Year Book of Medicine 2015

1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. 1. Osteoarthritis - p. 9 5. Use of a Validated Algorithm to Judge the Appropriateness of Total Knee Arthroplasty in the United States: A Multicenter Longitudinal Cohort Study - p. 10 6. Acupuncture for Chronic Knee Pain: A Randomized Clinical Trial - p. 11 7. Effect of Weight Maintenance on Symptoms of Knee Osteoarthritis in Obese Patients: A Twelve-Month Randomized Controlled Trial - p. 12 8. Circulating C reactive protein in osteoarthritis: a systematic review and meta-analysis - p. 13 9. 2. Osteoporosis and Other Metabolic Diseases of Bone - p. 14 10. Romosozumab in Postmenopausal Women with Low Bone Mineral Density - p. 15 11. Rheumatoid Arthritis - p. 16 12. Socioeconomic Disparities in the Health of African Americans With Rheumatoid Arthritis From the Southeastern United States - p. 17 13. Being overweight or obese and risk of developing rheumatoid arthritis among women: a prospective cohort study - p. 18 14. Medication Risk Communication During Rheumatology Office Visits - p. 19 15. 4. Sjogren's Syndrome - p. 20 16. Identification of lymphoma predictors in patients with primary Sjögren's syndrome: a systematic literature review and meta-analysis - p. 21 17. Efficacy and safety of belimumab in primary Sjögren's syndrome: results of the BELISS open-label phase II study - p. 22 18. 5. Systemic Lypus Erythematosus - p. 23 19. Treatment of Lupus Nephritis With Abatacept: The Abatacept and Cyclophosphamide Combination Efficacy and Safety Study - p. 24 20. Increased Congenital Heart Defects in Children Born to Women With Systemic Lupus Erythematosus: Results From the Offspring of Systemic Lupus Erythematosus Mothers Registry Study - p. 25 21. 6. Drug Toxicity - p. 26 22. The Risk of Toxic Retinopathy in Patients on Long-term Hydroxychloroquine Therapy - p. 27 23. Phenotype Standardization for Statin-Induced Myotoxicity - p. 28 24. 7. Seronegative Spondyloarthropathies - p. 29 25. Risk of major cardiovascular events in patients with psoriatic arthritis, psoriasis and rheumatoid arthritis: a population-based cohort study - p. 30 26. Erosions and Sclerosis on Radiographs Precede the Subsequent Development of Syndesmophytes at the Same Site: A Twelve-Year Prospective Followup of Patients With Ankylosing Spondylitis - p. 31 27. 8. Myopathies - p. 32 28. Inflammatory Muscle Diseases - p. 33 29. 9. Vasculities - p. 34 30. Rituximab versus Azathioprine for Maintenance in ANCA-Associated Vasculitis - p. 35 31. Rituximab for the treatment of relapses in antineutrophil cytoplasmic antibody-associated vasculitis - p. 36 32. 10. Miscellaneous Rheumatic Diseases and Therapies - p. 37 33. Apremilast for Behçet's Syndrome—A Phase 2, Placebo-Controlled Study - p. 38 34. The diagnostic utility of serum IgG4 concentrations in IgG4-related disease - p. 39 35. 11. Gout and Other Crystal Diseases - p. 40 36. Risk of Incident Diabetes in Patients With Gout: A Cohort Study - p. 41 37. Increased risk of vascular disease associated with gout: a retrospective, matched cohort study in the UK Clinical Practice Research Datalink - p. 42 38. 12. Chronic Juvenile Diseases - p. 43 39. Choosing Wisely: The American College of Rheumatology's Top 5 for Pediatric Rheumatology - p. 44 40. 13. Bacterial Infections - p. 45 41. Antibiotic Treatment Strategies for Community-Acquired Pneumonia in Adults - p. 46 42. Chronic Coinfections in Patients Diagnosed with Chronic Lyme Disease: A Systematic Review - p. 47 43. Cellulitis Recurrence Score: A tool for predicting recurrence of lower limb cellulitis - p. 48 44. Clindamycin versus Trimethoprim–Sulfamethoxazole for Uncomplicated Skin Infections - p. 49 45. Antibiotic treatment for 6 weeks versus 12 weeks in patients with pyogenic vertebral osteomyelitis: an open-label, non-inferiority, randomised, controlled trial - p. 50 46. 