For nearly 40 years, the Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, a publication of the American Society for Bone and Mineral Research (ASBMR), has been the leading comprehensive reference on bone and mineral health. In this fully revised 10th Edition, Dr. John P. Bilezikian and an expert editorial team of 34 global leaders and more than 300 contributing authors provide unsurpassed coverage of bone biology and bone diseases in a manner readily accessible to students, basic and clinical scientists, and practitioners.
1. 47. Introduction to Genetics - p. 324 2. 48. Animal Models: Genetic Manipulation - p. 335 3. 49. Animal Models: Allelic Determinants for BMD - p. 345 4. 50. Human Genome-Wide Association Studies - p. 351 5. 51. Whole Genome- and Exome-Sequencing Studies - p. 358 6. 52. Big Data Analysis and Machine Learning in Human Genetics - p. 363 7. 53. Epigenomics and Multi-Omics in Bone Research - p. 367 8. 54. Polygenic Risk Scores and Mendelian Randomization - p. 372 9. 55. Translational Genetics of Osteoporosis: From Population Association to Individualized Assessment - p. 377 10. SECTION VI. OSTEOPOROSIS I (EPIDEMIOLOGY AND ETIOLOGIES) - p. 381 11. 56. Osteoporosis: An Overview - p. 382 12. 57. The Epidemiology of Osteoporotic Fractures - p. 388 13. 58. Fracture Liaison Services - p. 394 14. 59. Sex Steroids and the Pathogenesis of Osteoporosis - p. 400 15. 60. Transplantation Osteoporosis - p. 406 16. 61. Premenopausal Osteoporosis - p. 416 17. 62. Osteoporosis in Men - p. 423 18. 63. Inflammation-Induced Bone Loss in the Rheumatic Diseases - p. 428 19. 64. Glucocorticoid-Induced Osteoporosis - p. 434 20. 65. Human Immunodeficiency Virus and Bone - p. 440 21. 66. Effects on the Skeleton From Medications Used to Treat Nonskeletal Disorders - p. 446 22. 67. Diabetes and Fracture Risk - p. 453 23. 68. Obesity and Bariatric Surgery - p. 460 24. 69. Sarcopenia and Osteoporosis - p. 467 25. 70. Management of Osteoporosis in Chronic Kidney Disease - p. 475 26. 71. Other Secondary Causes of Osteoporosis - p. 482 27. 72. Infiltrative Marrow Disorders and Osteoporosis - p. 488 28. 73. The Effect of COVID-19 on Bone - p. 494 29. SECTION VII. OSTEOPOROSIS II (THERAPEUTICS) - p. 499 30. 74. Overview of Strategies for Managing Osteoporosis in Postmenopausal Women - p. 500 31. 75. Exercise for Osteoporotic Fracture Prevention and Management - p. 505 32. 76. Prevention of Falls - p. 511 33. 77. Nutritional Support of Bone Health in Older Adults - p. 517 34. 78. Estrogens, Selective Estrogen Receptor Modulators, and Tissue-Selective Estrogen Complex - p. 523 35. 79. Bisphosphonates for Postmenopausal Osteoporosis - p. 529 36. 80. Denosumab - p. 535 37. 81. Teriparatide and Abaloparatide Treatment for Osteoporosis - p. 540 38. 82. Anti-Sclerostin Therapy for Osteoporosis - p. 546 39. 83. Considerations for Osteoporosis Management in Medically Complex Older Patients - p. 553 40. 84. Combination Anabolic and Antiresorptive Therapy for Osteoporosis - p. 560 41. SECTION VIII. METABOLIC BONE DISEASES - p. 567 42. 85. Approach to Parathyroid Disorders - p. 568 43. 86. Primary Hyperparathyroidism - p. 573 44. 87. Familial States of Primary Hyperparathyroidism - p. 583 45. 88. Nonparathyroid Hypercalcemia - p. 591 46. 89. Hypocalcemia: Definition, Etiology, Pathogenesis, Diagnosis, and Management - p. 597 47. 90. Hypoparathyroidism: Diagnosis, Evaluation and Management - p. 604 48. 91. Pseudohypoparathyroidism - p. 615 49. 92. Disorders of Phosphate Homeostasis - p. 629 50. 93. Rickets and Osteomalacia - p. 637 51. 94. Pathophysiology and Treatment of Chronic Kidney Disease-Mineral and Bone Disorder - p. 647 52. 95. Disorders of Mineral Metabolism in Childhood - p. 655 53. 96. Paget Disease of Bone - p. 663 54. 97. Epidemiology, Diagnosis, Evaluation, and Treatment of Nephrolithiasis - p. 670 55. 98. Immobilization and Burns: Other Conditions Associated With Osteoporosis - p. 676 56. SECTION IX. METABOLIC BONE ISSUES IN ORTHOPEDICS - p. 681 57. 99. Introduction: What Every Specialist in Metabolic Bone Diseases Should Know About Orthopedics - p. 682 58. 100. What Every Orthopedic Surgeon Should Know About Metabolic Bone Disease - p. 685 59. 