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For four decades, physicians and other healthcare providers have trusted Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases to provide expert guidance on the diagnosis and treatment of these complex disorders. The 9th Edition continues the tradition of excellence with newly expanded chapters, increased global coverage, and regular updates to keep you at the forefront of this vitally important field. Meticulously updated by Drs. John E. Bennett, Raphael Dolin, and Martin J. Blaser, this comprehensive, two-volume masterwork puts the latest information on challenging infectious diseases at your fingertips.

  • Provides more in-depth coverage of epidemiology, etiology, pathology, microbiology, immunology, and treatment of infectious agents than any other infectious disease resource
  • Features an increased focus on antibiotic stewardship; new antivirals for influenza, cytomegalovirus, hepatitis C, hepatitis B., and immunizations; and new recommendations for vaccination against infection with pneumococci, papillomaviruses, hepatitis A, and pertussis
  • Covers newly recognized enteroviruses causing paralysis (E-A71, E-D68); emerging viral infections such as Ebola, Zika, Marburg, SARS, and MERS; and important updates on prevention and treatment of C. difficile infection, including new tests that diagnose or falsely over-diagnose infectious diseases
  • Offers fully revised content on bacterial pathogenesis, antibiotic use and toxicity, the human microbiome and its effects on health and disease, immunological mechanisms and immunodeficiency, and probiotics and alternative approaches to treatment of infectious diseases
  • Discusses up-to-date topics such as use of the new PCR panels for diagnosis of meningitis, diarrhea and pneumonia; current management of infected orthopedic implant infections; newly recognized infections transmitted by black-legged ticks in the USA: Borrelia miyamotoi and Powassan virus; infectious complications of new drugs for cancer; new drugs for resistant bacteria and mycobacteria; new guidelines for diagnosis and therapy of HIV infections; and new vaccines against herpes zoster, influenza, meningococci
  • PPID continues its tradition of including leading experts from a truly global community, including authors from Australia, Canada and countries in Europe, Asia, and South America
  • Includes regular updates online for the life of the edition
  • Features more than 1,500 high-quality, full-color photographs—with hundreds new to this edition
  • Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices

1. Chapter 114: Introduction to Eye Infections - p. g0015 2. Chapter 115: Microbial Conjunctivitis - p. g0015 3. Chapter 116: Microbial Keratitis - p. g0015 4. Chapter 117: Endophthalmitis - p. g0015 5. Chapter 118: Infectious Causes of Uveitis - p. g0015 6. Chapter 119: Periocular Infections - p. g0015 7. N: Hepatitis - p. g0015 8. Chapter 120: Viral Hepatitis - p. g0015 9. O: Acquired Immunodeficiency Syndrome - p. g0015 10. Chapter 121: Global Perspectives on Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome - p. g0015 11. Chapter 122: Epidemiology and Prevention of AIDS and HIV Infection, Including Preexposure Prophylaxis and HIV Vaccine Development - p. g0015 12. Chapter 123: Diagnosis of Human Immunodeficiency Virus Infection - p. g0015 13. Chapter 124: The Immunology of Human Immunodeficiency Virus Infection - p. g0015 14. Chapter 125: General Clinical Manifestations of Human Immunodeficiency Virus Infection (Including Acute Retroviral Syndrome and Oral, Cutaneous, Renal, Ocular, Metabolic, and Cardiac Diseases) - p. g0015 15. Chapter 126: Pulmonary Manifestations of Human Immunodeficiency Virus Infection - p. g0015 16. Chapter 127: Gastrointestinal, Hepatobiliary, and Pancreatic Manifestations of Human Immunodeficiency Virus Infection - p. g0015 17. Chapter 128: Neurologic Diseases Caused by Human Immunodeficiency Virus Type 1 and Opportunistic Infections - p. g0015 18. Chapter 129: Human Immunodeficiency Virus Infection in Women - p. g0015 19. Chapter 130: Pediatric Human Immunodeficiency Virus Infection - p. g0015 20. Chapter 131: Antiretroviral Therapy for Human Immunodeficiency Virus Infection - p. g0015 21. Chapter 132: Management of Opportunistic Infections Associated With Human Immunodeficiency Virus Infection - p. g0015 22. P: Miscellaneous Syndromes - p. g0015 23. Chapter 133: Chronic Fatigue Syndrome (Systemic Exertion Intolerance Disease) - p. g0015 24. Volume 2 - p. g0015 25. III: Infectious Diseases and Their Etiologic Agents - p. g0015 26. A: Viral Diseases - p. g0015 27. Chapter 134: Biology of Viruses and Viral Diseases - p. g0015 28. i: DNA Viruses - p. g0015 29. a: Poxviridae - p. g0015 30. Chapter 135: Orthopoxviruses: Vaccinia (Smallpox Vaccine), Variola (Smallpox), Monkeypox, and Cowpox - p. g0015 31. Chapter 136: Other Poxviruses That Infect Humans: Parapoxviruses (Including Orf Virus), Molluscum Contagiosum, and Yatapoxviruses - p. g0015 32. b: Herpesviridae - p. g0015 33. Chapter 137: Introduction to Herpesviridae - p. g0015 34. Chapter 138: Herpes Simplex Virus - p. g0015 35. Chapter 139: Chickenpox and Herpes Zoster (Varicella-Zoster Virus) - p. g0015 