14. Vaccines - p. 51 47. Legislative Prescriptions for Controlling Nonmedical Vaccine Exemptions - p. 52 48. Long-Term Efficacy of a Hepatitis E Vaccine - p. 53 49. A Case-Control Study to Estimate the Effectiveness of Maternal Pertussis Vaccination in Protecting Newborn Infants in England and Wales, 2012–2013 - p. 54 50. Antibody-driven design of a human cytomegalovirus gHgLpUL128L subunit vaccine that selectively elicits potent neutralizing antibodies - p. 55 51. A Randomized, Controlled Trial of an Aerosolized Vaccine against Measles - p. 56 52. Clinical efficacy and safety of a novel tetravalent dengue vaccine in healthy children in Asia: a phase 3, randomised, observer-masked, placebo-controlled trial - p. 57 53. 15. Viral Infections - p. 58 54. Chikungunya Virus Transmission Found in the United States: US Health Authorities Brace for Wider Spread - p. 59 55. Viremic Relapse after HIV-1 Remission in a Perinatally Infected Child - p. 60 56. A Case of Severe Ebola Virus Infection Complicated by Gram-Negative Septicemia - p. 61 57. Assessment of the potential for international dissemination of Ebola virus via commercial air travel during the 2014 west African outbreak - p. 62 58. 16. Tuberculosis - p. 63 59. Acquired Rifampicin Resistance in Thrice-Weekly Antituberculosis Therapy: Impact of HIV and Antiretroviral Therapy - p. 64 60. Prevention of Anti–Tumor Necrosis Factor–Associated Tuberculosis: A 10-Year Longitudinal Cohort Study - p. 65 61. Whole genome sequencing: A new paradigm in the surveillance and control of human tuberculosis - p. 66 62. 17. Clinical Diagnostics - p. 67 63. MALDI-TOF MS for the Diagnosis of Infectious Diseases - p. 68 64. A Comparison of Lyme Disease Serologic Test Results From 4 Laboratories in Patients With Persistent Symptoms After Antibiotic Treatment - p. 69 65. 18. Health Care Associated Infections - p. 71 66. Toward a True Bacteriotherapy for Clostridium difficile Infection - p. 72 67. Association Between Prehospital Vitamin D Status and Hospital-Acquired Clostridium difficile Infections - p. 73 68. Colonization With Toxinogenic C. difficile Upon Hospital Admission, and Risk of Infection: A Systematic Review and Meta-Analysis - p. 74 69. 19. New Antibiotics - p. 75 70. A new antibiotic kills pathogens without detectable resistance - p. 76 71. 20. Miscellaneous - p. 77 72. An enteric virus can replace the beneficial function of commensal bacteria - p. 78 73. Do Human Extraintestinal Escherichia coli Infections Resistant to Expanded-Spectrum Cephalosporins Originate From Food-Producing Animals? A Systematic Review - p. 79 74. Decolonization of Children After Incision and Drainage for MRSA Abscess: A Retrospective Cohort Study - p. 80 75. Efficacy and Safety of the Mosquitocidal Drug Ivermectin to Prevent Malaria Transmission After Treatment: A Double-Blind, Randomized, Clinical Trial - p. 81 76. Effect of Biofilms on Recalcitrance of Staphylococcal Joint Infection to Antibiotic Treatment - p. 82 77. Association Between Hospitalization for Pneumonia and Subsequent Risk of Cardiovascular Disease - p. 83 78. 21. Supportive Care - p. 84 79. A Personalized Approach to Assessing and Managing Pain in Patients With Cancer - p. 85 80. Supportive and palliative radiation oncology service: Impact of a dedicated service on palliative cancer care - p. 86 81. Voice Quality After Treatment of Early Vocal Cord Cancer: A Randomized Trial Comparing Laser Surgery With Radiation Therapy - p. 87 82. Managing Body Image Difficulties of Adult Cancer Patients: Lessons From Available Research - p. 88 83. Effect of Communication Skills Training Program for Oncologists Based on Patient Preferences for Communication When Receiving Bad News: A Randomized Controlled Trial - p. 89 84. Tadalafil for Prevention of Erectile Dysfunction After Radiotherapy for Prostate Cancer: The Radiation Therapy Oncology Group [0831] Randomized Clinical Trial - p. 90 85. 