Histone Modifications in Therapy provides an in-depth analysis of the role of histone mechanisms in major diseases and the promise of targeting histone modifications for disease prevention and treatment. Here, researchers, clinicians and students will discover a thorough, evidence-based discussion of the biology of histones, the diseases engaged by aberrant histone modifications, and pathways with therapeutic potential. Expert chapter addresses the role of histone modifications across a variety of disorders, including cancer, neuropsychiatric, neurodegenerative, cardiac, metabolic, infectious, bacterial, autoimmune and inflammatory disorders, among others. In relation to these disease types, histone modifications are discussed, both as mechanisms of prevention and possible treatment.
A concluding chapter brings together future perspectives for targeting histone modifications in therapy and next steps in research.
1. Cover image - p. page_i 2. Title page - p. page_i 3. Table of Contents - p. page_i 4. Copyright - p. page_iv 5. Contributors - p. page_xi 6. Editors biography - p. page_xv 7. Preface - p. page_xvii 8. Chapter 1: Histone modifications in diseases - p. page_1 9. Section I: Targeting histone modifications for cancer treatment - p. page_15 10. Chapter 2: HDAC inhibitors in cancer therapy - p. page_19 11. Chapter 3: HAT inhibitors in cancer therapy - p. page_51 12. Chapter 4: Targeting DOT1L for mixed-lineage rearranged leukemia - p. page_81 13. Chapter 5: BET mechanisms in cancer - p. page_101 14. Chapter 6: Histone demethylase inhibitors and their potential in cancer treatment - p. page_143 15. Chapter 7: Targeting chromatin remodelers in urological tumors - p. page_179 16. Section II: Targeting histone modifications for infectious disease - p. page_213 17. Chapter 8: The therapeutic potential of epigenetic manipulation during infectious diseases - p. page_217 18. Chapter 9: Targeting histone deacetylases for bacterial infections - p. page_237 19. Chapter 10: Targeting histone epigenetics to control viral infections - p. page_255 20. Section III: Targeting histone modifications for treating other pathologies - p. page_292 21. Chapter 11: Targeting histone modifications in psychotic disorders - p. page_295 22. Chapter 12: Epigenetic treatment of neurodegenerative disorders - p. page_311 23. Chapter 13: Histone modification as a potential preventative and therapeutic approach for cardiovascular disease - p. page_337 24. Chapter 14: The potentiality of histone deacetylase inhibitors for diabetes and obesity - p. page_361 25. Chapter 15: Targeting histone modifications in cancer immunotherapy - p. page_373 26. Chapter 16: Epigenetic drug development for autoimmune and inflammatory diseases - p. page_395 27. Chapter 17: Present and future perspectives for targeting histone modifications in therapy - p. page_415 28. Index - p. page_459
Histone Modifications in Therapy provides an in-depth analysis of the role of histone mechanisms in major diseases and the promise of targeting histone modifications for disease prevention and treatment. Here, researchers, clinicians and students will discover a thorough, evidence-based discussion of the biology of histones, the diseases engaged by aberrant histone modifications, and pathways with therapeutic potential. Expert chapter addresses the role of histone modifications across a variety of disorders, including cancer, neuropsychiatric, neurodegenerative, cardiac, metabolic, infectious, bacterial, autoimmune and inflammatory disorders, among others. In relation to these disease types, histone modifications are discussed, both as mechanisms of prevention and possible treatment.
A concluding chapter brings together future perspectives for targeting histone modifications in therapy and next steps in research.
1. Cover image - p. page_i 2. Title page - p. page_i 3. Table of Contents - p. page_i 4. Copyright - p. page_iv 5. Contributors - p. page_xi 6. Editors biography - p. page_xv 7. Preface - p. page_xvii 8. Chapter 1: Histone modifications in diseases - p. page_1 9. Section I: Targeting histone modifications for cancer treatment - p. page_15 10. Chapter 2: HDAC inhibitors in cancer therapy - p. page_19 11. Chapter 3: HAT inhibitors in cancer therapy - p. page_51 12. Chapter 4: Targeting DOT1L for mixed-lineage rearranged leukemia - p. page_81 13. Chapter 5: BET mechanisms in cancer - p. page_101 14. Chapter 6: Histone demethylase inhibitors and their potential in cancer treatment - p. page_143 15. Chapter 7: Targeting chromatin remodelers in urological tumors - p. page_179 16. Section II: Targeting histone modifications for infectious disease - p. page_213 17. Chapter 8: The therapeutic potential of epigenetic manipulation during infectious diseases - p. page_217 18. Chapter 9: Targeting histone deacetylases for bacterial infections - p. page_237 19. Chapter 10: Targeting histone epigenetics to control viral infections - p. page_255 20. Section III: Targeting histone modifications for treating other pathologies - p. page_292 21. Chapter 11: Targeting histone modifications in psychotic disorders - p. page_295 22. Chapter 12: Epigenetic treatment of neurodegenerative disorders - p. page_311 23. Chapter 13: Histone modification as a potential preventative and therapeutic approach for cardiovascular disease - p. page_337 24. Chapter 14: The potentiality of histone deacetylase inhibitors for diabetes and obesity - p. page_361 25. Chapter 15: Targeting histone modifications in cancer immunotherapy - p. page_373 26. Chapter 16: Epigenetic drug development for autoimmune and inflammatory diseases - p. page_395 27. Chapter 17: Present and future perspectives for targeting histone modifications in therapy - p. page_415 28. Index - p. page_459
