This issue features internationally renowned experts who have provided their expertise on a variety of topics related to the importance of vitamin D. It was not until feed back loops were identified between Vitamin D production and parathyroid hormone, phosphate that it earned its place as a true endocrine hormone. Current social and economic conditions have brought it back into the limelight with outbreaks of rickets and osteomalacia even in developed countries. However its complex regulation, together with the identification and characterization of the vitamin D receptor and its role in influencing multiple genetic pathways and function has heralded a new era highlighting its importance in health and disease. This includes its role in auto immune diseases such as multiple sclerosis, diabetes mellitus, cancer especially breast and prostate, skin, neurological and cognitive disorders and infectious diseases such as tuberculosis. We now know that adequate levels of vitamin D it is important in preventing falls and fracture. The need for supplementation and the amount recommended has also changed considerably from what we previously considered sufficient. The ongoing development of selective active analogs of vitamin D targeted to specific organs and function leads to the exciting possibility of improving outcomes of diseases associated with vitamin D regulation.
1. Cover image - p. 1 2. Title Page - p. 2 3. Table of Contents - p. 3 4. Contributors - p. 4 5. Forthcoming Issues - p. 5 6. Preface - p. 6 7. Vitamin D: Metabolism - p. 7 8. The Vitamin D Receptor: New Paradigms for the Regulation of Gene Expression by 1,25-Dihydroxyvitamin D3 - p. 13 9. Assessment and Interpretation of Circulating 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D in the Clinical Environment - p. 22 10. Low Vitamin D Status: Definition, Prevalence, Consequences, and Correction - p. 32 11. Maternal Vitamin D Status: Implications for the Development of Infantile Nutritional Rickets - p. 38 12. Osteomalacia as a Result of Vitamin D Deficiency - p. 49 13. Genetic Disorders and Defects in Vitamin D Action - p. 54 14. Vitamin D and Fracture Prevention - p. 62 15. Vitamin D in Kidney Disease: Pathophysiology and the Utility of Treatment - p. 66 16. Vitamin D and the Immune System: New Perspectives on an Old Theme - p. 71 17. Vitamin D: Extraskeletal Health - p. 80 18. The Role of Vitamin D in Cancer Prevention and Treatment - p. 90 19. Vitamin D and Diabetes - p. 102 20. Vitamin D Analogs - p. 118 21. Index - p. 132
This issue features internationally renowned experts who have provided their expertise on a variety of topics related to the importance of vitamin D. It was not until feed back loops were identified between Vitamin D production and parathyroid hormone, phosphate that it earned its place as a true endocrine hormone. Current social and economic conditions have brought it back into the limelight with outbreaks of rickets and osteomalacia even in developed countries. However its complex regulation, together with the identification and characterization of the vitamin D receptor and its role in influencing multiple genetic pathways and function has heralded a new era highlighting its importance in health and disease. This includes its role in auto immune diseases such as multiple sclerosis, diabetes mellitus, cancer especially breast and prostate, skin, neurological and cognitive disorders and infectious diseases such as tuberculosis. We now know that adequate levels of vitamin D it is important in preventing falls and fracture. The need for supplementation and the amount recommended has also changed considerably from what we previously considered sufficient. The ongoing development of selective active analogs of vitamin D targeted to specific organs and function leads to the exciting possibility of improving outcomes of diseases associated with vitamin D regulation.
1. Cover image - p. 1 2. Title Page - p. 2 3. Table of Contents - p. 3 4. Contributors - p. 4 5. Forthcoming Issues - p. 5 6. Preface - p. 6 7. Vitamin D: Metabolism - p. 7 8. The Vitamin D Receptor: New Paradigms for the Regulation of Gene Expression by 1,25-Dihydroxyvitamin D3 - p. 13 9. Assessment and Interpretation of Circulating 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D in the Clinical Environment - p. 22 10. Low Vitamin D Status: Definition, Prevalence, Consequences, and Correction - p. 32 11. Maternal Vitamin D Status: Implications for the Development of Infantile Nutritional Rickets - p. 38 12. Osteomalacia as a Result of Vitamin D Deficiency - p. 49 13. Genetic Disorders and Defects in Vitamin D Action - p. 54 14. Vitamin D and Fracture Prevention - p. 62 15. Vitamin D in Kidney Disease: Pathophysiology and the Utility of Treatment - p. 66 16. Vitamin D and the Immune System: New Perspectives on an Old Theme - p. 71 17. Vitamin D: Extraskeletal Health - p. 80 18. The Role of Vitamin D in Cancer Prevention and Treatment - p. 90 19. Vitamin D and Diabetes - p. 102 20. Vitamin D Analogs - p. 118 21. Index - p. 132