22. Geriatric Oncology - p. 91 86. Radiation Treatment in Older Patients: A Framework for Clinical Decision Making - p. 92 87. Receipt of Guideline-Concordant Treatment in Elderly Prostate Cancer Patients - p. 93 88. 23. Prostate Cancer - p. 94 89. Dosimetric analysis of radiation therapy oncology group 0321: The importance of urethral dose - p. 95 90. Short-term androgen suppression and radiotherapy versus intermediate-term androgen suppression and radiotherapy, with or without zoledronic acid, in men with locally advanced prostate cancer (TROG 03.04 RADAR): an open-label, randomised, phase 3 factorial trial - p. 96 91. Low Rates of Adjuvant Radiation in Patients With Nonmetastatic Prostate Cancer With High-Risk Pathologic Features - p. 97 92. RTOG 95-17, a Phase II trial to evaluate brachytherapy as the sole method of radiation therapy for Stage I and II breast carcinoma—year-5 toxicity and cosmesis - p. 98 93. Comparative Effectiveness Study of Patient-Reported Outcomes After Proton Therapy or Intensity-Modulated Radiotherapy for Prostate Cancer - p. 99 94. Impact of Dose to the Bladder Trigone on Long-Term Urinary Function After High-Dose Intensity Modulated Radiation Therapy for Localized Prostate Cancer - p. 100 95. Enzalutamide in Metastatic Prostate Cancer before Chemotherapy - p. 101 96. Stereotactic Body Radiation Therapy Versus Intensity-Modulated Radiation Therapy for Prostate Cancer: Comparison of Toxicity - p. 102 97. The Impact of Definitive Local Therapy for Lymph Node–Positive Prostate Cancer: A Population-Based Study - p. 103 98. Declining use of brachytherapy for the treatment of prostate cancer - p. 104 99. Gleason 6 Prostate Cancer: Serious Malignancy or Toothless Lion? - p. 105 100. AR-V7 and Resistance to Enzalutamide and Abiraterone in Prostate Cancer - p. 106 101. Radical Prostatectomy or Watchful Waiting in Early Prostate Cancer - p. 107 102. 24. Breast Cancer - p. 108 103. Cognitive Impairment in Older Patients With Breast Cancer Before Systemic Therapy: Is There an Interaction Between Cancer and Comorbidity? - p. 109 104. Society of Surgical Oncology–American Society for Radiation Oncology Consensus Guideline on Margins for Breast-Conserving Surgery With Whole-Breast Irradiation in Stages I and II Invasive Breast Cancer - p. 110 105. Uptake and Costs of Hypofractionated vs Conventional Whole Breast Irradiation After Breast Conserving Surgery in the United States, 2008–2013 - p. 111 106. Hypofractionation for Breast Cancer: Lessons Learned From Our Neighbors to the North and Across the Pond - p. 112 107. 25. Myeloid Suppressor Cell Tumors - p. 113 108. Autologous Transplantation and Maintenance Therapy in Multiple Myeloma - p. 114 109. 26. Cancer Screening - p. 115 110. Final Trial Report of Sentinel-Node Biopsy versus Nodal Observation in Melanoma - p. 116 111. Considerations for Observational Research Using Large Data Sets in Radiation Oncology - p. 117 112. Chemoradiation Therapy Sequencing for Resected Pancreatic Adenocarcinoma in the National Cancer Data Base - p. 118 113. Current Status and Recommendations for the Future of Research, Teaching, and Testing in the Biological Sciences of Radiation Oncology: Report of the American Society for Radiation Oncology Cancer Biology/Radiation Biology Task Force, Executive Summary - p. 119 114. National Trends in Prostate Cancer Screening Among Older American Men With Limited 9-Year Life Expectancies: Evidence of an Increased Need for Shared Decision Making - p. 120 115. Proton Radiation Therapy for Head and Neck Cancer: A Review of the Clinical Experience to Date - p. 121 116. Multitarget Stool DNA Testing for Colorectal-Cancer Screening - p. 122 117. Bevacizumab plus Radiotherapy–Temozolomide for Newly Diagnosed Glioblastoma - p. 123 118. 