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This issue of Heart Failure Clinics examines Heart Failure with Preserved Ejection Fraction (HFPEF). The followings aspects of HFPEF are addressed: epidemiology, etiologic factors and pathophysiology, diagnosis, clinical spectrum, imaging, invasive hemodynamic characterization, exercise physiology, natriuretic peptides, novel biomarkers, differential diagnoses and comorbidities, outcomes, clinical trials, current therapeutic approach, and novel therapeutic targets.

1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Contributors - p. 4 5. Contents - p. 5 6. Forthcoming Issues - p. 7 7. Foreword - p. 8 8. Preface - p. 9 9. Epidemiology of Heart Failure with Preserved Ejection Fraction - p. 10 10. Causes and Pathophysiology of Heart Failure with Preserved Ejection Fraction - p. 18 11. Diagnosis of Heart Failure with Preserved Ejection Fraction - p. 26 12. Phenotypic Spectrum of Heart Failure with Preserved Ejection Fraction - p. 31 13. Imaging in Heart Failure with Preserved Ejection Fraction - p. 39 14. Invasive Hemodynamic Characterization of Heart Failure with Preserved Ejection Fraction - p. 49 15. Exercise Physiology in Heart Failure and Preserved Ejection Fraction - p. 57 16. Natriuretic Peptides in Heart Failure with Preserved Ejection Fraction - p. 62 17. Novel Biomarkers in Heart Failure with Preserved Ejection Fraction - p. 73 18. Comorbidities and Differential Diagnosis in Heart Failure with Preserved Ejection Fraction - p. 80 19. Outcomes in Patients with Heart Failure with Preserved Ejection Fraction - p. 92 20. Clinical Trials in Patients with Heart Failure and Preserved Left Ventricular Ejection Fraction - p. 99 21. Current Therapeutic Approach in Heart Failure with Preserved Ejection Fraction - p. 108 22. Index - p. 118

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This issue of Heart Failure Clinics examines Heart Failure with Preserved Ejection Fraction (HFPEF). The followings aspects of HFPEF are addressed: epidemiology, etiologic factors and pathophysiology, diagnosis, clinical spectrum, imaging, invasive hemodynamic characterization, exercise physiology, natriuretic peptides, novel biomarkers, differential diagnoses and comorbidities, outcomes, clinical trials, current therapeutic approach, and novel therapeutic targets.

1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Contributors - p. 4 5. Contents - p. 5 6. Forthcoming Issues - p. 7 7. Foreword - p. 8 8. Preface - p. 9 9. Epidemiology of Heart Failure with Preserved Ejection Fraction - p. 10 10. Causes and Pathophysiology of Heart Failure with Preserved Ejection Fraction - p. 18 11. Diagnosis of Heart Failure with Preserved Ejection Fraction - p. 26 12. Phenotypic Spectrum of Heart Failure with Preserved Ejection Fraction - p. 31 13. Imaging in Heart Failure with Preserved Ejection Fraction - p. 39 14. Invasive Hemodynamic Characterization of Heart Failure with Preserved Ejection Fraction - p. 49 15. Exercise Physiology in Heart Failure and Preserved Ejection Fraction - p. 57 16. Natriuretic Peptides in Heart Failure with Preserved Ejection Fraction - p. 62 17. Novel Biomarkers in Heart Failure with Preserved Ejection Fraction - p. 73 18. Comorbidities and Differential Diagnosis in Heart Failure with Preserved Ejection Fraction - p. 80 19. Outcomes in Patients with Heart Failure with Preserved Ejection Fraction - p. 92 20. Clinical Trials in Patients with Heart Failure and Preserved Left Ventricular Ejection Fraction - p. 99 21. Current Therapeutic Approach in Heart Failure with Preserved Ejection Fraction - p. 108 22. Index - p. 118

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