The Autoimmune Diseases, Sixth Edition, emphasizes the "3 P’s" of 21st Century medicine: precision, prediction and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ("omics") coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients. Chapters emphasize the immunologic basis of the disease as well as the use of immunologic diagnostic methods and treatments.
The book also covers several cross-cutting issues related to the recognition and treatment of autoimmune diseases, including chapters on the measurement of autoantibodies and T cells, the use of biomarkers as early predictors of disease, and new methods of treatment.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. List of Contributors - p. xvii 7. Acknowledgment - p. xxiii 8. Part I: General Considerations - p. pgxxiii 9. Chapter 1. Autoimmune Disease: Reflections and Projections - p. 3 10. Chapter 2. Autoimmunity: A History of the Early Struggle for Recognition - p. 9 11. Chapter 3. General Features of Autoimmune Disease - p. 17 12. Chapter 4. Innate and Adaptive Systems of Immunity - p. 45 13. Part-II: Adaptive Immunity and Autoimmune Disease—T & B Cells - p. 59 14. Chapter 5. Immunological Tolerance—T Cells - p. 65 15. Chapter 6. T Cells and Their Subsets in Autoimmunity - p. 91 16. Chapter 7. The Role of Invariant Natural Killer T Cells in Autoimmune Diseases - p. 117 17. Chapter 8. B-Cell Development: How to Become One of the Chosen Ones - p. 155 18. Chapter 9. B Cell Activation and B Cell Tolerance - p. 171 19. Part III: Cells and Molecules of the Immune System - p. 184 20. Chapter 10. Macrophages and Autoimmunity - p. 191 21. Chapter 11. Dendritic Cells in Autoimmune Disease - p. 213 22. Chapter 12. Natural Killer Cells - p. 229 23. Chapter 13. Granulocytes: Neutrophils, Basophils, Eosinophils - p. 243 24. Chapter 14. The Roles and Contributions of the Complement System in the Pathophysiology of Autoimmune Diseases - p. 263 25. Chapter 15. Cytokines, Their Receptors and Signals - p. 275 26. Chapter 16. Cell Death and Autoimmune Disease - p. 291 27. Chapter 17. Autophagy in Autoimmunity - p. 305 28. Chapter 18. Effector Mechanisms in Autoimmunity - p. 319 29. Chapter 19. Diet, the Gut Microbiome, and Autoimmune Diseases - p. 331 30. Part IV: Initiators of Autoimmune Disease - p. 340 31. Chapter 20. Noninfectious Environmental Agents and Autoimmunity - p. 345 32. Chapter 21. Microbial Infection as a Trigger of T-Cell Autoimmunity - p. 363 33. Chapter 22. Autoimmune Diseases: The Role for Vaccines - p. 375 34. Chapter 23. Genetic Predisposition, Humans - p. 383 35. Chapter 24. Sexual Dimorphism in the Immune System - p. 419 36. Chapter 25. Epigenetics of Autoimmune Diseases - p. 429 37. Chapter 26. Genetic Predisposition to Autoimmune Diseases Conferred by the Major Histocompatibility Complex: Utility of Animal Models - p. 467 38. Part V: Models of Autoimmune Disease - p. 485 39. Chapter 27. Animal Models of Organ-Specific Autoimmune Disease - p. 493 40. Chapter 28. Autoimmunity in Primary Immunodeficiency Disorders - p. 513 41. Chapter 29. Animal Models: Systemic Autoimmune Diseases - p. 533 42. Part VI: Multisystem Autoimmune Diseases - p. 545 43. Chapter 30. Systemic Lupus Erythematosus - p. 555 44. Chapter 31. Systemic Sclerosis (Scleroderma) - p. 575 45. Chapter 32. Antiphospholipid Syndrome - p. 607 46. Chapter 33. Sjogren’s