36. Chapter 140: Cytomegalovirus - p. g0015 37. Chapter 141: Epstein-Barr Virus (Infectious Mononucleosis, Epstein-Barr Virus–Associated Malignant Diseases, and Other Diseases) - p. g0015 38. Chapter 142: Human Herpesvirus Types 6 and 7 (Exanthem Subitum) - p. g0015 39. Chapter 143: Kaposi Sarcoma–Associated Herpesvirus (Human Herpesvirus 8) - p. g0015 40. Chapter 144: Herpes B Virus - p. g0015 41. c: Adenoviridae - p. g0015 42. Chapter 145: Adenoviruses - p. g0015 43. d: Papillomaviridae - p. g0015 44. Chapter 146: Papillomaviruses - p. g0015 45. Chapter 147: JC, BK, and Other Polyomaviruses: Progressive Multifocal Leukoencephalopathy (PML) - p. g0015 46. e: Hepadnaviridae - p. g0015 47. Chapter 148: Hepatitis B Virus - p. g0015 48. Chapter 149: Hepatitis Delta Virus - p. g0015 49. f: Parvoviridae - p. g0015 50. Chapter 150: Human Parvoviruses, Including Parvovirus B19V and Human Bocaparvoviruses - p. g0015 51. ii: RNA Viruses - p. g0015 52. a: Reoviridae - p. g0015 53. Chapter 151: Orthoreoviruses and Orbiviruses - p. g0015 54. Chapter 152: Coltiviruses (Colorado Tick Fever Virus) and Seadornaviruses - p. g0015 55. Chapter 153: Rotaviruses - p. g0015 56. b: Togaviridae - p. g0015 57. Chapter 154: Alphaviruses (Chikungunya, Eastern Equine Encephalitis) - p. g0015 58. Chapter 155: Rubella Virus (German Measles) - p. g0015 59. c: Flaviviridae - p. g0015 60. Chapter 156: Flaviviruses (Dengue, Yellow Fever, Japanese Encephalitis, West Nile Encephalitis, Usutu Encephalitis, St. Louis Encephalitis, Tick-Borne Encephalitis, Kyasanur Forest Disease, Alkhurma Hemorrhagic Fever, Zika) - p. g0015 61. Chapter 157: Hepatitis C - p. g0015 62. d: Coronaviridae - p. g0015 63. Chapter 158: Coronaviruses, Including Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) - p. g0015 64. e: Paramyxoviridae - p. g0015 65. Chapter 159: Parainfluenza Viruses - p. g0015 66. Chapter 160: Mumps Virus - p. g0015 67. Chapter 161: Respiratory Syncytial Virus - p. g0015 68. Chapter 162: Human Metapneumovirus - p. g0015 69. Chapter 163: Measles Virus (Rubeola) - p. g0015 70. Chapter 164: Zoonotic Paramyxoviruses: Nipah, Hendra, and Menangle Viruses - p. g0015 71. f: Rhabdoviridae - p. g0015 72. Chapter 165: Vesicular Stomatitis Virus and Related Vesiculoviruses (Chandipura Virus) - p. g0015 73. Chapter 166: Rabies (Rhabdoviruses) - p. g0015 74. g: Filoviridae - p. g0015 75. Chapter 167: Marburg and Ebola Virus Hemorrhagic Fevers - p. g0015 76. h: Orthomyxoviridae - p. g0015 77. Chapter 168: Influenza Viruses, Including Avian Influenza and Swine Influenza - p. g0015 78. i: Bunyaviridae - p. g0015 79. Chapter 169: California Encephalitis, Hantavirus Pulmonary Syndrome, Hantavirus Hemorrhagic Fever With Renal Syndrome, and Bunyavirus Hemorrhagic Fevers - p. g0015 80. j: Arenaviridae - p. g0015 81. Chapter 170: Lymphocytic Choriomeningitis Virus, Lassa Virus, and the South American Hemorrhagic Fevers (Arenaviruses) - p. g0015 82. k: Retroviridae - p. g0015 83. Chapter 171: Human T-Cell Leukemia Viruses (HTLV-1, HTLV-2) - p. g0015 84. Chapter 172: Human Immunodeficiency Viruses - p. g0015 85. l: Picornaviridae - p. g0015 86. Chapter 173: Introduction to the Human Enteroviruses and Parechoviruses - p. g0015 87. Chapter 174: Poliovirus - p. g0015 88. Chapter 175: Coxsackieviruses, Echoviruses, and Numbered Enteroviruses (EV-A71, EVD-68, EVD-70) - p. g0015 89. Chapter 176: Parechoviruses - p. g0015 90. Chapter 177: Hepatitis A Virus - p. g0015 91. Chapter 178: Rhinovirus - p. g0015 92. iii: Caliciviridae and Other Gastrointestinal - p. g0015 93. Chapter 179: Noroviruses and Sapoviruses (Caliciviruses) - p. g0015 94. Chapter 180: Astroviruses and Picobirnaviruses - p. g0015 95. iv: Unclassified Viruses - p. g0015 96. Chapter 181: Hepatitis E Virus - p. g0015 97. B: Prion Diseases - p. g0015 98. Chapter 182: Prions and Prion Disease of the Central Nervous System (Transmissible Neurodegenerative Diseases) - p. g0015 99. C: Chlamydial Diseases - p. g0015 100. Chapter 183: Chlamydia trachomatis (Trachoma and Urogenital Infections) - p. g0015 101. Chapter 184: Psittacosis (Due to Chlamydia psittaci) - p. g0015 102. Chapter 185: Chlamydia pneumoniae - p. g0015 103. D: Mycoplasma Diseases - p. g0015 104. Chapter 186: Mycoplasma pneumoniae and Atypical Pneumonia - p. g0015 105. Chapter 187: Genital Mycoplasmas: Mycoplasma genitalium, Mycoplasma hominis, and Ureaplasma Species - p. g0015 106. E: Rickettsioses, Ehrlichioses, and Anaplasmoses - p. g0015 107. Chapter 188: Introduction to Rickettsioses, Ehrlichioses, and Anaplasmoses - p. g0015 108. Chapter 189: Rickettsia rickettsii and Other Spotted Fever Group Rickettsiae (Rocky Mountain Spotted Fever and Other Spotted Fevers) - p. g0015 109. Chapter 190: Rickettsia akari (Rickettsialpox) - p. g0015 110. Chapter 191: Coxiella burnetii (Q Fever) - p. g0015 111. Chapter 192: Rickettsia prowazekii (Epidemic or Louse-Borne Typhus) - p. g0015 112. Chapter 193: Rickettsia typhi (Murine Typhus) - p. g0015 113. Chapter 194: Orientia tsutsugamushi (Scrub Typhus) - p. g0015 114. Chapter 195: Ehrlichia chaffeensis (Human Monocytotropic Ehrlichiosis), Anaplasma phagocytophilum (Human Granulocytotropic Anaplasmosis), and Other Anaplasmataceae - p. g0015 115. F: Bacterial Diseases - p. g0015 