27. Gynecologic Cancers - p. 124 119. The role of postoperative radiation therapy for endometrial cancer: Executive Summary of an American Society for Radiation Oncology evidence-based guideline - p. 125 120. Patterns of Radiation Therapy Practice for Patients Treated for Intact Cervical Cancer in 2005 to 2007: A Quality Research in Radiation Oncology Study - p. 126 121. 28. Colorectal Cancer - p. 127 122. Effect of PET Before Liver Resection on Surgical Management for Colorectal Adenocarcinoma Metastases: A Randomized Clinical Trial - p. 128 123. 29. Mediators and Modofiers of kidney Disease - p. 129 124. Mid-Adulthood Risk Factor Profiles for CKD - p. 130 125. Low Serum Bicarbonate and Kidney Function Decline: The Multi-Ethnic Study of Atherosclerosis (MESA) - p. 131 126. High Dietary Acid Load Predicts ESRD among Adults with CKD - p. 132 127. The Association between a Mediterranean-Style Diet and Kidney Function in the Northern Manhattan Study Cohort - p. 133 128. Association of Walking with Survival and RRT Among Patients with CKD Stages 3–5 - p. 134 129. Inhibition of Periostin Expression Protects against the Development of Renal Inflammation and Fibrosis - p. 135 130. 30. Hypertension and Kidney Disease - p. 136 131. Time-Updated Systolic Blood Pressure and the Progression of Chronic Kidney Disease: A Cohort Study - p. 137 132. Effects of Intensive Low-Salt Diet Education on Albuminuria among Nondiabetic Patients with Hypertension Treated with Olmesartan: A Single-Blinded Randomized, Controlled Trial - p. 138 133. A Controlled Trial of Renal Denervation for Resistant Hypertension - p. 139 134. Blood Pressure in Early Autosomal Dominant Polycystic Kidney Disease - p. 140 135. 31. Diabetes and Kidney Disease - p. 141 136. Renal Outcomes in Patients with Type 1 Diabetes and Macroalbuminuria - p. 142 137. Improved Glycemic Control and Risk of ESRD in Patients with Type 1 Diabetes and Proteinuria - p. 143 138. Metformin in Patients With Type 2 Diabetes and Kidney Disease: A Systematic Review - p. 144 139. Effect of Pentoxifylline on Renal Function and Urinary Albumin Excretion in Patients with Diabetic Kidney Disease: The PREDIAN Trial - p. 145 140. 32. Acute Kidney Injury - p. 146 141. The impact of using estimated GFR versus creatinine clearance on the evaluation of recovery from acute kidney injury in the ICU - p. 147 142. Kidney Function After Off-Pump or On-Pump Coronary Artery Bypass Graft Surgery: A Randomized Clinical Trial - p. 148 143. Acute Kidney Injury After Coronary Artery Bypass Grafting and Long-Term Risk of End-Stage Renal Disease - p. 149 144. A systematic review and meta-analysis indicates underreporting of renal dysfunction following endovascular aneurysm repair - p. 150 145. Risk of AKI with Gentamicin as Surgical Prophylaxis - p. 151 146. Vancomycin-Associated Nephrotoxicity in the Critically Ill: A Retrospective Multivariate Regression Analysis - p. 152 147. Atypical Antipsychotic Drugs and the Risk for Acute Kidney Injury and Other Adverse Outcomes in Older Adults: A Population-Based Cohort Study - p. 153 148. Nephrotoxic Effects of Common and Emerging Drugs of Abuse - p. 154 149. Explaining the Racial Difference in AKI Incidence - p. 155 150. 