Features, Transmission, Detection, and Case Studies in COVID-19 examines the effects of the virus on the body, as well as its transmission and clinical profile. This volume begins with an introduction to the virus and its pathogenesis, transmission, and avoidance, followed by sections on pulmonary and cardiovascular effects, obesity, diabetes, the liver, detection issues, and biomarkers. Vaccines and treatment are also discussed. Specific case studies covered include hypoxia, acute kidney injury, pneumonia, and neurological effects. This volume is relevant for all clinicians and scientists working to ensure the best outcomes for patients with COVID-19.
1. Features, Transmission, Detection, and Case Studies in COVID-19 - p. i 2. Cover - p. i 3. Title Page - p. iii 4. Copyright Page - p. iv 5. Table of Contents - p. iv 6. Contributors - p. xix 7. Preface - p. xxv 8. Chapter 1 Involvement of body systems by Coronavirus Disease 2019 (COVID-19) - p. 3 9. Chapter 2 Early warning of SARS-CoV-2 infection - p. 13 10. Chapter 3 Mobile phones and their use to study dynamics of the COVID-19 pandemic - p. 25 11. Chapter 4 Cis regulatory elements: A novel communication route between the host cell and the SARS-CoV-2 genome - p. 41 12. Chapter 5 SARS-CoV-2 ORF8: Structure, evolution, molecular function, and its contribution to the pathogenicity of the virus - p. 53 13. Chapter 6 SARS-CoV-2 spike protein binding ligands and its application in COVID-19 therapeutics - p. 65 14. Chapter 7 SARS-CoV-2 bulldozes the autophagy pathway and unhinges mitochondrial quality control thereby driving neurodegeneration—A hypothesis - p. 79 15. Chapter 8 The Omicron variant of SARS-CoV-2 - p. 97 16. Chapter 9 Monitoring SARS-CoV-2 spread in hospitals and health facilities - p. 111 17. Chapter 10 Computational analysis of mutations in SARS-CoV-2 variants spike protein and protein interactions - p. 123 18. Chapter 11 Airborne transmission of SARS-CoV-2 - p. 141 19. Chapter 12 Reducing transmission of SARS-CoV-2 with face masks: Its potential protective effects - p. 153 20. Chapter 13 Digital twin of ventilation system against COVID-19 transmission and infection risk - p. 163 21. Chapter 14 Pets and SARS-CoV-2: Their role in disease epidemiology - p. 171 22. Chapter 15 SARS-CoV-2 transmission in dental practice - p. 179 23. Chapter 16 SARS-CoV-2 compared with influenza and respiratory syncytial virus in terms of vertical transmission - p. 191 24. Chapter 17 Reducing droplets and aerosols in the surgical setting and applications to the COVID-19 pandemic - p. 201 25. Chapter 18 SARS-CoV motion dynamics: Linking in droplet size - p. 213 26. Chapter 19 Ventilation and airborne particles in classrooms: Implications from the COVID-19 pandemic - p. 221 27. Chapter 20 Indoor transmission of the SARS-CoV-2 virus through aerosols emitted by e-cigarettes - p. 237 28. Chapter 21 The impact of COVID-19 on first responders - p. 255 29. Chapter 22 COVID-19 and suspected drug-induced liver injury - p. 267 30. Chapter 23 Pulmonary fibrosis in COVID-19 - p. 287 31. Chapter 24 The effect of SARS-CoV-2 infection on cancer: Clinical correlation and potential pathological mechanism - p. 297 32. Chapter 25 Severe SARS-CoV-2, platelet-endothelium interactions, and cardiovascular injury - p. 309 33. Chapter 26 Cardiometabolic syndrome and COVID-19: Pathophysiological aspects - p. 321 34. Chapter 27 COVID-19 and type 1 and 2 diabetes: An overview - p. 333 35. Chapter 28 COVID-19 and older adults: An overview - p. 343 36. Chapter 29 COVID-19 and male fertility - p. 353 37. Chapter 30 COVID-19 and obesity: An overview - p. 365 38. Chapter 31 COVID-19 vaccines and their impact: An overview - p. 379 39. Chapter 32 Exploring the promise of COVID-19 vaccines: A review of preclinical studies - p. 389 40. Chapter 33 Drugs actively being investigated for use in COVID-19 - p. 401 41. Chapter 34 The biology of neutralizing antibody therapy with REGEN-COV - p. 415 42. Chapter 35 The intensive care unit and percutaneous tracheostomy in patients with coronavirus disease 2019 - p. 