Year Book of Pathology and Laboratory Medicine 2015

1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. 1.1. Outcomes Analysis - p. 7 5. The Modern Pathologist: Lab Data Deliverer, Interpreter, and Diagnostician - p. 8 6. Anatomic and Clinical Pathology Boot Camps: Filling Pathology-Specific Gaps in Undergraduate Medical Education - p. 9 7. A clinician's perspective on laboratory utilization management - p. 10 8. Cancer Tracking: Clinician Compliance and Program Outcome - p. 11 9. RP Implementation: Specimen Management - p. 12 10. Are Amended Surgical Pathology Reports Getting to the Correct Responsible Care Provider? - p. 13 11. Analysis of Addenda in Anatomic Pathology as a Quality Monitoring Initiative - p. 14 12. Communicating diagnostic uncertainty in surgical pathology reports: Disparities between sender and receiver - p. 15 13. Surgical pathology and the patient: a systematic review evaluating the primary audience of pathology reports - p. 16 14. A Team-Based Approach to Autopsy Education: Integrating Anatomic and Clinical Pathology at the Rotation Level - p. 17 15. Recognition and Discrimination of Tissue-Marking Dye Color by Surgical Pathologists: Recommendations to Avoid Errors in Margin Assessment - p. 18 16. Q-Probes Studies in Anatomic Pathology: Quality Improvement Through Targeted Benchmarking - p. 19 17. A systematic analysis of commonly used antibodies in cancer diagnostics - p. 20 18. Interpretive Diagnostic Error Reduction in Surgical Pathology and Cytology: Guideline From the College of American Pathologists Pathology and Laboratory Quality Center and the Association of Directors of Anatomic and Surgical Pathology - p. 21 19. Utilization management in anatomic pathology - p. 22 20. The Wonderful Colors of the Hematoxylin–Eosin Stain in Diagnostic Surgical Pathology - p. 23 21. Variable fidelity of tissue-marking dyes in surgical pathology - p. 24 22. Turnaround Time for Large or Complex Specimens in Surgical Pathology: A College of American Pathologists Q-Probes Study of 56 Institutions - p. 25 23. 2.1. Hepatobiliary System and Pancreas - p. 26 24. Acute Liver Allograft Antibody-Mediated Rejection: An Inter-Institutional Study of Significant Histopathological Features - p. 27 25. SALL4 Immunoreactivity Predicts Prognosis in Western Hepatocellular Carcinoma Patients but Is a Rare Event: A Study of 236 Cases - p. 28 26. Update on the New Classification of Hepatic Adenomas: Clinical, Molecular, and Pathologic Characteristics - p. 29 27. Diagnostic utility and limitations of glutamine synthetase and serum amyloid-associated protein immunohistochemistry in the distinction of focal nodular hyperplasia and inflammatory hepatocellular adenoma. - p. 30 28. Different collagen types show distinct rates of increase from early to late stages of hepatitis C-related liver fibrosis - p. 31 29. Quantification of portal–bridging fibrosis area more accurately reflects fibrosis stage and liver stiffness than whole fibrosis or perisinusoidal fibrosis areas in chronic hepatitis C - p. 32 30. Discrepancy rates in liver biopsy reporting - p. 33 31. Poorly differentiated neuroendocrine carcinomas of the pancreas: a clinicopathologic analysis of 44 cases - p. 34 32. Congestive hepatic fibrosis score: a novel histologic assessment of clinical severity - p. 35 33. Immunohistochemical distinction between intrahepatic cholangiocarcinoma and pancreatic ductal adenocarcinoma - p. 36 34. Aberrant Centrizonal Features in Chronic Hepatic Venous Outflow Obstruction: Centrilobular Mimicry of Portal-based Disease - p. 37 35. Automatic classification of white regions in liver biopsies by supervised machine learning - p. 38 36. 3. 1. Cytopathology - p. 39 37. Increasing the sensitivity of endocervical curettings by performing ThinPrep® Pap on transport container fluid: is diagnostic material going down the drain? - p. 40 38. Role of endoscopic ultrasound fine-needle aspiration evaluating adrenal gland enlargement or mass - p. 41 39. Making Mock-FNA Smears from Fresh Surgical Pathology Specimens to Improve Smear Preparation Technique and to Create Cytohistological Correlation Series - p. 42 40. ‘Suspicious for Papillary Thyroid Carcinoma’ before and after The Bethesda System for Reporting Thyroid Cytopathology: Impact of Standardized Terminology - p. 43 41. Investigating MicroRNA Expression Profiles in Pancreatic Cystic Neoplasms - p. 44 42. An Assessment of Gynecological Cytology Screening Practices Among Health Care Providers Nationwide - p. 45 43. The Utility of Liquid-Based Cytology in Salivary Gland Fine-Needle Aspirates: Experience of an Academic Institution - p. 46 44. 