A volume in the popular Pattern Recognition Series, Practical Hepatic Pathology: A Diagnostic Approach features completely updated and reorganized content, resulting in a truly practical guide to understanding liver pathology. Dr. Romil Saxena presents interpretation of liver biopsies according to a pattern-based approach that begins with recognition of the predominant histological pattern of injury, followed by identification of secondary features and appropriate work-up that lead you away from pitfalls to the best diagnosis.
1. Instructions for online access - p. 722 2. Cover image - p. ii 3. Title page - p. ii 4. Table of Contents - p. iii 5. Series Page - p. i 6. Copyright - p. iv 7. Dedication - p. v 8. Contributors - p. vii 9. Series Preface - p. xi 10. Preface - p. xiii 11. Acknowledgments - p. xv 12. Pattern-Based Approach to Diagnosis - p. xix 13. Virtual Slide Box - p. li 14. Section I. Basic Concepts in Liver Pathology - p. lxiv 15. 1. Microscopic Anatomy, Basic Terms, and Elemental Lesions - p. 3 16. Section II. Clinical, Laboratory, and Radiologic Features of Liver Disease - p. 29 17. 2. Clinical Features of Liver Disease - p. 33 18. 3. Laboratory Tests in Liver Disease - p. 43 19. 4. Investigative Imaging of the Liver - p. 55 20. Section III. Liver Diseases of Childhood - p. 66 21. 5. Liver Diseases of Childhood - p. 69 22. Section IV. Metabolic Diseases of the Liver - p. 87 23. 6. Medical Genetics and Biochemistry in Diagnosis and Management - p. 91 24. 7. Histologic Patterns of Metabolic Liver Diseases - p. 101 25. 8. Liver in Wilson Disease - p. 125 26. 9. Liver Disease in Alpha-1 Antitrypsin Deficiency - p. 133 27. 10. Liver Disease in Cystic Fibrosis - p. 143 28. 11. Liver Disease in Iron Overload - p. 151 29. 12. Nonalcoholic Fatty Liver Disease - p. 167 30. Definitions and Synonyms - p. 168 31. Incidence and Demographics - p. 168 32. Clinical Manifestations - p. 169 33. Radiology - p. 169 34. Gross Pathology - p. 170 35. Microscopic Pathology - p. 170 36. Grading and Staging - p. 176 37. Differential Diagnosis - p. 179 38. Nonalcoholic Fatty Liver Disease Outside the Context of Metabolic Syndrome - p. 179 39. Ancillary Diagnostic Tests - p. 182 40. Genetics - p. 182 41. Treatment and Prognosis - p. 183 42. Section V. Infectious Diseases of the Liver - p. 187 43. 13. Acute Viral Hepatitis - p. 191 44. 14. Hepatitis B - p. 211 45. 15. Hepatitis C - p. 223 46. 16. Chronic Hepatitis: Grading and Staging - p. 233 47. 17. Human Immunodeficiency Virus Infection of the Liver - p. 247 48. 18. Nonviral Infections of the Liver - p. 265 49. Section VI. Granulomatous Diseases of the Liver - p. 286 50. 19. Hepatic Granulomas: Differential Diagnosis - p. 289 51. 20. Hepatic Sarcoidosis - p. 301 52. Section VII. Autoimmune Hepatitis - p. 305 53. 21. Autoimmune Hepatitis and Overlap Syndromes - p. 309 54. Section VIII. Drug- and Toxin-Induced Liver Injury - p. 315 55. 22. Metabolism of Drugs and Xenobiotics - p. 319 56. 23. Liver Injury Due to Drugs and Herbal Agents - p. 327 57. Brief Historical Overview - p. 327 58. Incidence and Demographics - p. 328 59. Clinical Manifestations - p. 330 60. Microscopic Pathology - p. 331 61. Grading and Staging - p. 364 62. Differential Diagnosis - p. 365 63. Establishing Causality - p. 365 64. Ancillary Diagnostic Studies - p. 366 65. Genetics - p. 367 66. Treatment and Prognosis - p. 367 67. Figure Acknowledgments - p. 368 68. 24. Alcohol-Induced Liver Disease - p. 371 69. Incidence and Demographics - p. 372 70. Clinical Manifestations - p. 372 71. Noninvasive Assessment of Alcoholic Liver Disease - p. 373 72. Gross Pathology - p. 373 73. Microscopic Pathology - p. 373 74. Histologic Variants - p. 380 75. Grading and Staging - p. 382 76. Role of Liver Biopsy - p. 382 77. Focal Liver Lesions in Alcoholic Liver Disease - p. 382 78. Differential Diagnosis - p. 383 79. Interactions with Other Liver Diseases - p. 384 80. Genetics - p. 384 81. Treatment and Prognosis - p. 385 82. Section IX. Disorders of the Bile Ducts, Bile Formation, and Secretion - p. 390 83. 