Clinical Pharmacology During Pregnancy, Second Edition is written for clinicians, physicians, midwives, nurses, pharmacists and other medical professionals involved in the care of women during pregnancy. The book focuses on the impact of pregnancy on drug disposition and includes coverage of treatments for diseases of specific body systems as well as essential content on dosing and efficacy. This update includes substantially expanded sections on the ethics of pharmacological research in pregnancy and physiologic changes, along with new sections on patient reported outcomes in pregnancy, delivery and postnatal care, and the use of pharmacokinetic and pharmacodynamic approaches to estimate maternal, placental and fetal dosing.
The broad range of this book encompasses analgesics, antiasthmatics, antidepressants, heart and circulatory drugs, vitamins and herbal supplements, and more. Topics in chemotherapy and substance abuse are also covered, as are research issues, including clinical trial design and ethical considerations.
1. Chapter 1. Introduction - p. 1 2. Chapter 2. Physiologic changes during pregnancy - p. 5 3. Chapter 3. Impact of pregnancy on maternal pharmacokinetics of medications - p. 19 4. Chapter 4. Medications and the breastfeeding mother - p. 47 5. Chapter 5. Fetal drug therapy - p. 61 6. Chapter 6. Treating the placenta: an evolving therapeutic concept - p. 79 7. Chapter 7. Conducting randomized controlled pharmaceutical trials in the pregnant population: challenges and solutions - p. 93 8. Pharmacogenomics in pregnancy - p. 111 9. Chapter 9. Anesthetic drugs - p. 125 10. Chapter 10. The management of asthma during pregnancy - p. 141 11. Chapter 11. Nausea and vomiting of pregnancy - p. 155 12. Chapter 12. Clinical pharmacology of anti-infectives during pregnancy - p. 177 13. Chapter 13. Chemotherapy in pregnancy - p. 203 14. Chapter 14. Substance abuse in pregnancy - p. 221 15. Chapter 15. Diabetes in pregnancy - p. 251 16. Chapter 16. Cardiovascular medications in pregnancy - p. 271 17. Chapter 17. Antidepressants in pregnancy - p. 311 18. Chapter 18. Uterotonics and tocolytics - p. 323 19. Chapter 19. Antenatal thyroid disease and pharmacotherapy in pregnancy - p. 339 20. Chapter 20. Management of dermatological conditions in pregnancy - p. 357 21. Chapter 21. Herbs and alternative remedies - p. 377 22. Chapter 22. Envenomations and antivenom during pregnancy - p. 389 23. Chapter 23. Gastrointestinal disorders - p. 409 24. Chapter 24. Challenges in predicting the pharmacokinetics of drugs in premature and mature newborns: example with piperacillin and tazobactam - p. 437 25. Index - p. 457
Clinical Pharmacology During Pregnancy, Second Edition is written for clinicians, physicians, midwives, nurses, pharmacists and other medical professionals involved in the care of women during pregnancy. The book focuses on the impact of pregnancy on drug disposition and includes coverage of treatments for diseases of specific body systems as well as essential content on dosing and efficacy. This update includes substantially expanded sections on the ethics of pharmacological research in pregnancy and physiologic changes, along with new sections on patient reported outcomes in pregnancy, delivery and postnatal care, and the use of pharmacokinetic and pharmacodynamic approaches to estimate maternal, placental and fetal dosing.
The broad range of this book encompasses analgesics, antiasthmatics, antidepressants, heart and circulatory drugs, vitamins and herbal supplements, and more. Topics in chemotherapy and substance abuse are also covered, as are research issues, including clinical trial design and ethical considerations.
1. Chapter 1. Introduction - p. 1 2. Chapter 2. Physiologic changes during pregnancy - p. 5 3. Chapter 3. Impact of pregnancy on maternal pharmacokinetics of medications - p. 19 4. Chapter 4. Medications and the breastfeeding mother - p. 47 5. Chapter 5. Fetal drug therapy - p. 61 6. Chapter 6. Treating the placenta: an evolving therapeutic concept - p. 79 7. Chapter 7. Conducting randomized controlled pharmaceutical trials in the pregnant population: challenges and solutions - p. 93 8. Pharmacogenomics in pregnancy - p. 111 9. Chapter 9. Anesthetic drugs - p. 125 10. Chapter 10. The management of asthma during pregnancy - p. 141 11. Chapter 11. Nausea and vomiting of pregnancy - p. 155 12. Chapter 12. Clinical pharmacology of anti-infectives during pregnancy - p. 177 13. Chapter 13. Chemotherapy in pregnancy - p. 203 14. Chapter 14. Substance abuse in pregnancy - p. 221 15. Chapter 15. Diabetes in pregnancy - p. 251 16. Chapter 16. Cardiovascular medications in pregnancy - p. 271 17. Chapter 17. Antidepressants in pregnancy - p. 311 18. Chapter 18. Uterotonics and tocolytics - p. 323 19. Chapter 19. Antenatal thyroid disease and pharmacotherapy in pregnancy - p. 339 20. Chapter 20. Management of dermatological conditions in pregnancy - p. 357 21. Chapter 21. Herbs and alternative remedies - p. 377 22. Chapter 22. Envenomations and antivenom during pregnancy - p. 389 23. Chapter 23. Gastrointestinal disorders - p. 409 24. Chapter 24. Challenges in predicting the pharmacokinetics of drugs in premature and mature newborns: example with piperacillin and tazobactam - p. 437 25. Index - p. 457