101. Perioperative Bone Health Optimization for Orthopedic Patients - p. 700 60. 102. Corrective Orthopedic Surgery for Individuals With Rare Bone Disease and Skeletal Deformities - p. 705 61. 103. Postfracture Rehabilitation of Osteoporosis: Management and Braces - p. 711 62. 104. Stress and Insufficiency Fractures and the Treatment of Nonunions - p. 723 63. 105. Fractures in Children: How to Differentiate Between Metabolic and Genetic Bone Disorders and Abuse - p. 730 64. 106. Kyphoplasty and Vertebroplasty - p. 735 65. 107. Bone Stress Injuries - p. 741 66. 108. The Biomechanics of Gait Disturbances - p. 747 67. 109. AFF (Surgical Aspects, Prophylactic Nailing of the Contralateral Side) - p. 752 68. SECTION X. CANCER AND BONE - p. 760 69. 110. Clinical and Preclinical Imaging in Osseous Metastatic Disease - p. 762 70. 111. Myeloma Bone Disease and Other Hematological Malignancies - p. 770 71. 112. Osteosarcoma - p. 777 72. 113. Skeletal Complications of Breast and Prostate Cancer and Their Therapies - p. 782 73. 114. Bone Cancer and Pain - p. 787 74. 115. Radiation Therapy–Induced Osteoporosis - p. 793 75. 116. Skeletal Complications of Childhood Cancer - p. 797 76. 117. Medical Prevention and Treatment of Bone Metastases - p. 802 77. 118. Radiotherapy of Skeletal Metastases - p. 810 78. 119. Concepts and Surgical Treatment of Metastatic Bone Disease - p. 818 79. 120. Osteocytes and Bone Malignancies - p. 824 80. SECTION XI. PEDIATRIC AND ADULT RARE BONE DISEASES - p. 831 81. 121. Sclerosing Bone Disorders - p. 832 82. 122. Fibrous Dysplasia/McCune-Albright Syndrome - p. 844 83. 123. The Osteochondrodysplasias - p. 851 84. 124. Hyperphosphatemic Tumoral Calcinosis - p. 856 85. 125. Fibrodysplasia Ossificans Progressiva and Progressive Osseous Heteroplasia - p. 862 86. 126. Osteogenesis Imperfecta - p. 867 87. 127. Skeletal Manifestations of Marfan Syndrome and Marfan-Related Disorders - p. 873 88. 128. Hypophosphatasia and Other Enzyme Deficiencies Affecting the Skeleton - p. 880 89. 129. Ischemic and Infiltrative Disorders of Bone - p. 885 90. SECTION XII. ORAL AND MAXILLOFACIAL BIOLOGY AND PATHOLOGY - p. 893 91. 130. Craniofacial Morphogenesis - p. 894 92. 131. Development and Structure of Teeth and Periodontium - p. 899 93. 132. Genetic Craniofacial Disorders Affecting the Dentition - p. 908 94. 133. Genetic Disorders Affecting Craniofacial Bones - p. 913 95. 134. Pathology of the Hard Tissues of the Jaws - p. 921 96. 135. Medication Related Osteonecrosis of the Jaw - p. 928 97. 136. Alveolar Bone Homeostasis in Health and Disease - p. 933 98. 137. Oral Manifestations of Metabolic Bone Diseases - p. 938 99. 138. Dental Implants and Osseous Healing in the Oral Cavity - p. 943 100. SECTION XIII. INTEGRATIVE PHYSIOLOGY OF THE SKELETON - p. 949 101. 139. Integrative Physiology of the Skeleton - p. 950 102. 140. The Hematopoietic Niche and Bone - p. 955 103. 141. Adipocytes and Bone - p. 965 104. 142. The Vasculature and Bone - p. 973 105. 143. Immune Cells Relevant to Bone - p. 977 106. 144. Metabolic Regulation of Skeletal Cell Function During Endochondral Ossification - p. 988 107. 145. Bioenergetics of Bone - p. 995 108. 146. Central Neuronal Control of Bone Remodeling - p. 1002 109. 147. Peripheral Neuronal Control of Bone Remodeling and Repair - p. 1007 110. 148. Pituitary Hormones in Regulating Skeletal Homeostasis - p. 1014 111. 149. Neuropsychiatric Disorders and the Skeleton - p. 1025 112. 150. Systemic Iron Homeostasis and Bone Metabolism - p. 1031 113. Index - p. 1039
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For nearly 40 years, the Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, a publication of the American Society for Bone and Mineral Research (ASBMR), has been the leading comprehensive reference on bone and mineral health. In this fully revised 10th Edition, Dr. John P. Bilezikian and an expert editorial team of 34 global leaders and more than 300 contributing authors provide unsurpassed coverage of bone biology and bone diseases in a manner readily accessible to students, basic and clinical scientists, and practitioners.
