The announcement that we had decoded the human genome in 2000 ushered in a new and unique era in biomedical research and clinical medicine. This Third Edition of Principles of Gender-Specific Medicine focuses, as in the past two editions, on the essentials of sexual dimorphism in human physiology and pathophysiology, but emphasizes the latest information about molecular biology and genomic science in a variety of disciplines. Thus, this edition is a departure from the previous two; the editor solicited individual manuscripts from innovative scientists in a variety of fields rather than the traditional arrangement of sections devoted to the various subspecialties of medicine edited by section chiefs. Wherever it was available, these authors incorporated the latest information about the impact of the genome and the elements that modify its expression on human physiology and illness. All chapters progress translationally from basic science to the clinical applications of gender-specific therapy and suggest the most important topics for future investigation.
This book is essential reading for all biomedical investigators and medical educators involved in gender-specific medicine. It will also be useful for primary care practitioners who need information about the importance of sex and gender in the prevention, diagnosis and treatment of illness.
Winner of the 2018 PROSE Award in Clinical Medicine from the Association of American Publishers!
1. Principles of Gender-Specific Medicine - p. i 2. Cover - p. i 3. Title Page - p. i 4. Copyright - p. iv 5. Table of Contents - p. iv 6. Dedication - p. v 7. Praise for Principles of Gender-Specific Medicine, 3rd edition - p. vii 8. List of Contributors - p. xvi 9. Foreword - p. xix 10. Foreword - p. xix 11. Chapter 1 Normal and Variant Sex Development - p. 1 12. Chapter 2 Gender Diagnoses - p. 17 13. Chapter 3 Gender Identity in Disorders of Sex Development - p. 27 14. Chapter 4 Female Sexual Function - p. 45 15. Chapter 5 Fertility Treatment and Preservation in Transgender Men and Women - p. 61 16. Chapter 6 Standards of Care for the Health of Transsexual, Transgender, and Gender-Nonconforming People - p. 69 17. Chapter 7 Sex-Dependent and -Independent Mechanisms in External Genitalia Development - p. 77 18. Chapter 8 The Transsexual Adult - p. 91 19. Chapter 9 Sexual and Gender Minority Individuals in Health Care - p. 107 20. Chapter 10 Sex Influences Exist at All Levels of Human Brain Function - p. 121 21. Chapter 11 Sex Differences in the Brain - p. 129 22. Chapter 12 Sexual Dimorphisms in the Nervous System of the Nematode Caenorhabditis elegans - p. 149 23. Chapter 13 Oxytocin and Brain Plasticity - p. 161 24. Chapter 14 Emotion and Gender-Specific Neural Processing in Men and Women - p. 183 25. Chapter 15 Behind the Mask - p. 203 26. Chapter 16 The Significance of Gender in Perinatal Medicine - p. 219 27. Chapter 17 Intrauterine Development of Sex Differences—Fetal Programming - p. 237 28. Chapter 18 Battle of the Sexes - p. 251 29. Chapter 19 All Cells Have a Sex - p. 269 30. Chapter 20 Sex-Specific Implications of Exposure to An Adverse Intrauterine Environment - p. 291 31. Chapter 21 Immune Response—The Impact of Biological Sex and Gender - p. 309 32. Chapter 22 Geoepidemiology and the Impact of Sex on Autoimmune Diseases - p. 323 33. Chapter 23 Gender and Gene Regulation in Human Immunity - p. 335 34. Chapter 24 Sex and Gender Specific