Natural Products and Drug Discovery: An Integrated Approach provides an applied overview of the field, from traditional medicinal targets, to cutting-edge molecular techniques. Natural products have always been of key importance to drug discovery, but as modern techniques and technologies have allowed researchers to identify, isolate, extract and synthesize their active compounds in new ways, they are once again coming to the forefront of drug discovery.
Combining the potential of traditional medicine with the refinement of modern chemical technology, the use of natural products as the basis for drugs can help in the development of more environmentally sound, economical, and effective drug discovery processes. Natural Products & Drug Discovery: An Integrated Approach reflects on the current changes in this field, giving context to the current shift and using supportive case studies to highlight the challenges and successes faced by researchers in integrating traditional medicinal sources with modern chemical technologies. It therefore acts as a useful reference to medicinal chemists, phytochemists, biochemists, pharma R&D professionals, and drug discovery students and researchers.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. List of Contributors - p. xix 6. Foreword - p. xxiii 7. Preface - p. xxv 8. Section I. Traditional Medicine and Drug Discovery - p. xxvi 9. Chapter 1. Drug Discovery From Ayurveda: Mode of Approach and Applications - p. 3 10. Chapter 2. Traditional and Folk Medicine as a Target for Drug Discovery - p. 29 11. Chapter 3. Bioactivity-Guided Phytofractions: An Emerging Natural Drug Discovery Tool for Safe and Effective Disease Management - p. 57 12. Chapter 4. Development of Chinese Herbal Health Products for the Prevention of Aging-Associated Diseases - p. 73 13. Chapter 5. Ethnobotany/Ethnopharmacology, and Bioprospecting: Issues on Knowledge and Uses of Medicinal Plants by Moroccan People - p. 105 14. Chapter 6. Chemotaxonomy of Medicinal Plants: Possibilities and Limitations - p. 119 15. Section II. Leads From Natural Products - p. 136 16. Chapter 7. The Role of Natural Products From Plants in the Development of Anticancer Agents - p. 139 17. Chapter 8. Plant Drugs in the Treatment of Osteoporosis - p. 179 18. Chapter 9. Phytodrugs and Immunomodulators for the Therapy of Leishmaniasis - p. 213 19. 1. Leishmaniasis - p. 213 20. 2. Therapeutic Agents for Leishmaniasis - p. 222 21. 3. Drug Targets in Leishmania - p. 228 22. 4. Approaches for Drug Screening of Natural Product Libraries Against Leishmania - p. 233 23. 5. Phytochemicals With Antileishmanial and Immunomodulatory Activities - p. 237 24. 6. Future Directions and Conclusions - p. 257 25. Chapter 10. Natural Products Targeting Inflammation Processes and Multiple Mediators - p. 277 26. Chapter 11. Biologically Functional Compounds From Mushroom-Forming Fungi - p. 309 27. Chapter 12. Natural Products in Lifestyle Diseases: In Vitro Screening - p. 327 28. Chapter 13. Common Toxic Plants and Their Forensic Significance - p. 349 29. Chapter 14. Role of Stress in Diseases and Its Remedial Approach by Herbal and Natural Products in Stress-Related Disease Management: Experimental Studies and Clinical Reports - p. 375 30. Chapter 15. Antiinflammatory Medicinal Plants: A Remedy for Most Disease Conditions? - p. 411 31. Section III. Herbal Drug Research - p. 431 32. Chapter 16. Techniques and Technologies for the Biodiscovery of Novel Small Molecule Drug Lead Compounds From Natural Products - p. 435 33. Chapter 17. Herb and Drug Interaction - p. 467 34. Chapter 18. Toxicity Studies Related to Medicinal Plants - p. 491 35. Chapter 19. Prebiotics: A Functional Food in Health and Disease - p. 507 36. Chapter 20. Cultivation of Medicinal and Aromatic Plants - p. 525 37. Chapter 21. Digitization of Traditional Knowledge - p. 555 38. Chapter 22. Good Agricultural Practices: Requirement for the Production of Quality Herbal Medicines - p. 607 39. Chapter 23. Fundamentals of Microwave-Based Sample Preparation for Plant-Based Drug Discovery - p. 633 40. Author Index - p. 643 41. Subject Index - p. 701
Natural Products and Drug Discovery: An Integrated Approach provides an applied overview of the field, from traditional medicinal targets, to cutting-edge molecular techniques. Natural products have always been of key importance to drug discovery, but as modern techniques and technologies have allowed researchers to identify, isolate, extract and synthesize their active compounds in new ways, they are once again coming to the forefront of drug discovery.