33. Selected Topics in Clinical Nephrology - p. 156 151. Implementation of a CKD Checklist for Primary Care Providers - p. 157 152. Retinopathy and Progression of CKD: The CRIC Study - p. 158 153. Chronic NSAID use and long-term decline of renal function in a prospective rheumatoid arthritis cohort study - p. 159 154. Predictors of Autosomal Dominant Polycystic Kidney Disease Progression - p. 160 155. CKD and the Risk of Incident Cancer - p. 161 156. Ultrasonography versus Computed Tomography for Suspected Nephrolithiasis - p. 162 157. Effect of Sodium Zirconium Cyclosilicate on Potassium Lowering for 28 Days Among Outpatients With Hyperkalemia: The HARMONIZE Randomized Clinical Trial - p. 163 158. Association of Anti-PLA2R Antibodies with Outcomes after Immunosuppressive Therapy in Idiopathic Membranous Nephropathy - p. 164 159. 34. Issues in Severe CKD and Dialysis - p. 165 160. ESRD and Death after Heart Failure in CKD - p. 166 161. Meta-Analysis of Methicillin-Resistant Staphylococcus aureus Colonization and Risk of Infection in Dialysis Patients - p. 167 162. Cognitive Function and All-Cause Mortality in Maintenance Hemodialysis Patients - p. 168 163. Utilization of Acute Care among Patients with ESRD Discharged Home from Skilled Nursing Facilities - p. 169 164. CKD in Elderly Patients Managed without Dialysis: Survival, Symptoms, and Quality of Life - p. 170 165. 35. Asthma. Allergy and Cystic Fibrosis - p. 171 166. Asthma: pathogenesis and novel drugs for treatment - p. 172 167. Management of acute loss of asthma control in the yellow zone: A practice parameter - p. 173 168. Comprehensive efficacy of omalizumab for severe refractory asthma: a time-series observational study - p. 175 169. Impact of exhaled nitric oxide measurements on treatment decisions in an asthma specialty clinic - p. 178 170. 36. Chronic Obstructive Pulmonary Disease - p. 179 171. The association between childhood asthma and adult chronic obstructive pulmonary disease - p. 180 172. Pneumothorax Risk Factors in Smokers with and without Chronic Obstructive Pulmonary Disease - p. 181 173. Prognostic evaluation of COPD patients: GOLD 2011 versus BODE and the COPD comorbidity index COTE - p. 182 174. Performance of the BODE index in patients with α1-antitrypsin deficiency-related COPD - p. 183 175. Physical Activity as a Predictor of Thirty-Day Hospital Readmission after a Discharge for a Clinical Exacerbation of Chronic Obstructive Pulmonary Disease - p. 184 176. Coronary artery calcification is increased in patients with COPD and associated with increased morbidity and mortality - p. 185 177. 37. Lung Cancer - p. 186 178. Cancer Statistics, 2014 - p. 187 179. Is Previous Respiratory Disease a Risk Factor for Lung Cancer? - p. 188 180. Global Effects of Smoking, of Quitting, and of Taxing Tobacco - p. 189 181. Electronic Cigarettes: A Position Statement of the Forum of International Respiratory Societies - p. 190 182. Components Necessary for High Quality Lung Cancer Screening: American College of Chest Physicians and American Thoracic Society Policy Statement - p. 191 183. 38. Pleural, Interstitial Lung and Pulmonary Vascular Disease - p. 192 184. Relationship of DNA Methylation and Gene Expression in Idiopathic Pulmonary Fibrosis - p. 193 185. Randomized Trial of Acetylcysteine in Idiopathic Pulmonary Fibrosis - p. 194 186. A Phase 3 Trial of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis - p. 195 187. Comparison of Pleural Pressure Measuring Instruments - p. 196 188. Pharmacologic Therapy for Pulmonary Arterial Hypertension in Adults: CHEST Guideline and Expert Panel Report - p. 197 189. 39. Community-Acquired Pneumonia - p. 198 190. Rates and Risk Factors for Recurrent Pneumonia in Patients Hospitalized With Community-Acquired Pneumonia: Population-Based Prospective Cohort Study With 5 Years of Follow-up - p. 199 191. Diagnoses of Early and Late Readmissions after Hospitalization for Pneumonia: A Systematic Review - p. 200 192. Lower Respiratory Tract Virus Findings in Mechanically Ventilated Patients With Severe Community-Acquired Pneumonia - p. 201 193. Association of Azithromycin With Mortality and Cardiovascular Events Among Older Patients Hospitalized With Pneumonia - p. 202 194. 