Syndrome - p. 635 47. Chapter 34. Rheumatoid Arthritis - p. 659 48. Chapter 35. Juvenile Idiopathic Arthritis - p. 675 49. Chapter 36. Spondyloarthritides - p. 691 50. Chapter 37. The Autoimmune Myopathies - p. 703 51. Chapter 38. Immunoglobulin G4-Related Disease - p. 715 52. Part VII: Organ Specific Autoimmune Diseases - p. 725 53. Section 1: Endocrine - p. 725 54. Chapter 39. Polyendocrine Syndromes - p. 731 55. Chapter 40. Thyroid Disease - p. 749 56. Chapter 41. Autoimmune (Type 1) Diabetes - p. 769 57. Chapter 42. Adrenalitis - p. 789 58. Chapter 43. Autoimmune Hypophysitis - p. 815 59. Section 2: Gastrointestiol Diseases - p. 828 60. Chapter 44. Autoimmune Gastritis and Pernicious Anemia - p. 833 61. Chapter 45. Celiac Disease - p. 849 62. Chapter 46. Inflammatory Bowel Disease - p. 871 63. Section 3: Blood Diseases - p. 890 64. Chapter 47. Autoimmune Hemolytic Anemia - p. 897 65. Chapter 48. Immune Thrombocytopenia: A Complex Autoimmune Disease - p. 911 66. Chapter 49. Acquired Aplastic Anemia - p. 923 67. Chapter 50. Autoimmune Clotting Dysfunction - p. 935 68. Section 4: Neurological Diseases - p. 949 69. Chapter 51. Multiple Sclerosis - p. 961 70. Chapter 52. Peripheral Neuropathies - p. 987 71. Chapter 53. Myasthenia Gravis and Related Disorders - p. 1011 72. Chapter 54. Ocular Disease - p. 1035 73. Chapter 55. Immune-Mediated Inner Ear Disease - p. 1051 74. Chapter 56. Autoimmune and Autoantibody-Associated Encephalomyelopathies - p. 1067 75. Section 5: Liver Diseases - p. 1099 76. Chapter 57. Hepatitis - p. 1117 77. Chapter 58. Primary Biliary Cholangitis - p. 1149 78. Chapter 59. Autoimmune Pancreatitis and Immunoglobulin G4–Related Disease - p. 1173 79. Section 6: Skin & Sexual Organ Diseases - p. 1183 80. Chapter 60. Autoimmune Bullous Skin Diseases: Pemphigus and Pemphigoid - p. 1191 81. Chapter 61. Nonbullous Skin Diseases: Alopecia Areata, Vitiligo, Psoriasis, and Urticaria - p. 1211 82. Chapter 62. Autoimmune Orchitis and Autoimmune Oophoritis - p. 1235 83. Section 7: Heart, Lung and Kidney Diseases - p. 1246 84. Chapter 63. Rheumatic Fever and Rheumatic Heart Disease - p. 1255 85. Chapter 64. Myocarditis and Dilated Cardiomyopathy - p. 1269 86. Chapter 65. Necrotizing Arteritis and Small-Vessel Vasculitis - p. 1285 87. Chapter 66. Large and Medium-Vessel Vasculitides - p. 1313 88. Chapter 67. Idiopathic and Autoimmune Interstitial Lung Disease - p. 1335 89. Chapter 68. Autoimmune Diseases in the Kidney - p. 1355 90. Part VIII: Management - p. 1363 91. Chapter 69. Autoantibody Assays: Performance, Interpretation, and Standardization - p. 1369 92. Chapter 70. Prevention of Autoimmune Disease: The Type 1 Diabetes Paradigm - p. 1391 93. Chapter 71. Treatment of Autoimmune Disease: Established Therapies - p. 1415 94. Chapter 72. Emerging Biological and Molecular Therapies in Autoimmune Disease - p. 1437 95. Part IX: Miscellaneous - p. 1451 96. Chapter 73. Cameos: Candidates and Curiosities - p. 1461 97. Index - p. 1475
The Autoimmune Diseases, Sixth Edition, emphasizes the "3 P’s" of 21st Century medicine: precision, prediction and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ("omics") coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients. Chapters emphasize the immunologic basis of the disease as well as the use of immunologic diagnostic methods and treatments.