116. Chapter 196: Introduction to Bacteria and Bacterial Diseases - p. g0015 117. i: Gram-Positive Cocci - p. g0015 118. Chapter 197: Staphylococcus aureus (Including Staphylococcal Toxic Shock Syndrome) - p. g0015 119. Chapter 198: Staphylococcus epidermidis and Other Coagulase-Negative Staphylococci - p. g0015 120. Chapter 199: Classification of Streptococci - p. g0015 121. Chapter 200: Streptococcus pyogenes - p. g0015 122. Chapter 201: Nonsuppurative Poststreptococcal Sequelae: Rheumatic Fever and Glomerulonephritis - p. g0015 123. Chapter 202: Streptococcus pneumoniae - p. g0015 124. Chapter 203: Enterococcus Species, Streptococcus gallolyticus Group, and Leuconostoc Species - p. g0015 125. Chapter 204: Streptococcus agalactiae (Group B Streptococci) - p. g0015 126. Chapter 205: Viridans Streptococci, Nutritionally Variant Streptococci, and Groups C and G Streptococci - p. g0015 127. Chapter 206: Streptococcus anginosus Group - p. g0015 128. ii: Gram-Positive Bacilli - p. g0015 129. Chapter 207: Corynebacterium diphtheriae (Diphtheria) - p. g0015 130. Chapter 208: Other Coryneform Bacteria, Arcanobacterium haemolyticum, and Rhodococci - p. g0015 131. Chapter 209: Listeria monocytogenes - p. g0015 132. Chapter 210: Bacillus anthracis (Anthrax) - p. g0015 133. Chapter 211: Bacillus Species and Related Genera Other Than Bacillus anthracis - p. g0015 134. Chapter 212: Erysipelothrix rhusiopathiae - p. g0015 135. Chapter 213: Whipple Disease - p. g0015 136. iii: Gram-Negative Cocci - p. g0015 137. Chapter 214: Neisseria meningitidis - p. g0015 138. Chapter 215: Neisseria gonorrhoeae (Gonorrhea) - p. g0015 139. Chapter 216: Moraxella catarrhalis, Kingella, and Other Gram-Negative Cocci - p. g0015 140. iv: Gram-Negative Bacilli - p. g0015 141. Chapter 217: Vibrio cholerae - p. g0015 142. Chapter 218: Other Pathogenic Vibrios - p. g0015 143. Chapter 219: Campylobacter jejuni and Related Species - p. g0015 144. Chapter 220: Helicobacter pylori and Other Gastric Helicobacter Species - p. g0015 145. Chapter 221: Enterobacteriaceae - p. g0015 146. Chapter 222: Pseudomonas aeruginosa and Other Pseudomonas Species - p. g0015 147. Chapter 223: Stenotrophomonas maltophilia and Burkholderia cepacia Complex - p. g0015 148. Chapter 224: Burkholderia pseudomallei and Burkholderia mallei: Melioidosis and Glanders - p. g0015 149. Chapter 225: Acinetobacter Species - p. g0015 150. Chapter 226: Salmonella Species - p. g0015 151. Chapter 227: Bacillary Dysentery: Shigella and Enteroinvasive Escherichia coli - p. g0015 152. Chapter 228: Haemophilus Species, Including H. influenzae and H. ducreyi (Chancroid) - p. g0015 153. Chapter 229: Brucellosis (Brucella Species) - p. g0015 154. Chapter 230: Francisella tularensis (Tularemia) - p. g0015 155. Chapter 231: Pasteurella Species - p. g0015 156. Chapter 232: Plague (Yersinia pestis) - p. g0015 157. Chapter 233: Yersinia enterocolitica and Yersinia pseudotuberculosis - p. g0015 158. Chapter 234: Bordetella pertussis - p. g0015 159. Chapter 235: Rat-Bite Fever: Streptobacillus moniliformis and Spirillum minus - p. g0015 160. Chapter 236: Legionnaires’ Disease and Pontiac Fever - p. g0015 161. Chapter 237: Capnocytophaga - p. g0015 162. Chapter 238: Bartonella, Including Cat-Scratch Disease - p. g0015 163. Chapter 239: Klebsiella granulomatis (Donovanosis, Granuloma Inguinale) - p. g0015 164. Chapter 240: Other Gram-Negative and Gram-Variable Bacilli - p. g0015 165. v: Spirochetes - p. g0015 166. Chapter 241: Syphilis (Treponema pallidum) - p. g0015 167. Chapter 242: Endemic Treponematoses - p. g0015 168. Chapter 243: Leptospira Species (Leptospirosis) - p. g0015 169. Chapter 244: Relapsing Fever Caused by Borrelia Species - p. g0015 170. Chapter 245: Lyme Disease (Lyme Borreliosis) Due to Borrelia burgdorferi - p. g0015 171. vi: Anaerobic Bacteria - p. g0015 172. Chapter 246: Anaerobic Infections: General Concepts - p. g0015 173. Chapter 247: Clostridioides difficile (Formerly Clostridium difficile) Infection - p. g0015 174. Chapter 248: Tetanus (Clostridium tetani) - p. g0015 175. Chapter 249: Botulism (Clostridium botulinum) - p. g0015 176. Chapter 250: Diseases Caused by Clostridium - p. g0015 177. Chapter 251: Bacteroides, Prevotella, Porphyromonas, and Fusobacterium Species (and Other Medically Important Anaerobic Gram-Negative Bacilli) - p. g0015 178. Chapter 252: Anaerobic Cocci and Anaerobic Gram-Positive Nonsporulating Bacilli - p. g0015 179. vii: Mycobacterial Diseases - p. g0015 180. Chapter 253: Mycobacterium tuberculosis - p. g0015 181. Chapter 254: Leprosy (Mycobacterium leprae) - p. g0015 182. Chapter 255: Mycobacterium avium Complex - p. g0015 183. Chapter 256: Infections Caused by Nontuberculous Mycobacteria Other Than Mycobacterium avium Complex - p. g0015 184. viii: Higher Bacterial Diseases - p. g0015 185. Chapter 257: Nocardia Species - p. g0015 186. Chapter 258: Agents of Actinomycosis - p. g0015 187. G: Mycoses - p. g0015 188. Chapter 259: Introduction to Mycoses - p. g0015 189. Chapter 260: Candida Species - p. g0015 190. Chapter 261: Aspergillus Species - p. g0015 191. Chapter 262: Agents of Mucormycosis and Entomophthoramycosis - p. g0015 192. Chapter 263: Sporothrix schenckii - p. g0015 193. Chapter 264: Agents of