Handbook of the Biology of Aging, Ninth Edition, provides a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology. The book focuses on the trend of ‘big data’ approaches in the biological sciences, presenting new strategies to analyze, interpret and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and metabolomics methodologies applied to aging related problems. Sections cover longevity pathways and interventions that modulate aging, innovative tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, and much more.
1. Introduction - p. 77 2. Sirtuin-driven lifespan extension in invertebrates - p. 78 3. Sirtuin enzymatic activity - p. 79 4. Sirtuins and mammalian longevity - p. 83 5. Genetic variants of human sirtuin genes - p. 86 6. Sirtuins as modulators of responses to caloric restriction - p. 91 7. Roles for sirtuins in diverse disease states - p. 94 8. Cancer - p. 94 9. Metabolic syndrome - p. 104 10. Cardiovascular dysfunction - p. 111 11. Inflammatory signaling - p. 116 12. Neurodegenerative disease - p. 118 13. Pharmacological modulation of sirtuin activity - p. 121 14. Conclusions - p. 125 15. Acknowledgments - p. 126 16. References - p. 127 17. Chapter 6. Integrative genomics of aging - p. 151 18. Chapter 7. Thermogenesis and aging - p. 173 19. Chapter 8. Yeast as a model organism for aging research - p. 183 20. Chapter 9. Model organisms (invertebrates) - p. 199 21. Chapter 10. NIA Interventions Testing Program: A collaborative approach for investigating interventions to promote healthy aging - p. 219 22. Chapter 11. Aging in nonhuman primates - p. 237 23. Part II: Organ systems in humans and other animals, human health and longevity - p. 244 24. Chapter 12. Senotherapeutics: Experimental therapy of cellular senescence - p. 251 25. Chapter 13. The role of neurosensory systems in the modulation of aging - p. 285 26. Chapter 14. Aging of the sensory systems: hearing and vision disorders - p. 297 27. Chapter 15. Cardiac aging - p. 323 28. Chapter 16. The aging immune system: Dysregulation, compensatory mechanisms, and prospects for intervention - p. 345 29. Chapter 17. Microbiome changes in aging - p. 367 30. Chapter 18. Lipidomics of aging - p. 391 31. Chapter 19. Trends in morbidity, healthy life expectancy, and the compression of morbidity - p. 405 32. Author Index - p. 415 33. A - p. 415 34. B - p. 416 35. C - p. 417 36. D - p. 419 37. E - p. 420 38. F - p. 420 39. G - p. 421 40. H - p. 422 41. I - p. 424 42. J - p. 424 43. K - p. 424 44. L - p. 426 45. M - p. 428 46. N - p. 429 47. O - p. 430 48. P - p. 431 49. Q - p. 432 50. R - p. 432 51. S - p. 433 52. T - p. 435 53. U - p. 436 54. V - p. 436 55. W - p. 436 56. X - p. 438 57. Y - p. 438 58. Z - p. 438 59. Subject Index - p. 441
Handbook of the Biology of Aging, Ninth Edition, provides a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology. The book focuses on the trend of ‘big data’ approaches in the biological sciences, presenting new strategies to analyze, interpret and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and metabolomics methodologies applied to aging related problems. Sections cover longevity pathways and interventions that modulate aging, innovative tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, and much more.
1. Introduction - p. 77 2. Sirtuin-driven lifespan extension in invertebrates - p. 78 3. Sirtuin enzymatic activity - p. 79 4. Sirtuins and mammalian longevity - p. 83 5. Genetic variants of human sirtuin genes - p. 86 6. Sirtuins as modulators of responses to caloric restriction - p. 91 7. Roles for sirtuins in diverse disease states - p. 94 8. Cancer - p. 94 9. Metabolic syndrome - p. 104 10. Cardiovascular dysfunction - p. 111 11. Inflammatory signaling - p. 116 12. Neurodegenerative disease - p. 118 13. Pharmacological modulation of sirtuin activity - p. 121 14. Conclusions - p. 125 15. Acknowledgments - p. 126 16. References - p. 127 17. Chapter 6. Integrative genomics of aging - p. 151 18. Chapter 7. Thermogenesis and aging - p. 173 19. Chapter 8. Yeast as a model organism for aging research - p. 183 20. Chapter 9. Model organisms (invertebrates) - p. 199 21. Chapter 10. NIA Interventions Testing Program: A collaborative approach for investigating interventions to promote healthy aging - p. 219 22. Chapter 11. Aging in nonhuman primates - p. 237 23. Part II: Organ systems in humans and other animals, human health and longevity - p. 244 24. Chapter 12. Senotherapeutics: Experimental therapy of cellular senescence - p. 251 25. Chapter 13. The role of neurosensory systems in the modulation of aging - p. 285 26. Chapter 14. Aging of the sensory systems: hearing and vision disorders - p. 297 27. Chapter 15. Cardiac aging - p. 323 28. Chapter 16. The aging immune system: Dysregulation, compensatory mechanisms, and prospects for intervention - p. 345 29. Chapter 17. Microbiome changes in aging - p. 367 30. Chapter 18. Lipidomics of aging - p. 391 31. Chapter 19. Trends in morbidity, healthy life expectancy, and the compression of morbidity - p. 405 32. Author Index - p. 415 33. A - p. 415 34. B - p. 416 35. C - p. 417 36. D - p. 419 37. E - p. 420 38. F - p. 420 39. G - p. 421 40. H - p. 422 41. I - p. 424 42. J - p. 424 43. K - p. 424 44. L - p. 426 45. M - p. 428 46. N - p. 429 47. O - p. 430 48. P - p. 431 49. Q - p. 432 50. R - p. 432 51. S - p. 433 52. T - p. 435 53. U - p. 436 54. V - p. 436 55. W - p. 436 56. X - p. 438 57. Y - p. 438 58. Z - p. 438 59. Subject Index - p. 441
