Practical Process Research and Development, Third Edition provides a concise, comprehensive, step-by-step framework to support understanding and implement organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries.
The book has been heavily updated for its third edition, whilst retaining the basic spirit and structure of the first two editions. Half of the cited references were published after the second edition. It describes steps to prepare active compounds in a cost-effective manner. The chapters on safety and workup have been expanded. Continuous flow operations are discussed in a chapter and highlighted throughout the book. It also provides hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection, optimising catalytic reactions, chiral syntheses, troubleshooting, and green chemistry.
Practical Process Research and Development, Third Edition is written primarily for organic chemists as well as chemical engineers. It is well suited for experienced researchers and for those beginning research in industry. It will be useful for drug discovery chemists and for others who want an accessible insight into industrial process R&D.
1. Chapter 1. Introduction to Practical Process Research & Development - p. 1 2. Chapter 2. Process Safety - p. 37 3. Chapter 3. Route Design - p. 73 4. Chapter 4. Reagent Selection - p. 107 5. I Introduction - p. 107 6. II Peptide Coupling - p. 110 7. III Strong Bases - p. 114 8. IV Phase Transfer Catalysis (PTC) - p. 118 9. V Oxidations - p. 124 10. VI Reductions - p. 129 11. VII Reductive Amination and Alkylation alternatives - p. 134 12. VIII Biotransformations - p. 142 13. IX Organocatalysis - p. 147 14. X Photochemistry Applications - p. 149 15. XI Electroorganic Synthesis - p. 151 16. XII Perspective - p. 154 17. XIII Questions to Ponder - p. 155 18. Chapter 5. Solvent Selection - p. 173 19. Chapter 6. Water as Beneficial or Harmful Ingredient - p. 215 20. Chapter 7. Considerations for Scale-Up - p. 233 21. Chapter 8. In-Process Controls and Analyses - p. 255 22. Chapter 9. Process Optimization by Minimizing Impurities - p. 275 23. Chapter 10. Optimizing Organometallic Reactions - p. 315 24. Chapter 11. Workup - p. 347 25. Chapter 12. Purification, Crystallization and Isolation - p. 397 26. Chapter 13. Final Product Form and Impurities - p. 441 27. Chapter 14. Continuous Flow Operations - p. 467 28. Chapter 15. Scale-up Concerns and Process Implementation - p. 499 29. Chapter 16. Troubleshooting, and Summary - p. 511 30. Chapter 17. Some Answers to Questions to Ponder - p. 523 31. Abbreviations - p. 535 32. Index - p. 539
Practical Process Research and Development, Third Edition provides a concise, comprehensive, step-by-step framework to support understanding and implement organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries.
The book has been heavily updated for its third edition, whilst retaining the basic spirit and structure of the first two editions. Half of the cited references were published after the second edition. It describes steps to prepare active compounds in a cost-effective manner. The chapters on safety and workup have been expanded. Continuous flow operations are discussed in a chapter and highlighted throughout the book. It also provides hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection, optimising catalytic reactions, chiral syntheses, troubleshooting, and green chemistry.
Practical Process Research and Development, Third Edition is written primarily for organic chemists as well as chemical engineers. It is well suited for experienced researchers and for those beginning research in industry. It will be useful for drug discovery chemists and for others who want an accessible insight into industrial process R&D.
1. Chapter 1. Introduction to Practical Process Research & Development - p. 1 2. Chapter 2. Process Safety - p. 37 3. Chapter 3. Route Design - p. 73 4. Chapter 4. Reagent Selection - p. 107 5. I Introduction - p. 107 6. II Peptide Coupling - p. 110 7. III Strong Bases - p. 114 8. IV Phase Transfer Catalysis (PTC) - p. 118 9. V Oxidations - p. 124 10. VI Reductions - p. 129 11. VII Reductive Amination and Alkylation alternatives - p. 134 12. VIII Biotransformations - p. 142 13. IX Organocatalysis - p. 147 14. X Photochemistry Applications - p. 149 15. XI Electroorganic Synthesis - p. 151 16. XII Perspective - p. 154 17. XIII Questions to Ponder - p. 155 18. Chapter 5. Solvent Selection - p. 173 19. Chapter 6. Water as Beneficial or Harmful Ingredient - p. 215 20. Chapter 7. Considerations for Scale-Up - p. 233 21. Chapter 8. In-Process Controls and Analyses - p. 255 22. Chapter 9. Process Optimization by Minimizing Impurities - p. 275 23. Chapter 10. Optimizing Organometallic Reactions - p. 315 24. Chapter 11. Workup - p. 347 25. Chapter 12. Purification, Crystallization and Isolation - p. 397 26. Chapter 13. Final Product Form and Impurities - p. 441 27. Chapter 14. Continuous Flow Operations - p. 467 28. Chapter 15. Scale-up Concerns and Process Implementation - p. 499 29. Chapter 16. Troubleshooting, and Summary - p. 511 30. Chapter 17. Some Answers to Questions to Ponder - p. 523 31. Abbreviations - p. 535 32. Index - p. 539