The book also covers several cross-cutting issues related to the recognition and treatment of autoimmune diseases, including chapters on the measurement of autoantibodies and T cells, the use of biomarkers as early predictors of disease, and new methods of treatment.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. List of Contributors - p. xvii 7. Acknowledgment - p. xxiii 8. Part I: General Considerations - p. pgxxiii 9. Chapter 1. Autoimmune Disease: Reflections and Projections - p. 3 10. Chapter 2. Autoimmunity: A History of the Early Struggle for Recognition - p. 9 11. Chapter 3. General Features of Autoimmune Disease - p. 17 12. Chapter 4. Innate and Adaptive Systems of Immunity - p. 45 13. Part-II: Adaptive Immunity and Autoimmune Disease—T & B Cells - p. 59 14. Chapter 5. Immunological Tolerance—T Cells - p. 65 15. Chapter 6. T Cells and Their Subsets in Autoimmunity - p. 91 16. Chapter 7. The Role of Invariant Natural Killer T Cells in Autoimmune Diseases - p. 117 17. Chapter 8. B-Cell Development: How to Become One of the Chosen Ones - p. 155 18. Chapter 9. B Cell Activation and B Cell Tolerance - p. 171 19. Part III: Cells and Molecules of the Immune System - p. 184 20. Chapter 10. Macrophages and Autoimmunity - p. 191 21. Chapter 11. Dendritic Cells in Autoimmune Disease - p. 213 22. Chapter 12. Natural Killer Cells - p. 229 23. Chapter 13. Granulocytes: Neutrophils, Basophils, Eosinophils - p. 243 24. Chapter 14. The Roles and Contributions of the Complement System in the Pathophysiology of Autoimmune Diseases - p. 263 25. Chapter 15. Cytokines, Their Receptors and Signals - p. 275 26. Chapter 16. Cell Death and Autoimmune Disease - p. 291 27. Chapter 17. Autophagy in Autoimmunity - p. 305 28. Chapter 18. Effector Mechanisms in Autoimmunity - p. 319 29. Chapter 19. Diet, the Gut Microbiome, and Autoimmune Diseases - p. 331 30. Part IV: Initiators of Autoimmune Disease - p. 340 31. Chapter 20. Noninfectious Environmental Agents and Autoimmunity - p. 345 32. Chapter 21. Microbial Infection as a Trigger of T-Cell Autoimmunity - p. 363 33. Chapter 22. Autoimmune Diseases: The Role for Vaccines - p. 375 34. Chapter 23. Genetic Predisposition, Humans - p. 383 35. Chapter 24. Sexual Dimorphism in the Immune System - p. 419 36. Chapter 25. Epigenetics of Autoimmune Diseases - p. 429 37. Chapter 26. Genetic Predisposition to Autoimmune Diseases Conferred by the Major Histocompatibility Complex: Utility of Animal Models - p. 467 38. Part V: Models of Autoimmune Disease - p. 485 39. Chapter 27. Animal Models of Organ-Specific Autoimmune Disease - p. 493 40. Chapter 28. Autoimmunity in Primary Immunodeficiency Disorders - p. 513 41. Chapter 29. Animal Models: Systemic Autoimmune Diseases - p. 533 42. Part VI: Multisystem Autoimmune Diseases - p. 545 43. Chapter 30. Systemic Lupus Erythematosus - p. 555 44. Chapter 31. Systemic Sclerosis (Scleroderma) - p. 575 45. Chapter 32. Antiphospholipid Syndrome - p. 607 46. Chapter 33. Sjogren’s