Bio-Instructive Scaffolds for Musculoskeletal Tissue Engineering and Regenerative Medicine explores musculoskeletal tissue growth and development across populations, ranging from elite athletes to the elderly. The regeneration and reparation of musculoskeletal tissues present the unique challenges of requiring both the need to withstand distinct forces applied to the body and ability to support cell populations.
The book is separated into sections based on tissue type, including bone, cartilage, ligament and tendon, muscle, and musculoskeletal tissue interfaces. Within each tissue type, the chapters are subcategorized into strategies focused on cells, hydrogels, polymers, and other materials (i.e. ceramics and metals) utilized in musculoskeletal tissue engineering applications.
In each chapter, the relationships that exist amongst the strategy, stem cell differentiation and somatic cell specialization at the intracellular level are emphasized. Examples include intracellular signaling through growth factor delivery, geometry sensing of the surrounding network, and cell signaling that stems from altered population dynamics.
1. Part I: Introduction - p. xii 2. Chapter 1: Bio-Instructive Cues in Scaffolds for Musculoskeletal Tissue Engineering and Regenerative Medicine - p. xii 3. Chapter 2: Functionalizing With Bioactive Peptides to Generate Bio-Instructive Scaffolds - p. 35 4. Part II: Bone - p. 52 5. Chapter 3: Bio-Instructive Scaffolds for Bone Regeneration - p. 52 6. Part III: Tendon/Ligament - p. 84 7. Chapter 4: Bio-Instructive Scaffolds for Tendon/Ligament Regeneration - p. 84 8. Part IV: Cartilage - p. 112 9. Chapter 5: Bio-Instructive Scaffolds for Cartilage Regeneration - p. 112 10. Part V: Muscle - p. 135 11. Chapter 6: Ultrastructure and Biomechanics of Skeletal Muscle ECM: Implications in Tissue Regeneration - p. 135 12. Chapter 7: Bio-Instructive Scaffolds for Muscle Regeneration: NonCrosslinked Polymers - p. 160 13. Chapter 8: Bio-Instructive Scaffolds for Skeletal Muscle Regeneration: Conductive Materials - p. 186 14. Part VI: Musculoskeletal Interfaces - p. 199 15. Chapter 9: Bio-Instructive Scaffolds for Musculoskeletal Interfaces - p. 199 16. Index - p. 235
Bio-Instructive Scaffolds for Musculoskeletal Tissue Engineering and Regenerative Medicine explores musculoskeletal tissue growth and development across populations, ranging from elite athletes to the elderly. The regeneration and reparation of musculoskeletal tissues present the unique challenges of requiring both the need to withstand distinct forces applied to the body and ability to support cell populations.
The book is separated into sections based on tissue type, including bone, cartilage, ligament and tendon, muscle, and musculoskeletal tissue interfaces. Within each tissue type, the chapters are subcategorized into strategies focused on cells, hydrogels, polymers, and other materials (i.e. ceramics and metals) utilized in musculoskeletal tissue engineering applications.
In each chapter, the relationships that exist amongst the strategy, stem cell differentiation and somatic cell specialization at the intracellular level are emphasized. Examples include intracellular signaling through growth factor delivery, geometry sensing of the surrounding network, and cell signaling that stems from altered population dynamics.
1. Part I: Introduction - p. xii 2. Chapter 1: Bio-Instructive Cues in Scaffolds for Musculoskeletal Tissue Engineering and Regenerative Medicine - p. xii 3. Chapter 2: Functionalizing With Bioactive Peptides to Generate Bio-Instructive Scaffolds - p. 35 4. Part II: Bone - p. 52 5. Chapter 3: Bio-Instructive Scaffolds for Bone Regeneration - p. 52 6. Part III: Tendon/Ligament - p. 84 7. Chapter 4: Bio-Instructive Scaffolds for Tendon/Ligament Regeneration - p. 84 8. Part IV: Cartilage - p. 112 9. Chapter 5: Bio-Instructive Scaffolds for Cartilage Regeneration - p. 112 10. Part V: Muscle - p. 135 11. Chapter 6: Ultrastructure and Biomechanics of Skeletal Muscle ECM: Implications in Tissue Regeneration - p. 135 12. Chapter 7: Bio-Instructive Scaffolds for Muscle Regeneration: NonCrosslinked Polymers - p. 160 13. Chapter 8: Bio-Instructive Scaffolds for Skeletal Muscle Regeneration: Conductive Materials - p. 186 14. Part VI: Musculoskeletal Interfaces - p. 199 15. Chapter 9: Bio-Instructive Scaffolds for Musculoskeletal Interfaces - p. 199 16. Index - p. 235