Combining the potential of traditional medicine with the refinement of modern chemical technology, the use of natural products as the basis for drugs can help in the development of more environmentally sound, economical, and effective drug discovery processes. Natural Products & Drug Discovery: An Integrated Approach reflects on the current changes in this field, giving context to the current shift and using supportive case studies to highlight the challenges and successes faced by researchers in integrating traditional medicinal sources with modern chemical technologies. It therefore acts as a useful reference to medicinal chemists, phytochemists, biochemists, pharma R&D professionals, and drug discovery students and researchers.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. List of Contributors - p. xix 6. Foreword - p. xxiii 7. Preface - p. xxv 8. Section I. Traditional Medicine and Drug Discovery - p. xxvi 9. Chapter 1. Drug Discovery From Ayurveda: Mode of Approach and Applications - p. 3 10. Chapter 2. Traditional and Folk Medicine as a Target for Drug Discovery - p. 29 11. Chapter 3. Bioactivity-Guided Phytofractions: An Emerging Natural Drug Discovery Tool for Safe and Effective Disease Management - p. 57 12. Chapter 4. Development of Chinese Herbal Health Products for the Prevention of Aging-Associated Diseases - p. 73 13. Chapter 5. Ethnobotany/Ethnopharmacology, and Bioprospecting: Issues on Knowledge and Uses of Medicinal Plants by Moroccan People - p. 105 14. Chapter 6. Chemotaxonomy of Medicinal Plants: Possibilities and Limitations - p. 119 15. Section II. Leads From Natural Products - p. 136 16. Chapter 7. The Role of Natural Products From Plants in the Development of Anticancer Agents - p. 139 17. Chapter 8. Plant Drugs in the Treatment of Osteoporosis - p. 179 18. Chapter 9. Phytodrugs and Immunomodulators for the Therapy of Leishmaniasis - p. 213 19. 1. Leishmaniasis - p. 213 20. 2. Therapeutic Agents for Leishmaniasis - p. 222 21. 3. Drug Targets in Leishmania - p. 228 22. 4. Approaches for Drug Screening of Natural Product Libraries Against Leishmania - p. 233 23. 5. Phytochemicals With Antileishmanial and Immunomodulatory Activities - p. 237 24. 6. Future Directions and Conclusions - p. 257 25. Chapter 10. Natural Products Targeting Inflammation Processes and Multiple Mediators - p. 277 26. Chapter 11. Biologically Functional Compounds From Mushroom-Forming Fungi - p. 309 27. Chapter 12. Natural Products in Lifestyle Diseases: In Vitro Screening - p. 327 28. Chapter 13. Common Toxic Plants and Their Forensic Significance - p. 349 29. Chapter 14. Role of Stress in Diseases and Its Remedial Approach by Herbal and Natural Products in Stress-Related Disease Management: Experimental Studies and Clinical Reports - p. 375 30. Chapter 15. Antiinflammatory Medicinal Plants: A Remedy for Most Disease Conditions? - p. 411 31. Section III. Herbal Drug Research - p. 431 32. Chapter 16. Techniques and Technologies for the Biodiscovery of Novel Small Molecule Drug Lead Compounds From Natural Products - p. 435 33. Chapter 17. Herb and Drug Interaction - p. 467 34. Chapter 18. Toxicity Studies Related to Medicinal Plants - p. 491 35. Chapter 19. Prebiotics: A Functional Food in Health and Disease - p. 507 36. Chapter 20. Cultivation of Medicinal and Aromatic Plants - p. 525 37. Chapter 21. Digitization of Traditional Knowledge - p. 555 38. Chapter 22. Good Agricultural Practices: Requirement for the Production of Quality Herbal Medicines - p. 607 39. Chapter 23. Fundamentals of Microwave-Based Sample Preparation for Plant-Based Drug Discovery - p. 633 40. Author Index - p. 643 41. Subject Index - p. 701