40. Sleep Disorders - p. 203 195. Obstructive Sleep Apnea and Severe Maternal-Infant Morbidity/Mortality in the United States, 1998-2009 - p. 204 196. Role of Sleep Apnea and Continuous Positive Airway Pressure Therapy in the Incidence of Stroke or Coronary Heart Disease in Women - p. 205 197. Nocturnal intermittent hypoxia predicts prevalent hypertension in the European Sleep Apnoea Database cohort study - p. 206 198. Diabetes Mellitus Prevalence and Control in Sleep-Disordered Breathing: The European Sleep Apnea Cohort (ESADA) Study - p. 207 199. Sleep Restriction Therapy for Insomnia is Associated with Reduced Objective Total Sleep Time, Increased Daytime Somnolence, and Objectively Impaired Vigilance: Implications for the Clinical Management of Insomnia Disorder - p. 208 200. A Randomized Controlled Trial of Mindfulness Meditation for Chronic Insomnia - p. 209 201. 41. Critical Care Medicine - p. 210 202. Catheter-Directed Thrombolytic Intervention Is Effective for Patients with Massive and Submassive Pulmonary Embolism - p. 211 203. Early Management of Severe Sepsis: Concepts and Controversies - p. 212 204. Difficult Airway Management for Novice Physicians: A Randomized Trial Comparing Direct and Video-Assisted Laryngoscopy - p. 213 205. Preparing an ICU room to welcome a critically ill patient with Ebola virus disease - p. 214 206. 42. Arrhythmias - p. 215 207. Rivaroxaban vs. vitamin K antagonists for cardioversion in atrial fibrillation - p. 216 208. 43. Cardiomyopathy - p. 217 209. Angiotensin–Neprilysin Inhibition versus Enalapril in Heart Failure - p. 218 210. Cardiac Remodeling in Response to 1 Year of Intensive Endurance Training - p. 219 211. Association between renal function and cardiovascular structure and function in heart failure with preserved ejection fraction - p. 220 212. Cardiac Positron Emission Tomography Enhances Prognostic Assessments of Patients With Suspected Cardiac Sarcoidosis - p. 221 213. Association Between Frequency of Atrial and Ventricular Ectopic Beats and Biventricular Pacing Percentage and Outcomes in Patients With Cardiac Resynchronization Therapy - p. 222 214. 44. Chronic Coronary Artery Diesase - p. 223 215. Association of NSAID Use With Risk of Bleeding and Cardiovascular Events in Patients Receiving Antithrombotic Therapy After Myocardial Infarction - p. 224 216. Ivabradine in Stable Coronary Artery Disease without Clinical Heart Failure - p. 225 217. Long-Term Use of Ticagrelor in Patients with Prior Myocardial Infarction - p. 226 218. Efficacy of a Device to Narrow the Coronary Sinus in Refractory Angina - p. 227 219. 45. Coronary Intervention Procedures - p. 228 220. Cardioverter defibrillator implantation without induction of ventricular fibrillation: a single-blind, non-inferiority, randomised controlled trial (SIMPLE) - p. 229 221. A Randomized Comparison of Drug-Eluting Balloon Versus Everolimus-Eluting Stent in Patients With Bare-Metal Stent–In-Stent Restenosis: The RIBS V Clinical Trial (Restenosis Intra-Stent of Bare Metal Stents: Paclitaxel-eluting Balloon vs. Everolimus-eluting Stent) - p. 230 222. Everolimus-Eluting Stents or Bypass Surgery for Multivessel Coronary Disease - p. 231 223. 46. Non-Invasive Testing - p. 232 224. T1 mapping and survival in systemic light-chain amyloidosis - p. 233 225. Outcomes of Anatomical versus Functional Testing for Coronary Artery Disease - p. 234 226. 47. Risk Factors - p. 235 227. Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1·25 million people - p. 236 228. Percutaneous closure of patent foramen ovale in patients with cryptogenic embolism: a network meta-analysis - p. 237 229. Efficacy and Safety of Alirocumab in Reducing Lipids and Cardiovascular Events - p. 238 230. 