4.1. Head and Neck - p. 47 45. Epidemiological Trends in Head and Neck Cancer and Aids in Diagnosis - p. 48 46. Lymphoepithelial-like carcinomas of the head and neck - p. 49 47. Papillary Thyroid Carcinoma in a Branchial Cleft Cyst without a Thyroid Primary: Navigating a Diagnostic Dilemma - p. 50 48. Polymorphous Low Grade Adenocarcinoma has a Consistent p63+/p40− Immunophenotype that Helps Distinguish it from Adenoid Cystic Carcinoma and Cellular Pleomorphic Adenoma - p. 51 49. Multifocal Fibrosing Thyroiditis and Its Association with Papillary Thyroid Carcinoma Using BRAF Pyrosequencing - p. 52 50. SMARCB1 (INI-1)-deficient Carcinomas of the Sinonasal Tract - p. 53 51. Prognostic features in mucoepidermoid carcinoma of major salivary glands with emphasis on tumour histologic grading - p. 54 52. Pediatric sinonasal tumors in the United States: incidence and outcomes - p. 56 53. Basal Cell Adenocarcinoma and Basal Cell Adenoma of the Salivary Glands: A Clinicopathological Review of Seventy Tumors with Comparison of Morphologic Features and Growth Control Indices - p. 57 54. A Prospective Assessment Defining the Limitations of Thyroid Nodule Pathologic Evaluation - p. 58 55. Malignant triton tumour of the sinonasal tract: Case report and literature review - p. 59 56. Cerebellopontine Angle and Intracanalicular Masses Mimicking Vestibular Schwannomas - p. 60 57. Recent advances in the diagnostic pathology of salivary carcinomas - p. 61 58. 5.1. Kidney - p. 62 59. Defining the spectrum of immunoglobulin A–dominant/codominant glomerular deposition in diabetic nephropathy - p. 63 60. Focal and segmental glomerulosclerosis: clinical and kidney biopsy correlations - p. 64 61. Tuberous Sclerosis–associated Renal Cell Carcinoma: A Clinicopathologic Study of 57 Separate Carcinomas in 18 Patients - p. 65 62. Validation of a histopathologic classification scheme for antineutrophil cytoplasmic antibody–associated glomerulonephritis - p. 66 63. Granulomatosis With Polyangiitis Presenting as a Renal Tumor - p. 67 64. Rhabdoid Differentiation is Associated With Aggressive Behavior in Renal Cell Carcinoma: A Clinicopathologic Analysis of 76 Cases With Clinical Follow-up - p. 68 65. Diagnostic Approach to Eosinophilic Renal Neoplasms - p. 69 66. Biopsy-Proven Acute Interstitial Nephritis, 1993-2011: A Case Series - p. 70 67. Membranous-like glomerulopathy with masked IgG kappa deposits - p. 71 68. The reproducibility and predictive value on outcome of renal biopsies from expanded criteria donors - p. 72 69. Best Practices Recommendations in the Application of Immunohistochemistry in the Kidney Tumors: Report From the International Society of Urologic Pathology Consensus Conference - p. 73 70. 6.1. Female Genital Tract - p. 75 71. The role of immunohistochemistry in the evaluation of gynecologic pathology: a single institutional experience - p. 76 72. Endometrial stromal tumours revisited: an update based on the 2014 WHO classification - p. 77 73. The Utility of Immunohistochemistry in the Differential Diagnosis of Gynecologic Disorders - p. 78 74. Low Grade Serous Ovarian Carcinoma: From the molecular characterization to the best therapeutic strategy - p. 79 75. Assessment of endometrial sampling as a predictor of final surgical pathology in endometrial cancer - p. 80 76. 7.1. Breast - p. 81 77. Concomitant Detection of HER2 Protein and Gene Alterations by Immunohistochemistry (IHC) and Silver Enhanced In Situ Hybridization (SISH) Identifies HER2 Positive Breast Cancer with and without Gene Amplification - p. 82 78. Second opinion in breast pathology: policy, practice and perception - p. 83 79. Effects of tissue decalcification on the quantification of breast cancer biomarkers by digital image analysis - p. 84 80. Breast cancer detection in axillary sentinel lymph nodes: the impact of the method of pathologic examination - p. 85 81. A Targetable Androgen Receptor–Positive Breast Cancer Subtype Hidden Among the Triple-Negative Cancers - p. 86 82. Estrogen Receptor Expression Is High but Is of Lower Intensity in Tubular Carcinoma Than in Well-Differentiated Invasive Ductal Carcinoma - p. 87 83. 