Phytochemicals as Lead Compounds for New Drug Discovery presents complete coverage of the recent advances in the discovery of phytochemicals from medicinal plants as models to the development of new drugs and chemical entities. Functional bioactive compounds of plant origin have been an invaluable source for many human therapeutic drugs and have played a major role in the treatment of diseases around the world. These compounds possess enormous structural and chemical diversity and have led to many important discoveries. This book presents fundament concepts and factors affecting the choice for plant-based products, as well as recent advances in computer-aided drug discovery and FDA drug candidacy acceptance criteria. It also details the various bioactive lead compounds and molecular targets for a range of life-threatening diseases including cancer, diabetes, and neurodegenerative diseases.
Written by a global team of experts, Phytochemicals as Lead Compounds for New Drug Discovery is an ideal resource for drug developers, phytochemists, plant biochemists, food and medicinal chemists, nutritionists and toxicologists, chemical ecologists, taxonomists, analytical chemists, and other researchers in those fields. It will also be very valuable to professors, students, and researchers in this domain.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. List of contributors - p. xi 6. Biography - p. xv 7. Part I. Plants as natural sources of drugs - p. xvi 8. Chapter 1. Plant secondary metabolites as lead compounds for the production of potent drugs - p. 3 9. Chapter 2. Factors affecting the choice for plant-based products in drug discoveries - p. 15 10. Chapter 3. Advances in computer-aided drug discovery - p. 25 11. Chapter 4. FDA drug candidacy acceptance criteria and steps: problems and way forward - p. 39 12. Part II. Biofunctional leads for drug development - p. 63 13. Chapter 5. Bioactive lead compounds and molecular targets for the treatment of heart diseases - p. 67 14. Chapter 6. Natural bioactive lead compounds effective against haematological malignancies - p. 95 15. Chapter 7. Adjunct therapeutic potential of phytochemicals against cancer - p. 117 16. Chapter 8. Antidiabetic lead compounds and targets for drug development - p. 127 17. Chapter 9. Antiobesity functional leads and targets for drug development - p. 143 18. Chapter 10. Phytochemicals as therapeutic interventions in neurodegenerative diseases - p. 161 19. Chapter 11. Organosulfur phytochemicals against metabolic and neurodegenerative diseases: benefits and risks - p. 179 20. Chapter 12. Lead compounds with the potentials for the treatment of chronic liver diseases - p. 195 21. Chapter 13. Bioactive lead compounds effective against skin diseases - p. 211 22. Chapter 14. Phytochemicals as emerging therapeutic agents for alopecia treatment - p. 221 23. Chapter 15. Antiviral phytocompounds for drug development: a data mining studies - p. 239 24. Chapter 16. Shikimic acid as intermediary model for the production of drugs effective against influenza virus - p. 245 25. Chapter 17. Antimicrobial lead compounds from marine plants - p. 257 26. Chapter 18. Antibacterial lead compounds and their targets for drug development - p. 275 27. Chapter 19. Awareness and current therapeutic strategies of malaria - p. 293 28. Chapter 20. Bioactive lead compounds and targets for the development of antimalarial drugs - p. 305 29. Chapter 21. Bioactive lead compounds and molecular targets for the development of antiinflammatory drugs - p. 317 30. Chapter 22. Functional lead compounds and targets for the development of drugs for the treatment of male infertility - p. 333 31. Chapter 23. Prenylated flavonoids as a promising drug discovery candidate: a pharmacological update - p. 347 32. Index - p. 357
Phytochemicals as Lead Compounds for New Drug Discovery presents complete coverage of the recent advances in the discovery of phytochemicals from medicinal plants as models to the development of new drugs and chemical entities. Functional bioactive compounds of plant origin have been an invaluable source for many human therapeutic drugs and have played a major role in the treatment of diseases around the world. These compounds possess enormous structural and chemical diversity and have led to many important discoveries. This book presents fundament concepts and factors affecting the choice for plant-based products, as well as recent advances in computer-aided drug discovery and FDA drug candidacy acceptance criteria. It also details the various bioactive lead compounds and molecular targets for a range of life-threatening diseases including cancer, diabetes, and neurodegenerative diseases.
Written by a global team of experts, Phytochemicals as Lead Compounds for New Drug Discovery is an ideal resource for drug developers, phytochemists, plant biochemists, food and medicinal chemists, nutritionists and toxicologists, chemical ecologists, taxonomists, analytical chemists, and other researchers in those fields. It will also be very valuable to professors, students, and researchers in this domain.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. List of contributors - p. xi 6. Biography - p. xv 7. Part I. Plants as natural sources of drugs - p. xvi 8. Chapter 1. Plant secondary metabolites as lead compounds for the production of potent drugs - p. 3 9. Chapter 2. Factors affecting the choice for plant-based products in drug discoveries - p. 15 10. Chapter 3. Advances in computer-aided drug discovery - p. 25 11. Chapter 4. FDA drug candidacy acceptance criteria and steps: problems and way forward - p. 39 12. Part II. Biofunctional leads for drug development - p. 63 13. Chapter 5. Bioactive lead compounds and molecular targets for the treatment of heart diseases - p. 67 14. Chapter 6. Natural bioactive lead compounds effective against haematological malignancies - p. 95 15. Chapter 7. Adjunct therapeutic potential of phytochemicals against cancer - p. 117 16. Chapter 8. Antidiabetic lead compounds and targets for drug development - p. 127 17. Chapter 9. Antiobesity functional leads and targets for drug development - p. 143 18. Chapter 10. Phytochemicals as therapeutic interventions in neurodegenerative diseases - p. 161 19. Chapter 11. Organosulfur phytochemicals against metabolic and neurodegenerative diseases: benefits and risks - p. 179 20. Chapter 12. Lead compounds with the potentials for the treatment of chronic liver diseases - p. 195 21. Chapter 13. Bioactive lead compounds effective against skin diseases - p. 211 22. Chapter 14. Phytochemicals as emerging therapeutic agents for alopecia treatment - p. 221 23. Chapter 15. Antiviral phytocompounds for drug development: a data mining studies - p. 239 24. Chapter 16. Shikimic acid as intermediary model for the production of drugs effective against influenza virus - p. 245 25. Chapter 17. Antimicrobial lead compounds from marine plants - p. 257 26. Chapter 18. Antibacterial lead compounds and their targets for drug development - p. 275 27. Chapter 19. Awareness and current therapeutic strategies of malaria - p. 293 28. Chapter 20. Bioactive lead compounds and targets for the development of antimalarial drugs - p. 305 29. Chapter 21. Bioactive lead compounds and molecular targets for the development of antiinflammatory drugs - p. 317 30. Chapter 22. Functional lead compounds and targets for the development of drugs for the treatment of male infertility - p. 333 31. Chapter 23. Prenylated flavonoids as a promising drug discovery candidate: a pharmacological update - p. 347 32. Index - p. 357