427 43. Chapter 36 Cardiac effects of drugs and vaccines used to treat and prevent COVID-19 - p. 439 44. Chapter 37 COVID-19 pandemic and isolation: Impact on sleep - p. 453 45. Chapter 38 Strategies in the COVID-19 pandemic: Disinfection of gloved hands - p. 465 46. Chapter 39 In silico studies of established antivirals targeting the SARS-CoV-2 RNA-dependent RNA polymerase - p. 475 47. Chapter 40 The COVID-19 cytokine storm and its immunomodulatory treatment - p. 489 48. Chapter 41 Safety and efficacy of nebulization for reducing the intensity of viral load and clinical manifestations in patients with COVID-19 - p. 507 49. Chapter 42 Bronchoalveolar lavage (BAL) and use in detection of SARS-CoV-2 - p. 517 50. Chapter 43 SARS-CoV-2 testing and vaccination among people who use drugs - p. 523 51. Chapter 44 Homocysteine as a biomarker in COVID-19 - p. 529 52. Chapter 45 Assessment of smell and taste in COVID-19 - p. 539 53. Chapter 46 S-gene analysis: RT-PCR and Sanger sequencing applied to SARS-CoV-2 virus - p. 551 54. Chapter 47 False-negative results in screening for SARS-CoV-2 - p. 563 55. Chapter 48 Sample pooling and SARS-CoV-2 assays - p. 575 56. Chapter 49 Biomarkers of invasive mechanical ventilation in obesity and metabolic syndrome in patients with COVID-19 - p. 587 57. Chapter 50 Hypoxia and heart-lung interactions in COVID-19: The significance of right heart dysfunction and shunt - p. 603 58. Chapter 51 Ulnar nerve dysfunction as COVID-19 sequelae - p. 617 59. Chapter 52 Case study: Coronavirus disease 2019 and acute kidney injury - p. 625 60. Chapter 53 Case study: The detection and treatment of an anterior pneumothorax in a patient with Coronavirus Disease 2019 pneumonia - p. 633 61. Chapter 54 Proposal and demonstration of a survey method for the prevention of airborne transmission: Case studies in healthcare and welfare facilities - p. 641 62. Chapter 55 Recommended resources for the features, transmission, and detection of Coronavirus Disease 2019 (COVID-19) - p. 651 63. Index - p. 659
Features, Transmission, Detection, and Case Studies in COVID-19 examines the effects of the virus on the body, as well as its transmission and clinical profile. This volume begins with an introduction to the virus and its pathogenesis, transmission, and avoidance, followed by sections on pulmonary and cardiovascular effects, obesity, diabetes, the liver, detection issues, and biomarkers. Vaccines and treatment are also discussed. Specific case studies covered include hypoxia, acute kidney injury, pneumonia, and neurological effects. This volume is relevant for all clinicians and scientists working to ensure the best outcomes for patients with COVID-19.
1. Features, Transmission, Detection, and Case Studies in COVID-19 - p. i 2. Cover - p. i 3. Title Page - p. iii 4. Copyright Page - p. iv 5. Table of Contents - p. iv 6. Contributors - p. xix 7. Preface - p. xxv 8. Chapter 1 Involvement of body systems by Coronavirus Disease 2019 (COVID-19) - p. 3 9. Chapter 2 Early warning of SARS-CoV-2 infection - p. 13 10. Chapter 3 Mobile phones and their use to study dynamics of the COVID-19 pandemic - p. 25 11. Chapter 4 Cis regulatory elements: A novel communication route between the host cell and the SARS-CoV-2 genome - p. 41 12. Chapter 5 SARS-CoV-2 ORF8: Structure, evolution, molecular function, and its contribution to the pathogenicity of the virus - p. 53 13. Chapter 6 SARS-CoV-2 spike protein binding ligands and its application in COVID-19 therapeutics - p. 65 14. Chapter 7 SARS-CoV-2 bulldozes the autophagy pathway and unhinges mitochondrial quality control thereby driving neurodegeneration—A hypothesis - p. 79 15. Chapter 8 The Omicron variant of SARS-CoV-2 - p. 97 16. Chapter 9 Monitoring SARS-CoV-2 spread in hospitals and health facilities - p. 111 17. Chapter 10 Computational analysis of mutations in SARS-CoV-2 variants spike protein and protein interactions - p. 123 18. Chapter 11 Airborne transmission of SARS-CoV-2 - p. 141 19. Chapter 12 Reducing transmission of SARS-CoV-2 with face masks: Its potential