Multidisciplinary Microfluidic and Nanofluidic Lab-on-a-Chip: Principles and Applications provides chemists, biophysicists, engineers, life scientists, biotechnologists, and pharmaceutical scientists with the principles behind the design, manufacture, and testing of life sciences microfluidic systems. This book serves as a reference for technologies and applications in multidisciplinary areas, with an emphasis on quickly developing or new emerging areas, including digital microfluidics, nanofluidics, papers-based microfluidics, and cell biology. The book offers practical guidance on how to design, analyze, fabricate, and test microfluidic devices and systems for a wide variety of applications including separations, disease detection, cellular analysis, DNA analysis, proteomics, and drug delivery.
Calculations, solved problems, data tables, and design rules are provided to help researchers understand microfluidic basic theory and principles and apply this knowledge to their own unique designs. Recent advances in microfluidics and microsystems for life sciences are impacting chemistry, biophysics, molecular, cell biology, and medicine for applications that include DNA analysis, drug discovery, disease research, and biofluid and environmental monitoring.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. List of contributors - p. xv 7. About the editors - p. xix 8. Preface - p. xxi 9. Part I: Microfluidic Techniques - p. xxii 10. Chapter 1. Fabrication of microfluidic chips - p. 3 11. Chapter 2. Fluid–substrate interactions - p. 37 12. Chapter 3. Magnetism in microfluidics: computational fluid dynamics simulations, mixing, transport, and control of fluids and particles at micro scale - p. 59 13. Chapter 4. Microfluidic capillary electrophoresis chip techniques: theory and different separation modes - p. 99 14. Part II: Applications - p. 136 15. Chapter 5. Cell manipulation and cellular analysis - p. 145 16. Chapter 6. Organ-on-a-chip - p. 181 17. Chapter 7. Recent advances in nucleic acid analysis and detection with microfluidic and nanofluidics - p. 199 18. Chapter 8. Conventional and unconventional methodologies for multiplex nucleic acid tests - p. 235 19. Chapter 9. Microfluidic protein analysis and applications - p. 257 20. Chapter 10. Microfluidics in three key aspects of the drug-development process: biomarker discovery, preclinical studies, and drug delivery systems - p. 275 21. Chapter 11. Fundamentals and applications of acoustics in microfluidics - p. 297 22. Part III: New Emerging Techniques & Applications - p. 315 23. Chapter 12. Rapid disease diagnosis using low-cost paper and paper-hybrid microfluidic devices - p. 325 24. Chapter 13. Energy harvesting and self-powered devices in droplet microfluidics - p. 361 25. Chapter 14. Integration of three-dimensional printing and microfluidics - p. 385 26. Chapter 15. Principles and applications of the nano-in-nano integration for multidisciplinary nanofluidics - p. 407 27. Chapter 16. Microfluidics for nanomaterial synthesis - p. 429 28. Index - p. 455
Multidisciplinary Microfluidic and Nanofluidic Lab-on-a-Chip: Principles and Applications provides chemists, biophysicists, engineers, life scientists, biotechnologists, and pharmaceutical scientists with the principles behind the design, manufacture, and testing of life sciences microfluidic systems. This book serves as a reference for technologies and applications in multidisciplinary areas, with an emphasis on quickly developing or new emerging areas, including digital microfluidics, nanofluidics, papers-based microfluidics, and cell biology. The book offers practical guidance on how to design, analyze, fabricate, and test microfluidic devices and systems for a wide variety of applications including separations, disease detection, cellular analysis, DNA analysis, proteomics, and drug delivery.
Calculations, solved problems, data tables, and design rules are provided to help researchers understand microfluidic basic theory and principles and apply this knowledge to their own unique designs. Recent advances in microfluidics and microsystems for life sciences are impacting chemistry, biophysics, molecular, cell biology, and medicine for applications that include DNA analysis, drug discovery, disease research, and biofluid and environmental monitoring.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. List of contributors - p. xv 7. About the editors - p. xix 8. Preface - p. xxi 9. Part I: Microfluidic Techniques - p. xxii 10. Chapter 1. Fabrication of microfluidic chips - p. 3 11. Chapter 2. Fluid–substrate interactions - p. 37 12. Chapter 3. Magnetism in microfluidics: computational fluid dynamics simulations, mixing, transport, and control of fluids and particles at micro scale - p. 59 13. Chapter 4. Microfluidic capillary electrophoresis chip techniques: theory and different separation modes - p. 99 14. Part II: Applications - p. 136 15. Chapter 5. Cell manipulation and cellular analysis - p. 145 16. Chapter 6. Organ-on-a-chip - p. 181 17. Chapter 7. Recent advances in nucleic acid analysis and detection with microfluidic and nanofluidics - p. 199 18. Chapter 8. Conventional and unconventional methodologies for multiplex nucleic acid tests - p. 235 19. Chapter 9. Microfluidic protein analysis and applications - p. 257 20. Chapter 10. Microfluidics in three key aspects of the drug-development process: biomarker discovery, preclinical studies, and drug delivery systems - p. 275 21. Chapter 11. Fundamentals and applications of acoustics in microfluidics - p. 297 22. Part III: New Emerging Techniques & Applications - p. 315 23. Chapter 12. Rapid disease diagnosis using low-cost paper and paper-hybrid microfluidic devices - p. 325 24. Chapter 13. Energy harvesting and self-powered devices in droplet microfluidics - p. 361 25. Chapter 14. Integration of three-dimensional printing and microfluidics - p. 385 26. Chapter 15. Principles and applications of the nano-in-nano integration for multidisciplinary nanofluidics - p. 407 27. Chapter 16. Microfluidics for nanomaterial synthesis - p. 429 28. Index - p. 455