Syndrome - p. 635 47. Chapter 34. Rheumatoid Arthritis - p. 659 48. Chapter 35. Juvenile Idiopathic Arthritis - p. 675 49. Chapter 36. Spondyloarthritides - p. 691 50. Chapter 37. The Autoimmune Myopathies - p. 703 51. Chapter 38. Immunoglobulin G4-Related Disease - p. 715 52. Part VII: Organ Specific Autoimmune Diseases - p. 725 53. Section 1: Endocrine - p. 725 54. Chapter 39. Polyendocrine Syndromes - p. 731 55. Chapter 40. Thyroid Disease - p. 749 56. Chapter 41. Autoimmune (Type 1) Diabetes - p. 769 57. Chapter 42. Adrenalitis - p. 789 58. Chapter 43. Autoimmune Hypophysitis - p. 815 59. Section 2: Gastrointestiol Diseases - p. 828 60. Chapter 44. Autoimmune Gastritis and Pernicious Anemia - p. 833 61. Chapter 45. Celiac Disease - p. 849 62. Chapter 46. Inflammatory Bowel Disease - p. 871 63. Section 3: Blood Diseases - p. 890 64. Chapter 47. Autoimmune Hemolytic Anemia - p. 897 65. Chapter 48. Immune Thrombocytopenia: A Complex Autoimmune Disease - p. 911 66. Chapter 49. Acquired Aplastic Anemia - p. 923 67. Chapter 50. Autoimmune Clotting Dysfunction - p. 935 68. Section 4: Neurological Diseases - p. 949 69. Chapter 51. Multiple Sclerosis - p. 961 70. Chapter 52. Peripheral Neuropathies - p. 987 71. Chapter 53. Myasthenia Gravis and Related Disorders - p. 1011 72. Chapter 54. Ocular Disease - p. 1035 73. Chapter 55. Immune-Mediated Inner Ear Disease - p. 1051 74. Chapter 56. Autoimmune and Autoantibody-Associated Encephalomyelopathies - p. 1067 75. Section 5: Liver Diseases - p. 1099 76. Chapter 57. Hepatitis - p. 1117 77. Chapter 58. Primary Biliary Cholangitis - p. 1149 78. Chapter 59. Autoimmune Pancreatitis and Immunoglobulin G4–Related Disease - p. 1173 79. Section 6: Skin & Sexual Organ Diseases - p. 1183 80. Chapter 60. Autoimmune Bullous Skin Diseases: Pemphigus and Pemphigoid - p. 1191 81. Chapter 61. Nonbullous Skin Diseases: Alopecia Areata, Vitiligo, Psoriasis, and Urticaria - p. 1211 82. Chapter 62. Autoimmune Orchitis and Autoimmune Oophoritis - p. 1235 83. Section 7: Heart, Lung and Kidney Diseases - p. 1246 84. Chapter 63. Rheumatic Fever and Rheumatic Heart Disease - p. 1255 85. Chapter 64. Myocarditis and Dilated Cardiomyopathy - p. 1269 86. Chapter 65. Necrotizing Arteritis and Small-Vessel Vasculitis - p. 1285 87. Chapter 66. Large and Medium-Vessel Vasculitides - p. 1313 88. Chapter 67. Idiopathic and Autoimmune Interstitial Lung Disease - p. 1335 89. Chapter 68. Autoimmune Diseases in the Kidney - p. 1355 90. Part VIII: Management - p. 1363 91. Chapter 69. Autoantibody Assays: Performance, Interpretation, and Standardization - p. 1369 92. Chapter 70. Prevention of Autoimmune Disease: The Type 1 Diabetes Paradigm - p. 1391 93. Chapter 71. Treatment of Autoimmune Disease: Established Therapies - p. 1415 94. Chapter 72. Emerging Biological and Molecular Therapies in Autoimmune Disease - p. 1437 95. Part IX: Miscellaneous - p. 1451 96. Chapter 73. Cameos: Candidates and Curiosities - p. 1461 97. Index - p. 1475
