Copper in N-Heterocyclic Chemistry provides an overview of copper-catalyzed synthesis and functionalization of N-heterocyclic compounds, covering all recent developments in a way that is ideal for researchers and students working in the area of synthetic organic chemistry and medicinal chemistry. The book explores N-heterocyclic compounds as unique structural units in the development of natural products and pharmaceuticals, along with the remarkable progress made in the area of high atom economic strategies, and more recently, copper-catalyzed C-H activation and its applications in organic synthesis. Readers will find troubleshooting protocols, as well as the advantages and limitations of each method discussed.
As copper catalysts show versatile chemical reactivity in many aspects, including their oxidation states 0–3 are accessible and their ability to facilitate bond formations due to their ability to serve as Lewis acids, oxidizing agents and catalysts, this book is an ideal resource on the topics explored.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iii 6. Contributors - p. ix 7. About the editor - p. x 8. Preface - p. xiii 9. Chapter 1. Copper-catalyzed synthesis of aziridines - p. 21 10. Chapter 2. Copper catalysis for imidazoles and pyrazoles - p. 49 11. Chapter 3. Copper catalysis in the synthesis of 1,2,3-triazoles and tetrazoles - p. 75 12. Chapter 4. Copper catalysis for pyridines and pyrimidines - p. 115 13. Chapter 5. Copper catalysis for triazines - p. 161 14. Chapter 6. Copper catalysis for pyrazines and quinoxalines - p. 221 15. Chapter 7. Copper catalysis for the synthesis of quinolines and isoquinolines - p. 249 16. Chapter 8. Copper-mediated synthesis of quinazolines and related benzodiazines - p. 289 17. Chapter 9. Copper catalysis for large rings - p. 333 18. Copper catalysis for saturated N-heterocycles via C–H functionalization - p. 363 19. Pursuit for simple and efficient ligands promoting copper-catalyzed Ullmann type reactions for N-aryl heterocycles and aromatic amines - p. 399 20. Chapter 12. Solid supported copper for N-heterocycles - p. 431 21. Copper catalysis for biologically active N-heterocycles - p. 457 22. Index - p. 479
Copper in N-Heterocyclic Chemistry provides an overview of copper-catalyzed synthesis and functionalization of N-heterocyclic compounds, covering all recent developments in a way that is ideal for researchers and students working in the area of synthetic organic chemistry and medicinal chemistry. The book explores N-heterocyclic compounds as unique structural units in the development of natural products and pharmaceuticals, along with the remarkable progress made in the area of high atom economic strategies, and more recently, copper-catalyzed C-H activation and its applications in organic synthesis. Readers will find troubleshooting protocols, as well as the advantages and limitations of each method discussed.
As copper catalysts show versatile chemical reactivity in many aspects, including their oxidation states 0–3 are accessible and their ability to facilitate bond formations due to their ability to serve as Lewis acids, oxidizing agents and catalysts, this book is an ideal resource on the topics explored.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iii 6. Contributors - p. ix 7. About the editor - p. x 8. Preface - p. xiii 9. Chapter 1. Copper-catalyzed synthesis of aziridines - p. 21 10. Chapter 2. Copper catalysis for imidazoles and pyrazoles - p. 49 11. Chapter 3. Copper catalysis in the synthesis of 1,2,3-triazoles and tetrazoles - p. 75 12. Chapter 4. Copper catalysis for pyridines and pyrimidines - p. 115 13. Chapter 5. Copper catalysis for triazines - p. 161 14. Chapter 6. Copper catalysis for pyrazines and quinoxalines - p. 221 15. Chapter 7. Copper catalysis for the synthesis of quinolines and isoquinolines - p. 249 16. Chapter 8. Copper-mediated synthesis of quinazolines and related benzodiazines - p. 289 17. Chapter 9. Copper catalysis for large rings - p. 333 18. Copper catalysis for saturated N-heterocycles via C–H functionalization - p. 363 19. Pursuit for simple and efficient ligands promoting copper-catalyzed Ullmann type reactions for N-aryl heterocycles and aromatic amines - p. 399 20. Chapter 12. Solid supported copper for N-heterocycles - p. 431 21. Copper catalysis for biologically active N-heterocycles - p. 457 22. Index - p. 479
