The ability to intervene at the earliest phases in the pathogenesis of a chronic rheumatic disease caused by auto-inflammatory, autoimmune, or tissue injury mechanisms has th epotential to prevent disease manifestations and consequences, limited loss of quality of life, comorbidity, and costs to society. This issue is dedicated to exploring the stages of rheumatic disease, biologic mechanisms contributing to the pathogenesis along with possible ways to study and screen for persons at risk with the ultimate goal of finding ways to prevent these devastating diseases.
1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Contributors - p. 4 5. Forthcoming Issues - p. 8 6. Foreword - p. 9 7. Preface: Preclinical Rheumatic Disease - p. 10 8. Preclinical Inflammatory Rheumatic Diseases - p. 12 9. Gout - p. 19 10. Insights from Populations at Risk for the Future Development of Classified Rheumatoid Arthritis - p. 33 11. Preclinical Systemic Lupus Erythematosus - p. 42 12. Genetics, Environment, and Gene-Environment Interactions in the Development of Systemic Rheumatic Diseases - p. 51 13. Is Preclinical Autoimmunity Benign? - p. 63 14. Detecting the Earliest Signs of Rheumatoid Arthritis - p. 69 15. Recognition of Preclinical and Early Disease in Axial Spondyloarthritis - p. 76 16. Identifying and Treating Preclinical and Early Osteoarthritis - p. 83 17. Mucosal Immune Responses to Microbiota in the Development of Autoimmune Disease - p. 90 18. Challenges in Imaging in Preclinical Rheumatoid Arthritis - p. 99 19. Identification of Self-antigen–specific T Cells Reflecting Loss of Tolerance in Autoimmune Disease Underpins Preventative Immunotherapeutic Strategies in Rheumatoid Arthritis - p. 103 20. Prediction of Future Rheumatoid Arthritis - p. 112 21. Prevention of Rheumatic Diseases - p. 123 22. Developing Evidence-Based Screening Recommendations, with Consideration for Rheumatology - p. 132 23. Lessons from Type 1 Diabetes for Understanding Natural History and Prevention of Autoimmune Disease - p. 137 24. Index - p. 146
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The ability to intervene at the earliest phases in the pathogenesis of a chronic rheumatic disease caused by auto-inflammatory, autoimmune, or tissue injury mechanisms has th epotential to prevent disease manifestations and consequences, limited loss of quality of life, comorbidity, and costs to society. This issue is dedicated to exploring the stages of rheumatic disease, biologic mechanisms contributing to the pathogenesis along with possible ways to study and screen for persons at risk with the ultimate goal of finding ways to prevent these devastating diseases.
1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Contributors - p. 4 5. Forthcoming Issues - p. 8 6. Foreword - p. 9 7. Preface: Preclinical Rheumatic Disease - p. 10 8. Preclinical Inflammatory Rheumatic Diseases - p. 12 9. Gout - p. 19 10. Insights from Populations at Risk for the Future Development of Classified Rheumatoid Arthritis - p. 33 11. Preclinical Systemic Lupus Erythematosus - p. 42 12. Genetics, Environment, and Gene-Environment Interactions in the Development of Systemic Rheumatic Diseases - p. 51 13. Is Preclinical Autoimmunity Benign? - p. 63 14. Detecting the Earliest Signs of Rheumatoid Arthritis - p. 69 15. Recognition of Preclinical and Early Disease in Axial Spondyloarthritis - p. 76 16. Identifying and Treating Preclinical and Early Osteoarthritis - p. 83 17. Mucosal Immune Responses to Microbiota in the Development of Autoimmune Disease - p. 90 18. Challenges in Imaging in Preclinical Rheumatoid Arthritis - p. 99 19. Identification of Self-antigen–specific T Cells Reflecting Loss of Tolerance in Autoimmune Disease Underpins Preventative Immunotherapeutic Strategies in Rheumatoid Arthritis - p. 103 20. Prediction of Future Rheumatoid Arthritis - p. 112 21. Prevention of Rheumatic Diseases - p. 123 22. Developing Evidence-Based Screening Recommendations, with Consideration for Rheumatology - p. 132 23. Lessons from Type 1 Diabetes for Understanding Natural History and Prevention of Autoimmune Disease - p. 137 24. Index - p. 146
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