Aspects—From Cells to Cardiovascular Disease - p. 341 35. Chapter 25 Estrogen - p. 363 36. Chapter 26 The Sexually Dimorphic Characteristics of the Pathophysiology and Treatment of Atrial Fibrillation - p. 381 37. Chapter 27 Gender Differences in Chronic Obstructive Pulmonary Disease—Current Knowledge and Deficits - p. 391 38. Chapter 28 Cancer - p. 401 39. Chapter 29 An Updated Overview of the Gender-Specific Response to Infection - p. 417 40. Chapter 30 Gender-Based Differences in Mortality in Indian Children Aged 5 to 14 years - p. 435 41. Chapter 31 Consideration of Biological Sex in Translating Regenerative Stem Cell Therapies - p. 443 42. Chapter 32 Adipose-Derived Stem Cells in Regenerative Medicine - p. 459 43. Chapter 33 Sex, Gender, and Pain - p. 481 44. Chapter 34 Sex and Gender Differences in Trauma Victims Presenting for Treatment - p. 497 45. Chapter 35 Women Do Worse Than Men—Gender-Specific Differences in Burn Patients - p. 513 46. Chapter 36 Exercise Physiology in Men and Women - p. 525 47. Chapter 37 Musculoskeletal Complaints in Male and Female Instrumental Musicians - p. 543 48. Chapter 38 Nutritional Genomics and Biological Sex - p. 557 49. Chapter 39 Microbiome - p. 569 50. Chapter 40 Sex and Gender Differences in Sleep Disorders - p. 585 51. Chapter 41 Gender Differences in Bladder and Kidney Cancers - p. 603 52. Chapter 42 The Complex Challenge of Blood Pressure Regulation - p. 611 53. Chapter 43 Gender at the Interface of Renal Aging - p. 621 54. Chapter 44 Gender Differences in Mobility of Elderly - p. 639 55. Chapter 45 Personalized Medicine in Space Flight, Part I - p. 655 56. Chapter 46 Personalized Medicine in Space Flight, Part II - p. 673 57. Chapter 47 Robots and Gender - p. 695 58. Chapter 48 Cyborgs - p. 705 59. Chapter 49 Precision Medicine and Challenges in Research and Clinical Implementation - p. 717 60. Chapter 50 Gender-Specific Medicine in Pharmaceutical Drug Discovery and Development - p. 733 61. Index - p. 743
The announcement that we had decoded the human genome in 2000 ushered in a new and unique era in biomedical research and clinical medicine. This Third Edition of Principles of Gender-Specific Medicine focuses, as in the past two editions, on the essentials of sexual dimorphism in human physiology and pathophysiology, but emphasizes the latest information about molecular biology and genomic science in a variety of disciplines. Thus, this edition is a departure from the previous two; the editor solicited individual manuscripts from innovative scientists in a variety of fields rather than the traditional arrangement of sections devoted to the various subspecialties of medicine edited by section chiefs. Wherever it was available, these authors incorporated the latest information about the impact of the genome and the elements that modify its expression on human physiology and illness. All chapters progress translationally from basic science to the clinical applications of gender-specific therapy and suggest the most important topics for future investigation.
This book is essential reading for all biomedical investigators and medical educators involved in gender-specific medicine. It will also be useful for primary care practitioners who need information about the importance of sex and gender in the prevention, diagnosis and treatment of illness.
Winner of the 2018 PROSE Award in Clinical Medicine from the Association of American Publishers!