48. Valvular Heart Disease - p. 239 231. Survival and Outcomes Following Bioprosthetic vs Mechanical Mitral Valve Replacement in Patients Aged 50 to 69 Years - p. 240 232. Surgical Treatment of Moderate Ischemic Mitral Regurgitation - p. 241 233. 49. Acute Coronary Syndromes - p. 242 234. Outcomes 1 Year after Thrombus Aspiration for Myocardial Infarction - p. 243 235. 50. Esophagus - p. 244 236. Hospital and surgeon volume in relation to long-term survival after oesophagectomy: systematic review and meta-analysis - p. 245 237. Efficacy of Transoral Fundoplication vs Omeprazole for Treatment of Regurgitation in a Randomized Controlled Trial - p. 246 238. Long-term recurrence of neoplasia and Barrett's epithelium after complete endoscopic resection - p. 247 239. 51. Stomach - p. 248 240. Peptic Ulcer Bleeding Risk. The Role of Helicobacter Pylori Infection in NSAID/Low-Dose Aspirin Users - p. 249 241. 52. Small Bowel - p. 250 242. Small Amounts of Gluten in Subjects With Suspected Nonceliac Gluten Sensitivity: A Randomized, Double-Blind, Placebo-controlled, Cross-Over Trial - p. 251 243. Effect of Antidepressants and Psychological Therapies, Including Hypnotherapy, in Irritable Bowel Syndrome: Systematic Review and Meta-Analysis - p. 252 244. Lack of Utility of Symptoms and Signs at First Presentation as Predictors of Inflammatory Bowel Disease in Secondary Care - p. 253 245. 53. Colon - p. 254 246. The Effect of Fiber Supplementation on Irritable Bowel Syndrome: A Systematic Review and Meta-analysis - p. 255 247. Efficacy of Prebiotics, Probiotics, and Synbiotics in Irritable Bowel Syndrome and Chronic Idiopathic Constipation: Systematic Review and Meta-analysis - p. 256 248. Incidence, Prevalence, and Temporal Trends of Microscopic Colitis: A Systematic Review and Meta-Analysis - p. 257 249. Burden of Clostridium difficile Infection in the United States - p. 258 250. A Randomized, Placebo-Controlled Trial of Lubiprostone for Opioid-Induced Constipation in Chronic Noncancer Pain - p. 259 251. Optimizing Adequacy of Bowel Cleansing for Colonoscopy: Recommendations From the US Multi-Society Task Force on Colorectal Cancer - p. 260 252. Incidence of Colonic Neoplasia in Patients With Serrated Polyposis Syndrome Who Undergo Annual Endoscopic Surveillance - p. 261 253. Long-Term Colorectal-Cancer Mortality after Adenoma Removal - p. 262 254. Multitarget Stool DNA Testing for Colorectal-Cancer Screening - p. 263 255. 54. Pancreas - p. 264 256. American Gastroenterological Association Institute Guideline on the Diagnosis and Management of Asymptomatic Neoplastic Pancreatic Cysts - p. 265 257. New Diagnosis of Chronic Pancreatitis: Risk of Missing an Underlying Pancreatic Cancer - p. 266 258. 55. Liver - p. 267 259. Nonalcoholic Steatohepatitis Is the Second Leading Etiology of Liver Disease Among Adults Awaiting Liver Transplantation in the United States - p. 268 260. ACG Clinical Guideline: The Diagnosis and Management of Focal Liver Lesions - p. 269 261. ABT-450, Ritonavir, Ombitasvir, and Dasabuvir Achieves 97% and 100% Sustained Virologic Response With or Without Ribavirin in Treatment-Experienced Patients With HCV Genotype 1b Infection - p. 270 262. 56. Obesity - p. 271 263. Quantitative Gastrointestinal and Psychological Traits Associated With Obesity and Response to Weight-Loss Therapy - p. 272 264. 57. Miscellaneous - p. 273 265. Appropriate and timely antimicrobial therapy in cirrhotic patients with spontaneous bacterial peritonitis-associated septic shock: a retrospective cohort study - p. 274 266. Proton Pump Inhibitor Usage and the Risk of Myocardial Infarction in the General Population - p. 275 267. The Risks of Thromboembolism Vs. Recurrent Gastrointestinal Bleeding after Interruption of Systemic Anticoagulation in Hospitalized Inpatients With Gastrointestinal Bleeding: A Prospective Study - p. 276 268. 