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This issue of Clinics in Chest Medicine focuses on Acute Respiratory Distress Syndrome and covers topics such as: Epidemiology and Definitions of ARDS and Early Acute Lung Injury, Environmental Risk Factors for ARDS, Clinical and Biological Heterogeneity in ARDS: Direct vs. Indirect Lung Injury,Obesity and Nutrition, Important Immunomodulators in ARDS?, Beyond SNPs—Genetics, Genomics and Other Omic Approaches to ARDS, Clinical Approach to the Patient with ARDS, The Immunocompromised Patient with ARDS: Role of Invasive Diagnostic Strategies, Clinical Trial Design in Prevention and Treatment of ARDS, Beyond Low Tidal Volume—Ventilating the Patient with ARDS, Prone Positioning in ARDS, and more!

1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Contributors - p. 4 5. CME Accreditation Page - p. 8 6. Forthcoming Issues - p. 9 7. Preface: ARDS: New Mechanistic Insights, New Therapeutic Directions - p. 10 8. Evolving Epidemiology and Definitions of the Acute Respiratory Distress Syndrome and Early Acute Lung Injury - p. 11 9. Environmental Risk Factors for Acute Respiratory Distress Syndrome - p. 22 10. Clinical and Biological Heterogeneity in Acute Respiratory Distress Syndrome - p. 31 11. Obesity and Nutrition in Acute Respiratory Distress Syndrome - p. 42 12. Beyond Single-Nucleotide Polymorphisms - p. 56 13. Approach to the Patient with the Acute Respiratory Distress Syndrome - p. 65 14. Invasive Diagnostic Strategies in Immunosuppressed Patients with Acute Respiratory Distress Syndrome - p. 73 15. Clinical Trial Design in Prevention and Treatment of Acute Respiratory Distress Syndrome - p. 84 16. Beyond Low Tidal Volumes - p. 97 17. Prone Positioning for Acute Respiratory Distress Syndrome - p. 107 18. The Use of Paralytics in Patients with Acute Respiratory Distress Syndrome - p. 114 19. Extracorporeal Circulatory Approaches to Treat Acute Respiratory Distress Syndrome - p. 123 20. Steroids for Acute Respiratory Distress Syndrome? - p. 134 21. Endogenous and Exogenous Cell-Based Pathways for Recovery from Acute Respiratory Distress Syndrome - p. 143 22. Muscle Wasting and Early Mobilization in Acute Respiratory Distress Syndrome - p. 152 23. Index - p. 161

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This issue of Clinics in Chest Medicine focuses on Acute Respiratory Distress Syndrome and covers topics such as: Epidemiology and Definitions of ARDS and Early Acute Lung Injury, Environmental Risk Factors for ARDS, Clinical and Biological Heterogeneity in ARDS: Direct vs. Indirect Lung Injury,Obesity and Nutrition, Important Immunomodulators in ARDS?, Beyond SNPs—Genetics, Genomics and Other Omic Approaches to ARDS, Clinical Approach to the Patient with ARDS, The Immunocompromised Patient with ARDS: Role of Invasive Diagnostic Strategies, Clinical Trial Design in Prevention and Treatment of ARDS, Beyond Low Tidal Volume—Ventilating the Patient with ARDS, Prone Positioning in ARDS, and more!

1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Contributors - p. 4 5. CME Accreditation Page - p. 8 6. Forthcoming Issues - p. 9 7. Preface: ARDS: New Mechanistic Insights, New Therapeutic Directions - p. 10 8. Evolving Epidemiology and Definitions of the Acute Respiratory Distress Syndrome and Early Acute Lung Injury - p. 11 9. Environmental Risk Factors for Acute Respiratory Distress Syndrome - p. 22 10. Clinical and Biological Heterogeneity in Acute Respiratory Distress Syndrome - p. 31 11. Obesity and Nutrition in Acute Respiratory Distress Syndrome - p. 42 12. Beyond Single-Nucleotide Polymorphisms - p. 56 13. Approach to the Patient with the Acute Respiratory Distress Syndrome - p. 65 14. Invasive Diagnostic Strategies in Immunosuppressed Patients with Acute Respiratory Distress Syndrome - p. 73 15. Clinical Trial Design in Prevention and Treatment of Acute Respiratory Distress Syndrome - p. 84 16. Beyond Low Tidal Volumes - p. 97 17. Prone Positioning for Acute Respiratory Distress Syndrome - p. 107 18. The Use of Paralytics in Patients with Acute Respiratory Distress Syndrome - p. 114 19. Extracorporeal Circulatory Approaches to Treat Acute Respiratory Distress Syndrome - p. 123 20. Steroids for Acute Respiratory Distress Syndrome? - p. 134 21. Endogenous and Exogenous Cell-Based Pathways for Recovery from Acute Respiratory Distress Syndrome - p. 143 22. Muscle Wasting and Early Mobilization in Acute Respiratory Distress Syndrome - p. 152 23. Index - p. 161

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