Some of the more recent efforts in tuberculosis (TB) and trypanosomiasis drug discovery from both Product Development Partnerships (PDPs) and academia are highlighted in this this volume. Drug discovery approaches include both target- and phenotypic whole cell screening- approaches. Regarding the latter, mechanism of action studies through target identification are also illustrated.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Contributors - p. ix 6. Preface - p. xi 7. Chapter One: Tuberculosis - p. xii 8. Chapter Two: Antituberculosis agents: Beyond medicinal chemistry rules - p. 25 9. Chapter Three: Development of MmpL3 inhibitors for tuberculosis treatment - p. 69 10. Chapter Four: Inhibitors of enzymes in the electron transport chain of Mycobacterium tuberculosis - p. 96 11. Chapter Five: Recent advances in the design of inhibitors of mycobacterial transcriptional regulators to boost thioamides anti-tubercular activity and circumvent acquired-resistance - p. 130 12. Chapter Six: Sustainable anti-trypanosomatid drugs: An aspirational goal for medicinal chemistry - p. 152
Some of the more recent efforts in tuberculosis (TB) and trypanosomiasis drug discovery from both Product Development Partnerships (PDPs) and academia are highlighted in this this volume. Drug discovery approaches include both target- and phenotypic whole cell screening- approaches. Regarding the latter, mechanism of action studies through target identification are also illustrated.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Contributors - p. ix 6. Preface - p. xi 7. Chapter One: Tuberculosis - p. xii 8. Chapter Two: Antituberculosis agents: Beyond medicinal chemistry rules - p. 25 9. Chapter Three: Development of MmpL3 inhibitors for tuberculosis treatment - p. 69 10. Chapter Four: Inhibitors of enzymes in the electron transport chain of Mycobacterium tuberculosis - p. 96 11. Chapter Five: Recent advances in the design of inhibitors of mycobacterial transcriptional regulators to boost thioamides anti-tubercular activity and circumvent acquired-resistance - p. 130 12. Chapter Six: Sustainable anti-trypanosomatid drugs: An aspirational goal for medicinal chemistry - p. 152
