Neuro-Urology Research: A Comprehensive Overview describes the current status of the neuro-urology field, discusses potential future directions and explains the latest neuroscience tools that can be used in neuro-urology research. The first section provides an overview of the circuit-based interrogation of subcortical and spinal networks involved in bladder filling and voiding. The second section discusses the translational potential of research for patients including specific chapters on the sensation of bladder stretch, bladder pain, the effects of hormones and the potential results of neurodegeneration on bladder function. The third section compares traditional and current studies determining the need for addressing or readdressing principles or adjusting dogma. Section four introduces techniques including optogenetic manipulation and calcium imaging of neural activity, and on how these methods can be applied to neuro-urology research. The fifth and final section proposes studies in directions that have remained underexplored or otherwise controversial. Perfect for all currently researching neuro-urology, this detailed understanding of the cellular and synaptic circuits that control bladder filling and voiding and of the circuitry regulating bladder function, has the potential to inform the development of newer therapeutics for treating LUTS.
1. Title of Book - p. vii 2. Cover - p. vii 3. Title page - p. vii 4. Copyright - p. viii 5. Table of Contents - p. viii 6. Contributors - p. ix 7. About the editor - p. xi 8. Preface - p. xiii 9. Acknowledgments - p. xv 10. Chapter 1 Neuro-urology research: a comprehensive overview - p. 1 11. Chapter 2 Barrington's nucleus: a century of progress identifying neurons that control micturition - p. 31 12. Chapter 3 Voluntary versus reflex micturition control - p. 53 13. Chapter 4 The bladder as a readout in neuroscience research - p. 82 14. Chapter 5 How treatment of lower urinary tract symptoms can benefit from basic research - p. 105 15. Chapter 6 “Translational effects of neuro-urology research on clinical practice”; Patient population–specific lower urinary tract symptoms - p. 121 16. Chapter 7 Effect of androgens and estrogens on bladder/lower urinary tract function - p. 141 17. Chapter 8 Transcriptomic identification of cell types in the lower urinary tract - p. 159 18. Chapter 9 Exploring urinary bladder neural circuitry through calcium imaging - p. 169 19. Chapter 10 The periaqueductal gray and control of bladder function - p. 193 20. Chapter 11 Impact of spinal neuromodulation on spinal neural networks controlling lower urinary tract function - p. 209 21. Chapter 12 Neural control of continence - p. 219 22. Index - p. 233
Neuro-Urology Research: A Comprehensive Overview describes the current status of the neuro-urology field, discusses potential future directions and explains the latest neuroscience tools that can be used in neuro-urology research. The first section provides an overview of the circuit-based interrogation of subcortical and spinal networks involved in bladder filling and voiding. The second section discusses the translational potential of research for patients including specific chapters on the sensation of bladder stretch, bladder pain, the effects of hormones and the potential results of neurodegeneration on bladder function. The third section compares traditional and current studies determining the need for addressing or readdressing principles or adjusting dogma. Section four introduces techniques including optogenetic manipulation and calcium imaging of neural activity, and on how these methods can be applied to neuro-urology research. The fifth and final section proposes studies in directions that have remained underexplored or otherwise controversial. Perfect for all currently researching neuro-urology, this detailed understanding of the cellular and synaptic circuits that control bladder filling and voiding and of the circuitry regulating bladder function, has the potential to inform the development of newer therapeutics for treating LUTS.
1. Title of Book - p. vii 2. Cover - p. vii 3. Title page - p. vii 4. Copyright - p. viii 5. Table of Contents - p. viii 6. Contributors - p. ix 7. About the editor - p. xi 8. Preface - p. xiii 9. Acknowledgments - p. xv 10. Chapter 1 Neuro-urology research: a comprehensive overview - p. 1 11. Chapter 2 Barrington's nucleus: a century of progress identifying neurons that control micturition - p. 31 12. Chapter 3 Voluntary versus reflex micturition control - p. 53 13. Chapter 4 The bladder as a readout in neuroscience research - p. 82 14. Chapter 5 How treatment of lower urinary tract symptoms can benefit from basic research - p. 105 15. Chapter 6 “Translational effects of neuro-urology research on clinical practice”; Patient population–specific lower urinary tract symptoms - p. 121 16. Chapter 7 Effect of androgens and estrogens on bladder/lower urinary tract function - p. 141 17. Chapter 8 Transcriptomic identification of cell types in the lower urinary tract - p. 159 18. Chapter 9 Exploring urinary bladder neural circuitry through calcium imaging - p. 169 19. Chapter 10 The periaqueductal gray and control of bladder function - p. 193 20. Chapter 11 Impact of spinal neuromodulation on spinal neural networks controlling lower urinary tract function - p. 209 21. Chapter 12 Neural control of continence - p. 219 22. Index - p. 233