25. Fibrocystic Liver Diseases - p. 393 84. 26. Primary Biliary Cholangitis - p. 409 85. 27. Primary Sclerosing Cholangitis - p. 423 86. 28. Loss of Intrahepatic Bile Ducts - p. 433 87. 29. Intrahepatic Cholestasis - p. 445 88. Section X. Vascular Disorders of the Liver - p. 464 89. 30. Vascular Disorders of the Liver - p. 467 90. Section XI. Tumors and Tumor-like Lesions of the Liver - p. 483 91. 31. Premalignant and Early Malignant Hepatocellular Lesions in Chronic Hepatitis/Cirrhosis - p. 487 92. 32. Benign Hepatocellular Tumors - p. 507 93. 33. Hepatocellular Carcinoma - p. 529 94. 34. Benign and Malignant Tumors of Bile Ducts - p. 545 95. 35. Liver Tumors of Childhood - p. 555 96. 36. Miscellaneous Liver Tumors and Tumor-like Lesions - p. 583 97. Section XII. Concepts in Liver Pathology - p. 601 98. 37. Clinical Aspects of Liver Transplantation - p. 605 99. 38. Pathology of Liver Transplantation - p. 629 100. Evaluation of Donor Biopsies - p. 630 101. Preservation–Reperfusion Injury - p. 633 102. Rejection - p. 634 103. Central Perivenulitis - p. 642 104. Recurrent Diseases - p. 643 105. De Novo Diseases - p. 653 106. Posttransplant Lymphoproliferative Disease - p. 655 107. Surgical Complications - p. 655 108. Infections - p. 656 109. Changes in Late Protocol Biopsies - p. 658 110. Section XIII. Evolving Concepts in Liver Pathology - p. 662 111. 39. Biphenotypic Primary Liver Carcinoma - p. 665 112. 40. Regression of Liver Fibrosis: From Myth to Reality - p. 671 113. 41. Cirrhosis: A Term in Need of a Makeover - p. 679 114. Index - p. 687
A volume in the popular Pattern Recognition Series, Practical Hepatic Pathology: A Diagnostic Approach features completely updated and reorganized content, resulting in a truly practical guide to understanding liver pathology. Dr. Romil Saxena presents interpretation of liver biopsies according to a pattern-based approach that begins with recognition of the predominant histological pattern of injury, followed by identification of secondary features and appropriate work-up that lead you away from pitfalls to the best diagnosis.
1. Instructions for online access - p. 722 2. Cover image - p. ii 3. Title page - p. ii 4. Table of Contents - p. iii 5. Series Page - p. i 6. Copyright - p. iv 7. Dedication - p. v 8. Contributors - p. vii 9. Series Preface - p. xi 10. Preface - p. xiii 11. Acknowledgments - p. xv 12. Pattern-Based Approach to Diagnosis - p. xix 13. Virtual Slide Box - p. li 14. Section I. Basic Concepts in Liver Pathology - p. lxiv 15. 1. Microscopic Anatomy, Basic Terms, and Elemental Lesions - p. 3 16. Section II. Clinical, Laboratory, and Radiologic Features of Liver Disease - p. 29 17. 2. Clinical Features of Liver Disease - p. 33 18. 3. Laboratory Tests in Liver Disease - p. 43 19. 4. Investigative Imaging of the Liver - p. 55 20. Section III. Liver Diseases of Childhood - p. 66 21. 5. Liver Diseases of Childhood - p. 69 22. Section IV. Metabolic Diseases of the Liver - p. 87 23. 6. Medical Genetics and Biochemistry in Diagnosis and Management - p. 91 24. 7. Histologic Patterns of Metabolic Liver Diseases - p. 101 25. 8. Liver in Wilson Disease - p. 125 26. 9. Liver Disease in Alpha-1 Antitrypsin Deficiency - p. 133 27. 10. Liver Disease in Cystic Fibrosis - p. 143 28. 11. Liver Disease in Iron Overload - p. 151 29. 