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Guest edited by David Hunter, this issue of Rheumatic Disease Clinics provides an update on the latest diagnosis, treatment and long-term management strategies for osteoarthritis. Topics to be covered include pathogenesis, joint mechanics, imaging of osteoarthritis, muscle and disease genesis, disease modification, and surgical strategies for treatment.

1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Contributors - p. 4 5. Forthcoming Issues - p. 5 6. Foreword - p. 6 7. Osteoarthritis - p. 7 8. Epidemiology of Osteoarthritis - p. 9 9. The Measurement of Joint Mechanics and Their Role in Osteoarthritis Genesis and Progression - p. 20 10. Diagnosis and Clinical Presentation of Osteoarthritis - p. 35 11. Imaging of Osteoarthritis - p. 45 12. The Health and Structural Consequences of Acute Knee Injuries Involving Rupture of the Anterior Cruciate Ligament - p. 62 13. Chronic Disease Management - p. 71 14. Update on the Role of Muscle in the Genesis and Management of Knee Osteoarthritis - p. 82 15. Disease Modification - p. 102 16. Nonarthroplasty Hip Surgery for Early Osteoarthritis - p. 108 17. Surgery for Osteoarthritis of the Knee - p. 115 18. Targeting Care - p. 121 19. Index - p. 132

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Guest edited by David Hunter, this issue of Rheumatic Disease Clinics provides an update on the latest diagnosis, treatment and long-term management strategies for osteoarthritis. Topics to be covered include pathogenesis, joint mechanics, imaging of osteoarthritis, muscle and disease genesis, disease modification, and surgical strategies for treatment.

1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Contributors - p. 4 5. Forthcoming Issues - p. 5 6. Foreword - p. 6 7. Osteoarthritis - p. 7 8. Epidemiology of Osteoarthritis - p. 9 9. The Measurement of Joint Mechanics and Their Role in Osteoarthritis Genesis and Progression - p. 20 10. Diagnosis and Clinical Presentation of Osteoarthritis - p. 35 11. Imaging of Osteoarthritis - p. 45 12. The Health and Structural Consequences of Acute Knee Injuries Involving Rupture of the Anterior Cruciate Ligament - p. 62 13. Chronic Disease Management - p. 71 14. Update on the Role of Muscle in the Genesis and Management of Knee Osteoarthritis - p. 82 15. Disease Modification - p. 102 16. Nonarthroplasty Hip Surgery for Early Osteoarthritis - p. 108 17. Surgery for Osteoarthritis of the Knee - p. 115 18. Targeting Care - p. 121 19. Index - p. 132

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