protective effects - p. 153 20. Chapter 13 Digital twin of ventilation system against COVID-19 transmission and infection risk - p. 163 21. Chapter 14 Pets and SARS-CoV-2: Their role in disease epidemiology - p. 171 22. Chapter 15 SARS-CoV-2 transmission in dental practice - p. 179 23. Chapter 16 SARS-CoV-2 compared with influenza and respiratory syncytial virus in terms of vertical transmission - p. 191 24. Chapter 17 Reducing droplets and aerosols in the surgical setting and applications to the COVID-19 pandemic - p. 201 25. Chapter 18 SARS-CoV motion dynamics: Linking in droplet size - p. 213 26. Chapter 19 Ventilation and airborne particles in classrooms: Implications from the COVID-19 pandemic - p. 221 27. Chapter 20 Indoor transmission of the SARS-CoV-2 virus through aerosols emitted by e-cigarettes - p. 237 28. Chapter 21 The impact of COVID-19 on first responders - p. 255 29. Chapter 22 COVID-19 and suspected drug-induced liver injury - p. 267 30. Chapter 23 Pulmonary fibrosis in COVID-19 - p. 287 31. Chapter 24 The effect of SARS-CoV-2 infection on cancer: Clinical correlation and potential pathological mechanism - p. 297 32. Chapter 25 Severe SARS-CoV-2, platelet-endothelium interactions, and cardiovascular injury - p. 309 33. Chapter 26 Cardiometabolic syndrome and COVID-19: Pathophysiological aspects - p. 321 34. Chapter 27 COVID-19 and type 1 and 2 diabetes: An overview - p. 333 35. Chapter 28 COVID-19 and older adults: An overview - p. 343 36. Chapter 29 COVID-19 and male fertility - p. 353 37. Chapter 30 COVID-19 and obesity: An overview - p. 365 38. Chapter 31 COVID-19 vaccines and their impact: An overview - p. 379 39. Chapter 32 Exploring the promise of COVID-19 vaccines: A review of preclinical studies - p. 389 40. Chapter 33 Drugs actively being investigated for use in COVID-19 - p. 401 41. Chapter 34 The biology of neutralizing antibody therapy with REGEN-COV - p. 415 42. Chapter 35 The intensive care unit and percutaneous tracheostomy in patients with coronavirus disease 2019 - p. 427 43. Chapter 36 Cardiac effects of drugs and vaccines used to treat and prevent COVID-19 - p. 439 44. Chapter 37 COVID-19 pandemic and isolation: Impact on sleep - p. 453 45. Chapter 38 Strategies in the COVID-19 pandemic: Disinfection of gloved hands - p. 465 46. Chapter 39 In silico studies of established antivirals targeting the SARS-CoV-2 RNA-dependent RNA polymerase - p. 475 47. Chapter 40 The COVID-19 cytokine storm and its immunomodulatory treatment - p. 489 48. Chapter 41 Safety and efficacy of nebulization for reducing the intensity of viral load and clinical manifestations in patients with COVID-19 - p. 507 49. Chapter 42 Bronchoalveolar lavage (BAL) and use in detection of SARS-CoV-2 - p. 517 50. Chapter 43 SARS-CoV-2 testing and vaccination among people who use drugs - p. 523 51. Chapter 44 Homocysteine as a biomarker in COVID-19 - p. 529 52. Chapter 45 Assessment of smell and taste in COVID-19 - p. 539 53. Chapter 46 S-gene analysis: RT-PCR and Sanger sequencing applied to SARS-CoV-2 virus - p. 551 54. Chapter 47 False-negative results in screening for SARS-CoV-2 - p. 563 55. Chapter 48 Sample pooling and SARS-CoV-2 assays - p. 575 56. Chapter 49 Biomarkers of invasive mechanical ventilation in obesity and metabolic syndrome in patients with COVID-19 - p. 587 57. Chapter 50 Hypoxia and heart-lung interactions in COVID-19: The significance of right heart dysfunction and shunt - p. 603 58. Chapter 51 Ulnar nerve dysfunction as COVID-19 sequelae - p. 617 59. Chapter 52 Case study: Coronavirus disease 2019 and acute kidney injury - p. 625 60. Chapter 53 Case study: The detection and treatment of an anterior pneumothorax in a patient with Coronavirus Disease 2019 pneumonia - p. 633 61. Chapter 54 Proposal and demonstration of a survey method for the prevention of airborne transmission: Case studies in healthcare and welfare facilities - p. 641 62. Chapter 55 Recommended resources for the features, transmission, and detection of Coronavirus Disease 2019 (COVID-19) - p. 651 63. Index - p. 659