12. Nonalcoholic Fatty Liver Disease - p. 167 30. Definitions and Synonyms - p. 168 31. Incidence and Demographics - p. 168 32. Clinical Manifestations - p. 169 33. Radiology - p. 169 34. Gross Pathology - p. 170 35. Microscopic Pathology - p. 170 36. Grading and Staging - p. 176 37. Differential Diagnosis - p. 179 38. Nonalcoholic Fatty Liver Disease Outside the Context of Metabolic Syndrome - p. 179 39. Ancillary Diagnostic Tests - p. 182 40. Genetics - p. 182 41. Treatment and Prognosis - p. 183 42. Section V. Infectious Diseases of the Liver - p. 187 43. 13. Acute Viral Hepatitis - p. 191 44. 14. Hepatitis B - p. 211 45. 15. Hepatitis C - p. 223 46. 16. Chronic Hepatitis: Grading and Staging - p. 233 47. 17. Human Immunodeficiency Virus Infection of the Liver - p. 247 48. 18. Nonviral Infections of the Liver - p. 265 49. Section VI. Granulomatous Diseases of the Liver - p. 286 50. 19. Hepatic Granulomas: Differential Diagnosis - p. 289 51. 20. Hepatic Sarcoidosis - p. 301 52. Section VII. Autoimmune Hepatitis - p. 305 53. 21. Autoimmune Hepatitis and Overlap Syndromes - p. 309 54. Section VIII. Drug- and Toxin-Induced Liver Injury - p. 315 55. 22. Metabolism of Drugs and Xenobiotics - p. 319 56. 23. Liver Injury Due to Drugs and Herbal Agents - p. 327 57. Brief Historical Overview - p. 327 58. Incidence and Demographics - p. 328 59. Clinical Manifestations - p. 330 60. Microscopic Pathology - p. 331 61. Grading and Staging - p. 364 62. Differential Diagnosis - p. 365 63. Establishing Causality - p. 365 64. Ancillary Diagnostic Studies - p. 366 65. Genetics - p. 367 66. Treatment and Prognosis - p. 367 67. Figure Acknowledgments - p. 368 68. 24. Alcohol-Induced Liver Disease - p. 371 69. Incidence and Demographics - p. 372 70. Clinical Manifestations - p. 372 71. Noninvasive Assessment of Alcoholic Liver Disease - p. 373 72. Gross Pathology - p. 373 73. Microscopic Pathology - p. 373 74. Histologic Variants - p. 380 75. Grading and Staging - p. 382 76. Role of Liver Biopsy - p. 382 77. Focal Liver Lesions in Alcoholic Liver Disease - p. 382 78. Differential Diagnosis - p. 383 79. Interactions with Other Liver Diseases - p. 384 80. Genetics - p. 384 81. Treatment and Prognosis - p. 385 82. Section IX. Disorders of the Bile Ducts, Bile Formation, and Secretion - p. 390 83. 25. Fibrocystic Liver Diseases - p. 393 84. 26. Primary Biliary Cholangitis - p. 409 85. 27. Primary Sclerosing Cholangitis - p. 423 86. 28. Loss of Intrahepatic Bile Ducts - p. 433 87. 29. Intrahepatic Cholestasis - p. 445 88. Section X. Vascular Disorders of the Liver - p. 464 89. 30. Vascular Disorders of the Liver - p. 467 90. Section XI. Tumors and Tumor-like Lesions of the Liver - p. 483 91. 31. Premalignant and Early Malignant Hepatocellular Lesions in Chronic Hepatitis/Cirrhosis - p. 487 92. 32. Benign Hepatocellular Tumors - p. 507 93. 33. Hepatocellular Carcinoma - p. 529 94. 34. Benign and Malignant Tumors of Bile Ducts - p. 545 95. 35. Liver Tumors of Childhood - p. 555 96. 36. Miscellaneous Liver Tumors and Tumor-like Lesions - p. 583 97. Section XII. Concepts in Liver Pathology - p. 601 98. 37. Clinical Aspects of Liver Transplantation - p. 605 99. 38. Pathology of Liver Transplantation - p. 629 100. Evaluation of Donor Biopsies - p. 630 101. Preservation–Reperfusion Injury - p. 633 102. Rejection - p. 634 103. Central Perivenulitis - p. 642 104. Recurrent Diseases - p. 643 105. De Novo Diseases - p. 653 106. Posttransplant Lymphoproliferative Disease - p. 655 107. Surgical Complications - p. 655 108. Infections - p. 656 109. Changes in Late Protocol Biopsies - p. 658 110. Section XIII. Evolving Concepts in Liver Pathology - p. 662 111. 39. Biphenotypic Primary Liver Carcinoma - p. 665 112. 40. Regression of Liver Fibrosis: From Myth to Reality - p. 671 113. 41. Cirrhosis: A Term in Need of a Makeover - p. 679 114. Index - p. 687