Chromoblastomycosis - p. g0015 194. Chapter 265: Agents of Mycetoma - p. g0015 195. Chapter 266: Cryptococcosis (Cryptococcus neoformans and Cryptococcus gattii) - p. g0015 196. Chapter 267: Histoplasma capsulatum (Histoplasmosis) - p. g0015 197. Chapter 268: Blastomycosis - p. g0015 198. Chapter 269: Coccidioidomycosis (Coccidioides Species) - p. g0015 199. Chapter 270: Dermatophytosis (Ringworm) and Other Superficial Mycoses - p. g0015 200. Chapter 271: Paracoccidioidomycosis - p. g0015 201. Chapter 272: Uncommon Fungi and Related Species - p. g0015 202. Chapter 273: Pneumocystis Species - p. g0015 203. Chapter 274: Microsporidiosis - p. g0015 204. H: Protozoal Diseases - p. g0015 205. Chapter 275: Introduction to Protozoal Diseases - p. g0015 206. Chapter 276: Entamoeba Species, Including Amebic Colitis and Liver Abscess - p. g0015 207. Chapter 277: Free-Living Amebae - p. g0015 208. Chapter 278: Malaria (Plasmodium Species) - p. g0015 209. Chapter 279: Leishmania Species: Visceral (Kala-Azar), Cutaneous, and Mucosal Leishmaniasis - p. g0015 210. Chapter 280: Trypanosoma Species (American Trypanosomiasis, Chagas Disease): Biology of Trypanosomes - p. g0015 211. Chapter 281: Agents of African Trypanosomiasis (Sleeping Sickness) - p. g0015 212. Chapter 282: Toxoplasma gondii - p. g0015 213. Chapter 283: Giardia lamblia - p. g0015 214. Chapter 284: Trichomonas vaginalis - p. g0015 215. Chapter 285: Babesia Species - p. g0015 216. Chapter 286: Cryptosporidiosis (Cryptosporidium Species) - p. g0015 217. Chapter 287: Cyclospora cayetanensis, Cystoisospora belli, Sarcocystis Species, Balantidium coli, and Blastocystis Species - p. g0015 218. I: Diseases Due to Toxic Algae - p. g0015 219. Chapter 288: Human Illness Associated With Harmful Algal Blooms - p. g0015 220. J: Diseases Due to Helminths - p. g0015 221. Chapter 289: Introduction to Helminth Infections - p. g0015 222. Chapter 290: Intestinal Nematodes (Roundworms) - p. g0015 223. Chapter 291: Tissue Nematodes, Including Trichinellosis, Dracunculiasis, Filariasis, Loiasis, and Onchocerciasis - p. g0015 224. Chapter 292: Trematodes (Schistosomes and Liver, Intestinal, and Lung Flukes) - p. g0015 225. Chapter 293: Tapeworms (Cestodes) - p. g0015 226. Chapter 294: Visceral Larva Migrans and Other Uncommon Helminth Infections - p. g0015 227. K: Ectoparasitic Diseases - p. g0015 228. Chapter 295: Introduction to Ectoparasitic Diseases - p. g0015 229. Chapter 296: Lice (Pediculosis) - p. g0015 230. Chapter 297: Scabies - p. g0015 231. Chapter 298: Myiasis and Tungiasis - p. g0015 232. Chapter 299: Mites, Including Chiggers - p. g0015 233. Chapter 300: Ticks, Including Tick Paralysis - p. g0015 234. L: Diseases of Unknown Etiology - p. g0015 235. Chapter 301: Kawasaki Disease - p. g0015 236. IV: Special Problems - p. g0015 237. A: Nosocomial Infections - p. g0015 238. Chapter 302: Infection Prevention and Control in the Health Care Setting - p. g0015 239. Chapter 303: Disinfection, Sterilization, and Control of Hospital Waste - p. g0015 240. Chapter 304: Infections Caused by Percutaneous Intravascular Devices - p. g0015 241. Chapter 305: Nosocomial Pneumonia - p. g0015 242. Chapter 306: Health Care–Associated Urinary Tract Infections - p. g0015 243. Chapter 307: Health Care–Acquired Hepatitis - p. g0015 244. Chapter 308: Transfusion- and Transplantation-Transmitted Infections - p. g0015 245. B: Infections in Special Hosts - p. g0015 246. Chapter 309: Infections in the Immunocompromised Host: General Principles - p. g0015 247. Chapter 310: Prophylaxis and Empirical Therapy of Infection in Cancer Patients - p. g0015 248. Chapter 311: Infections in Recipients of Hematopoietic Stem Cell Transplants - p. g0015 249. Chapter 312: Infections in Solid-Organ Transplant Recipients - p. g0015 250. Chapter 313: Infections in Patients With Spinal Cord Injury - p. g0015 251. Chapter 314: Infections in Older Adults - p. g0015 252. Chapter 315: Infections in Asplenic Patients - p. g0015 253. Chapter 316: Infections in Injection Drug Users - p. g0015 254. Chapter 317: Surgical Site Infections and Antimicrobial Prophylaxis - p. g0015 255. C: Surgical- and Trauma-Related Infections - p. g0015 256. Chapter 318: Burns - p. g0015 257. Chapter 319: Bites - p. g0015 258. D: Immunization - p. g0015 259. Chapter 320: Immunization - p. g0015 260. E: Zoonoses - p. g0015 261. Chapter 321: Zoonoses - p. g0015 262. F: Protection of Travelers - p. g0015 263. Chapter 322: Protection of Travelers - p. g0015 264. Chapter 323: Infections in Returning Travelers - p. g0015 265. Index - p. g0015

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Descripción

For four decades, physicians and other healthcare providers have trusted Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases to provide expert guidance on the diagnosis and treatment of these complex disorders. The 9th Edition continues the tradition of excellence with newly expanded chapters, increased global coverage, and regular updates to keep you at the forefront of this vitally important field. Meticulously updated by Drs. John E. Bennett, Raphael Dolin, and Martin J. Blaser, this comprehensive, two-volume masterwork puts the latest information on challenging infectious diseases at your fingertips.