8.1. Lung and Mediastinum - p. 88 84. Pulmonary Adenocarcinoma With Signet Ring Cell Features: A Comprehensive Study From 3 Distinct Patient Cohorts - p. 89 85. Interobserver Variability for the WHO Classification of Pulmonary Carcinoids - p. 90 86. Immunohistochemical study of 36 cases of pulmonary sarcomatoid carcinoma—sensitivity of TTF-1 is superior to napsin - p. 91 87. Pulmonary Large Cell Carcinoma Lacking Squamous Differentiation Is Clinicopathologically Indistinguishable From Solid-Subtype Adenocarcinoma - p. 92 88. ALK Rearrangement in a Large Series of Consecutive Non–Small Cell Lung Cancers: Comparison Between a New Immunohistochemical Approach and Fluorescence In Situ Hybridization for the Screening of Patients Eligible for Crizotinib Treatment - p. 93 89. Surgical pathology of pleural coccidioidomycosis: a clinicopathological study of 36 cases - p. 94 90. The Presence of Anti-HLA Donor-Specific Antibodies in Lung Allograft Recipients Does Not Correlate With C4d Immunofluorescence in Transbronchial Biopsy Specimens - p. 95 91. Lung Tumors Masquerading as Desquamative Interstitial Pneumonia (DIP): Report of 7 Cases and Review of the Literature - p. 96 92. Approach to Lung Biopsies From Patients With Pneumothorax - p. 97 93. Clinicopathologic features associated with relapse in cryptogenic organizing pneumonia - p. 98 94. Prognostic Significance of Adenocarcinoma In Situ, Minimally Invasive Adenocarcinoma, and Nonmucinous Lepidic Predominant Invasive Adenocarcinoma of the Lung in Patients With Stage I Disease - p. 99 95. Banff 2013 Meeting Report: Inclusion of C4d-Negative Antibody-Mediated Rejection and Antibody-Associated Arterial Lesions - p. 100 96. p16 FISH Deletion in Surface Epithelial Mesothelial Proliferations Is Predictive of Underlying Invasive Mesothelioma - p. 103 97. 9.1. Cardiovascular - p. 104 98. Sudden Cardiac Death: A Modern Pathology Approach to Hypertrophic Cardiomyopathy - p. 105 99. Pathologic diagnosis of antibody-mediated rejection in endomyocardial biopsy after heart transplantation based on renewed International Society for Heart and Lung Transplantation criteria - p. 106 100. 10.1. Gastrointestinal System - p. 107 101. Diagnosis of inflammatory bowel disease: Potential role of molecular biometrics - p. 108 102. Challenges Posed to Pathologists in the Detection of KRAS Mutations in Colorectal Cancers - p. 109 103. Association between Helicobacter pylori and Barrett's Esophagus: A Case–Control Study - p. 110 104. Guidelines for Diagnosis and Treatment of Carcinoma of the Esophagus April 2012 edited by the Japan Esophageal Society - p. 111 105. Utility of ancillary stains for Helicobacter pylori in near-normal gastric biopsies - p. 112 106. Traditional serrated adenomas (TSAs) admixed with other serrated (so-called precursor) polyps and conventional adenomas: a frequent occurrence - p. 113 107. HER2/neu Testing in Gastric Cancer by Immunohistochemistry: Assessment of Interlaboratory Variation - p. 114 108. 11.1. Hematolymphoid - p. 115 109. Utility of bone marrow examination for workup of fever of unknown origin in patients with HIV/AIDS - p. 116 110. Differentiating Benign From Malignant Bone Marrow B-Cell Lymphoid Aggregates: A Statistical Analysis of Distinguishing Features - p. 117 111. Molecular Genetic Biomarkers in Myeloid Malignancies - p. 118 112. Specialist integrated haematological malignancy diagnostic services: an Activity Based Cost (ABC) analysis of a networked laboratory service model - p. 119 113. Systematic Review of the Effectiveness of Fine-Needle Aspiration and/or Core Needle Biopsy for Subclassifying Lymphoma - p. 120 114. 12.1. Neuropathology - p. 121 115. Evaluation of simultaneous muscle and nerve biopsies for the diagnosis of neuromuscular diseases - p. 122 116. A Unique Four-Hub Protein Cluster Associates to Glioblastoma Progression - p. 123 117. 13.1. Soft Tissue and Bone - p. 124 118. Gastrointestinal stromal tumors with exon 8 c-kit gene mutation might occur at extragastric sites and have metastasis-prone nature - p. 125 119. Histopathological Diagnostic Discrepancies in Soft Tissue Tumours Referred to a Specialist Centre: Reassessment in the Era of Ancillary Molecular Diagnosis - p. 126 120. Clinical and morphological characteristics of osteoid osteoma and osteoblastoma: a retrospective single-center analysis of 204 patients - p. 127 121. An Update on the Application of Newly Described Immunohistochemical Markers in Soft Tissue Pathology - p. 128 122. 