angiotensin-Converting Enzyme Inhibitors - p. ii 47. 3.10 Anticoagulant Rodenticides - p. ii 48. 3.11 Anticonvulsants: Newer Agents - p. ii 49. 3.12 Antihistamines (non-sedating) - p. ii 50. 3.13 Antihistamines (sedating) - p. ii 51. 3.14 Arsenic - p. ii 52. 3.15 Baclofen - p. ii 53. 3.16 Barbiturates - p. ii 54. 3.17 Benzodiazepines - p. ii 55. 3.18 Benztropine - p. ii 56. 3.19 Beta-Blockers - p. ii 57. 3.20 Bupropion - p. ii 58. 3.21 Button Batteries - p. ii 59. 3.22 Calcium Channel Blockers - p. ii 60. 3.23 Cannabinoids (marijuana) - p. ii 61. 3.24 Carbamazepine - p. ii 62. 3.25 Carbon Monoxide - p. ii 63. 3.26 Chloroquine and Hydroxychloroquine - p. ii 64. 3.27 Chloral Hydrate - p. ii 65. 3.28 Clonidine - p. ii 66. 3.29 Clozapine - p. ii 67. 3.30 Cocaine - p. ii 68. 3.31 Colchicine - p. ii 69. 3.32 Corrosives - p. ii 70. 3.33 Cyanide - p. ii 71. 3.34 Digoxin: Acute Overdose - p. ii 72. 3.35 Digoxin: Chronic Poisoning - p. ii 73. 3.36 Diphenoxylate–Atropine - p. ii 74. 3.37 Gamma-Hydroxybutyrate (GHB) - p. ii 75. 3.38 Glyphosate - p. ii 76. 3.39 Hydrocarbons - p. ii 77. 3.40 Hydrofluoric Acid - p. ii 78. 3.41 Hydrogen Peroxide - p. ii 79. 3.42 Insulin - p. ii 80. 3.43 Iron - p. ii 81. 3.44 Isoniazid - p. ii 82. 3.45 Lead - p. ii 83. 3.46 Lithium: Acute Overdose - p. ii 84. 3.47 Lithium: Chronic Poisoning - p. ii 85. 3.48 Local Anaesthetic Agents - p. ii 86. 3.49 Mercury - p. ii 87. 3.50 Metformin - p. ii 88. 3.51 Methotrexate - p. ii 89. 3.52 Mirtazapine - p. ii 90. 3.53 Monoamine Oxidase Inhibitors (MAOIs) - p. ii 91. 3.54 New Oral Anticoagulants - p. ii 92. 3.55 Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) - p. ii 93. 3.56 Olanzapine - p. ii 94. 3.57 Opioids - p. ii 95. 3.58 Organochlorines - p. ii 96. 3.59 Organophosphorus Agents (organophosphates and carbamates) - p. ii 97. 3.60 Paracetamol: Acute Overdose - p. ii 98. 3.61 Paracetamol: Modified-Release Formulations - p. ii 99. 3.62 Paracetamol: Repeated Supratherapeutic Ingestion - p. ii 100. 3.63 Paraquat - p. ii 101. 3.64 Phenothiazines and Butyrophenones (antipsychotic agents) - p. ii 102. 3.65 Phenytoin - p. ii 103. 3.66 Potassium Chloride - p. ii 104. 3.67 Quetiapine - p. ii 105. 3.68 Quinine - p. ii 106. 3.69 Risperidone - p. ii 107. 3.70 Salicylates - p. ii 108. 3.71 Selective Serotonin Reuptake Inhibitors (SSRIs) - p. ii 109. 3.72 Strychnine - p. ii 110. 3.73 Sulfonylureas - p. ii 111. 3.74 Theophylline - p. ii 112. 3.75 Thyroxine - p. ii 113. 3.76 Tramadol - p. ii 114. 3.77 Tricyclic Antidepressants (TCAs) - p. ii 115. 3.78 Valproic Acid (sodium valproate) - p. ii 116. 3.79 Venlafaxine and Desvenlafaxine - p. ii 117. 3.80 Warfarin - p. ii 118. Review Questions - p. ii 119. Chapter 4: Antidotes - p. ii 120. 4.1 Atropine - p. ii 121. 4.2 Calcium - p. ii 122. 4.3 Cyproheptadine - p. ii 123. 4.4 Desferrioxamine - p. ii 124. 4.5 Dicobalt Edetate - p. ii 125. 4.6 Digoxin Immune Fab - p. ii 126. 4.7 Dimercaprol - p. ii 127. 4.8 Ethanol - p. ii 128. 4.9 Flumazenil - p. ii 129. 4.10 Folinic Acid - p. ii 130. 4.11 Fomepizole - p. ii 131. 4.12 Glucose - p. ii 132. 4.13 Hydroxocobalamin - p. ii 133. 4.14 Insulin (high-dose) - p. ii 134. 4.15 Intravenous Lipid Emulsion - p. ii 135. 4.16 Methylene Blue - p. ii 136. 4.17 N-Acetylcysteine - p. ii 137. 4.18 Naloxone - p. ii 138. 4.19 Octreotide - p. ii 139. 4.20 Penicillamine - p. ii 140. 4.21 Physostigmine - p. ii 141. 4.22 Pralidoxime - p. ii 142. 4.23 Pyridoxine - p. ii 143. 4.24 Sodium Bicarbonate - p. ii 144. 4.25 Sodium Calcium Edetate - p. ii 145. 4.26 Sodium Thiosulfate - p. ii 146. 4.27 Succimer - p. ii 147. 4.28 Vitamin K - p. ii 148. Review Questions - p. ii 149. Chapter 5: Envenomings - p. ii 150. Chapter 6: Antivenoms - p. ii 151. Appendices - p. ii 152. Poisons Information Telephone Numbers - p. ii 153. Example ECGs - p. ii 154. Conversion Factors and Therapeutic Ranges for Important Toxins - p. ii 155. Alcohol Pathways - p. ii 156. Therapeutic Over-Warfarinisation - p. ii 157. Management of Allergic Reactions to Antivenoms - p. ii 158. Index - p. ii