1. Principles of Gender-Specific Medicine - p. i 2. Cover - p. i 3. Title Page - p. i 4. Copyright - p. iv 5. Table of Contents - p. iv 6. Dedication - p. v 7. Praise for Principles of Gender-Specific Medicine, 3rd edition - p. vii 8. List of Contributors - p. xvi 9. Foreword - p. xix 10. Foreword - p. xix 11. Chapter 1 Normal and Variant Sex Development - p. 1 12. Chapter 2 Gender Diagnoses - p. 17 13. Chapter 3 Gender Identity in Disorders of Sex Development - p. 27 14. Chapter 4 Female Sexual Function - p. 45 15. Chapter 5 Fertility Treatment and Preservation in Transgender Men and Women - p. 61 16. Chapter 6 Standards of Care for the Health of Transsexual, Transgender, and Gender-Nonconforming People - p. 69 17. Chapter 7 Sex-Dependent and -Independent Mechanisms in External Genitalia Development - p. 77 18. Chapter 8 The Transsexual Adult - p. 91 19. Chapter 9 Sexual and Gender Minority Individuals in Health Care - p. 107 20. Chapter 10 Sex Influences Exist at All Levels of Human Brain Function - p. 121 21. Chapter 11 Sex Differences in the Brain - p. 129 22. Chapter 12 Sexual Dimorphisms in the Nervous System of the Nematode Caenorhabditis elegans - p. 149 23. Chapter 13 Oxytocin and Brain Plasticity - p. 161 24. Chapter 14 Emotion and Gender-Specific Neural Processing in Men and Women - p. 183 25. Chapter 15 Behind the Mask - p. 203 26. Chapter 16 The Significance of Gender in Perinatal Medicine - p. 219 27. Chapter 17 Intrauterine Development of Sex Differences—Fetal Programming - p. 237 28. Chapter 18 Battle of the Sexes - p. 251 29. Chapter 19 All Cells Have a Sex - p. 269 30. Chapter 20 Sex-Specific Implications of Exposure to An Adverse Intrauterine Environment - p. 291 31. Chapter 21 Immune Response—The Impact of Biological Sex and Gender - p. 309 32. Chapter 22 Geoepidemiology and the Impact of Sex on Autoimmune Diseases - p. 323 33. Chapter 23 Gender and Gene Regulation in Human Immunity - p. 335 34. Chapter 24 Sex and Gender Specific Aspects—From Cells to Cardiovascular Disease - p. 341 35. Chapter 25 Estrogen - p. 363 36. Chapter 26 The Sexually Dimorphic Characteristics of the Pathophysiology and Treatment of Atrial Fibrillation - p. 381 37. Chapter 27 Gender Differences in Chronic Obstructive Pulmonary Disease—Current Knowledge and Deficits - p. 391 38. Chapter 28 Cancer - p. 401 39. Chapter 29 An Updated Overview of the Gender-Specific Response to Infection - p. 417 40. Chapter 30 Gender-Based Differences in Mortality in Indian Children Aged 5 to 14 years - p. 435 41. Chapter 31 Consideration of Biological Sex in Translating Regenerative Stem Cell Therapies - p. 443 42. Chapter 32 Adipose-Derived Stem Cells in Regenerative Medicine - p. 459 43. Chapter 33 Sex, Gender, and Pain - p. 481 44. Chapter 34 Sex and Gender Differences in Trauma Victims Presenting for Treatment - p. 497 45. Chapter 35 Women Do Worse Than Men—Gender-Specific Differences in Burn Patients - p. 513 46. Chapter 36 Exercise Physiology in Men and Women - p. 525 47. Chapter 37 Musculoskeletal Complaints in Male and Female Instrumental Musicians - p. 543 48. Chapter 38 Nutritional Genomics and Biological Sex - p. 557 49. Chapter 39 Microbiome - p. 569 50. Chapter 40 Sex and Gender Differences in Sleep Disorders - p. 585 51. Chapter 41 Gender Differences in Bladder and Kidney Cancers - p. 603 52. Chapter 42 The Complex Challenge of Blood Pressure Regulation - p. 611 53. Chapter 43 Gender at the Interface of Renal Aging - p. 621 54. Chapter 44 Gender Differences in Mobility of Elderly - p. 639 55. Chapter 45 Personalized Medicine in Space Flight, Part I - p. 655 56. Chapter 46 Personalized Medicine in Space Flight, Part II - p. 673 57. Chapter 47 Robots and Gender - p. 695 58. Chapter 48 Cyborgs - p. 705 59. Chapter 49 Precision Medicine and Challenges in Research and Clinical Implementation - p. 717 60. Chapter 50 Gender-Specific Medicine in Pharmaceutical Drug Discovery and Development - p. 733 61. Index - p. 743