1. 47. Introduction to Genetics - p. 324 2. 48. Animal Models: Genetic Manipulation - p. 335 3. 49. Animal Models: Allelic Determinants for BMD - p. 345 4. 50. Human Genome-Wide Association Studies - p. 351 5. 51. Whole Genome- and Exome-Sequencing Studies - p. 358 6. 52. Big Data Analysis and Machine Learning in Human Genetics - p. 363 7. 53. Epigenomics and Multi-Omics in Bone Research - p. 367 8. 54. Polygenic Risk Scores and Mendelian Randomization - p. 372 9. 55. Translational Genetics of Osteoporosis: From Population Association to Individualized Assessment - p. 377 10. SECTION VI. OSTEOPOROSIS I (EPIDEMIOLOGY AND ETIOLOGIES) - p. 381 11. 56. Osteoporosis: An Overview - p. 382 12. 57. The Epidemiology of Osteoporotic Fractures - p. 388 13. 58. Fracture Liaison Services - p. 394 14. 59. Sex Steroids and the Pathogenesis of Osteoporosis - p. 400 15. 60. Transplantation Osteoporosis - p. 406 16. 61. Premenopausal Osteoporosis - p. 416 17. 62. Osteoporosis in Men - p. 423 18. 63. Inflammation-Induced Bone Loss in the Rheumatic Diseases - p. 428 19. 64. Glucocorticoid-Induced Osteoporosis - p. 434 20. 65. Human Immunodeficiency Virus and Bone - p. 440 21. 66. Effects on the Skeleton From Medications Used to Treat Nonskeletal Disorders - p. 446 22. 67. Diabetes and Fracture Risk - p. 453 23. 68. Obesity and Bariatric Surgery - p. 460 24. 69. Sarcopenia and Osteoporosis - p. 467 25. 70. Management of Osteoporosis in Chronic Kidney Disease - p. 475 26. 71. Other Secondary Causes of Osteoporosis - p. 482 27. 72. Infiltrative Marrow Disorders and Osteoporosis - p. 488 28. 73. The Effect of COVID-19 on Bone - p. 494 29. SECTION VII. OSTEOPOROSIS II (THERAPEUTICS) - p. 499 30. 74. Overview of Strategies for Managing Osteoporosis in Postmenopausal Women - p. 500 31. 75. Exercise for Osteoporotic Fracture Prevention and Management - p. 505 32. 76. Prevention of Falls - p. 511 33. 77. Nutritional Support of Bone Health in Older Adults - p. 517 34. 78. Estrogens, Selective Estrogen Receptor Modulators, and Tissue-Selective Estrogen Complex - p. 523 35. 79. Bisphosphonates for Postmenopausal Osteoporosis - p. 529 36. 80. Denosumab - p. 535 37. 81. Teriparatide and Abaloparatide Treatment for Osteoporosis - p. 540 38. 82. Anti-Sclerostin Therapy for Osteoporosis - p. 546 39. 83. Considerations for Osteoporosis Management in Medically Complex Older Patients - p. 553 40. 84. Combination Anabolic and Antiresorptive Therapy for Osteoporosis - p. 560 41. SECTION VIII. METABOLIC BONE DISEASES - p. 567 42. 85. Approach to Parathyroid Disorders - p. 568 43. 86. Primary Hyperparathyroidism - p. 573 44. 87. Familial States of Primary Hyperparathyroidism - p. 583 45. 88. Nonparathyroid Hypercalcemia - p. 591 46. 89. Hypocalcemia: Definition, Etiology, Pathogenesis, Diagnosis, and Management - p. 597 47. 90. Hypoparathyroidism: Diagnosis, Evaluation and Management - p. 604 48. 91. Pseudohypoparathyroidism - p. 615 49. 92. Disorders of Phosphate Homeostasis - p. 629 50. 93. Rickets and Osteomalacia - p. 637 51. 94. Pathophysiology and Treatment of Chronic Kidney Disease-Mineral and Bone Disorder - p. 647 52. 95. Disorders of Mineral Metabolism in Childhood - p. 655 53. 96. Paget Disease of Bone - p. 663 54. 97. Epidemiology, Diagnosis, Evaluation, and Treatment of Nephrolithiasis - p. 670 55. 98. Immobilization and Burns: Other Conditions Associated With Osteoporosis - p. 676 56. SECTION IX. METABOLIC BONE ISSUES IN ORTHOPEDICS - p. 681 57. 99. Introduction: What Every Specialist in Metabolic Bone Diseases Should Know About Orthopedics - p. 682 58. 100. What Every Orthopedic Surgeon Should Know About Metabolic Bone Disease - p. 685 59. 