Neuropsychiatric Disorders and Epigenetics is a comprehensive reference for the epigenetic basis of most common neuropsychiatric disorders. The volume is organized into chapters representing individual neuropsychiatric disorders, from addition to obesity contributed by leading experts in their respective fields. The epigenetic aspects of each disorder are discussed, in the context of the full range of epigenetic mechanisms including DNA modification, histone post-translational modification, chromatin organization and non-coding RNA. A particular emphasis is placed on potential epigenetic interventions, when the effects of environmental stimuli on epigenetic states is particularly relevant o disease.
Recent discoveries in epigenetic research enabled by epic advances in genomic technologies have positioned the field for broad translation to therapeutic interventions for previously unmanageable disorders Neuropsychiatric disorders represent a prime target of epigenetic interventions as they are highly debilitating, often chronic diseases with enormous costs to society. Thus, this volume will help define epigenetics as a key player in neuropsychiatric disorders, highlighting the full spectrum of epigenetic mechanisms underlying such disorders and introducing the vast range of epigenetic therapies under development.
1. Chapter 1: Introduction to neuropsychiatric disorders and epigenetics - p. xix 2. Chapter 2: Environmental factors and epigenetics of neuropsychiatric disorders - p. 8 3. Chapter 3: Epigenetic biomarkers in neuropsychiatric disorders - p. 33 4. Section II: Epigenetics of Neuropsychiatric Disorders - p. 66 5. Chapter 4: Epigenetics and cognitive disorders—translational aspects - p. 66 6. Chapter 5: Epigenetics in pervasive developmental disorders: translational aspects - p. 91 7. Chapter 6: Epigenetic causes of intellectual disability—the fragile X syndrome paradigm - p. 106 8. Chapter 7: Epigenetics of attention-deficit hyperactivity disorder - p. 127 9. Chapter 8: The epigenetics of brain aging and psychiatric disorders - p. 140 10. Chapter 9: Epigenetics and Down syndrome - p. 162 11. Chapter 10: Epigenetics and multiple sclerosis - p. 184 12. Chapter 11: Epigenetics and migraine - p. 213 13. Chapter 12: The role of epigenetics in the pathophysiology of epilepsy - p. 231 14. Chapter 13: Epigenetic dysregulation in brain tumors and neurodevelopment - p. 260 15. Chapter 14: Epigenetics and cerebrovascular diseases - p. 276 16. Chapter 15: Epigenetics and eating disorders - p. 298 17. Chapter 16: Epigenetics and obesity - p. 307 18. Chapter 17: Epigenetics and drug addiction: translational aspects - p. 334 19. Chapter 18: Epigenetics and alcohol use disorders - p. 360 20. Section III: Summary and Outlook - p. 397 21. Chapter 19: Neuropsychiatric disorders and epigenetics: summary and outlook - p. 397 22. Index - p. 407
Neuropsychiatric Disorders and Epigenetics is a comprehensive reference for the epigenetic basis of most common neuropsychiatric disorders. The volume is organized into chapters representing individual neuropsychiatric disorders, from addition to obesity contributed by leading experts in their respective fields. The epigenetic aspects of each disorder are discussed, in the context of the full range of epigenetic mechanisms including DNA modification, histone post-translational modification, chromatin organization and non-coding RNA. A particular emphasis is placed on potential epigenetic interventions, when the effects of environmental stimuli on epigenetic states is particularly relevant o disease.
Recent discoveries in epigenetic research enabled by epic advances in genomic technologies have positioned the field for broad translation to therapeutic interventions for previously unmanageable disorders Neuropsychiatric disorders represent a prime target of epigenetic interventions as they are highly debilitating, often chronic diseases with enormous costs to society. Thus, this volume will help define epigenetics as a key player in neuropsychiatric disorders, highlighting the full spectrum of epigenetic mechanisms underlying such disorders and introducing the vast range of epigenetic therapies under development.
1. Chapter 1: Introduction to neuropsychiatric disorders and epigenetics - p. xix 2. Chapter 2: Environmental factors and epigenetics of neuropsychiatric disorders - p. 8 3. Chapter 3: Epigenetic biomarkers in neuropsychiatric disorders - p. 33 4. Section II: Epigenetics of Neuropsychiatric Disorders - p. 66 5. Chapter 4: Epigenetics and cognitive disorders—translational aspects - p. 66 6. Chapter 5: Epigenetics in pervasive developmental disorders: translational aspects - p. 91 7. Chapter 6: Epigenetic causes of intellectual disability—the fragile X syndrome paradigm - p. 106 8. Chapter 7: Epigenetics of attention-deficit hyperactivity disorder - p. 127 9. Chapter 8: The epigenetics of brain aging and psychiatric disorders - p. 140 10. Chapter 9: Epigenetics and Down syndrome - p. 162 11. Chapter 10: Epigenetics and multiple sclerosis - p. 184 12. Chapter 11: Epigenetics and migraine - p. 213 13. Chapter 12: The role of epigenetics in the pathophysiology of epilepsy - p. 231 14. Chapter 13: Epigenetic dysregulation in brain tumors and neurodevelopment - p. 260 15. Chapter 14: Epigenetics and cerebrovascular diseases - p. 276 16. Chapter 15: Epigenetics and eating disorders - p. 298 17. Chapter 16: Epigenetics and obesity - p. 307 18. Chapter 17: Epigenetics and drug addiction: translational aspects - p. 334 19. Chapter 18: Epigenetics and alcohol use disorders - p. 360 20. Section III: Summary and Outlook - p. 397 21. Chapter 19: Neuropsychiatric disorders and epigenetics: summary and outlook - p. 397 22. Index - p. 407