  • Provides more in-depth coverage of epidemiology, etiology, pathology, microbiology, immunology, and treatment of infectious agents than any other infectious disease resource
  • Features an increased focus on antibiotic stewardship; new antivirals for influenza, cytomegalovirus, hepatitis C, hepatitis B., and immunizations; and new recommendations for vaccination against infection with pneumococci, papillomaviruses, hepatitis A, and pertussis
  • Covers newly recognized enteroviruses causing paralysis (E-A71, E-D68); emerging viral infections such as Ebola, Zika, Marburg, SARS, and MERS; and important updates on prevention and treatment of C. difficile infection, including new tests that diagnose or falsely over-diagnose infectious diseases
  • Offers fully revised content on bacterial pathogenesis, antibiotic use and toxicity, the human microbiome and its effects on health and disease, immunological mechanisms and immunodeficiency, and probiotics and alternative approaches to treatment of infectious diseases
  • Discusses up-to-date topics such as use of the new PCR panels for diagnosis of meningitis, diarrhea and pneumonia; current management of infected orthopedic implant infections; newly recognized infections transmitted by black-legged ticks in the USA: Borrelia miyamotoi and Powassan virus; infectious complications of new drugs for cancer; new drugs for resistant bacteria and mycobacteria; new guidelines for diagnosis and therapy of HIV infections; and new vaccines against herpes zoster, influenza, meningococci
  • PPID continues its tradition of including leading experts from a truly global community, including authors from Australia, Canada and countries in Europe, Asia, and South America
  • Includes regular updates online for the life of the edition
  • Features more than 1,500 high-quality, full-color photographs—with hundreds new to this edition
  • Enhanced eBook version included with purchase, which allows you to access all of the text, figures, and references from the book on a variety of devices

1. Chapter 114: Introduction to Eye Infections - p. g0015 2. Chapter 115: Microbial Conjunctivitis - p. g0015 3. Chapter 116: Microbial Keratitis - p. g0015 4. Chapter 117: Endophthalmitis - p. g0015 5. Chapter 118: Infectious Causes of Uveitis - p. g0015 6. Chapter 119: Periocular Infections - p. g0015 7. N: Hepatitis - p. g0015 8. Chapter 120: Viral Hepatitis - p. g0015 9. O: Acquired Immunodeficiency Syndrome - p. g0015 10. Chapter 121: Global Perspectives on Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome - p. g0015 11. Chapter 122: Epidemiology and Prevention of AIDS and HIV Infection, Including Preexposure Prophylaxis and HIV Vaccine Development - p. g0015 12. Chapter 123: Diagnosis of Human Immunodeficiency Virus Infection - p. g0015 13. Chapter 124: The Immunology of Human Immunodeficiency Virus Infection - p. g0015 14. Chapter 125: General Clinical Manifestations of Human Immunodeficiency Virus Infection (Including Acute Retroviral Syndrome and Oral, Cutaneous, Renal, Ocular, Metabolic, and Cardiac Diseases) - p. g0015 15. Chapter 126: Pulmonary Manifestations of Human Immunodeficiency Virus Infection - p. g0015 16. Chapter 127: Gastrointestinal, Hepatobiliary, and Pancreatic Manifestations of Human Immunodeficiency Virus Infection - p. g0015 17. Chapter 128: Neurologic Diseases Caused by Human Immunodeficiency Virus Type 1 and Opportunistic Infections - p. g0015 18. Chapter 129: Human Immunodeficiency Virus Infection in Women - p. g0015 19. Chapter 130: Pediatric Human Immunodeficiency Virus Infection - p. g0015 20. Chapter 131: Antiretroviral Therapy for Human Immunodeficiency Virus Infection - p. g0015 21. Chapter 132: Management of Opportunistic Infections Associated With Human Immunodeficiency Virus Infection - p. g0015 22. P: Miscellaneous Syndromes - p. g0015 23. Chapter 133: Chronic Fatigue Syndrome (Systemic Exertion Intolerance Disease) - p. g0015 24. Volume 2 - p. g0015 25. III: Infectious Diseases and Their Etiologic Agents - p. g0015 26. A: Viral Diseases - p. g0015 27. Chapter 134: Biology of Viruses and Viral Diseases - p. g0015 28. i: DNA Viruses - p. g0015 29. a: Poxviridae - p. g0015 30. Chapter 135: Orthopoxviruses: Vaccinia (Smallpox Vaccine), Variola (Smallpox), Monkeypox, and Cowpox - p. g0015 31. Chapter 136: Other Poxviruses That Infect Humans: Parapoxviruses (Including Orf Virus), Molluscum Contagiosum, and Yatapoxviruses - p. g0015 32. b: Herpesviridae - p. g0015 33. Chapter 137: Introduction to Herpesviridae - p. g0015 34. Chapter 138: Herpes Simplex Virus - p. g0015 35. Chapter 139: Chickenpox and Herpes Zoster (Varicella-Zoster Virus) - p. g0015 36. Chapter 140: Cytomegalovirus - p. g0015 37. Chapter 141: Epstein-Barr Virus (Infectious Mononucleosis, Epstein-Barr Virus–Associated Malignant Diseases, and Other Diseases) - p. g0015 38. Chapter 142: Human Herpesvirus Types 6 and 7 (Exanthem Subitum) - p. g0015 39. Chapter 