101. Perioperative Bone Health Optimization for Orthopedic Patients - p. 700 60. 102. Corrective Orthopedic Surgery for Individuals With Rare Bone Disease and Skeletal Deformities - p. 705 61. 103. Postfracture Rehabilitation of Osteoporosis: Management and Braces - p. 711 62. 104. Stress and Insufficiency Fractures and the Treatment of Nonunions - p. 723 63. 105. Fractures in Children: How to Differentiate Between Metabolic and Genetic Bone Disorders and Abuse - p. 730 64. 106. Kyphoplasty and Vertebroplasty - p. 735 65. 107. Bone Stress Injuries - p. 741 66. 108. The Biomechanics of Gait Disturbances - p. 747 67. 109. AFF (Surgical Aspects, Prophylactic Nailing of the Contralateral Side) - p. 752 68. SECTION X. CANCER AND BONE - p. 760 69. 110. Clinical and Preclinical Imaging in Osseous Metastatic Disease - p. 762 70. 111. Myeloma Bone Disease and Other Hematological Malignancies - p. 770 71. 112. Osteosarcoma - p. 777 72. 113. Skeletal Complications of Breast and Prostate Cancer and Their Therapies - p. 782 73. 114. Bone Cancer and Pain - p. 787 74. 115. Radiation Therapy–Induced Osteoporosis - p. 793 75. 116. Skeletal Complications of Childhood Cancer - p. 797 76. 117. Medical Prevention and Treatment of Bone Metastases - p. 802 77. 118. Radiotherapy of Skeletal Metastases - p. 810 78. 119. Concepts and Surgical Treatment of Metastatic Bone Disease - p. 818 79. 120. Osteocytes and Bone Malignancies - p. 824 80. SECTION XI. PEDIATRIC AND ADULT RARE BONE DISEASES - p. 831 81. 121. Sclerosing Bone Disorders - p. 832 82. 122. Fibrous Dysplasia/McCune-Albright Syndrome - p. 844 83. 123. The Osteochondrodysplasias - p. 851 84. 124. Hyperphosphatemic Tumoral Calcinosis - p. 856 85. 125. Fibrodysplasia Ossificans Progressiva and Progressive Osseous Heteroplasia - p. 862 86. 126. Osteogenesis Imperfecta - p. 867 87. 127. Skeletal Manifestations of Marfan Syndrome and Marfan-Related Disorders - p. 873 88. 128. Hypophosphatasia and Other Enzyme Deficiencies Affecting the Skeleton - p. 880 89. 129. Ischemic and Infiltrative Disorders of Bone - p. 885 90. SECTION XII. ORAL AND MAXILLOFACIAL BIOLOGY AND PATHOLOGY - p. 893 91. 130. Craniofacial Morphogenesis - p. 894 92. 131. Development and Structure of Teeth and Periodontium - p. 899 93. 132. Genetic Craniofacial Disorders Affecting the Dentition - p. 908 94. 133. Genetic Disorders Affecting Craniofacial Bones - p. 913 95. 134. Pathology of the Hard Tissues of the Jaws - p. 921 96. 135. Medication Related Osteonecrosis of the Jaw - p. 928 97. 136. Alveolar Bone Homeostasis in Health and Disease - p. 933 98. 137. Oral Manifestations of Metabolic Bone Diseases - p. 938 99. 138. Dental Implants and Osseous Healing in the Oral Cavity - p. 943 100. SECTION XIII. INTEGRATIVE PHYSIOLOGY OF THE SKELETON - p. 949 101. 139. Integrative Physiology of the Skeleton - p. 950 102. 140. The Hematopoietic Niche and Bone - p. 955 103. 141. Adipocytes and Bone - p. 965 104. 142. The Vasculature and Bone - p. 973 105. 143. Immune Cells Relevant to Bone - p. 977 106. 144. Metabolic Regulation of Skeletal Cell Function During Endochondral Ossification - p. 988 107. 145. Bioenergetics of Bone - p. 995 108. 146. Central Neuronal Control of Bone Remodeling - p. 1002 109. 147. Peripheral Neuronal Control of Bone Remodeling and Repair - p. 1007 110. 148. Pituitary Hormones in Regulating Skeletal Homeostasis - p. 1014 111. 149. Neuropsychiatric Disorders and the Skeleton - p. 1025 112. 150. Systemic Iron Homeostasis and Bone Metabolism - p. 1031 113. Index - p. 1039
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