14.1. Pediatrics - p. 129 123. Effect of interference from hemolysis, icterus and lipemia on routine pediatric clinical chemistry assays - p. 130 124. Incidence and Outcome of Documented Fungal Endocarditis - p. 131 125. Quantification of Sickle Cells in the Peripheral Smear as a Marker of Disease Severity - p. 132 126. 15.1. Techniques/Molecular - p. 133 127. Selective Pathology Fellowships: Diverse, Innovative, and Valuable Subspecialty Training - p. 134 128. Diagnosis of major cancer resection specimens with virtual slides: impact of a novel digital pathology workstation - p. 135 129. Interinstitutional Whole Slide Imaging Teleconsultation Service Development: Assessment Using Internal Training and Clinical Consultation Cases - p. 136 130. The College of American Pathologists Guidelines for Whole Slide Imaging Validation Are Feasible for Pediatric Pathology: A Pediatric Pathology Practice Experience - p. 137 131. Diagnosis of major cancer resection specimens with virtual slides: impact of a novel digital pathology workstation - p. 138 132. Practicing Pathology in the Era of Big Data and Personalized Medicine - p. 139 133. Validation of a whole slide imaging system for primary diagnosis in surgical pathology: A community hospital experience - p. 140 134. 16.1. Urinary Bladder and Male Gential Tract - p. 141 135. Are Ureaplasma spp. a Cause of Nongonococcal Urethritis? A Systematic Review and Meta-Analysis - p. 142 136. The Critical Role of the Pathologist in Determining Eligibility for Active Surveillance as a Management Option in Patients With Prostate Cancer: Consensus Statement With Recommendations Supported by the College of American Pathologists, International Society of Urological Pathology, Association of Directors of Anatomic and Surgical Pathology, the New Zealand Society of Pathologists, and the Prostate Cancer Foundation - p. 143 137. The Application of Immunohistochemical Biomarkers in Urologic Surgical Pathology - p. 145 138. Recurrent papillary urothelial neoplasm of low malignant potential. Subtle architectural disorder detected by quantitative analysis in DAXX-immunostained tissue sections - p. 146 139. 17.1. Clinical Chemistry - p. 147 140. Clinical biochemistry laboratory rejection rates due to various types of preanalytical errors - p. 148 141. Harmonization: the Sample, the Measurement, and the Report - p. 149 142. Measurements for 8 Common Analytes in Native Sera Identify Inadequate Standardization among 6 Routine Laboratory Assays - p. 150 143. 18.1. Clinical Microbiology - p. 151 144. Emerging Rapid Resistance Testing Methods for Clinical Microbiology Laboratories and Their Potential Impact on Patient Management - p. 152 145. Evaluation of the decision support system for antimicrobial treatment, TREAT, in an acute medical ward of a university hospital - p. 153 146. Fungal Infections in Liver Transplant Patients Admitted to the Intensive Care Unit - p. 154 147. Pathogenesis of Necrotizing Enterocolitis: Modeling the Innate Immune Response - p. 155 148. The aetiology of pharyngotonsillitis in adolescents and adults – Fusobacterium necrophorum is commonly found - p. 156 149. Testing quality of a self-monitoring blood glucose sensor with an auto-coding mechanism when used by patients versus technicians - p. 157 150. 19.1. Cytogenetics and Molecular Pathology - p. 158 151. Practicing Pathology in the Era of Big Data and Personalized Medicine - p. 159 152. 20.1. Hematology and Immunology - p. 160 153. Verification and Standardization of Blood Cell Counters for Routine Clinical Laboratory Tests - p. 161 154. 21.1. Laboratory Management and Outcomes - p. 162 155. Risk Management in the Clinical Laboratory - p. 163 156. The quality of laboratory aspects of troponin testing in clinical practice guidelines and consensus documents needs to be improved - p. 164 157. Clinical Consequences of Specimen Rejection: A College of American Pathologists Q-Probes Analysis of 78 Clinical Laboratories - p. 165 158. Immunohistochemistry Practices of Cytopathology Laboratories: A Survey of Participants in the College of American Pathologists Nongynecologic Cytopathology Education Program - p. 166 159. Clinical Consequences of Specimen Rejection: A College of American Pathologists Q-Probes Analysis of 78 Clinical Laboratories - p. 167