58. Diabetes Mellitus - p. 277 269. Preserved β-Cell Function in Type 1 Diabetes by Mesenchymal Stromal Cells - p. 278 270. Assessment of β-Cell Mass and α- and β-Cell Survival and Function by Arginine Stimulation in Human Autologous Islet Recipients - p. 279 271. Impact of Islet Autoimmunity on the Progressive β-cell Functional Decline in Type 2 Diabetes - p. 280 272. PD-L1–Driven Tolerance Protects Neurogenin3-Induced Islet Neogenesis to Reverse Established Type 1 Diabetes in NOD Mice - p. 281 273. High Calorie Intake Is Associated With Worsening Insulin Resistance and β-Cell Function in Hispanic Women After Gestational Diabetes Mellitus - p. 282 274. Tight Glycemic Control and Use of Hypoglycemic Medications in Older Veterans With Type 2 Diabetes and Comorbid Dementia - p. 283 275. Follow-up of Glycemic Control and Cardiovascular Outcomes in Type 2 Diabetes - p. 284 276. Fibroblast growth factor 21 analogue LY2405319 lowers blood glucose in streptozotocin-induced insulin-deficient diabetic mice by restoring brown adipose tissue function - p. 285 277. Determinants of Adherence to Diabetes Medications: Findings From a Large Pharmacy Claims Database - p. 286 278. Effects of 60-day head-down bed rest on osteocalcin, glycolipid metabolism and their association with or without resistance training - p. 287 279. Incretin-Based Therapy and Risk of Acute Pancreatitis: A Nationwide Population-Based: Case-Control Study - p. 288 280. Efficacy and Safety of Saxagliptin in Older Participants in the SAVOR-TIMI 53 Trial - p. 289 281. Diabetic Kidney Disease: A Report From an ADA Consensus Conference - p. 290 282. Noninvasive In Vivo Imaging of Diabetes-Induced Renal Oxidative Stress and Response to Therapy Using Hyperpolarized 13C Dehydroascorbate Magnetic Resonance - p. 291 283. Insulin Sensitivity Is an Important Determinant of Renal Health in Adolescents With Type 2 Diabetes - p. 292 284. Serum High-Sensitivity C-Reactive Protein Levels Are Associated With High Risk of Development, Not Progression, of Diabetic Nephropathy Among Japanese Type 2 Diabetic Patients: A Prospective Cohort Study (Diabetes Distress and Care Registry at Tenri [DDCRT7]) - p. 293 285. Peripheral Neuropathy and Nerve Dysfunction in Individuals at High Risk for Type 2 Diabetes: The PROMISE Cohort - p. 294 286. Liraglutide and the Preservation of Pancreatic β-Cell Function in Early Type 2 Diabetes: The LIBRA Trial - p. 295 287. 59. Obesity - p. 296 288. Adjusting Glucose-Stimulated Insulin Secretion for Adipose Insulin Resistance: An Index of β-Cell Function in Obese Adults - p. 297 289. Anorexia and Impaired Glucose Metabolism in Mice With Hypothalamic Ablation of Glut4 Neurons - p. 298 290. Cardiorespiratory Fitness and Incident Diabetes: The FIT (Henry Ford ExercIse Testing) Project - p. 299 291. 60. Lipoproteins, Atherosclerosis and Cardiovascular Risk - p. 300 292. Preventable Major Cardiovascular Events Associated With Uncontrolled Glucose, Blood Pressure, and Lipids and Active Smoking in Adults With Diabetes With and Without Cardiovascular Disease: A Contemporary Analysis - p. 301 293. Metformin Inhibits Monocyte-to-Macrophage Differentiation via AMPK-Mediated Inhibition of STAT3 Activation: Potential Role in Atherosclerosis - p. 302 294. 61. Reproductive Endocrinology - p. 303 295. Each Degree of Glucose Intolerance in Pregnancy Predicts Distinct Trajectories of β-Cell Function, Insulin Sensitivity, and Glycemia in the First 3 Years Postpartum - p. 304 296. Placental Insufficiency Decreases Pancreatic Vascularity and Disrupts Hepatocyte Growth Factor Signaling in the Pancreatic Islet Endothelial Cell in Fetal Sheep - p. 305