143: Kaposi Sarcoma–Associated Herpesvirus (Human Herpesvirus 8) - p. g0015 40. Chapter 144: Herpes B Virus - p. g0015 41. c: Adenoviridae - p. g0015 42. Chapter 145: Adenoviruses - p. g0015 43. d: Papillomaviridae - p. g0015 44. Chapter 146: Papillomaviruses - p. g0015 45. Chapter 147: JC, BK, and Other Polyomaviruses: Progressive Multifocal Leukoencephalopathy (PML) - p. g0015 46. e: Hepadnaviridae - p. g0015 47. Chapter 148: Hepatitis B Virus - p. g0015 48. Chapter 149: Hepatitis Delta Virus - p. g0015 49. f: Parvoviridae - p. g0015 50. Chapter 150: Human Parvoviruses, Including Parvovirus B19V and Human Bocaparvoviruses - p. g0015 51. ii: RNA Viruses - p. g0015 52. a: Reoviridae - p. g0015 53. Chapter 151: Orthoreoviruses and Orbiviruses - p. g0015 54. Chapter 152: Coltiviruses (Colorado Tick Fever Virus) and Seadornaviruses - p. g0015 55. Chapter 153: Rotaviruses - p. g0015 56. b: Togaviridae - p. g0015 57. Chapter 154: Alphaviruses (Chikungunya, Eastern Equine Encephalitis) - p. g0015 58. Chapter 155: Rubella Virus (German Measles) - p. g0015 59. c: Flaviviridae - p. g0015 60. Chapter 156: Flaviviruses (Dengue, Yellow Fever, Japanese Encephalitis, West Nile Encephalitis, Usutu Encephalitis, St. Louis Encephalitis, Tick-Borne Encephalitis, Kyasanur Forest Disease, Alkhurma Hemorrhagic Fever, Zika) - p. g0015 61. Chapter 157: Hepatitis C - p. g0015 62. d: Coronaviridae - p. g0015 63. Chapter 158: Coronaviruses, Including Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) - p. g0015 64. e: Paramyxoviridae - p. g0015 65. Chapter 159: Parainfluenza Viruses - p. g0015 66. Chapter 160: Mumps Virus - p. g0015 67. Chapter 161: Respiratory Syncytial Virus - p. g0015 68. Chapter 162: Human Metapneumovirus - p. g0015 69. Chapter 163: Measles Virus (Rubeola) - p. g0015 70. Chapter 164: Zoonotic Paramyxoviruses: Nipah, Hendra, and Menangle Viruses - p. g0015 71. f: Rhabdoviridae - p. g0015 72. Chapter 165: Vesicular Stomatitis Virus and Related Vesiculoviruses (Chandipura Virus) - p. g0015 73. Chapter 166: Rabies (Rhabdoviruses) - p. g0015 74. g: Filoviridae - p. g0015 75. Chapter 167: Marburg and Ebola Virus Hemorrhagic Fevers - p. g0015 76. h: Orthomyxoviridae - p. g0015 77. Chapter 168: Influenza Viruses, Including Avian Influenza and Swine Influenza - p. g0015 78. i: Bunyaviridae - p. g0015 79. Chapter 169: California Encephalitis, Hantavirus Pulmonary Syndrome, Hantavirus Hemorrhagic Fever With Renal Syndrome, and Bunyavirus Hemorrhagic Fevers - p. g0015 80. j: Arenaviridae - p. g0015 81. Chapter 170: Lymphocytic Choriomeningitis Virus, Lassa Virus, and the South American Hemorrhagic Fevers (Arenaviruses) - p. g0015 82. k: Retroviridae - p. g0015 83. Chapter 171: Human T-Cell Leukemia Viruses (HTLV-1, HTLV-2) - p. g0015 84. Chapter 172: Human Immunodeficiency Viruses - p. g0015 85. l: Picornaviridae - p. g0015 86. Chapter 173: Introduction to the Human Enteroviruses and Parechoviruses - p. g0015 87. Chapter 174: Poliovirus - p. g0015 88. Chapter 175: Coxsackieviruses, Echoviruses, and Numbered Enteroviruses (EV-A71, EVD-68, EVD-70) - p. g0015 89. Chapter 176: Parechoviruses - p. g0015 90. Chapter 177: Hepatitis A Virus - p. g0015 91. Chapter 178: Rhinovirus - p. g0015 92. iii: Caliciviridae and Other Gastrointestinal - p. g0015 93. Chapter 179: Noroviruses and Sapoviruses (Caliciviruses) - p. g0015 94. Chapter 180: Astroviruses and Picobirnaviruses - p. g0015 95. iv: Unclassified Viruses - p. g0015 96. Chapter 181: Hepatitis E Virus - p. g0015 97. B: Prion Diseases - p. g0015 98. Chapter 182: Prions and Prion Disease of the Central Nervous System (Transmissible Neurodegenerative Diseases) - p. g0015 99. C: Chlamydial Diseases - p. g0015 100. Chapter 183: Chlamydia trachomatis (Trachoma and Urogenital Infections) - p. g0015 101. Chapter 184: Psittacosis (Due to Chlamydia psittaci) - p. g0015 102. Chapter 185: Chlamydia pneumoniae - p. g0015 103. D: Mycoplasma Diseases - p. g0015 104. Chapter 186: Mycoplasma pneumoniae and Atypical Pneumonia - p. g0015 105. Chapter 187: Genital Mycoplasmas: Mycoplasma genitalium, Mycoplasma hominis, and Ureaplasma Species - p. g0015 106. E: Rickettsioses, Ehrlichioses, and Anaplasmoses - p. g0015 107. Chapter 188: Introduction to Rickettsioses, Ehrlichioses, and Anaplasmoses - p. g0015 108. Chapter 189: Rickettsia rickettsii and Other Spotted Fever Group Rickettsiae (Rocky Mountain Spotted Fever and Other Spotted Fevers) - p. g0015 109. Chapter 190: Rickettsia akari (Rickettsialpox) - p. g0015 110. Chapter 191: Coxiella burnetii (Q Fever) - p. g0015 111. Chapter 192: Rickettsia prowazekii (Epidemic or Louse-Borne Typhus) - p. g0015 112. Chapter 193: Rickettsia typhi (Murine Typhus) - p. g0015 113. Chapter 194: Orientia tsutsugamushi (Scrub Typhus) - p. g0015 114. Chapter 195: Ehrlichia chaffeensis (Human Monocytotropic Ehrlichiosis), Anaplasma phagocytophilum (Human Granulocytotropic Anaplasmosis), and Other Anaplasmataceae - p. g0015 115. F: Bacterial Diseases - p. g0015 116. Chapter 196: Introduction to Bacteria and Bacterial Diseases - p. g0015 117. i: Gram-Positive Cocci - p. g0015 118. Chapter 197: Staphylococcus aureus (Including Staphylococcal Toxic Shock Syndrome) - p. g0015 119. Chapter 198: Staphylococcus epidermidis and Other Coagulase-Negative Staphylococci - p. g0015 120. Chapter 199: Classification of Streptococci - p. g0015 121. Chapter 200: Streptococcus pyogenes - p. g0015 122. Chapter 201: Nonsuppurative Poststreptococcal Sequelae: Rheumatic Fever and Glomerulonephritis - p. g0015 123. Chapter 202: Streptococcus pneumoniae - p. g0015 124. Chapter 203: Enterococcus Species, Streptococcus gallolyticus Group, and Leuconostoc Species - p. g0015 125. Chapter 204: Streptococcus agalactiae (Group B Streptococci) - p. g0015 126. Chapter 205: Viridans Streptococci, Nutritionally Variant Streptococci, and Groups C and G Streptococci - p. g0015 127. Chapter 206: Streptococcus anginosus Group - p. g0015 128. ii: Gram-Positive Bacilli - p. g0015 129. Chapter 207: Corynebacterium diphtheriae (Diphtheria) - p. g0015 130. Chapter 208: Other Coryneform Bacteria, Arcanobacterium haemolyticum, and Rhodococci - p. g0015 131. Chapter 209: Listeria monocytogenes - p. g0015 132. Chapter 210: Bacillus anthracis (Anthrax) - p. g0015 133. Chapter 211: Bacillus Species and Related Genera Other Than Bacillus anthracis - p. g0015 134. Chapter 212: Erysipelothrix rhusiopathiae - p. g0015 135. Chapter 213: Whipple Disease - p. g0015 136. iii: Gram-Negative Cocci - p. g0015 137. Chapter 214: Neisseria meningitidis - p. g0015 138. Chapter 215: Neisseria gonorrhoeae (Gonorrhea) - p. g0015 139. Chapter 216: Moraxella catarrhalis, Kingella, and Other Gram-Negative Cocci - p. g0015 140. iv: Gram-Negative Bacilli - p. g0015 141. Chapter 217: Vibrio cholerae - p. g0015 142. Chapter 218: Other Pathogenic Vibrios - p. g0015 143. Chapter 219: Campylobacter jejuni and Related Species - p. g0015 144. Chapter 220: Helicobacter pylori and Other Gastric Helicobacter Species - p. g0015 145. Chapter 221: Enterobacteriaceae - p. g0015 146. Chapter 222: Pseudomonas aeruginosa and Other Pseudomonas Species - p. g0015 147. Chapter 223: Stenotrophomonas maltophilia and Burkholderia cepacia Complex - p. g0015 148. Chapter 224: Burkholderia pseudomallei and Burkholderia mallei: Melioidosis and Glanders - p. g0015 149. Chapter 225: Acinetobacter Species - p. g0015 150. Chapter 226: Salmonella Species - p. g0015 151. Chapter 227: Bacillary Dysentery: Shigella and Enteroinvasive Escherichia coli - p. g0015 152. Chapter 228: Haemophilus Species, Including H. influenzae and H. ducreyi (Chancroid) - p. g0015 153. Chapter 229: Brucellosis (Brucella Species) - p. g0015 154. Chapter 230: Francisella tularensis (Tularemia) - p. g0015 155. Chapter 231: Pasteurella Species - p. g0015 156. Chapter 232: Plague (Yersinia pestis) - p. g0015 157. Chapter 233: Yersinia enterocolitica and Yersinia pseudotuberculosis - p. g0015 158. Chapter 234: Bordetella pertussis - p. g0015 159. Chapter 235: Rat-Bite Fever: Streptobacillus moniliformis and Spirillum minus - p. g0015 160. Chapter 236: Legionnaires’ Disease and Pontiac Fever - p. g0015 161. Chapter 237: Capnocytophaga - p. g0015 162. Chapter 238: Bartonella, Including Cat-Scratch Disease - p. g0015 163. Chapter 239: Klebsiella granulomatis (Donovanosis, Granuloma Inguinale) - p. g0015 164. Chapter 240: Other Gram-Negative and Gram-Variable Bacilli - p. g0015 165. v: Spirochetes - p. g0015 166. Chapter 241: Syphilis (Treponema pallidum) - p. g0015 167. Chapter 242: Endemic Treponematoses - p. g0015 168. Chapter 243: Leptospira Species (Leptospirosis) - p. g0015 169. Chapter 244: Relapsing Fever Caused by Borrelia Species - p. g0015 170. Chapter 245: Lyme Disease (Lyme Borreliosis) Due to Borrelia burgdorferi - p. g0015 171. vi: Anaerobic Bacteria - p. g0015 172. Chapter 246: Anaerobic Infections: General Concepts - p. g0015 173. Chapter 247: Clostridioides difficile (Formerly Clostridium difficile) Infection - p. g0015 174. Chapter 248: Tetanus (Clostridium tetani) - p. g0015 175. Chapter 249: Botulism (Clostridium botulinum) - p. g0015 176. Chapter 250: Diseases Caused by Clostridium - p. g0015 177. Chapter 251: Bacteroides, Prevotella, Porphyromonas, and Fusobacterium Species (and Other Medically Important Anaerobic Gram-Negative Bacilli) - p. g0015 178. Chapter 252: Anaerobic Cocci and Anaerobic Gram-Positive Nonsporulating Bacilli - p. g0015 179. vii: Mycobacterial Diseases - p. g0015 180. Chapter 253: Mycobacterium tuberculosis - p. g0015 181. Chapter 254: Leprosy (Mycobacterium leprae) - p. g0015 182. Chapter 255: Mycobacterium avium Complex - p. g0015 183. Chapter 256: Infections Caused by Nontuberculous Mycobacteria Other Than Mycobacterium avium Complex - p. g0015 184. viii: Higher Bacterial Diseases - p. g0015 185. Chapter 257: Nocardia Species - p. g0015 186. Chapter 258: Agents of Actinomycosis - p. g0015 