This 2e of Toxoplasma gondii reflects the significant advances in the field in the last 5 years, including new information on the genomics, epigenomics and proteomics of T. gondii as well as a new understanding of the population biology and genetic diversity of this organism. T. gondii remains the best model system for studying the entire Apicomplexa group of protozoans, which includes Malaria, making this new edition essential for a broad group of researchers and scientists.
Toxoplasmosis is caused by a one-celled protozoan parasite known as T. gondii. The infection produces a wide range of clinical syndromes in humans, land and sea mammals, and various bird species. Most humans contract toxoplasmosis by eating contaminated, raw or undercooked meat (particularly pork), vegetables, or milk products; by coming into contact with the T. gondii eggs from cat feces; or by drinking contaminated water. The parasite damages the ocular and central nervous systems, causing behavioral and personality alterations as well as fatal necrotizing encephalitis. It is especially dangerous for the fetus of an infected pregnant woman and for individuals with compromised immune systems, such as HIV-infected patients.
1. 12.1 Introduction - p. 390 2. 12.2 Invasion: A Rapid and Active Process Unique to Apicomplexan Parasites - p. 391 3. 12.3 Invasion: A Tightly Coupled Secretion Machinery - p. 393 4. 12.4 Micronemes - p. 397 5. 12.5 Rhoptries - p. 418 6. 12.6 Dense Granules - p. 435 7. 12.7 Conclusions - p. 444 8. References - p. 444 9. Chapter 13. The Toxoplasma Cytoskeleton: Structures, Proteins and Processes - p. 444 10. Chapter 14. Interactions Between Toxoplasma Effectors and Host Immune Responses - p. 498 11. Chapter 15. Bradyzoite Development - p. 517 12. Chapter 16. Development and Application of Classical Genetics in Toxoplasma gondii - p. 545 13. Chapter 17. Genetic Manipulation of Toxoplasma gondii - p. 573 14. Chapter 18. Epigenetic and Genetic Factors that Regulate Gene Expression in Toxoplasma gondii - p. 608 15. Chapter 19. ToxoDB: An Integrated Functional Genomic Resource for Toxoplasma and Other Sarcocystidae - p. 640 16. Chapter 20. Comparative Aspects of Nucleotide and Amino Acid Metabolism in Toxoplasma gondii and Other Apicomplexa - p. 661 17. Chapter 21. Toxoplasma gondii Chemical Biology - p. 699 18. Chapter 22. Proteomics of Toxoplasma gondii - p. 727 19. Chapter 23. Cerebral Toxoplasmosis: Pathogenesis, Host Resistance and Behavioural Consequences - p. 751 20. Chapter 24. Innate Immunity to Toxoplasma gondii - p. 789 21. Chapter 25. Adaptive Immunity and Genetics of the Host Immune Response - p. 812 22. Abstract - p. 812 23. Acknowledgements - p. 821 24. 25.1 Introduction - p. 821 25. 25.2 Mouse Genetic Studies - p. 824 26. 25.3 Studies of Lewis and Fischer Rats - p. 865 27. 25.4 Studies in Humans Concerning Genes that Confer Resistance or Susceptibility and the Use of Murine Models with Human Transgenes - p. 869 28. 25.5 Influence of Parasite Strain on Immune Response and Disease in Murine Models - p. 937 29. 25.6 General Aspects of Immunity - p. 939 30. 25.7 Immunological Control in Animal Models - p. 953 31. 25.8 Immunological Control in Humans - p. 958 32. 25.9 Influence of Co-Infection with Other Pathogens - p. 963 33. 25.10 Pregnancy and Congenital Disease - p. 963 34. 25.11 Summary and Conclusions - p. 966 35. References - p. 967 36. Chapter 26. Vaccination against Toxoplasmosis: Current Status and Future Prospects - p. 967 37. Epilogue - p. 1037 38. Index - p. 1037
This 2e of Toxoplasma gondii reflects the significant advances in the field in the last 5 years, including new information on the genomics, epigenomics and proteomics of T. gondii as well as a new understanding of the population biology and genetic diversity of this organism. T. gondii remains the best model system for studying the entire Apicomplexa group of protozoans, which includes Malaria, making this new edition essential for a broad group of researchers and scientists.
Toxoplasmosis is caused by a one-celled protozoan parasite known as T. gondii. The infection produces a wide range of clinical syndromes in humans, land and sea mammals, and various bird species. Most humans contract toxoplasmosis by eating contaminated, raw or undercooked meat (particularly pork), vegetables, or milk products; by coming into contact with the T. gondii eggs from cat feces; or by drinking contaminated water. The parasite damages the ocular and central nervous systems, causing behavioral and personality alterations as well as fatal necrotizing encephalitis. It is especially dangerous for the fetus of an infected pregnant woman and for individuals with compromised immune systems, such as HIV-infected patients.
1. 12.1 Introduction - p. 390 2. 12.2 Invasion: A Rapid and Active Process Unique to Apicomplexan Parasites - p. 391 3. 12.3 Invasion: A Tightly Coupled Secretion Machinery - p. 393 4. 12.4 Micronemes - p. 397 5. 12.5 Rhoptries - p. 418 6. 12.6 Dense Granules - p. 435 7. 12.7 Conclusions - p. 444 8. References - p. 444 9. Chapter 13. The Toxoplasma Cytoskeleton: Structures, Proteins and Processes - p. 444 10. Chapter 14. Interactions Between Toxoplasma Effectors and Host Immune Responses - p. 498 11. Chapter 15. Bradyzoite Development - p. 517 12. Chapter 16. Development and Application of Classical Genetics in Toxoplasma gondii - p. 545 13. Chapter 17. Genetic Manipulation of Toxoplasma gondii - p. 573 14. Chapter 18. Epigenetic and Genetic Factors that Regulate Gene Expression in Toxoplasma gondii - p. 608 15. Chapter 19. ToxoDB: An Integrated Functional Genomic Resource for Toxoplasma and Other Sarcocystidae - p. 640 16. Chapter 20. Comparative Aspects of Nucleotide and Amino Acid Metabolism in Toxoplasma gondii and Other Apicomplexa - p. 661 17. Chapter 21. Toxoplasma gondii Chemical Biology - p. 699 18. Chapter 22. Proteomics of Toxoplasma gondii - p. 727 19. Chapter 23. Cerebral Toxoplasmosis: Pathogenesis, Host Resistance and Behavioural Consequences - p. 751 20. Chapter 24. Innate Immunity to Toxoplasma gondii - p. 789 21. Chapter 25. Adaptive Immunity and Genetics of the Host Immune Response - p. 812 22. Abstract - p. 812 23. Acknowledgements - p. 821 24. 25.1 Introduction - p. 821 25. 25.2 Mouse Genetic Studies - p. 824 26. 25.3 Studies of Lewis and Fischer Rats - p. 865 27. 25.4 Studies in Humans Concerning Genes that Confer Resistance or Susceptibility and the Use of Murine Models with Human Transgenes - p. 869 28. 25.5 Influence of Parasite Strain on Immune Response and Disease in Murine Models - p. 937 29. 25.6 General Aspects of Immunity - p. 939 30. 25.7 Immunological Control in Animal Models - p. 953 31. 25.8 Immunological Control in Humans - p. 958 32. 25.9 Influence of Co-Infection with Other Pathogens - p. 963 33. 25.10 Pregnancy and Congenital Disease - p. 963 34. 25.11 Summary and Conclusions - p. 966 35. References - p. 967 36. Chapter 26. Vaccination against Toxoplasmosis: Current Status and Future Prospects - p. 967 37. Epilogue - p. 1037 38. Index - p. 1037