187. G: Mycoses - p. g0015 188. Chapter 259: Introduction to Mycoses - p. g0015 189. Chapter 260: Candida Species - p. g0015 190. Chapter 261: Aspergillus Species - p. g0015 191. Chapter 262: Agents of Mucormycosis and Entomophthoramycosis - p. g0015 192. Chapter 263: Sporothrix schenckii - p. g0015 193. Chapter 264: Agents of Chromoblastomycosis - p. g0015 194. Chapter 265: Agents of Mycetoma - p. g0015 195. Chapter 266: Cryptococcosis (Cryptococcus neoformans and Cryptococcus gattii) - p. g0015 196. Chapter 267: Histoplasma capsulatum (Histoplasmosis) - p. g0015 197. Chapter 268: Blastomycosis - p. g0015 198. Chapter 269: Coccidioidomycosis (Coccidioides Species) - p. g0015 199. Chapter 270: Dermatophytosis (Ringworm) and Other Superficial Mycoses - p. g0015 200. Chapter 271: Paracoccidioidomycosis - p. g0015 201. Chapter 272: Uncommon Fungi and Related Species - p. g0015 202. Chapter 273: Pneumocystis Species - p. g0015 203. Chapter 274: Microsporidiosis - p. g0015 204. H: Protozoal Diseases - p. g0015 205. Chapter 275: Introduction to Protozoal Diseases - p. g0015 206. Chapter 276: Entamoeba Species, Including Amebic Colitis and Liver Abscess - p. g0015 207. Chapter 277: Free-Living Amebae - p. g0015 208. Chapter 278: Malaria (Plasmodium Species) - p. g0015 209. Chapter 279: Leishmania Species: Visceral (Kala-Azar), Cutaneous, and Mucosal Leishmaniasis - p. g0015 210. Chapter 280: Trypanosoma Species (American Trypanosomiasis, Chagas Disease): Biology of Trypanosomes - p. g0015 211. Chapter 281: Agents of African Trypanosomiasis (Sleeping Sickness) - p. g0015 212. Chapter 282: Toxoplasma gondii - p. g0015 213. Chapter 283: Giardia lamblia - p. g0015 214. Chapter 284: Trichomonas vaginalis - p. g0015 215. Chapter 285: Babesia Species - p. g0015 216. Chapter 286: Cryptosporidiosis (Cryptosporidium Species) - p. g0015 217. Chapter 287: Cyclospora cayetanensis, Cystoisospora belli, Sarcocystis Species, Balantidium coli, and Blastocystis Species - p. g0015 218. I: Diseases Due to Toxic Algae - p. g0015 219. Chapter 288: Human Illness Associated With Harmful Algal Blooms - p. g0015 220. J: Diseases Due to Helminths - p. g0015 221. Chapter 289: Introduction to Helminth Infections - p. g0015 222. Chapter 290: Intestinal Nematodes (Roundworms) - p. g0015 223. Chapter 291: Tissue Nematodes, Including Trichinellosis, Dracunculiasis, Filariasis, Loiasis, and Onchocerciasis - p. g0015 224. Chapter 292: Trematodes (Schistosomes and Liver, Intestinal, and Lung Flukes) - p. g0015 225. Chapter 293: Tapeworms (Cestodes) - p. g0015 226. Chapter 294: Visceral Larva Migrans and Other Uncommon Helminth Infections - p. g0015 227. K: Ectoparasitic Diseases - p. g0015 228. Chapter 295: Introduction to Ectoparasitic Diseases - p. g0015 229. Chapter 296: Lice (Pediculosis) - p. g0015 230. Chapter 297: Scabies - p. g0015 231. Chapter 298: Myiasis and Tungiasis - p. g0015 232. Chapter 299: Mites, Including Chiggers - p. g0015 233. Chapter 300: Ticks, Including Tick Paralysis - p. g0015 234. L: Diseases of Unknown Etiology - p. g0015 235. Chapter 301: Kawasaki Disease - p. g0015 236. IV: Special Problems - p. g0015 237. A: Nosocomial Infections - p. g0015 238. Chapter 302: Infection Prevention and Control in the Health Care Setting - p. g0015 239. Chapter 303: Disinfection, Sterilization, and Control of Hospital Waste - p. g0015 240. Chapter 304: Infections Caused by Percutaneous Intravascular Devices - p. g0015 241. Chapter 305: Nosocomial Pneumonia - p. g0015 242. Chapter 306: Health Care–Associated Urinary Tract Infections - p. g0015 243. Chapter 307: Health Care–Acquired Hepatitis - p. g0015 244. Chapter 308: Transfusion- and Transplantation-Transmitted Infections - p. g0015 245. B: Infections in Special Hosts - p. g0015 246. Chapter 309: Infections in the Immunocompromised Host: General Principles - p. g0015 247. Chapter 310: Prophylaxis and Empirical Therapy of Infection in Cancer Patients - p. g0015 248. Chapter 311: Infections in Recipients of Hematopoietic Stem Cell Transplants - p. g0015 249. Chapter 312: Infections in Solid-Organ Transplant Recipients - p. g0015 250. Chapter 313: Infections in Patients With Spinal Cord Injury - p. g0015 251. Chapter 314: Infections in Older Adults - p. g0015 252. Chapter 315: Infections in Asplenic Patients - p. g0015 253. Chapter 316: Infections in Injection Drug Users - p. g0015 254. Chapter 317: Surgical Site Infections and Antimicrobial Prophylaxis - p. g0015 255. C: Surgical- and Trauma-Related Infections - p. g0015 256. Chapter 318: Burns - p. g0015 257. Chapter 319: Bites - p. g0015 258. D: Immunization - p. g0015 259. Chapter 320: Immunization - p. g0015 260. E: Zoonoses - p. g0015 261. Chapter 321: Zoonoses - p. g0015 262. F: Protection of Travelers - p. g0015 263. Chapter 322: Protection of Travelers - p. g0015 264. Chapter 323: Infections in Returning Travelers - p. g0015 265. Index - p. g0015

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